The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Alteration of Neuronal Firing Properties after In Vivo Experience in a FosGFP Transgenic Mouse
Open accessAbstract
Identifying the cells and circuits that underlie perception, behavior, and learning is a central goal of contemporary neuroscience. Although techniques such as lesion analysis, functional magnetic resonance imaging, 2-deoxyglucose studies, and induction of gene expression have been helpful in determining the brain areas responsible for particular functions, these methods are technically limited. Currently, there is no method that allows for the identification and electrophysiological characterization of individual neurons that are associated with a particular function in living tissue. We developed a strain of transgenic mice in which the expression of the green fluorescent protein (GFP) is controlled by the promoter of the activity-dependent gene c-fos. These mice enable an in vivo or ex vivo characterization of the cells and synapses that are activated by particular pharmacological and behavioral manipulations. Cortical and subcortical fosGFP expression could be induced in a regionally restricted manner after specific activation of neuronal ensembles. Using the fosGFP mice to identify discrete cortical areas, we found that neurons in sensory-spared areas rapidly regulate action potential threshold and spike frequency to decrease excitability. This method will enhance our ability to study the way neuronal networks are activated and changed by both experience and pharmacological manipulations. In addition, because activated neurons can be functionally characterized, this tool may enable the development of better pharmaceuticals that directly affect the neurons involved in disease states.
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Citations
Cites
Expression of c- fos Protein in Brain: Metabolic Mapping at the Cellular Level
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Self-citationStimulus-specific combinatorial functionality of neuronal c-fos enhancers
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A Brief Introduction to the Transduction of Neural Activity into Fos Signal
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“In this mouse, Fos-GFP fusion protein under c-fos promoter is expressed after strong neural activation (Barth et al., 2004).”
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Gateway reflex: neural activation-mediated immune cell gateways in the central nervous system
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Metadata
- Authors
- Barth, A. L., Gerkin, R. C., & Dean, K. L.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2004-07-21
- Volume
- 24
- Issue
- 29
- Pages
- 6466-6475
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2132708818
- Cited by
- 256
- References
- 2
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
