Dense functional and molecular readout of a circuit hub in sensory cortex
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Abstract
Although single-cell transcriptomics of the neocortex has uncovered more than 300 putative cell types, whether this molecular classification predicts distinct functional roles is unclear. We combined two-photon calcium imaging with spatial transcriptomics to functionally and molecularly investigate cortical circuits. We characterized behavior-related responses across major neuronal subclasses in layers 2 or 3 of the primary somatosensory cortex as mice performed a tactile working memory task. We identified an excitatory intratelencephalic cell type, Baz1a, that exhibits high tactile feature selectivity. Baz1a neurons homeostatically maintain stimulus responsiveness during altered experience and show persistent enrichment of subsets of immediately early genes. Functional and anatomical connectivity reveals that Baz1a neurons residing in upper portions of layers 2 or 3 preferentially innervate somatostatin-expressing inhibitory neurons. This motif defines a circuit hub that orchestrates local sensory processing in superficial layers of the neocortex.
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In mouse somatosensory cortex, higher sensory response is seen in a specific L2/3 IT excitatory transcriptomic type.
“in somatosensory cortex, higher sensory response is seen in a specific L2/3 IT excitatory transcriptomic type (Condylis et al., 2022).”
From What is a cell type and how to define it? (2022) · cites this paper as Condylis et al., 2022
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Self-citationDense Functional and Molecular Readout of a Circuit Hub in Sensory CortexPreprint
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What is a cell type and how to define it?
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- Authors
- Condylis, C., Ghanbari, A., Manjrekar, N., Bistrong, K., Yao, S., Yao, Z., Nguyen, T. N., Zeng, H., Tasic, B., & Chen, J. L.
- Affiliations
- Boston University (US)
- Allen Institute for Brain Science (US)
- Corresponding author
- Chen, Jerry L.
- ORCID
- Venue
- Science
- Published
- 2022-01-07
- Volume
- 375
- Issue
- 6576
- Pages
- eabl5981-eabl5981
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC9255671
- OpenAlex
- W4220679383
- Cited by
- 81
- References
- 68
- Citations by year
- 2026: 15 · 2025: 20 · 2024: 17 · 2023: 18 · 2022: 10 · 2021: 1
- FWCI
- 7.18
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Science (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Harvard NeuroDiscovery Center
- Richard and Susan Smith Family Foundation
- Whitehall Foundation
- National Alliance for Research on Schizophrenia and Depression
- National Institutes of Health
- National Institute of Mental Health (U19MH114830)
- National Institute of Neurological Disorders and Stroke (R01NS109965, F31NS111896, DP2NS111134)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- primary somatosensory cortex, tactile working memory, intratelencephalic neurons, somatostatin interneurons, layer 2/3, neuronal cell types, immediate early genes, functional connectivity, structural connectivity, neocortical circuits
- MeSH terms
- Animals, Behavior, Animal, Calcium, Memory, Short-Term, Mice, Inbred C57BL, Mice, Transgenic, Nerve Net, Neural Inhibition, Neurons, Somatosensory Cortex, Touch, Vibrissae, Gene Expression, Genes, fos, Mice, Transcriptome
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