A Role for the Macaque Anterior Cingulate Gyrus in Social Valuation
Abstract
Complex human social interaction is disrupted when the frontal lobe is damaged in disease, and in extreme cases patients are described as having acquired sociopathy. We compared, in macaques, the effects of lesions in subdivisions of the anterior cingulate and the orbitofrontal cortices believed to be anatomically homologous to those damaged in such patients. We show that the anterior cingulate gyrus in male macaques is critical for normal patterns of social interest in other individual male or female macaques. Conversely, the orbitofrontal cortex lesion had a marked effect only on responses to mildly fear-inducing stimuli. These results suggest that damage to the anterior cingulate gyrus may be the cause of changes in social interaction seen after frontal lobe damage.
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Anterior cingulate lesions around the genu reduce responsiveness to social cues.
“Other anterior cingulate lesions around the genu reduced responsiveness to social cues, implying that this region helps evaluate such stimuli (Rudebeck et al., 2006).”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Rudebeck et al., 2006
The anterior cingulate region helps evaluate social stimuli.
“Other anterior cingulate lesions around the genu reduced responsiveness to social cues, implying that this region helps evaluate such stimuli (Rudebeck et al., 2006).”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Rudebeck et al., 2006
Prior investigations in rodents and primates have provided evidence for neurons that encode information about other individuals, demonstrating changes in activity when animals observe another's appetitive or aversive experiences.
“Prior investigations in rodents and primates, for example, have provided evidence for the presence of neurons that encode information about other individuals, demonstrating changes in activity when the animals observe another’s appetitive or aversive experiences 1–11.”
From Reduced sociability and social agency encoding in adult Shank3-mutant mice are restored through gene re-expression in real time (2021) · cites this paper as [1]
The mPFC is an area suggested to be involved in social behavior and disorders such as ASD.
“Here, we used microelectrode arrays that were implanted in the animal’s mPFC (Extended Data Fig. 1b), an area suggested to be involved in social behavior 1,7,12,26,34 and disorders such as ASD 14,21,35,36.”
From Reduced sociability and social agency encoding in adult Shank3-mutant mice are restored through gene re-expression in real time (2021) · cites this paper as [1]
Previous investigations have provided insight into how discrete aspects of another animal's experience, such as receipt of reward, may be encoded by cells.
“Previous investigations have provided insight into how discrete aspects of another animal’s experience, such as receipt of reward, may be encoded by cells 1–7,9.”
From Reduced sociability and social agency encoding in adult Shank3-mutant mice are restored through gene re-expression in real time (2021) · cites this paper as [1]
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- Authors
- Rudebeck, P. H., Buckley, M. J., Walton, M. E., & Rushworth, M. F. S.
- Affiliations
- University of Oxford (GB)
- Corresponding author
- Rudebeck, P. H.
- Venue
- Science
- Published
- 2006-09
- Volume
- 313
- Issue
- 5791
- Pages
- 1310-1312
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1969866816
- Cited by
- 312
- References
- 27
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 9 · 2023: 5 · 2022: 10 · 2021: 28 · 2020: 15 · 2019: 11 · 2018: 17 · 2017: 20 · 2016: 18 · 2015: 15 · 2014: 12 · 2013: 22 · 2012: 20
- FWCI
- 9.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Social Psychology › Primate Behavior and Ecology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- anterior cingulate cortex, orbitofrontal cortex, social valuation, social interest, frontal lobe lesions, macaque, fear response, social behavior
- MeSH terms
- Analysis of Variance, Animals, Fear, Female, Frontal Lobe, Gyrus Cinguli, Macaca, Male, Reaction Time, Social Behavior, Social Perception
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