The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Essential Roles of Notch Signaling in Maintenance of Neural Stem Cells in Developing and Adult Brains
Open accessAbstract
Activation of Notch signaling induces the expression of transcriptional repressor genes such as Hes1 , leading to repression of proneural gene expression and maintenance of neural stem/progenitor cells. However, a requirement for Notch signaling in the telencephalon was not clear, because in Hes1;Hes3;Hes5 triple-mutant mice, neural stem/progenitor cells are depleted in most regions of the developing CNS, but not in the telencephalon. Here, we investigated a role for Notch signaling in the telencephalon by generating tamoxifen-inducible conditional knock-out mice that lack Rbpj , an intracellular signal mediator of all Notch receptors. When Rbpj was deleted in the embryonic brain, almost all telencephalic neural stem/progenitor cells prematurely differentiated into neurons and were depleted. When Rbpj was deleted in the adult brain, all neural stem cells differentiated into transit-amplifying cells and neurons. As a result, neurogenesis increased transiently, but 3 months later all neural stem cells were depleted and neurogenesis was totally lost. These results indicated an absolute requirement of Notch signaling for the maintenance of neural stem cells and a proper control of neurogenesis in both embryonic and adult brains.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“However, similar to the injured zebrafish retina, Notch signaling inhibits neural stem cell proliferation in the zebrafish and mouse brain (Chapouton et al., 2010; Imayoshi and Kageyama, 2011; Imayoshi et al., 2010).”
From HB-EGF is Necessary and Sufficient for Müller Glia Dedifferentiation and Retina Regeneration (2012) · cites this paper as Imayoshi et al., 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Gage, F. H. (2000) · Science · doi:10.1126/science.287.5457.1433 · Cited by 4,786
Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
Kopan, R., & Ilagan, M. X. G. (2009) · Cell · doi:10.1016/j.cell.2009.03.045 · Cited by 3,764
Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
Srinivas, S., Watanabe, T., Lin, C.-S., William, C. M., Tanabe, Y., Jessell, T. M., & Costantini, F. (2001) · BMC Developmental Biology · doi:10.1186/1471-213x-1-4 · Cited by 3,121
Mechanisms and Functional Implications of Adult Neurogenesis
Zhao, C., Deng, W., & Gage, F. H. (2008) · Cell · doi:10.1016/j.cell.2008.01.033 · Cited by 3,007
The Glial Nature of Embryonic and Adult Neural Stem Cells
Kriegstein, A., & Alvarez-Buylla, A. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135600 · Cited by 2,475
Noctor, S. C., Martínez-Cerdeño, V., Ivic, L., & Kriegstein, A. R. (2004) · Nature Neuroscience · doi:10.1038/nn1172 · Cited by 2,229
The cell biology of neurogenesis
Götz, M., & Huttner, W. B. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1739 · Cited by 2,130
ADULT NEUROGENESIS IN THE MAMMALIAN CENTRAL NERVOUS SYSTEM
Ming, G., & Song, H. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.051804.101459 · Cited by 1,891
Proneural genes and the specification of neural cell types
Bertrand, N., Castro, D. S., & Guillemot, F. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn874 · Cited by 1,572
Cited by
Sorted by citations
Items 101–200 of 709
Notch Signaling Alters Sensory or Neuronal Cell Fate Specification of Inner Ear Stem Cells
Jeon, S.-J., Fujioka, M., Kim, S.-C., & Edge, A. S. B. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6366-10.2011 · Cited by 102
Nelson, B. R., Hodge, R. D., Bedogni, F., & Hevner, R. F. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0791-13.2013 · Cited by 108
Notch Signaling Controls Generation of Motor Neurons in the Lesioned Spinal Cord of Adult Zebrafish
Dias, T. B., Yang, Y., Ogai, K., Becker, T., & Becker, C. G. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.6398-11.2012 · Cited by 100
Potential Therapies by Stem Cell‐Derived Exosomes in CNS Diseases: Focusing on the Neurogenic Niche
Luarte, A., Bátiz, L. F., Wyneken, Ú., & Lafourcade, C. (2016) · Stem Cells International · doi:10.1155/2016/5736059 · Cited by 100
Jeliazkova, P., Jörs, S., Lee, M., Zimber‐Strobl, U., Ferrer, J. P., Schmid, R. M., Siveke, J. T., & Geisler, F. (2013) · Hepatology · doi:10.1002/hep.26254 · Cited by 100
Neural Stem Cell Niches in Health and Diseases
Decimo, I., Bifari, F., Krampera, M., & Fumagalli, G. F. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212799859611 · Cited by 102
EphB Signaling Controls Lineage Plasticity of Adult Neural Stem Cell Niche Cells
Nomura, T., Göritz, C., Catchpole, T., Henkemeyer, M. J., & Frisén, J. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.11.009 · Cited by 99
Wang, X., Zhou, R., Xiong, Y., Zhou, L., Yan, X., Wang, M., Fan, L., Xie, C., Zhang, Y., Huang, Z., et al. (2021) · Cell Research · doi:10.1038/s41422-020-00451-z · Cited by 99
Rezza, A., Sennett, R., & Rendl, M. (2014) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-416022-4.00012-3 · Cited by 99
Evolution and development of the mammalian cerebral cortex
Molnár, Z., Kaas, J. H., de Carlos, J. A., Hevner, R. F., Lein, E., & Němec, P. (2014) · Brain Behavior and Evolution · doi:10.1159/000357753 · Cited by 93
Role of Notch signaling in neurovascular aging and Alzheimer’s disease
Kapoor, A., & Nation, D. A. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.12.011 · Cited by 95
Lu, S., Lu, C., Han, Q., Li, J., Du, Z., Liao, L., & Zhao, R. C. (2010) · Toxicology · doi:10.1016/j.tox.2010.10.011 · Cited by 93
Elsaeidi, F., Macpherson, P. C. D., Mills, E. A., Jui, J., Flannery, J. G., & Goldman, D. J. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.2126-17.2018 · Cited by 93
Unlocking epigenetic codes in neurogenesisPreprint
Yao, B., & Jin, P. (2014) · Genes & Development · doi:10.1101/gad.241547.114 · Cited by 97
Ménard, C., & Quirion, R. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00182 · Cited by 93
The Notch pathway in CNS homeostasis and neurodegeneration
Ho, D. M., Artavanis‐Tsakonas, S., & Louvi, A. (2020) · WIREs Developmental Biology · doi:10.1002/wdev.358 · Cited by 90
Blomfield, I. M., Rocamonde, B., Masdeu, M., Mulugeta, E., Vaga, S., van den Berg, D. L. C., Huillard, E., Guillemot, F., & Urbán, N. (2019) · eLife · doi:10.7554/elife.48561 · Cited by 94
Notch signaling in the brain: In good and bad times
Alberi, L. A., Hoey, S. E., Brai, E., Scotti, A. L., & Marathe, S. V. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.03.004 · Cited by 95
FGF Signaling Expands Embryonic Cortical Surface Area by Regulating Notch-Dependent Neurogenesis
Rash, B. G., Lim, H., Breunig, J. J., & Vaccarino, F. M. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4439-11.2011 · Cited by 97
Zhuang, P., Zhang, Y., Cui, G., Bian, Y., Zhang, M., Zhang, J., Liu, Y., Yang, X., Isaiah, A. O., Lin, Y., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035636 · Cited by 88
Than‐Trong, E., Ortica, S., Mella, S., Nepal, C., Alunni, A., & Bally‐Cuif, L. (2018) · Development · doi:10.1242/dev.161034 · Cited by 92
Regulation of active and quiescent somatic stem cells by Notch signaling
Sueda, R., & Kageyama, R. (2019) · Development Growth & Differentiation · doi:10.1111/dgd.12626 · Cited by 88
Self-citationNFIX Regulates Neural Progenitor Cell Differentiation During Hippocampal Morphogenesis
Heng, Y. H. E., McLeay, R. C., Harvey, T. J., Smith, A. G., Barry, G., Cato, K., Plachez, C., Little, E. B., Mason, S., Dixon, C. M., et al. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs307 · Cited by 87
Kopan, R., Chen, S., & Little, M. H. (2014) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-416022-4.00011-1 · Cited by 87
Kawai, H., Kawaguchi, D., Kuebrich, B. D., Kitamoto, T., Yamaguchi, M., Gotoh, Y., & Furutachi, S. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.0001-17.2017 · Cited by 85
Self-citationMünch, J., González-Rajal, Á., & de la Pompa, J. L. (2013) · Development · doi:10.1242/dev.087346 · Cited by 85
Notch1 maintains dormancy of olfactory horizontal basal cells, a reserve neural stem cell
Herrick, D. B., Lin, B., Peterson, J. N., Schnittke, N., & Schwob, J. E. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1701333114 · Cited by 84
Jones, K. M., Sarić, N., Russell, J. P., Andoniadou, C. L., Scambler, P. J., & Basson, M. A. (2014) · Stem Cells · doi:10.1002/stem.1822 · Cited by 83
Combining insoluble and soluble factors to steer stem cell fate
Dingal, P. C. D. P., & Discher, D. E. (2014) · Nature Materials · doi:10.1038/nmat3997 · Cited by 80
An Overview of Notch Signaling in Adult Tissue Renewal and Maintenance
Sato, C., Zhao, G., & Ilagan, M. X. G. (2012) · Current Alzheimer Research · doi:10.2174/156720512799361600 · Cited by 79
Folding brains: from development to disease modeling
Del-Valle-Anton, L., & Borrell, V. (2021) · Physiological Reviews · doi:10.1152/physrev.00016.2021 · Cited by 79
Zacharioudaki, E., Magadi, S. S., & Delidakis, C. (2012) · Development · doi:10.1242/dev.071779 · Cited by 78
Bergström, P., Agholme, L., Nazir, F. H., Şatır, T. M., Toombs, J., Wellington, H., Strandberg, J., Bontell, T. O., Kvartsberg, H., Holmström, M., et al. (2016) · Scientific Reports · doi:10.1038/srep29200 · Cited by 78
New neurons in adult brain: distribution, molecular mechanisms and therapies
Pino, A., Fumagalli, G. F., Bifari, F., & Decimo, I. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.07.003 · Cited by 83
Sarubbo, F., Moranta, D., & Pani, G. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.05.011 · Cited by 77
Estradiol and the Development of the Cerebral Cortex: An Unexpected Role?
Denley, M. C. S., Gatford, N. J. F., Sellers, K. J., & Srivastava, D. P. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00245 · Cited by 80
Meléndez, R. I., McGinty, J. F., Kalivas, P. W., & Becker, H. C. (2011) · Addiction Biology · doi:10.1111/j.1369-1600.2011.00357.x · Cited by 75
Interactions between VEGFR and Notch signaling pathways in endothelial and neural cells
Thomas, J., Baker, K. L., Han, J., Calvo, C. F., Nurmi, H. J., Eichmann, A., & Alitalo, K. K. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1312-6 · Cited by 77
Fathi, A., Hatami, M., Hajihoseini, V., Fattahi, F., Kiani, S., Baharvand, H., & Salekdeh, G. H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022856 · Cited by 74
Untangling Cortical Complexity During Development
Mukhtar, T., & Taylor, V. (2018) · Journal of Experimental Neuroscience · doi:10.1177/1179069518759332 · Cited by 81
Viales, R. R., Diotel, N., Ferg, M., Armant, O., Eich, J., Alunni, A., März, M., Bally‐Cuif, L., Rastegar, S., & Strähle, U. (2014) · Stem Cells · doi:10.1002/stem.1883 · Cited by 73
Wang, J., Cheng, A., Wakade, C. G., & Yu, R. K. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2275-14.2014 · Cited by 76
Li, L., Candelario, K. M., Thomas, K. A., Wang, R., Wright, K., Messier, A. M., & Cunningham, L. A. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4590-13.2014 · Cited by 73
Sox21 Promotes Hippocampal Adult Neurogenesis via the Transcriptional Repression of theHes5Gene
Matsuda, S., Kuwako, K.-I., Okano, H. J., Tsutsumi, S., Aburatani, H., Saga, Y., Matsuzaki, Y., Akaike, A., Sugimoto, H., & Okano, H. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5803-11.2012 · Cited by 73
Notch signaling as a master regulator of adult neurogenesis
Lampada, A., & Taylor, V. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1179011 · Cited by 86
Oncogenic and Tumor-Suppressive Functions of NOTCH Signaling in Glioma
Parmigiani, E., Taylor, V., & Giachino, C. (2020) · Cells · doi:10.3390/cells9102304 · Cited by 74
Visualization and genetic manipulation of adult neurogenesis using transgenic mice
Dhaliwal, J., & Lagace, D. C. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07600.x · Cited by 74
Genetic Methods to Identify and Manipulate Newly Born Neurons in the Adult Brain
Imayoshi, I., Sakamoto, M., & Kageyama, R. (2011) · Frontiers in Neuroscience · doi:10.3389/fnins.2011.00064 · Cited by 73
Self-citationPromoting 3D neuronal differentiation in hydrogel for spinal cord regeneration
Zhou, P., Xu, P., Guan, J., Zhang, C., Chang, J., Yang, F., Xiao, H., Sun, H., Zhang, Z., Wang, M., et al. (2020) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2020.111214 · Cited by 69
A Critical Role for Sox9 in Notch-Induced Astrogliogenesis and Stem Cell Maintenance
Martini, S., Bernoth, K., Main, H., Ortega, G. C., Lendahl, U., Just, U., & Schwanbeck, R. (2013) · Stem Cells · doi:10.1002/stem.1320 · Cited by 69
Baines, K. J., Hillier, D. M., Haddad, F. L., Rajakumar, N., Schmid, S., & Renaud, S. J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01145 · Cited by 73
Linking pathways in the developing and aging brain with neurodegeneration
Kovács, G. G., Adle‐Biassette, H., Milenković, I., Cipriani, S., van Scheppingen, J., & Aronica, E. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.03.045 · Cited by 69
Ghareghani, M., Zibara, K., Sadeghi, H., Dokoohaki, S., Sadeghi, H., Aryanpour, R., & Ghanbari, A. (2017) · Scientific Reports · doi:10.1038/s41598-017-04968-z · Cited by 68
Betancourt, J., Katzman, S. J., & Chen, B. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23373 · Cited by 67
DNA Methylation Dynamics in Neurogenesis
Wang, Z., Tang, B., He, Y., & Jin, P. (2016) · Epigenomics · doi:10.2217/epi.15.119 · Cited by 69
The Many Hats of Sonic Hedgehog Signaling in Nervous System Development and Disease
Belgacem, Y. H., Hamilton, A. M., Shim, S., Spencer, K. A., & Borodinsky, L. N. (2016) · Journal of Developmental Biology · doi:10.3390/jdb4040035 · Cited by 67
The Effect of Systemic Chemotherapy on Neurogenesis, Plasticity and Memory
Wigmore, P. (2012) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2012_235 · Cited by 66
Home sweet home: the neural stem cell niche throughout development and after injury
Ruddy, R. M., & Morshead, C. M. (2017) · Cell and Tissue Research · doi:10.1007/s00441-017-2658-0 · Cited by 72
Shin, Y., Yang, K., Han, S., Park, H., Heo, Y. S., Cho, S., & Chung, S. H. (2014) · Advanced Healthcare Materials · doi:10.1002/adhm.201300569 · Cited by 65
Boareto, M., Iber, D., & Taylor, V. (2017) · Development · doi:10.1242/dev.152520 · Cited by 65
Autophagy deficiency in neurodevelopmental disorders
Deng, Z., Zhou, X., Lu, J., & Yue, Z. (2021) · Cell & Bioscience · doi:10.1186/s13578-021-00726-x · Cited by 66
Aging and neurogenesis in the adult forebrain: what we have learned and where we should go from here
Hamilton, L. K., Joppé, S. E., Cochard, L. M., & Fernandes, K. J. L. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12207 · Cited by 74
Oscillatory control of bHLH factors in neural progenitors
Imayoshi, I., & Kageyama, R. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.07.006 · Cited by 66
Self-citationThe dark sides of amyloid in Alzheimer's disease pathogenesis
Sorrentino, P., Iuliano, A., Polverino, A., Jacini, F., & Sorrentino, G. (2014) · FEBS Letters · doi:10.1016/j.febslet.2013.12.038 · Cited by 64
P in1 promotes neuronal death in stroke by stabilizing N otch intracellular domain
Baik, S., Fane, M. E., Park, J. H., Cheng, Y., Fann, D. Y., Yun, U. J., Choi, Y., Park, J., Chai, B. H., Park, J. S., et al. (2015) · Annals of Neurology · doi:10.1002/ana.24347 · Cited by 63
The role of Extracellular Vesicles during CNS development
Sangani, N. B., Gomes, A. R., Curfs, L., & Reutelingsperger, C. P. M. (2021) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2021.102124 · Cited by 68
Aldh1L1 is expressed by postnatal neural stem cells in vivo
Foo, L. C., & Dougherty, J. D. (2013) · Glia · doi:10.1002/glia.22539 · Cited by 62
Desai, M., Ferrini, M. G., Han, G., Jellyman, J. K., & Ross, M. G. (2018) · Environmental Research · doi:10.1016/j.envres.2018.02.011 · Cited by 64
Control of Adult Neurogenesis by Short-Range Morphogenic-Signaling MoleculesPreprint
Choe, Y., Pleasure, S. J., & Mira, H. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018887 · Cited by 66
Developmental roles of brain histamine
Panula, P., Sundvik, M., & Karlstedt, K. A. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.01.001 · Cited by 62
Endo, M., Doi, R., Nishita, M., & Minami, Y. (2012) · Journal of Cell Science · doi:10.1242/jcs.097782 · Cited by 61
Li, J., Han, Y., Li, M., & Nie, C. (2019) · Cellular Reprogramming · doi:10.1089/cell.2018.0027 · Cited by 62
NUMB enhances Notch signaling by repressing ubiquitination of NOTCH1 intracellular domain
Luo, Z., Mu, L., Zheng, Y., Shen, W., Li, J., Xu, L., Zhong, B., Liu, Y., & Zhou, Y. (2019) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjz088 · Cited by 61
Gsx1 promotes locomotor functional recovery after spinal cord injury
Patel, M., Li, Y., Anderson, J., Castro-Pedrido, S., Skinner, R., Lei, S., Finkel, Z., Rodriguez, B., Esteban, F., Lee, K., et al. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.04.027 · Cited by 62
Neural Stem Cells as Potential Glioblastoma Cells of Origin
Loras, A., Bonet, L. G. G., Gutiérrez-Arroyo, J., Martínez‐Cadenas, C., & Marqués‐Torrejón, M. Á. (2023) · Life · doi:10.3390/life13040905 · Cited by 60
Villanueva, C., Jacquier, S., & de Roux, N. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036134 · Cited by 60
Dynamic expression and roles of Hes factors in neural development
Kageyama, R., Shimojo, H., & Imayoshi, I. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1888-7 · Cited by 60
Self-citationConserved and Divergent Features of Adult Neurogenesis in Zebrafish
Labusch, M., Mancini, L., Morizet, D., & Bally-Cuif, L. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00525 · Cited by 48
Direct Lineage Conversion of Adult Mouse Liver Cells and B Lymphocytes to Neural Stem Cells
Cassady, J. P., D’Alessio, A. C., Sarkar, S., Dani, V. S., Fan, Z. P., Ganz, K., Roessler, R., Sur, M., Young, R. A., & Jaenisch, R. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.10.001 · Cited by 59
Molecular Mechanism of Adult Neurogenesis and its Association with Human Brain Diseases
Liu, H., & Song, N. (2016) · Journal of Central Nervous System Disease · doi:10.4137/jcnsd.s32204 · Cited by 60
Singh, S., Mishra, A., Bharti, S., Tiwari, V., Singh, J., Parul, P., & Shukla, S. (2018) · Molecular Neurobiology · doi:10.1007/s12035-017-0860-4 · Cited by 58
Bierman, R. D., Safarians, G., Huang, J., Rajput, B., Chen, J. Y., Wang, Z. Z., & Seidlits, S. K. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202101577 · Cited by 58
Aujla, P. K., Naratadam, G. T., Xu, L., & Raetzman, L. T. (2013) · Development · doi:10.1242/dev.098681 · Cited by 57
A Notch1–neuregulin1 autocrine signaling loop contributes to melanoma growth
Zhang, K., Wong, P., Zhang, L., Jacobs, B., Borden, E. C., Aster, J. C., & Bedogni, B. (2012) · Oncogene · doi:10.1038/onc.2011.606 · Cited by 57
Fbxw7 regulates Notch to control specification of neural precursors for oligodendrocyte fate
Snyder, J. L., Kearns, C. A., & Appel, B. (2012) · Neural Development · doi:10.1186/1749-8104-7-15 · Cited by 57
Pasut, A., Chang, N. C., Gurriarán‐Rodríguez, U., Faulkes, S., Yin, H., Lacaria, M., Hong, M., & Rudnicki, M. A. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.001 · Cited by 59
Dray, N., Mancini, L., Binshtok, U., Cheysson, F., Supatto, W., Mahou, P., Bedu, S., Ortica, S., Than‐Trong, E., Krecsmarik, M., et al. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.03.014 · Cited by 57
Harada, Y., Yamada, M., Imayoshi, I., Kageyama, R., Suzuki, Y., Kuniya, T., Furutachi, S., Kawaguchi, D., & Gotoh, Y. (2021) · Nature Communications · doi:10.1038/s41467-021-26605-0 · Cited by 56
Self-citationHer9 represses neurogenic fate downstream of Tbx1 and retinoic acid signaling in the inner ear
Radosevic, M., Robert‐Moreno, A., Coolen, M., Bally‐Cuif, L., & Alsina, B. (2011) · Development · doi:10.1242/dev.056093 · Cited by 59
Neural stem cells: mechanisms and modeling
Yao, J., Mu, Y., & Gage, F. H. (2012) · Protein & Cell · doi:10.1007/s13238-012-2033-6 · Cited by 61
Kitagawa, M., Hojo, M., Imayoshi, I., Goto, M., Ando, M., Ohtsuka, T., Kageyama, R., & Miyamoto, S. (2013) · Mechanisms of Development · doi:10.1016/j.mod.2013.07.001 · Cited by 58
Self-citationZalc, A., Hayashi, S., Aurade, F., Bröhl, D., Chang, T. H., Mademtzoglou, D., Mourikis, P., Yao, Z., Cao, Y., Birchmeier, C., et al. (2014) · Development · doi:10.1242/dev.110155 · Cited by 56
Notching up neural stem cell homogeneity in homeostasis and disease
Giachino, C., & Taylor, V. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00032 · Cited by 59
Neogenin, a regulator of adult hippocampal neurogenesis, prevents depressive-like behavior
Sun, D., Sun, X.-D., Zhao, L., Lee, D.-H., Hu, J.-X., Tang, F., Pan, J., Mei, L., Zhu, X., & Xiong, W. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0019-2 · Cited by 56
Cell Signaling in Neuronal Stem Cells
Quiroz, E. N., Quiroz, R. N., Ahmad, M., Escorcia, L. G., Camacho, J. L. V., Fernandez-Ponce, C. M., & Aroca, G. (2018) · Cells · doi:10.3390/cells7070075 · Cited by 55
Enteric glia as a source of neural progenitors in adult zebrafish
McCallum, S. E., Obata, Y., Fourli, E., Boeing, S., Peddie, C. J., Xu, Q., Horswell, S. D., Kelsh, R. N., Collinson, L., Wilkinson, D. G., et al. (2020) · eLife · doi:10.7554/elife.56086 · Cited by 55
Neural stem cell survival factors
Ramasamy, S., Narayanan, G., Sankaran, S., Yu, Y. H., & Ahmed, S. (2013) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2013.02.004 · Cited by 54
Notch signaling via Hey1 and Id2b regulates Müller glia's regenerative response to retinal injury
Sahu, A., Devi, S., Jui, J., & Goldman, D. J. (2021) · Glia · doi:10.1002/glia.24075 · Cited by 54
Genetic visualization of notch signaling in mammalian neurogenesis
Imayoshi, I., Shimojo, H., Sakamoto, M., Ohtsuka, T., & Kageyama, R. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1151-x · Cited by 58
Self-citationJones, D., Mulholland, S. A., Pearson, D. M., Malley, D. S., Openshaw, S., Lambert, S. R., Liu, L., Bäcklund, L. M., Ichimura, K., & Collins, V. P. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0810-6 · Cited by 54
Metadata
- Authors
- Imayoshi, I., Sakamoto, M., Yamaguchi, M., Mori, K., & Kageyama, R.
- Affiliations
- Kyoto University (JP)
- The University of Tokyo (JP)
- Corresponding author
- Kageyama, Ryoichiro
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-03-03
- Volume
- 30
- Issue
- 9
- Pages
- 3489-3498
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6634119
- OpenAlex
- W2065569210
- Cited by
- 716
- References
- 58
- Citations by year
- 2026: 17 · 2025: 31 · 2024: 34 · 2023: 39 · 2022: 60 · 2021: 46 · 2020: 54 · 2019: 47 · 2018: 45 · 2017: 45 · 2016: 39 · 2015: 42 · 2014: 58 · 2013: 51 · 2012: 52
- FWCI
- 16.09
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Society for the Promotion of Science (21240028)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- Notch signaling, neural stem cells, neural stem/progenitor cells, RBPJ, Hes1, Hes5, telencephalon, neurogenesis, stem cell depletion, conditional knockout mice, adult brain, embryonic brain
- MeSH terms
- Aging, Animals, Cell Count, Mice, Transgenic, Nerve Regeneration, Neurons, Neurotoxins, Stem Cells, Telencephalon, Signal Transduction, Mice, Knockout, Gene Expression Regulation, Developmental, Cell Proliferation, Mice, Immunoglobulin J Recombination Signal Sequence-Binding Protein, Receptors, Notch, Neurogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
