The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Essential Roles of Notch Signaling in Maintenance of Neural Stem Cells in Developing and Adult Brains
Open accessAbstract
Activation of Notch signaling induces the expression of transcriptional repressor genes such as Hes1 , leading to repression of proneural gene expression and maintenance of neural stem/progenitor cells. However, a requirement for Notch signaling in the telencephalon was not clear, because in Hes1;Hes3;Hes5 triple-mutant mice, neural stem/progenitor cells are depleted in most regions of the developing CNS, but not in the telencephalon. Here, we investigated a role for Notch signaling in the telencephalon by generating tamoxifen-inducible conditional knock-out mice that lack Rbpj , an intracellular signal mediator of all Notch receptors. When Rbpj was deleted in the embryonic brain, almost all telencephalic neural stem/progenitor cells prematurely differentiated into neurons and were depleted. When Rbpj was deleted in the adult brain, all neural stem cells differentiated into transit-amplifying cells and neurons. As a result, neurogenesis increased transiently, but 3 months later all neural stem cells were depleted and neurogenesis was totally lost. These results indicated an absolute requirement of Notch signaling for the maintenance of neural stem cells and a proper control of neurogenesis in both embryonic and adult brains.
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“However, similar to the injured zebrafish retina, Notch signaling inhibits neural stem cell proliferation in the zebrafish and mouse brain (Chapouton et al., 2010; Imayoshi and Kageyama, 2011; Imayoshi et al., 2010).”
From HB-EGF is Necessary and Sufficient for Müller Glia Dedifferentiation and Retina Regeneration (2012) · cites this paper as Imayoshi et al., 2010
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Metadata
- Authors
- Imayoshi, I., Sakamoto, M., Yamaguchi, M., Mori, K., & Kageyama, R.
- Affiliations
- Kyoto University (JP)
- The University of Tokyo (JP)
- Corresponding author
- Kageyama, Ryoichiro
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-03-03
- Volume
- 30
- Issue
- 9
- Pages
- 3489-3498
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6634119
- OpenAlex
- W2065569210
- Cited by
- 716
- References
- 58
- Citations by year
- 2026: 17 · 2025: 31 · 2024: 34 · 2023: 39 · 2022: 60 · 2021: 46 · 2020: 54 · 2019: 47 · 2018: 45 · 2017: 45 · 2016: 39 · 2015: 42 · 2014: 58 · 2013: 51 · 2012: 52
- FWCI
- 16.09
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Society for the Promotion of Science (21240028)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- Notch signaling, neural stem cells, neural stem/progenitor cells, RBPJ, Hes1, Hes5, telencephalon, neurogenesis, stem cell depletion, conditional knockout mice, adult brain, embryonic brain
- MeSH terms
- Aging, Animals, Cell Count, Mice, Transgenic, Nerve Regeneration, Neurons, Neurotoxins, Stem Cells, Telencephalon, Signal Transduction, Mice, Knockout, Gene Expression Regulation, Developmental, Cell Proliferation, Mice, Immunoglobulin J Recombination Signal Sequence-Binding Protein, Receptors, Notch, Neurogenesis
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