Essential Roles of Notch Signaling in Maintenance of Neural Stem Cells in Developing and Adult Brains

Mammalian neural stem cells.

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Bone morphogenetic protein signaling regulates Id1-mediated neural stem cell quiescence in the adult zebrafish brain via a phylogenetically conserved enhancer module

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tDCS Accelerates the Rehabilitation of MCAO-Induced Motor Function Deficits via Neurogenesis Modulated by the Notch1 Signaling Pathway

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The circadian clock in adult neural stem cell maintenance

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Neural microvascular pericytes contribute to human adult neurogenesis

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Loss of postnatal quiescence of neural stem cells through mTOR activation upon genetic removal of cysteine string protein-α

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Functional rejuvenation of aged neural stem cells by Plagl2 and anti-Dyrk1a activityPreprint

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Mediterranean diet protects against a neuroinflammatory cortical transcriptome: Associations with brain volumetrics, peripheral inflammation, social isolation, and anxiety in nonhuman primates (Macaca fascicularis)

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Transcriptional Regulation and Specification of Neural Stem Cells

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Plant derived bioactive compounds and their potential to enhance adult neurogenesis

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Conditional Deletion of Notch1 and Notch2 Genes in Excitatory Neurons of Postnatal Forebrain Does Not Cause Neurodegeneration or Reduction of Notch mRNAs and Proteins

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Maternal high-fat diet affects Msi/Notch/Hes signaling in neural stem cells of offspring mice

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Mimicking Neural Stem Cell Niche by Biocompatible Substrates

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NOTCH Signaling Is Essential for Maturation, Self-Renewal, and Tri-Differentiation of In Vitro Derived Human Neural Stem Cells

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FGF2/EGF contributes to brain neuroepithelial precursor proliferation and neurogenesis in rat embryos: the involvement of embryonic cerebrospinal fluid

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Adult Neurogenesis in Epileptogenesis: An Update for Preclinical Finding and Potential Clinical Translation

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Lysosomes and signaling pathways for maintenance of quiescence in adult neural stem cells

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When cell cycle meets development

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Gestational Age and Sex Influence the Susceptibility of Human Neural Progenitor Cells to Low Levels of MeHg

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Endogenous neural precursor cells in health and disease

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Deciphering New Players in the Neurogenic Adult Hippocampal Niche

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Disruption of Sonic Hedgehog Signaling Accelerates Age-Related Neurogenesis Decline and Abolishes Stroke-Induced Neurogenesis and Leads to Increased Anxiety Behavior in Stroke Mice

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3D chitosan scaffolds support expansion of human neural stem cells in chemically defined condition

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The Role of Stem Cells in the Treatment of Cerebral Palsy: a Review

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Defined Culture Conditions Accelerate Small-molecule-assisted Neural Induction for the Production of Neural Progenitors from Human-induced Pluripotent Stem Cells

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Notch-activated mesenchymal stromal/stem cells enhance the protective effect against acetaminophen-induced acute liver injury by activating AMPK/SIRT1 pathway

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Role of gabra2, GABAA receptor alpha-2 subunit, in CNS development

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Effects of ADAM10 deletion on Notch-1 signaling pathway and neuronal maintenance in adult mouse brain

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Neuropathology of brain and spinal malformations in a case of monosomy 1p36

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Insights into the Biology and Therapeutic Applications of Neural Stem Cells

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GSK-3β activation accelerates early-stage consumption of Hippocampal Neurogenesis in senescent mice

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Criss‐crossing autism spectrum disorder and adult neurogenesis

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Biophysical Regulations of Epigenetic State and Notch Signaling in Neural Development Using Microgroove Substrates

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MYT1L in the making: emerging insights on functions of a neurodevelopmental disorder gene

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Early postnatal defects in neurogenesis in the 3xTg mouse model of Alzheimer’s disease

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Divide or Commit – Revisiting the Role of Cell Cycle Regulators in Adult Hippocampal Neurogenesis

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Astrocyte‐produced leukemia inhibitory factor expands the neural stem/progenitor pool following perinatal hypoxia–ischemia

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Evolving targets for anti-epileptic drug discovery

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Genomic structural variation: A complex but important driver of human evolution

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Glioblastoma Multiforme and Adult Neurogenesis in the Ventricular‐Subventricular Zone: A Review

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Alpha-7 Nicotinic Receptor Signaling Pathway Participates in the Neurogenesis Induced by ChAT-Positive Neurons in the Subventricular Zone

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Hyperhomocysteinemia-induced autophagy and apoptosis with downregulation of hairy enhancer of split 1/5 in cortical neurons in mice

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Protective Mechanism and Treatment of Neurogenesis in Cerebral Ischemia

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The significance of gene expression dynamics in neural stem cell regulation

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Perfluorinated Iodine Alkanes Promoted Neural Differentiation of mESCs by Targeting miRNA-34a-5p in Notch-Hes Signaling

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Current Opportunities for Targeting Dysregulated Neurodevelopmental Signaling Pathways in Glioblastoma

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The bHLH Transcription Factors in Neural Development and Therapeutic Applications for Neurodegenerative Diseases

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Loss of RBPj in Postnatal Excitatory Neurons Does Not Cause Neurodegeneration or Memory Impairments in Aged Mice

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Neuroinflammatory modulators of oligodendrogenesis

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Small RNAs have a big impact on regeneration

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LRIG1-Mediated Inhibition of EGF Receptor Signaling Regulates Neural Precursor Cell Proliferation in the Neocortex

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Sequential activation of transcriptional repressors promotes progenitor commitment by silencing stem cell identity genes

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BCL7A‐containing SWI/SNF/BAF complexes modulate mitochondrial bioenergetics during neural progenitor differentiation

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Tis21 is required for adult neurogenesis in the subventricular zone and for olfactory behavior regulating cyclins, BMP4, Hes1/5 and Ids

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Epigenomic Landscapes of hESC-Derived Neural Rosettes: Modeling Neural Tube Formation and Diseases

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DNA methylation inhibitor attenuates polyglutamine‐induced neurodegeneration by regulating Hes5

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HES1, two programs: promoting the quiescence and proliferation of adult neural stem cellsPreprint

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Adult hippocampal neurogenesis: New avenues for treatment of brain disorders

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Enhanced effect of combining bone marrow mesenchymal stem cells (BMMSCs) and pulsed electromagnetic fields (PEMF) to promote recovery after spinal cord injury in mice

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Reconstruction of ancestral brains: Exploring the evolutionary process of encephalization in amniotes

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Cerebrospinal fluid derived from progressive multiple sclerosis patients promotes neuronal and oligodendroglial differentiation of human neural precursor cells in vitro

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A novel stem cell type at the basal side of the subventricular zone maintains adult neurogenesis

Baur, K., Abdullah, Y., Mandl, C., Hölzl‐Wenig, G., Shi, Y., Schmidt-Edelkraut, U., Khatri, P. R., Hagenston, A. M., Irmler, M., Beckers, J., et al. (2022) · EMBO Reports · doi:10.15252/embr.202154078 · Cited by 22

Amyloid is essential but insufficient for Alzheimer causation: addition of subcellular cofactors is required for dementia

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Ranolazine protects against diabetic cardiomyopathy by activating the NOTCH1/NRG1 pathway

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Concordance of Several Subcellular Interactions Initiates Alzheimer’s Dementia: Their Reversal Requires Combination Treatment

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Protein S Negatively Regulates Neural Stem Cell Self-Renewal through Bmi-1 Signaling

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Dynamic Notch signalling regulates neural stem cell state progression in the Drosophila optic lobe

Contreras, E. G., Egger, B., Gold, K. S., & Brand, A. H. (2018) · Neural Development · doi:10.1186/s13064-018-0123-8 · Cited by 21

Activation of different neural precursor populations in the adult hippocampus: Does this lead to new neurons with discrete functions?

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Conditional Inactivation of Pen-2 in the Developing Neocortex Leads to Rapid Switch of Apical Progenitors to Basal Progenitors

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Adult Neural Stem Cell Regulation by Small Non-coding RNAs: Physiological Significance and Pathological Implications

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Reduced chromatin accessibility correlates with resistance to Notch activation

van den Ameele, J., Krautz, R., Cheetham, S. W., Donovan, A. P. A., Llorà-Batlle, O., Yakob, R., & Brand, A. H. (2022) · Nature Communications · doi:10.1038/s41467-022-29834-z · Cited by 20

Notch Signaling Imparts and Preserves Neural Stem Characteristics in the Adult Brain

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Deficiency of Ttyh1 downstream to Notch signaling results in precocious differentiation of neural stem cells

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Heterocellular Contacts with Mouse Brain Endothelial Cells Via Laminin and α6β1 Integrin Sustain Subventricular Zone (SVZ) Stem/Progenitor Cells Properties

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Generation and characterization of a Notch1 signaling‐specific reporter mouse line

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Exploring the potential relationship between Notch pathway genes expression and their promoter methylation in mice hippocampal neurogenesis

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Mash1-dependent Notch Signaling Pathway Regulates GABAergic Neuron-Like Differentiation from Bone Marrow-Derived Mesenchymal Stem Cells

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Jagged1 is Essential for Radial Glial Maintenance in the Cortical Proliferative Zone

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Emerging Role of Cellular Prion Protein in the Maintenance and Expansion of Glioma Stem Cells

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Adult Neurogenesis and Glial Oncogenesis: When the Process Fails

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Cellular and molecular attributes of neural stem cell niches in adult zebrafish brain

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Safflower Seed Oil, Containing Oleic Acid and Palmitic Acid, Enhances the Stemness of Cultured Embryonic Neural Stem Cells through Notch1 and Induces Neuronal Differentiation

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