Essential Roles of Notch Signaling in Maintenance of Neural Stem Cells in Developing and Adult Brains

Mammalian neural stem cells.

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Subventricular zone astrocytes are neural stem cells in the adult mammalian brain

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The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

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Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus

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Proneural genes and the specification of neural cell types

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Notch1 promotes mouse spinal neural stem and progenitor cells proliferation via p-p38-pax6 induced cyclin D1 activation

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ATM modulates subventricular zone neural stem cell maintenance and senescence through Notch signaling pathway

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Azithromycin induces neurotoxicity in zebrafish by interfering with the VEGF/Notch signaling pathway

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Notch-dependent RBPJκ inhibits proliferation of human cytotrophoblasts and their differentiation into extravillous trophoblasts

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Autophagy and Adult Neurogenesis: Discoveries Made Half a Century Ago Yet in their Infancy of being Connected

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Regulating cell fate of human amnion epithelial cells using natural compounds: an example of enhanced neural and pigment differentiation by 3,4,5-tri-O-caffeoylquinic acid

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Cannibalized erythroblasts accelerate developmental neurogenesis by regulating mitochondrial dynamics

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The Act of Controlling Adult Stem Cell Dynamics: Insights from Animal Models

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In vivo overactivation of the Notch signaling pathway in the developing cochlear epithelium

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Ochratoxin A at nanomolar concentration perturbs the homeostasis of neural stem cells in highly differentiated but not in immature three-dimensional brain cell cultures

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Expression of nuclear factor one A and ‐B in the olfactory bulb

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Evidence of Notch-Hesr-Nrf2 Axis in Muscle Stem Cells, but Absence of Nrf2 Has No Effect on Their Quiescent and Undifferentiated State

Yamaguchi, M., Murakami, S., Yoneda, T., Nakamura, M., Zhang, L., Uezumi, A., Fukuda, S., Kokubo, H., Tsujikawa, K., & Fukada, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0138517 · Cited by 16

Sfrp1 Modulates Cell-signaling Events Underlying Telencephalic Patterning, Growth and Differentiation

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Rapid and efficient gene delivery into the adult mouse brain via focal electroporation

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Moderate-Grade Germinal Matrix Haemorrhage Activates Cell Division in the Neonatal Mouse Subventricular Zone

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Research progress on the mechanisms of endogenous neural stem cell differentiation in spinal cord injury repair

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Mesenchymal-to-epithelial transition of perivascular cells contributes to endometrial re-epithelialization

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Stage-specific expression patterns and co-targeting relationships among miRNAs in the developing mouse cerebral cortex

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Notch Signaling Induces Retinal Stem-Like Properties in Perinatal Neural Retina Progenitors and Promotes Symmetric Divisions in Adult Retinal Stem Cells

Balenci, L., & van der Kooy, D. (2013) · Stem Cells and Development · doi:10.1089/scd.2013.0177 · Cited by 15

Could a Different View of Quiescence Help Us Understand How Neurogenesis Is Regulated?

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Investigation of the mechanism of enhanced and directed differentiation of neural stem cells by an atmospheric plasma jet: A gene-level study

Zhao, S., Han, R., Li, Y., Lu, C., Chen, X., Xiong, Z., & Mao, X. (2019) · Journal of Applied Physics · doi:10.1063/1.5060650 · Cited by 15

Minimally Invasive Delivery of Microbeads with Encapsulated, Viable and Quiescent Neural Stem Cells to the Adult Subventricular Zone

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The mitochondrial unfolded protein response in human microglia disrupts neuronal–glial communication and promotes senescence

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Redox Homeostasis and Beyond: The Role of Wild-Type Isocitrate Dehydrogenases for the Pathogenesis of Glioblastoma

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Presenilin Regulates Retinotectal Synapse Formation through EphB2 Receptor Processing

Liu, Z., Thakar, A., Santoro, S. W., & Pratt, K. G. (2018) · Developmental Neurobiology · doi:10.1002/dneu.22638 · Cited by 14

Temperature sensitivity of Notch signaling underlies species-specific developmental plasticity and robustness in amniote brains

Nomura, T., Nagao, K., Shirai, R., Gotoh, H., Umeda, M., & Ono, K. (2022) · Nature Communications · doi:10.1038/s41467-021-27707-5 · Cited by 16

Promoting Endogenous Neurogenesis as a Treatment for Alzheimer’s Disease

Zhang, Q., Liu, J., Chen, L., & Zhang, M. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-03145-2 · Cited by 15

Rho/ROCK-dependent inhibition of 3T3-L1 adipogenesis by G-protein-deamidating dermonecrotic toxins: differential regulation of Notch1, Pref1/Dlk1, and β-catenin signaling

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Role of Notch and its oncogenic signaling crosstalk in glioma and glioma stem cells

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Dual Role of Rbpj in the Maintenance of Neural Progenitor Cells and Neuronal Migration in Cortical Development

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Proinflammatory S100A9 Regulates Differentiation and Aggregation of Neural Stem Cells

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Assessing the Neurotoxicity of a Sub-Optimal Dose of Rotenone in Zebrafish (Danio rerio) and the Possible Neuroactive Potential of Valproic Acid, Combination of Levodopa and Carbidopa, and Lactic Acid Bacteria Strains

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Pharmacological Notch pathway inhibition leads to cell cycle arrest and stimulates ascl1 and neurogenin2 genes expression in dental pulp stem cells-derived neurospheres

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Numb and Alzheimer’s Disease: The Current Picture

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Transit Amplifying Progenitors in the Cerebellum: Similarities to and Differences from Transit Amplifying Cells in Other Brain Regions and between Species

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SOX10 mediates glioblastoma cell-state plasticity

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Integrated omics reveals disease-associated radial glia-like cells with epigenetically dysregulated interferon response in multiple sclerosis

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NRF2: An emerging role in neural stem cell regulation and neurogenesis

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Devo-Aging: Intersections Between Development and Aging

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From Youthful Vigor to Aging Decline: Unravelling the Intrinsic and Extrinsic Determinants of Hippocampal Neural Stem Cell Aging

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Inhibition of Notch signaling alters the phenotype of orthotopic tumors formed from glioblastoma multiforme neurosphere cells but does not hamper intracranial tumor growth regardless of endogene Notch pathway signature

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Metabolic Factors and Adult Neurogenesis: Impacts of Chinese Herbal Medicine on Brain Repair in Neurological Diseases

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Regulation by commensal bacteria of neurogenesis in the subventricular zone of adult mouse brain

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Neuronal differentiation of human iPS cells induced by baicalin via regulation of bHLH gene expression

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Notch Signaling Activation Enhances Human Adipose-Derived Stem Cell Retinal Differentiation

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Deficiency of Fhl2 leads to delayed neuronal cell migration and premature astrocyte differentiation

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Notch Dosage: Jagged1 Haploinsufficiency Is Associated With Reduced Neuronal Division and Disruption of Periglomerular Interneurons in Mice

Blackwood, C. A., Bailetti, A. A., Nandi, S., Gridley, T., & Hébert, J. M. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00113 · Cited by 13

Transcriptional and Chromatin Accessibility Profiling of Neural Stem Cells Differentiating into Astrocytes Reveal Dynamic Signatures Affected under Inflammatory Conditions

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Transmembrane Protein Ttyh1 Maintains the Quiescence of Neural Stem Cells Through Ca2+/NFATc3 Signaling

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Notch signaling in mammalian hair cell regeneration.

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Postnatal Neural Stem Cells: Probing Their Competence for Cortical Repair

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Deconstructing Neurogenesis, Transplantation and Genome-Editing as Neural Repair Strategies in Brain Disease

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Hes1 oscillation frequency correlates with activation of neural stem cells

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RBPJ is disrupted in a case of proximal 4p deletion syndrome with epilepsy

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Prosaposin maintains adult neural stem cells in a state associated with deep quiescence

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Tools to study neural and glioma stem cell quiescence.

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Npas3 regulates stemness maintenance of radial glial cells and neuronal migration in the developing mouse cerebral cortex

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EGFL7 loss correlates with increased VEGF-D expression, upregulating hippocampal adult neurogenesis and improving spatial learning and memory

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Endothelial-neurosphere crosstalk in microwell arrays regulates self-renewal and differentiation of human neural stem cells

Yang, K., Lee, J. S., Han, S., Jin, Y., Cho, A., Chang, G.-E., Cheong, E., Yang, J. H., Chung, S. H., & Cho, S. (2019) · Journal of Industrial and Engineering Chemistry · doi:10.1016/j.jiec.2019.02.021 · Cited by 10

Aromatase and Estrogens

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Similarities and differences in tissue distribution of DLK1 and DLK2 during E16.5 mouse embryogenesis

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Notch Signaling and MicroRNA: The Dynamic Duo Steering Between Neurogenesis and Glioblastomas

Javed, Z., Khan, K., Raza, Q., Sadia, H., Shah, F. A., Ahmad, T., Bentivegna, A., Bazzoni, R., Setzer, W. N., Alshehri, M. M., et al. (2021) · Cellular and Molecular Biology · doi:10.14715/cmb/2021.67.2.6 · Cited by 9

Strength of interactions in the Notch gene regulatory network determines patterning and fate in the notochord

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IL-22 Promotes Neural Stem Cell Self-Renewal in the Adult Brain

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Notch directs telencephalic development and controls neocortical neuron fate determination by regulating microRNA levels

Han, J. S., Fishman-Williams, E., Decker, S. C., Hino, K., Reyes, R. V., Brown, N. L., Simó, S., & Torre, A. L. (2023) · Development · doi:10.1242/dev.201408 · Cited by 10

Enteric nervous system regeneration and functional cure of experimental digestive Chagas disease with trypanocidal chemotherapy

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Tamoxifen dosing for Cre-mediated recombination in experimental bronchopulmonary dysplasia

Ruiz‐Camp, J., Rodríguez‐Castillo, J. A., Herold, S., Mayer, K., Vadász, I., Tallquist, M. D., Seeger, W., Ahlbrecht, K., & Morty, R. E. (2016) · Transgenic Research · doi:10.1007/s11248-016-9987-8 · Cited by 9

Identifying the Unique Role of Notch3 in Adult Neural Stem Cell Maintenance

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Inhibitory effects of cigarette smoke extracts on neural differentiation of mouse embryonic stem cells

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Regulation of Neural Stem Cell Competency and Commitment during Indirect Neurogenesis

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TRIM32 Deficiency Impairs the Generation of Pyramidal Neurons in Developing Cerebral Cortex

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Glyphosate‐based herbicide induces long‐lasting impairment in neuronal and glial differentiation

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Interaction of Notch and gp130 Signaling in the Maintenance of Neural Stem and Progenitor Cells

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Overview of Genetic Tools and Techniques to Study Notch Signaling in Mice

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Parkin mediates neuroprotection through activation of Notch1 signaling

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Notch signaling blockade links transcriptome heterogeneity in quiescent neural stem cells with reactivation routes and potential

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Defective Neural Stem and Progenitor Cell Proliferation in Neurodevelopmental Disorders

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Neurogenesis in the Damaged Mammalian Brain

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CSPα in neurodegenerative diseases

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The Notch-mediated circuitry in the evolution and generation of new cell lineages: the tooth model

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TIMP3 promotes the maintenance of neural stem-progenitor cells in the mouse subventricular zone

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Dual Role of Rbpj in the Maintenance of Neural Progenitor Cells and Neuronal Migration in Cortical Development

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A Nucleolar Protein, Nepro, Is Essential for the Maintenance of Early Neural Stem Cells and Preimplantation Embryos

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