In vivo intracellular recording and perturbation of persistent activity in a neural integrator
Abstract
To investigate the mechanisms of persistent neural activity, we obtained in vivo intracellular recordings from neurons in an oculomotor neural integrator of the goldfish during spontaneous saccades and fixations. Persistent changes in firing rate following saccades were associated with step changes in interspike membrane potential that were correlated with changes in eye position. Perturbation of persistent activity with brief intracellular current pulses designed to mimic saccadic input only induced transient changes of firing rate and membrane potential. When neurons were hyperpolarized below action potential threshold, position-correlated step changes in membrane potential remained. Membrane potential fluctuations were greater during more depolarized steps. These results suggest that sustained changes in firing rate are supported not by either membrane multistability or changes in pacemaker currents, but rather by persistent changes in the rate or amplitude of synaptic inputs.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Within the oculomotor integrator, broad physiological and coarse anatomical evidence implicates recurrent excitatory interactions in generating attractor dynamics.
“Within the oculomotor integrator, there is broad physiological18–20 and coarse anatomical21 evidence implicating recurrent excitatory interactions in generating attractor dynamics.”
From Predicting modular functions and neural coding of behavior from a synaptic wiring diagram (2024) · cites this paper as [18]
Cites
Plum, F. (1960) · Archives of Neurology · doi:10.1001/archneur.1960.03840090124020 · Cited by 10,388 · see citing works
Cellular basis of working memory
Goldman-Rakic, P. S. (1995) · Neuron · doi:10.1016/0896-6273(95)90304-6 · Cited by 2,663 · see citing works
A Method of Measuring Eye Movemnent Using a Scieral Search Coil in a Magnetic Field
Robinson, D. A. (1963) · IEEE Transactions on Bio-medical Electronics · doi:10.1109/tbmel.1963.4322822 · Cited by 2,214 · see citing works
Neuron Activity Related to Short-Term Memory
Fuster, J. M., & Alexander, G. E. (1971) · Science · doi:10.1126/science.173.3997.652 · Cited by 2,085 · see citing works
A method of measuring eye movements using a scleral search coil in a magnetic field
Robinson, D. A. (1963) · Medical Entomology and Zoology · Cited by 1,709 · see citing works
Dendritic spines as basic functional units of neuronal integration
Yuste, R., & Denk, W. (1995) · Nature · doi:10.1038/375682a0 · Cited by 950 · see citing works
FOSTER, J. M. (1996) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-199606000-00014 · Cited by 755 · see citing works
Loss of the neural integrator of the oculomotor system from brain stem lesions in monkey
Cannon, S. C., & Robinson, D. A. (1987) · Journal of Neurophysiology · doi:10.1152/jn.1987.57.5.1383 · Cited by 728 · see citing works
Hounsgaard, J., Hultborn, H., Jespersen, B., & Kiehn, O. (1988) · The Journal of Physiology · doi:10.1113/jphysiol.1988.sp017336 · Cited by 700 · see citing works
Llinas, R. H., & Yarom, Y. (1986) · The Journal of Physiology · doi:10.1113/jphysiol.1986.sp016147 · Cited by 668 · see citing works
Impact of Network Activity on the Integrative Properties of Neocortical Pyramidal Neurons In Vivo
Alain Destexhe, A., & Paré, D. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.81.4.1531 · Cited by 621 · see citing works
How the brain keeps the eyes still
Seung, H. S. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.23.13339 · Cited by 534 · see citing works
Self-citationRole of abducens neurons in vestibuloocular reflex.
Skavenski, A. A., & Robinson, D. A. (1973) · Journal of Neurophysiology · doi:10.1152/jn.1973.36.4.724 · Cited by 497 · see citing works
Fuster, J. M. (1999) · Cited by 456 · see citing works
Neuronal activity in prepositus nucleus correlated with eye movement in the alert cat
López‐Barneo, J., Darlot, C., Berthoz, A., & Baker, R. (1982) · Journal of Neurophysiology · doi:10.1152/jn.1982.47.2.329 · Cited by 357 · see citing works
Self-citationStability of the memory of eye position in a recurrent network of conductance-based model neurons
Seung, H. S., Lee, D. D., Reis, B. Y., & Tank, D. W. (2000) · Neuron · doi:10.1016/s0896-6273(00)81155-1 · Cited by 339 · see citing works
Self-citationRobinson, D. A. (1989) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.12.030189.000341 · Cited by 323 · see citing works
McFarland, J. L., & Fuchs, A. F. (1992) · Journal of Neurophysiology · doi:10.1152/jn.1992.68.1.319 · Cited by 323 · see citing works
Calcium Coding and Adaptive Temporal Computation in Cortical Pyramidal Neurons
Wang, X. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.3.1549 · Cited by 285 · see citing works
Memory from the dynamics of intrinsic membrane currents
Marder, E., Abbott, L. F., Turrigiano, G. G., Liu, Z., & Golowasch, J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13481 · Cited by 281 · see citing works
Role of primate basal ganglia and frontal cortex in the internal generation of movements
Romo, R., & Schultz, W. (1992) · Experimental Brain Research · doi:10.1007/bf00227836 · Cited by 271 · see citing works
Role of primate basal ganglia and frontal cortex in the internal generation of movements
Romo, R., Scarnati, E., & Schultz, W. (1992) · Experimental Brain Research · doi:10.1007/bf00227835 · Cited by 266 · see citing works
Primate spinal interneurons show pre-movement instructed delay activity
Prut, Y., & Fetz, E. E. (1999) · Nature · doi:10.1038/44145 · Cited by 242 · see citing works
Linearization of F-I Curves by Adaptation
Ermentrout, B. (1998) · Neural Computation · doi:10.1162/089976698300017106 · Cited by 234 · see citing works
Absence of a stretch reflex in extraocular muscles of the monkey.
Keller, E. L., & Robinson, D. A. (1971) · Journal of Neurophysiology · doi:10.1152/jn.1971.34.5.908 · Cited by 195 · see citing works
Plateau potentials and active integration in the ‘final common pathway’ for motor behaviour
Kiehn, O. (1991) · Trends in Neurosciences · doi:10.1016/0166-2236(91)90023-n · Cited by 189 · see citing works
Role of primate basal ganglia and frontal cortex in the internal generation of movements
Schultz, W., & Romo, R. (1992) · Experimental Brain Research · doi:10.1007/bf00227834 · Cited by 176 · see citing works
A proposed neural network for the integrator of the oculomotor system
Cannon, S., Robinson, D. A., & Shamma, S. (1983) · Biological cybernetics · doi:10.1007/bf00320393 · Cited by 173 · see citing works
Molecular properties of brain sodium channels: an important target for anticonvulsant drugs.
Catterall, W. A. (1999) · PubMed · Cited by 173 · see citing works
Functional role of plateau potentials in vertebrate motor neurons
Kiehn, O., & Eken, T. (1998) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(98)80117-7 · Cited by 172 · see citing works
The characteristics of ‘end‐plate noise’ produced by different depolarizing drugs
Katz, B., & Miledi, R. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010213 · Cited by 172 · see citing works
Reuveni, I., Friedman, A., Amitai, Y., & Gutnick, M. J. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-11-04609.1993 · Cited by 133 · see citing works
Aksay, E., Baker, R., Seung, H. S., & Tank, D. W. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.84.2.1035 · Cited by 119 · see citing works
Self-citationEye position and eye velocity integrators reside in separate brainstem nuclei.
Pastor, Á. M., de la Cruz, R. R., & Baker, R. G. V. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.2.807 · Cited by 100 · see citing works
Self-citationMembrane potential oscillations underlying firing patterns in neocortical neurons
Amitai, Y. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90013-2 · Cited by 82 · see citing works
Discharge characteristics of medial rectus and abducens motoneurons in the goldfish
Pastor, Á. M., Torres, B., Delgado-Garcia, J. M., & Baker, R. (1991) · Journal of Neurophysiology · doi:10.1152/jn.1991.66.6.2125 · Cited by 81 · see citing works
Self-citationSpontaneous eye movements in restrained goldfish
Easter, S. S. (1971) · Vision Research · doi:10.1016/0042-6989(71)90244-6 · Cited by 72 · see citing works
Neural integration by short term potentiation
Shen, L. (1989) · Biological Cybernetics · doi:10.1007/bf00203180 · Cited by 61 · see citing works
Ca2+-Activated Nonselective Cationic Current (I CAN) in Turtle Motoneurons
Perrier, J., & Hounsgaard, J. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.82.2.730 · Cited by 58 · see citing works
A neurological integrator for the oculomotor control system
Kamath, B. Y., & Keller, E. L. (1976) · Mathematical Biosciences · doi:10.1016/0025-5564(76)90073-0 · Cited by 44 · see citing works
A Theoretical Neural Integrator
Rosen, M. (1972) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.1972.324139 · Cited by 33 · see citing works
Eye movements evoked by microstimulations in the brainstem of the alert cat
Godaux, E., Cheron, G. A., & Gravis, F. (1989) · Experimental Brain Research · doi:10.1007/bf00250571 · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Bogacz, R., Brown, E., Moehlis, J., Holmes, P. J., & Cohen, J. D. (2006) · Psychological Review · doi:10.1037/0033-295x.113.4.700 · Cited by 1,845 · see citing works
Neural Basis of a Perceptual Decision in the Parietal Cortex (Area LIP) of the Rhesus Monkey
Shadlen, M. N., & Newsome, W. T. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.86.4.1916 · Cited by 1,755 · see citing works
Synaptic reverberation underlying mnemonic persistent activity
Wang, X.-J. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01868-3 · Cited by 1,059 · see citing works
A role for neural integrators in perceptual decision making
Mazurek, M. E., Roitman, J. D., Ditterich, J., & Shadlen, M. N. (2003) · Cerebral Cortex · doi:10.1093/cercor/bhg097 · Cited by 620 · see citing works
Durstewitz, D., & Seamans, J. K. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.015 · Cited by 586 · see citing works
Huk, A. C., & Shadlen, M. N. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4684-04.2005 · Cited by 538 · see citing works
Mazor, O., & Laurent, G. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.032 · Cited by 484 · see citing works
Timing and Neural Encoding of Somatosensory Parametric Working Memory in Macaque Prefrontal Cortex
Brody, C. D. (2003) · Cerebral Cortex · doi:10.1093/cercor/bhg100 · Cited by 350 · see citing works
A Neural Representation of Categorization Uncertainty in the Human Brain
Grinband, J., Hirsch, J., & Ferrera, V. P. (2006) · Neuron · doi:10.1016/j.neuron.2006.01.032 · Cited by 330 · see citing works
Discrete attractor dynamics underlies persistent activity in the frontal cortex
Inagaki, H. K., Fontolan, L., Romani, S., & Svoboda, K. (2019) · Nature · doi:10.1038/s41586-019-0919-7 · Cited by 334 · see citing works
A neural circuit architecture for angular integration in Drosophila
Green, J., Adachi, A., Shah, K. K., Hirokawa, J. D., Magani, P. S., & Maimon, G. (2017) · Nature · doi:10.1038/nature22343 · Cited by 331 · see citing works
Persistent neural activity: prevalence and mechanisms
Major, G., & Tank, D. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.10.017 · Cited by 320 · see citing works
Self-citationDynamics of Spontaneous Activity in Neocortical Slices
Mao, B.-Q., Hamzei‐Sichani, F., Aronov, D., Froemke, R. C., & Yuste, R. (2001) · Neuron · doi:10.1016/s0896-6273(01)00518-9 · Cited by 319 · see citing works
Attractor and integrator networks in the brain
Khona, M., & Fiete, I. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-022-00642-0 · Cited by 314 · see citing works
Model for a robust neural integrator
Koulakov, A. A., Raghavachari, S., Kepecs, Á., & Lisman, J. E. (2002) · Nature Neuroscience · doi:10.1038/nn893 · Cited by 308 · see citing works
Specific evidence of low-dimensional continuous attractor dynamics in grid cells
Yoon, K., Buice, M. A., Barry, C., Hayman, R., Burgess, N., & Fiete, I. R. (2013) · Nature Neuroscience · doi:10.1038/nn.3450 · Cited by 296 · see citing works
Whole-Cell Recordings in Freely Moving Rats
Lee, A. K., Manns, I. D., Sakmann, B. J., & Brecht, M. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.004 · Cited by 253 · see citing works
Comparing the prefrontal cortex of rats and primates: Insights from electrophysiology
Seamans, J. K., Lapish, C. C., & Durstewitz, D. (2008) · Neurotoxicity Research · doi:10.1007/bf03033814 · Cited by 244 · see citing works
Seeing at a glance, smelling in a whiff: rapid forms of perceptual decision making
Uchida, N., Kepecs, Á., & Mainen, Z. F. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1933 · Cited by 231 · see citing works
Computational principles of memory
Chaudhuri, R., & Fiete, I. (2016) · Nature Neuroscience · doi:10.1038/nn.4237 · Cited by 213 · see citing works
Zylberberg, J., & Strowbridge, B. W. (2017) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-070815-014006 · Cited by 192 · see citing works
Memory search and the neural representation of context
Polyn, S. M., & Kahana, M. J. (2008) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2007.10.010 · Cited by 202 · see citing works
Optogenetic Localization and Genetic Perturbation of Saccade-Generating Neurons in Zebrafish
Schoonheim, P. J., Arrenberg, A. B., Del Bene, F., & Baier, H. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5193-09.2010 · Cited by 185 · see citing works
A neuromechanical strategy for mediolateral foot placement in walking humans
Rankin, B. L., Buffo, S. K., & Dean, J. C. (2014) · Journal of Neurophysiology · doi:10.1152/jn.00138.2014 · Cited by 178 · see citing works
Goldman, M. S. (2003) · Cerebral Cortex · doi:10.1093/cercor/bhg095 · Cited by 169 · see citing works
A Unified Approach to Building and Controlling Spiking Attractor Networks
Eliasmith, C. (2005) · Neural Computation · doi:10.1162/0899766053630332 · Cited by 167 · see citing works
Beck, J. C., Gilland, E., Tank, D. W., & Baker, R. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00311.2004 · Cited by 167 · see citing works
Self-citationTemporal integration by calcium dynamics in a model neuron
Loewenstein, Y., & Sompolinsky, H. (2003) · Nature Neuroscience · doi:10.1038/nn1109 · Cited by 148 · see citing works
The optokinetic response in zebrafish and its applications
Huang, Y. (2007) · Frontiers in bioscience · doi:10.2741/2810 · Cited by 142 · see citing works
Persistently active, pacemaker-like neurons in neocortex
Bon-Jégo, M. L. (2007) · Frontiers in Neuroscience · doi:10.3389/neuro.01.1.1.009.2007 · Cited by 146 · see citing works
Fundamental limits on persistent activity in networks of noisy neurons
Burak, Y., & Fiete, I. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117386109 · Cited by 135 · see citing works
Miri, A., Daie, K., Burdine, R. D., Aksay, E., & Tank, D. W. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00702.2010 · Cited by 138 · see citing works
Self-citationSpatial gradients and multidimensional dynamics in a neural integrator circuit
Miri, A., Daie, K., Arrenberg, A. B., Baier, H., Aksay, E., & Tank, D. W. (2011) · Nature Neuroscience · doi:10.1038/nn.2888 · Cited by 138 · see citing works
Self-citationA Pair of Inhibitory Neurons Are Required to Sustain Labile Memory in the Drosophila Mushroom Body
Pitman, J. L., Huetteroth, W., Burke, C. J., Krashes, M. J., Lai, S.-L., Lee, T., & Waddell, S. (2011) · Current Biology · doi:10.1016/j.cub.2011.03.069 · Cited by 137 · see citing works
Functional dissection of circuitry in a neural integrator
Aksay, E., Olasagasti, I., Mensh, B. D., Baker, R., Goldman, M. S., & Tank, D. W. (2007) · Nature Neuroscience · doi:10.1038/nn1877 · Cited by 134 · see citing works
Self-citationA Controlled Attractor Network Model of Path Integration in the Rat
Conklin, J., & Eliasmith, C. (2005) · Journal of Computational Neuroscience · doi:10.1007/s10827-005-6558-z · Cited by 127 · see citing works
Persistent Responses to Brief Stimuli: Feedback Excitation among Brainstem Neurons
Li, W., Soffe, S. R., Wolf, E., & Roberts, A. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4727-05.2006 · Cited by 118 · see citing works
Neural substrates of memory: From synapse to system
Dubnau, J., Chiang, A., & Tully, T. (2002) · Journal of Neurobiology · doi:10.1002/neu.10170 · Cited by 116 · see citing works
Real neuroscience in virtual worlds
Dombeck, D. A., & Reiser, M. B. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.10.015 · Cited by 114 · see citing works
Ziegler, S., Pedersen, M. L., Mowinckel, A. M., & Biele, G. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.09.002 · Cited by 110 · see citing works
Cervical dystonia: a neural integrator disorder
Shaikh, A. G., Zee, D. S., Crawford, J. D., & Jinnah, H. A. (2016) · Brain · doi:10.1093/brain/aww141 · Cited by 103 · see citing works
Multifunctional Fibers as Tools for Neuroscience and Neuroengineering
Canales, A., Park, S., Kilias, A., & Anikeeva, P. (2018) · Accounts of Chemical Research · doi:10.1021/acs.accounts.7b00558 · Cited by 102 · see citing works
A Model of the Effects of Applied Electric Fields on Neuronal Synchronization
Park, E.-H., Barreto, E., Gluckman, B. J., Schiff, S. J., & So, P. (2005) · Journal of Computational Neuroscience · doi:10.1007/s10827-005-0214-5 · Cited by 95 · see citing works
Representing information in cell assemblies: persistent activity mediated by semilunar granule cells
Larimer, P., & Strowbridge, B. W. (2009) · Nature Neuroscience · doi:10.1038/nn.2458 · Cited by 95 · see citing works
Yoshida, M., & Hasselmo, M. E. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5154-08.2009 · Cited by 94 · see citing works
Higher-Dimensional Neurons Explain the Tuning and Dynamics of Working Memory Cells
Singh, R., & Eliasmith, C. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4864-05.2006 · Cited by 89 · see citing works
A Distributed Recurrent Network Contributes to Temporally Precise Vocalizations
Hamaguchi, K., Tanaka, M., & MOONEY, R. D. (2016) · Neuron · doi:10.1016/j.neuron.2016.06.019 · Cited by 90 · see citing works
de Carrizosa, M. A. D., Morado-Díaz, C. J., Tena, J. J., Benítez‐Temiño, B., Pecero, M. L., Morcuende, S., de la Cruz, R. R., & Pastor, Á. M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5312-08.2009 · Cited by 88 · see citing works
Bass, A. H., & Chagnaud, B. P. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201886109 · Cited by 82 · see citing works
Attracting Dynamics of Frontal Cortex Ensembles during Memory-Guided Decision-Making
Balaguer‐Ballester, E., Lapish, C. C., Seamans, J. K., & Durstewitz, D. (2011) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002057 · Cited by 77 · see citing works
Fisher, D., Olasagasti, I., Tank, D. W., Aksay, E. R. F., & Goldman, M. S. (2013) · Neuron · doi:10.1016/j.neuron.2013.06.041 · Cited by 75 · see citing works
Self-citationNeural Algorithms and Circuits for Motor Planning
Inagaki, H., Chen, S., Daie, K., Finkelstein, A., Fontolan, L., Romani, S., & Svoboda, K. (2022) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-092021-121730 · Cited by 80 · see citing works
Electron Microscopic Reconstruction of Functionally Identified Cells in a Neural Integrator
Vishwanathan, A., Daie, K., Ramirez, A. D., Lichtman, J. W., Aksay, E. R. F., & Seung, H. S. (2017) · Current Biology · doi:10.1016/j.cub.2017.06.028 · Cited by 74 · see citing works
Self-citationPsychiatric Illnesses as Disorders of Network Dynamics
Durstewitz, D., Huys, Q. J. M., & Koppe, G. (2020) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2020.01.001 · Cited by 80 · see citing works
Sylvestre, P. A., Choi, J. T., & Cullen, K. E. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00123.2003 · Cited by 70 · see citing works
Takazawa, T., Saito, Y., Tsuzuki, K., & Ozawa, S. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00494.2004 · Cited by 69 · see citing works
Nonassociative learning as gated neural integrator and differentiator in stimulus-response pathways
Poon, C., & Young, D. L. (2006) · Behavioral and Brain Functions · doi:10.1186/1744-9081-2-29 · Cited by 68 · see citing works
Computing and Stability in Cortical Networks
Latham, P. E., & Nirenberg, S. (2004) · Neural Computation · doi:10.1162/089976604323057434 · Cited by 66 · see citing works
Hyperpolarization-activated graded persistent activity in the prefrontal cortex
Winograd, M., Alain Destexhe, A., & Sanchez-Vives, M. V. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800360105 · Cited by 62 · see citing works
Microfluidic valve with cored glass microneedle for microinjection
Lee, S., Jeong, W., & Beebe, D. J. (2003) · Lab on a Chip · doi:10.1039/b305692a · Cited by 64 · see citing works
Navarro‐López, J. D., Alvarado, J. C., Márquez‐Ruiz, J., Escudero, M., Delgado-Garcia, J. M., & Yajeya, J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0235-04.2004 · Cited by 58 · see citing works
Straka, H., & Simmers, J. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20965 · Cited by 56 · see citing works
Plasticity and tuning by visual feedback of the stability of a neural integrator
Major, G., Baker, R., Aksay, E. R. F., Mensh, B. D., Seung, H. S., & Tank, D. W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401970101 · Cited by 56 · see citing works
Self-citationHeeger, D. J., & Mackey, W. E. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1911633116 · Cited by 54 · see citing works
Balancing at the border of instability
Moreau, L., & Sontag, E. D. (2003) · Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics · doi:10.1103/physreve.68.020901 · Cited by 53 · see citing works
A tale of two species: Neural integration in zebrafish and monkeys
Joshua, M., & Lisberger, S. G. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2014.04.048 · Cited by 47 · see citing works
Spinal sensory neurons project onto the hindbrain to stabilize posture and enhance locomotor speed
Wu, M., Tano, M. C., Mirat, O., Lejeune, F., Roussel, J., Quan, F. B., Fidelin, K., & Wyart, C. (2021) · Current Biology · doi:10.1016/j.cub.2021.05.042 · Cited by 54 · see citing works
Nerve Growth Factor Regulates the Firing Patterns and Synaptic Composition of Motoneurons
de Carrizosa, M. A. D., Morado-Díaz, C. J., Morcuende, S., de la Cruz, R. R., & Pastor, Á. M. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0719-10.2010 · Cited by 47 · see citing works
Axmacher, N., & Miles, R. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2003.052225 · Cited by 47 · see citing works
A Neurobiological Approach to Acquired Nystagmus
Leigh, R. J., Das, V. E., & Seidman, S. H. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02835.x · Cited by 47 · see citing works
Fellous, J. (2003) · Cerebral Cortex · doi:10.1093/cercor/bhg098 · Cited by 47 · see citing works
Aksay, E., Baker, R., Seung, H. S., & Tank, D. W. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-34-10852.2003 · Cited by 45 · see citing works
Self-citationDual Encoding of Muscle Tension and Eye Position by Abducens Motoneurons
de Carrizosa, M. A. D., Morado-Díaz, C. J., Miller, J. M., de la Cruz, R. R., & Pastor, Á. M. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5416-10.2011 · Cited by 45 · see citing works
Spatial Patterns of Persistent Neural Activity Vary with the Behavioral Context of Short-Term Memory
Daie, K., Goldman, M. S., & Aksay, E. R. F. (2015) · Neuron · doi:10.1016/j.neuron.2015.01.006 · Cited by 42 · see citing works
Self-citationStraka, H., Beck, J. C., Pastor, Á. M., & Baker, R. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00334.2006 · Cited by 42 · see citing works
Self-citationNon-mammalian models for studying neural development and function
Marder, E. E. (2002) · Nature · doi:10.1038/417318a · Cited by 42 · see citing works
Idoux, E., Serafin, M., Fort, P., Vidal, P., Beraneck, M., Vibert, N., Mühlethaler, M., & Moore, L. E. (2006) · Journal of Neurophysiology · doi:10.1152/jn.01355.2005 · Cited by 42 · see citing works
Intracellular recording in behaving animals
Long, M. A., & Lee, A. K. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.10.013 · Cited by 41 · see citing works
Design of Continuous Attractor Networks with Monotonic Tuning Using a Symmetry Principle
Machens, C. K., & Brody, C. D. (2007) · Neural Computation · doi:10.1162/neco.2007.07-06-297 · Cited by 37 · see citing works
TRP Channels and Neural Persistent Activity
Reboreda, A., Jiménez‐Díaz, L., & Navarro‐López, J. D. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-0265-3_32 · Cited by 37 · see citing works
Brain calculus: neural integration and persistent activity
McCormick, D. A. (2001) · Nature Neuroscience · doi:10.1038/83917 · Cited by 37 · see citing works
Noorman, M., Hulse, B. K., Jayaraman, V., Romani, S., & Hermundstad, A. M. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01766-5 · Cited by 31 · see citing works
Membrane Potential-Dependent Modulation of Recurrent Inhibition in Rat Neocortex
Zhu, J., Jiang, M., Yang, M., Hou, H., & Shu, Y. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001032 · Cited by 34 · see citing works
Optical Physiology and Locomotor Behaviors of Wild-Type and Nacre Zebrafish
O’Malley, D. M., Sankrithi, N., Borla, M. A., Parker, S. K., Banden, S., Gahtan, E., & Detrich, H. W. (2004) · Methods in cell biology · doi:10.1016/s0091-679x(04)76013-6 · Cited by 33 · see citing works
Persistent activity and memory in the entorhinal cortex
Frank, L. M., & Brown, E. N. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00176-0 · Cited by 33 · see citing works
Beck, J. C., Rothnie, P., Straka, H., Wearne, S. L., & Baker, R. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00335.2006 · Cited by 32 · see citing works
Self-citationFunctional Diversity of Neurotrophin Actions on the Oculomotor System
Benítez‐Temiño, B., de Carrizosa, M. A. D., Morcuende, S., Matarredona, E. R., de la Cruz, R. R., & Pastor, Á. M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17122016 · Cited by 31 · see citing works
Teramae, J.-N., & Fukai, T. (2005) · Journal of Computational Neuroscience · doi:10.1007/s10827-005-5474-6 · Cited by 29 · see citing works
Koyluoglu, O. O., Pertzov, Y., Manohar, S., Husain, M., & Fiete, I. (2017) · eLife · doi:10.7554/elife.22225 · Cited by 28 · see citing works
Encoding of Eye Position in the Goldfish Horizontal Oculomotor Neural Integrator
Debowy, O., & Baker, R. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00313.2010 · Cited by 29 · see citing works
Self-citationRecruitment of motor neuronal persistent inward currents shapes withdrawal reflexes in the frog
Perrier, J., & Tresch, M. C. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.072769 · Cited by 29 · see citing works
Elucidating Neuronal Mechanisms Using Intracellular Recordings during Behavior
Lee, A. K., & Brecht, M. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2018.03.014 · Cited by 33 · see citing works
A Structural and Genotypic Scaffold Underlying Temporal Integration
Lee, M. M., Arrenberg, A. B., & Aksay, E. R. F. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.3045-14.2015 · Cited by 27 · see citing works
Self-citationVertical nanowire probes for intracellular signaling of living cells
Lee, K., Kim, I., Kim, S.-E., Jeong, D.-W., Kim, J., Rhim, H., Ahn, J.-P., Park, S. H., & Choi, H. (2014) · Nanoscale Research Letters · doi:10.1186/1556-276x-9-56 · Cited by 27 · see citing works
Predicting modular functions and neural coding of behavior from a synaptic wiring diagram
Vishwanathan, A., Sood, A., Wu, J., Ramirez, A. D., Yang, R., Kemnitz, N., Ih, D., Turner, N., Lee, K., Tartavull, I., et al. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01784-3 · Cited by 25 · see citing works
“…approach also incorporated a minimal set of key anatomical and physiological constraints such as known signs of connections 21,32 , physiological observations about the approximate linearity of oculomotor responses 18,49 and functional independence of the bilateral halves of the circuit 20,56 .”
Self-citationArcher fish fast hunting maneuver may be guided by directionally selective retinal ganglion cells
Tsvilling, V., Donchin, O., Shamir, M., & Segev, R. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07971.x · Cited by 25 · see citing works
Membrane properties of excitatory and inhibitory neurons in the rat prepositus hypoglossi nucleus
Shino, M., Ozawa, S., Furuya, N., & Saito, Y. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06204.x · Cited by 25 · see citing works
Ramp-to-threshold dynamics in a hindbrain population controls the timing of spontaneous saccades
Ramirez, A. D., & Aksay, E. R. F. (2021) · Nature Communications · doi:10.1038/s41467-021-24336-w · Cited by 24 · see citing works
Self-citationOestreich, J., & Zakon, H. H. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-18-08287.2002 · Cited by 23 · see citing works
Gq/11-Induced and Spontaneous Waves of Coordinated Network Activation in Developing Frontal Cortex
Calderon, D. P., Leverkova, N., & Peinado, A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2765-04.2005 · Cited by 23 · see citing works
- Authors
- Aksay, E., Gamkrelidze, G., Seung, H. S., Baker, R., & Tank, D. W.
- Affiliations
- Alcatel-Lucent (France) (FR)
- New York University (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Baker, R.
- Tank, D. W.
- Venue
- Nature Neuroscience
- Published
- 2001-02
- Volume
- 4
- Issue
- 2
- Pages
- 184-193
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W1608745771
- Cited by
- 201
- References
- 42
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 10 · 2023: 4 · 2022: 5 · 2021: 8 · 2020: 6 · 2019: 9 · 2018: 4 · 2017: 8 · 2016: 6 · 2015: 6 · 2014: 8 · 2013: 5 · 2012: 6
- FWCI
- 6.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- persistent activity, neural integrator, oculomotor system, goldfish, saccades, fixation, membrane potential, firing rate, synaptic input, eye position, pacemaker current
- MeSH terms
- Action Potentials, Animals, Differential Threshold, Electric Stimulation, Fixation, Ocular, Goldfish, Intracellular Membranes, Membrane Potentials, Neurons, Ocular Physiological Phenomena, Oculomotor Muscles, Reaction Time, Saccades
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
