Microdialysis measurement of cortical and hippocampal acetylcholine release during sleep-wake cycle in freely moving cats
Abstract
The variations of Acetylcholine (ACh) release in the cerebral cortex and dorsal hippocampus were monitored by microdialysis during the electroencephalographically recorded sleep-waking cycle in freely moving cats. The results show a state-dependent variation in ACh output in both the cortex and the hippocampus. ACh release increased by approximately 100% during quiet waking (QW) and by 175% during active waking (AW) as referred to slow wave sleep (SWS) baseline. In contrast, a clear difference between the two areas was observed during REM sleep. During this stage ACh release in the cortex reached approximately the same values observed during QW, while in the hippocampus ACh release rose to about 4-fold the level obtained during SWS or twice that of QW. The results support the idea that the increase in ACh release in the cortex reflects the desynchronized EEG of wakefulness and REM sleep, while the marked increase of ACh during REM in the hippocampus may be related to the sustained theta activity in this area.
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Microdialysis studies in naive animals have found low micromolar levels of endogenous acetylcholine in the hippocampus.
“Microdialysis studies in naı̈ve animals have found low micromolar levels of endogenous acetylcholine in the hippocampus (Marrosu et al, 1995).”
From Divergent Functional Effects of Sazetidine-A and Varenicline During Nicotine Withdrawal (2013) · cites this paper as Marrosu et al, 1995
Cholinergic modulation of the medial septum induces theta rhythm oscillations and theta rhythm is correlated with higher levels of acetylcholine in the hippocampus, while lesions of the cholinergic innervation reduce the magnitude of theta rhythm.
“On a network level, cholinergic modulation of the medial septum induces theta rhythm oscillations (Lawson and Bland, 1993) and theta rhythm is correlated with higher levels of acetylcholine in the hippocampus (Marrosu et al., 1995; Monmaur et al., 1997), while lesions of the cholinergic innervation reduce the magnitude of theta rhythm (Lee et al., 1994).”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Marrosu et al., 1995
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- Authors
- Marrosu, F., Portas, C., Mascia, M. S., Casu, M. A., Fà, M., Giagheddu, M., Imperato, A., & Gessa, G. L.
- Affiliations
- University of Cagliari (IT)
- Corresponding author
- Gessa, Gian Luigi
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1995-02
- Volume
- 671
- Issue
- 2
- Pages
- 329-332
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2092411461
- Cited by
- 480
- References
- 20
- Citations by year
- 2026: 6 · 2025: 16 · 2024: 10 · 2023: 12 · 2022: 16 · 2021: 20 · 2020: 13 · 2019: 18 · 2018: 20 · 2017: 31 · 2016: 18 · 2015: 22 · 2014: 23 · 2013: 11 · 2012: 24
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
- P-arch (Science and Technology Park of Sardinia) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- acetylcholine release, sleep-wake cycle, REM sleep, slow-wave sleep, cerebral cortex, dorsal hippocampus, cholinergic neurotransmission, theta activity, EEG desynchronization
- MeSH terms
- Acetylcholine, Animals, Cats, Cerebral Cortex, Electroencephalography, Hippocampus, Male, Sleep, Sleep, REM, Wakefulness, Microdialysis
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