Cited by 67Neural dynamics and brain functionNeuroscience and Neuropharmacology ResearchVisual perception and processing mechanisms

Cholinergic Modulation of Spindle Bursts in the Neonatal Rat Visual Cortex In Vivo

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Hanganu, Ileana L., Staiger, Jochen F., Ben-Ari, Yehezkel, Khazipov, Rustem·2007·The Journal of Neuroscience

Abstract

Acetylcholine (ACh) is known to shape the adult neocortical activity related to behavioral states and processing of sensory information. However, the impact of cholinergic input on the neonatal neuronal activity remains widely unknown. Early during development, the principal activity pattern in the primary visual (V1) cortex is the intermittent self-organized spindle burst oscillation that can be driven by the retinal waves. Here, we assessed the relationship between this early activity pattern and the cholinergic drive by either blocking or augmenting the cholinergic input and investigating the resultant effects on the activity of the rat visual cortex during the first postnatal week in vivo. Blockade of the muscarinic receptors by intracerebroventricular, intracortical, or supracortical atropine application decreased the occurrence of V1 spindle bursts by 50%, both the retina-independent and the optic nerve-mediated spindle bursts being affected. In contrast, blockade of acetylcholine esterase with physostigmine augmented the occurrence, amplitude, and duration of V1 spindle bursts. Whereas direct stimulation of the cholinergic basal forebrain nuclei increased the occurrence probability of V1 spindle bursts, their chronic immunotoxic lesion using 192 IgG-saporin decreased the occurrence of neonatal V1 oscillatory activity by 87%. Thus, the cholinergic input facilitates the neonatal V1 spindle bursts and may prime the developing cortex to operate specifically on relevant early (retinal waves) and later (visual input) stimuli.

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Crossref · 10.1523/jneurosci.5233-06.2007

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  • Around birth, the numerous cholinergic projections arising from the basal forebrain nuclei innervate the primary cortical regions where they influence cortical ultrastructure.

    “Around birth, the numerous cholinergic projections arising from the basal forebrain nuclei innervate the primary cortical regions where they influence cortical ultrastructure [210–213].”

    From Development of prefrontal cortex (2022) · cites this paper as [213]

    The Introduction describes abundant cholinergic afferents originating mainly in the basal forebrain and links cholinergic input to cortical development. The section on basal forebrain stimulation says these axons begin growing into cortical layers by birth. The paper discusses morphogenesis and circuit wiring, but does not establish an effect on cortical ultrastructure specifically. (LLM, conf=0.84)

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Authors
Hanganu, I. L., Staiger, J. F., Ben-Ari, Y., & Khazipov, R.
Affiliations
  • Inserm (FR)
  • University of Freiburg (DE)
Venue
The Journal of Neuroscience
Published
2007-05-23
Volume
27
Issue
21
Pages
5694-5705
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
OpenAlex
W1968879370
Cited by
67
References
156
Citations by year
2026: 3 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 5 · 2016: 6 · 2015: 3 · 2014: 5 · 2013: 6 · 2012: 6
FWCI
2.00
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, other-oa)
Funders
  • Deutsche Forschungsgemeinschaft
  • Agence Nationale de la Recherche
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
Keywords
cholinergic modulation, primary visual cortex, acetylcholine, muscarinic receptors, atropine, physostigmine, acetylcholinesterase, saporin lesion, retinal waves, cortical development, in vivo neuronal activity
MeSH terms
Animals, Animals, Newborn, Cholinergic Fibers, Male, Synaptic Transmission, Receptors, Muscarinic, Visual Cortex, Visual Pathways, Cholinergic Agents, Cholinergic Agonists, Cholinergic Antagonists, Rats

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