Rapid developmental switch in the mechanisms driving early cortical columnar networks
Abstract
The immature cerebral cortex self-organizes into local neuronal clusters long before it is activated by patterned sensory inputs. In the cortical anlage of newborn mammals, neurons coassemble through electrical or chemical synapses either spontaneously or by activation of transmitter-gated receptors. The neuronal network and the cellular mechanisms underlying this cortical self-organization process during early development are not completely understood. Here we show in an intact in vitro preparation of the immature mouse cerebral cortex that neurons are functionally coupled in local clusters by means of propagating network oscillations in the beta frequency range. In the newborn mouse, this activity requires an intact subplate and is strongly synchronized within a cortical column by gap junctions. With the developmental disappearance of the subplate at the end of the first postnatal week, activation of NMDA (N-methyl-D-aspartate) receptors in the immature cortical network is essential to generate this columnar activity pattern. Our findings show that during a brief developmental period the cortical network switches from a subplate-driven, gap-junction-coupled syncytium to a synaptic network acting through NMDA receptors to generate synchronized oscillatory activity, which may function as an early functional template for the development of the cortical columnar architecture.
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Around birth, the numerous cholinergic projections arising from the basal forebrain nuclei innervate the primary cortical regions where they influence cortical ultrastructure.
“Around birth, the numerous cholinergic projections arising from the basal forebrain nuclei innervate the primary cortical regions where they influence cortical ultrastructure [210–213].”
From Development of prefrontal cortex (2022) · cites this paper as [211]
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- Authors
- Dupont, E., Hanganu, I. L., Kilb, W., Hirsch, S., & Luhmann, H. J.
- Affiliations
- Johannes Gutenberg University Mainz (DE)
- Corresponding author
- Luhmann, Heiko J.
- Venue
- Nature
- Published
- 2005-12-04
- Volume
- 439
- Issue
- 7072
- Pages
- 79-83
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2081918193
- Cited by
- 324
- References
- 37
- Citations by year
- 2026: 9 · 2025: 3 · 2024: 10 · 2023: 8 · 2022: 11 · 2021: 12 · 2020: 16 · 2019: 13 · 2018: 11 · 2017: 20 · 2016: 16 · 2015: 13 · 2014: 18 · 2013: 21 · 2012: 24
- FWCI
- 7.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- cortical development, cortical columns, subplate, gap junctions, NMDA receptor, beta oscillations, network oscillations, neuronal synchronization, synapse maturation
- MeSH terms
- Action Potentials, Animals, Animals, Newborn, Carbachol, Electrophysiology, Mice, Inbred C57BL, Neurons, Somatosensory Cortex, Synapses, Receptors, N-Methyl-D-Aspartate, Gap Junctions, Mice
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