Visual–Procedural Memory Consolidation during Sleep Blocked by Glutamatergic Receptor Antagonists
Open accessAbstract
Visual cortex plasticity is enhanced by sleep. It is hypothesized that a reactivation of glutamatergic synapses is essential for this form of plasticity to occur after learning. To test this hypothesis, human subjects practiced a visual texture discrimination skill known to require post-training sleep for improvements to occur. During sleep, glutamatergic transmission was inhibited by administration of the two glutamate antagonists, caroverine and ketamine, targeting the ionotropic NMDA and AMPA receptors. Both substances given during consolidation sleep in a placebo controlled crossover design were able to prevent improvement of the skill measured the next morning. An off-line activation of glutamatergic synapses therefore seems to play a critical part in the consolidation of plastic changes in the visual cortex.
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Blocking NMDA or AMPA receptors by ketamine or caroverine during post-learning retention sleep completely abolished overnight gains on a visual texture discrimination task in humans.
“in humans, blocking of NMDA or AMPA receptors by infusion of ketamine or caroverine during post-learning retention sleep completely abolished overnight gains on a visual texture discrimination task (435)”
From About Sleep's Role in Memory (2013) · cites this paper as [435]
The Methods describe ketamine and caroverine infusions during post-learning sleep, and the Results report no statistically significant overnight improvement with either drug. However, the caroverine group had a small average gain (a 4.8 ms decrease in detection threshold), so “completely abolished” is stronger than the Results establish. (LLM, conf=0.87)
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“Consistent with this hypothesis, in humans, blocking of NMDA or AMPA receptors by infusion of ketamine or caroverine during post-learning retention sleep completely abolished overnight gains on a visual texture discrimination task (435), presumably mediated by local synaptic plastic changes in the visual cortex (1049,…”
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Self-citation
- Authors
- Gais, S., Rasch, B., Wagner, U., & Born, J.
- Affiliations
- University of Lübeck (DE)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2008-05-21
- Volume
- 28
- Issue
- 21
- Pages
- 5513-5518
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6670623
- OpenAlex
- W2158253208
- Cited by
- 47
- References
- 10
- Citations by year
- 2026: 1 · 2025: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 1 · 2014: 5 · 2013: 7 · 2012: 2
- FWCI
- 2.42
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (SFB654)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- memory consolidation, sleep, visual cortex plasticity, glutamatergic neurotransmission, NMDA receptor antagonists, AMPA receptor antagonists, ketamine, skill acquisition
- MeSH terms
- Adult, Discrimination Learning, Double-Blind Method, Humans, Ketamine, Male, Memory, Photic Stimulation, Quinoxalines, Sleep, Cross-Over Studies, Excitatory Amino Acid Antagonists
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