Cited by 264Memory and Neural MechanismsSleep and Wakefulness ResearchMemory Processes and Influences

Offline Persistence of Memory-Related Cerebral Activity during Active Wakefulness

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Peigneux, Philippe, Orban, Pierre, Balteau, Evelyne, Degueldre, Christian, Luxen, André, Laureys, Steven, Maquet, Pierre·2006·PLoS Biology

Abstract

Much remains to be discovered about the fate of recent memories in the human brain. Several studies have reported the reactivation of learning-related cerebral activity during post-training sleep, suggesting that sleep plays a role in the offline processing and consolidation of memory. However, little is known about how new information is maintained and processed during post-training wakefulness before sleep, while the brain is actively engaged in other cognitive activities. We show, using functional magnetic resonance imaging, that brain activity elicited during a new learning episode modulates brain responses to an unrelated cognitive task, during the waking period following the end of training. This post-training activity evolves in learning-related cerebral structures, in which functional connections with other brain regions are gradually established or reinforced. It also correlates with behavioral performance. These processes follow a different time course for hippocampus-dependent and hippocampus-independent memories. Our experimental approach allowed the characterization of the offline evolution of the cerebral correlates of recent memories, without the confounding effect of concurrent practice of the learned material. Results indicate that the human brain has already extensively processed recent memories during the first hours of post-training wakefulness, even when simultaneously coping with unrelated cognitive demands.

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  • Prior performance on procedural tasks produced relative enhanced activation in striatal and supplementary motor areas, whereas prior navigation performance enhanced activation in temporal lobe regions including the hippocampus.

    “Prior performance on the procedural tasks produced relative enhanced activation in striatal and supplementary motor areas, whereas prior navigation performance enhanced activation in temporal lobe regions including the hippocampus.”

    From About Sleep's Role in Memory (2013) · cites this paper as [913]

  • FMRI recordings in subjects performing a vigilance task indicated biased brain activation depending on whether the subjects had performed before on either a procedural serial reaction task or a spatial navigation.

    “FMRI recordings in subjects performing on a vigilance task indicated biased brain activation depending on whether the subjects had performed before on either a procedural serial reaction task or a spatial navigation (913).”

    From About Sleep's Role in Memory (2013) · cites this paper as [913]

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Research works printed but not linked: 2

  1. Penny W, Holmes A (2003) Random-effect analysis. In: Frackowiak R, Friston K, Frith C, Dolan R, Price C et al., editors. Human brain function. 2nd Edition. London: Academic Press. 1144 p.
  2. Friston K (2003) Introduction: Experimental design and statistical para- metric mapping. In: Frackowiak R, Friston K, Frith C, Dolan R, Price C et al., editors. Human brain function. 2nd Edition. London: Academic Press. 1144 p.

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Authors
Peigneux, P., Orban, P., Balteau, E., Degueldre, C., Luxen, A., Laureys, S., & Maquet, P.
Affiliations
University of Liège (BE)
Corresponding author
Peigneux, Philippe
Venue
PLoS Biology
Published
2006-03-28
Volume
4
Issue
4
Pages
e100
ISSN
  • 1544-9173 (ISSN-L)
  • 1545-7885
OpenAlex
W1964556794
Cited by
263
References
65
Citations by year
2026: 2 · 2025: 1 · 2024: 7 · 2023: 9 · 2022: 7 · 2021: 9 · 2020: 12 · 2019: 15 · 2018: 11 · 2017: 17 · 2016: 9 · 2015: 12 · 2014: 19 · 2013: 29 · 2012: 15
FWCI
8.74
Type
journal article
Language
en
Open access
Locations
  • PLoS Biology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Figshare (submittedVersion, cc-by)
  • ORBi (University of Liège) (submittedVersion, other-oa)
Funders
Fonds De La Recherche Scientifique - FNRS
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords
memory consolidation, wakefulness, memory reactivation, hippocampal-dependent memory, functional connectivity
MeSH terms
Adult, Cerebral Cortex, Cognition, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Memory, Time Factors, Wakefulness

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