Parvalbumin Is a Mobile Presynaptic Ca2+Buffer in the Calyx of Held that Accelerates the Decay of Ca2+and Short-Term Facilitation
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Presynaptic Ca 2+signaling plays a crucial role in short-term plasticity of synaptic transmission. Here, we studied the role of mobile endogenous presynaptic Ca 2+buffer(s) in modulating paired-pulse facilitation at a large excitatory nerve terminal in the auditory brainstem, the calyx of Held. To do so, we assessed the effect of presynaptic whole-cell recording, which should lead to the diffusional loss of endogenous mobile Ca 2+buffers, on paired-pulse facilitation and on intracellular Ca 2+concentration ([Ca 2+]i) transients evoked by action potentials. In unperturbed calyces briefly preloaded with the Ca 2+indicator fura-6F, the [Ca 2+]i transient decayed surprisingly fast (τ fast, ∼30 ms). Presynaptic whole-cell recordings made without additional Ca 2+buffers slowed the decay kinetics of [Ca 2+]i and paired-pulse facilitation (twofold to threefold), but the amplitude of the [Ca 2+]i transient was changed only marginally. The fast [Ca 2+]i decay was restored by adding the slow Ca 2+buffer EGTA (50–100 μ m) or parvalbumin (100 μ m), a Ca 2+-binding protein with slow Ca 2+-binding kinetics, to the presynaptic pipette solution. In contrast, the fast Ca 2+buffer fura-2 strongly reduced the amplitude of the [Ca 2+]i transient and slowed its decay, suggesting that the mobile endogenous buffer in calyces of Held has slow, rather than fast, binding kinetics. In parvalbumin knock-out mice, the decay of [Ca 2+]i and facilitation was slowed approximately twofold compared with wild-type mice, similar to what is observed during whole-cell recordings in rat calyces of Held. Thus, in young calyces of Held, a mobile Ca 2+buffer with slow binding kinetics, primarily represented by parvalbumin, accelerates the decay of spatially averaged [Ca 2+]i and paired-pulse facilitation.
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Absence of PV in PV-/- Pvalb neurons does not affect basal synaptic transmission but enhances facilitation and shortens delayed transmitter release.
“The absence of PV in PV-/- Pvalb neurons does not affect basal synaptic transmission, but enhances facilitation [49, 50] and shortens delayed transmitter release [51].”
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- Authors
- Müller, M., Felmy, F., Schwaller, B., & Schneggenburger, R.
- Affiliations
- École Polytechnique Fédérale de Lausanne (CH)
- Ludwig-Maximilians-Universität München (DE)
- University of Fribourg (CH)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-02-28
- Volume
- 27
- Issue
- 9
- Pages
- 2261-2271
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6673482
- OpenAlex
- W1975952480
- Cited by
- 155
- References
- 46
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 3 · 2023: 7 · 2022: 4 · 2021: 7 · 2020: 4 · 2019: 5 · 2018: 7 · 2017: 1 · 2016: 8 · 2015: 9 · 2014: 11 · 2013: 10 · 2012: 8
- FWCI
- 5.97
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- National Science Foundation
- Deutsche Forschungsgemeinschaft (TP B1)
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (100400, 3100A0)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- parvalbumin, calyx of Held, paired-pulse facilitation, short-term plasticity, calcium transients, fura-2, EGTA, auditory brainstem, excitatory synapses
- MeSH terms
- Animals, Brain Stem, Calcium, Calcium-Binding Proteins, Mice, Inbred C57BL, Synaptic Transmission, Neuronal Plasticity, Parvalbumins, Rats, Wistar, Receptors, Presynaptic, Mice, Knockout, Patch-Clamp Techniques, Mice, Rats, In Vitro Techniques
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