Development of global cortical networks in early infancy
Open accessAbstract
Human cognition and behaviors are subserved by global networks of neural mechanisms. Although the organization of the brain is a subject of interest, the process of development of global cortical networks in early infancy has not yet been clarified. In the present study, we explored developmental changes in these networks from several days to 6 months after birth by examining spontaneous fluctuations in brain activity, using multichannel near-infrared spectroscopy. We set up 94 measurement channels over the frontal, temporal, parietal, and occipital regions of the infant brain. The obtained signals showed complex time-series properties, which were characterized as 1/f fluctuations. To reveal the functional connectivity of the cortical networks, we calculated the temporal correlations of continuous signals between all the pairs of measurement channels. We found that the cortical network organization showed regional dependency and dynamic changes in the course of development. In the temporal, parietal, and occipital regions, connectivity increased between homologous regions in the two hemispheres and within hemispheres; in the frontal regions, it decreased progressively. Frontoposterior connectivity changed to a “U-shaped” pattern within 6 months: it decreases from the neonatal period to the age of 3 months and increases from the age of 3 months to the age of 6 months. We applied cluster analyses to the correlation coefficients and showed that the bilateral organization of the networks begins to emerge during the first 3 months of life. Our findings suggest that these developing networks, which form multiple clusters, are precursors of the functional cerebral architecture.
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From birth through the first two years of life, synchronization and homotopic coupling increase while between-module connectivity decreases, indicating greater functional specialization.
“synchronization and homotopic coupling from birth through the first two years of life (Gao et al., 2015b; Homae et al., 2010), concomitant with decreasing between-module connectivity (i.e. greater functional specialization).”
From Development of large-scale functional networks from birth to adulthood: A guide to the neuroimaging literature (2017) · cites this paper as Homae et al., 2010
From birth through age two, these modules markedly increase distributed synchronization and homotopic coupling.
“These latter modules also exhibit substantial growth of distributed synchronization and homotopic coupling from birth through the first two years of life (Gao et al., 2015b; Homae et al., 2010), concomitant”
From Development of large-scale functional networks from birth to adulthood: A guide to the neuroimaging literature (2017) · cites this paper as Homae et al., 2010
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Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482 · see citing works
Functional connectivity in the motor cortex of resting human brain using echo‐planar mri
Biswal, B., Zerrin Yetkin, F., Haughton, V. M., & Hyde, J. S. (1995) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910340409 · Cited by 9,812 · see citing works
The human brain is intrinsically organized into dynamic, anticorrelated functional networks
Fox, M. D., Snyder, A. Z., Vincent, J. L., Corbetta, M., Van Essen, D. C., & Raichle, M. E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504136102 · Cited by 8,553 · see citing works
Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging
Fox, M. D., & Raichle, M. E. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2201 · Cited by 6,700 · see citing works
Thresholding of statistical maps in functional neuroimaging using the false discovery rate
Genovese, C. R., Lazar, N. A., & Nichols, T. (2002) · NeuroImage · doi:10.1006/nimg.2001.1037 · Cited by 4,923 · see citing works
Jöbsis, F. F. (1977) · Science · doi:10.1126/science.929199 · Cited by 3,899 · see citing works
Neurodegenerative Diseases Target Large-Scale Human Brain Networks
Seeley, W. W., Crawford, R. K., Zhou, J., Miller, B. L., & Greicius, M. D. (2009) · Neuron · doi:10.1016/j.neuron.2009.03.024 · Cited by 2,350 · see citing works
Non-invasive optical spectroscopy and imaging of human brain function
Villringer, A., & Chance, B. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01132-6 · Cited by 1,621 · see citing works
Cerebral location of international 10–20 system electrode placement
Homan, R. W., Herman, J. H., & Purdy, P. D. (1987) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(87)90206-9 · Cited by 1,414 · see citing works
Neurophysiological Architecture of Functional Magnetic Resonance Images of Human Brain
Salvador, R. M., John Suckling, A., Coleman, M. R., Pickard, J. D., Menon, D. K., & Bullmore, E. T. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi016 · Cited by 1,334 · see citing works
Okamoto, M., Dan, H., Sakamoto, K., Takeo, K., Shimizu, K., Kohno, S., Oda, I., Isobe, S., Suzuki, T., Kohyama, K., et al. (2003) · NeuroImage · doi:10.1016/j.neuroimage.2003.08.026 · Cited by 1,320 · see citing works
CONSPEC and CONLERN: A two-process theory of infant face recognition.
Morton, J., & Johnson, M. H. (1991) · Psychological Review · doi:10.1037/0033-295x.98.2.164 · Cited by 1,115 · see citing works
Functional neuroimaging of speech perception in infants
Dehaene-Lambertz, G., Dehaene, S., & Hertz-Pannier, L. (2002) · Science · doi:10.1126/science.1077066 · Cited by 1,113 · see citing works
Using the International 10-20 EEG System for Positioning of Transcranial Magnetic Stimulation
Herwig, U., Satrapi, P., & Schönfeldt‐Lecuona, C. (2003) · Brain Topography · doi:10.1023/b:brat.0000006333.93597.9d · Cited by 1,103 · see citing works
Beyond the Visible???Imaging the Human Brain With Light
Obrig, H., & Villringer, A. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000043472.45775.29 · Cited by 894 · see citing works
The evolution of the arcuate fasciculus revealed with comparative DTI
Rilling, J. K., Glasser, M. F., Preuss, T. M., Ma, X., Zhao, T., Hu, X. P., & Behrens, T. E. J. (2008) · Nature Neuroscience · doi:10.1038/nn2072 · Cited by 866 · see citing works
Maturation of white matter in the human brain: A review of magnetic resonance studies.
Paus, T., Collins, D. L., Evans, A. C., Leonard, G., Pike, B., & Zijdenbos, A. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(00)00434-2 · Cited by 863 · see citing works
Mapping early brain development in autism
Courchesne, E., Pierce, K., Schumann, C. M., Redcay, E., Buckwalter, J. A., Kennedy, D. P., & Morgan, J. (2007) · Neuron · doi:10.1016/j.neuron.2007.10.016 · Cited by 860 · see citing works
The neural basis of cognitive development: A constructivist manifesto
Quartz, S. R., & B, T. J. S. A. (1997) · Behavioral and Brain Sciences · doi:10.1017/s0140525x97001581 · Cited by 856 · see citing works
Sounds and silence: An optical topography study of language recognition at birth
Peña, M., Maki, A., Kovac̆ić, D., Dehaene‐Lambertz, G., Koizumi, H., Bouquet, F., & Mehler, J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1934290100 · Cited by 735 · see citing works
Resting-state networks in the infant brain
Fransson, P., Skiöld, B., Horsch, S., Nordell, A., Blennow, M., Lagercrantz, H., & Åden, U. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704380104 · Cited by 696 · see citing works
Spatial and temporal analysis of human motor activity using noninvasive NIR topography
Maki, A., Yamashita, Y., Ito, Y., Watanabe, E., Mayanagi, Y., & Koizumi, H. (1995) · Medical Physics · doi:10.1118/1.597496 · Cited by 688 · see citing works
Gao, W., Zhu, H., Giovanello, K. S., Smith, J. K., Shen, D., Gilmore, J. H., & Lin, W. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811221106 · Cited by 601 · see citing works
Unrest at rest: Default activity and spontaneous network correlations
Buckner, R. L., & Vincent, J. L. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.01.010 · Cited by 523 · see citing works
Axon overproduction and elimination in the corpus callosum of the developing rhesus monkey
LaMantia, A., & RAKIC, P. T. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-07-02156.1990 · Cited by 511 · see citing works
Hermoye, L., Saint‐Martin, C., Cosnard, G., Lee, S., Kim, J., Nassogne, M., Menten, R., Clapuyt, P. R. M., Donohue, P., Hua, K., et al. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.08.017 · Cited by 422 · see citing works
Neural Plasticity: The Effects of Environment on the Development of the Cerebral Cortex
Huttenlocher, P. R. (2002) · doi:10.4159/9780674038936 · Cited by 421 · see citing works
Dubois, J., Dehaene‐Lambertz, G., Perrin, M., Mangin, J., Cointepas, Y., Duchesnay, É., Bihan, D. L., & Hertz‐Pannier, L. (2007) · Human Brain Mapping · doi:10.1002/hbm.20363 · Cited by 374 · see citing works
Exploring the false discovery rate in multichannel NIRS
Singh, A. K., & Dan, I. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.06.047 · Cited by 363 · see citing works
Brain imaging in awake infants by near-infrared optical topography
Taga, G., Asakawa, K., Maki, A., Konishi, Y., & Koizumi, H. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1932552100 · Cited by 294 · see citing works
Self-citationResting-state functional connectivity in the human brain revealed with diffuse optical tomography
White, B. R., Snyder, A. Z., Cohen, A. L., Petersen, S. E., Raichle, M. E., Schlaggar, B. L., & Culver, J. P. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.03.058 · Cited by 288 · see citing works
Neural Plasticity: The Effects of Environment on the Development of the Cerebral Cortex
Huttenlocher, P. R. (2002) · Cited by 269 · see citing works
Craniocerebral topography within the international 10–20 system
Steinmetz, H., Fürst, G., & Meyer, B.-U. (1989) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(89)90227-7 · Cited by 261 · see citing works
Infant speech perception activates Broca's area: a developmental magnetoencephalography study
Imada, T., Zhang, Y., Cheour, M., Taulu, S., Ahonen, A., & Kuhl, P. K. (2006) · NeuroReport · doi:10.1097/01.wnr.0000223387.51704.89 · Cited by 239 · see citing works
Neuronal models of cognitive functions
Changeux, J., & Dehaene, S. (1989) · Cognition · doi:10.1016/0010-0277(89)90006-1 · Cited by 218 · see citing works
The right hemisphere of sleeping infant perceives sentential prosody
Homae, F., Watanabe, H., Nakano, T., Asakawa, K., & Taga, G. (2006) · Neuroscience Research · doi:10.1016/j.neures.2005.12.006 · Cited by 197 · see citing works
Self-citationMinagawa‐Kawai, Y., Mori, K., Naoi, N., & Kojima, S. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1984-06.2007 · Cited by 156 · see citing works
Prosodic processing in the developing brain
Homae, F., Watanabe, H., Nakano, T., & Taga, G. (2007) · Neuroscience Research · doi:10.1016/j.neures.2007.05.005 · Cited by 148 · see citing works
Self-citationTaga, G., Konishi, Y., Maki, A., et al. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)00874-0 · Cited by 132 · see citing works
Self-citationPrécis ofNeuroconstructivism: How the Brain Constructs Cognition
Sirois, S., Spratling, M., Thomas, M. S. C., Westermann, G., Mareschal, D., & Johnson, M. H. (2008) · Behavioral and Brain Sciences · doi:10.1017/s0140525x0800407x · Cited by 120 · see citing works
Prefrontal Cortical Involvement in Young Infants' Analysis of Novelty
Nakano, T., Watanabe, H., Homae, F., & Taga, G. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn096 · Cited by 116 · see citing works
Self-citationModulation of VLA-4 and L-selectin expression on normal CD34+ cells during mobilization with G-CSF
Bellucci, R., Propris, M. S. D., Buccisano, F., et al. (1998) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1701522 · Cited by 108 · see citing works
The development of a human auditory localization response: A U-shaped function.
Muir, D. W., Clifton, R. K., & Clarkson, M. G. (1989) · Canadian Journal of Psychology/Revue Canadienne de Psychologie · doi:10.1037/h0084220 · Cited by 108 · see citing works
New non-invasive methods for assessing brain oxygenation and haemodynamics
Reynolds, E. O. R., Wyatt, J. S., Azzopardi, D., Delpy, D. T., Cady, E. B., Cope, M., & Wray, S. (1988) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a072289 · Cited by 105 · see citing works
Taga, G., Homae, F., & Watanabe, H. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.07.050 · Cited by 83 · see citing works
Self-citationFunctional activation in diverse regions of the developing brain of human infants
Watanabe, H., Homae, F., Nakano, T., & Taga, G. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.07.014 · Cited by 78 · see citing works
Self-citationTaga, G., & Asakawa, K. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.04.037 · Cited by 63 · see citing works
Self-citationBilateral hemodynamic responses to auditory stimulation in newborn infants
Kotilahti, K. M., Nissila, I. T., Huotilainen, M., et al. (2005) · Neuroreport · doi:10.1097/01.wnr.0000175247.35837.15 · Cited by 63 · see citing works
Anticipatory Cortical Activation Precedes Auditory Events in Sleeping Infants
Nakano, T., Homae, F., Watanabe, H., & Taga, G. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003912 · Cited by 39 · see citing works
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Ferrari, M., & Quaresima, V. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.03.049 · Cited by 2,274 · see citing works
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“These latter modules also exhibit substantial growth of distributed synchronization and homotopic coupling from birth through the first two years of life (Gao et al., 2015b; Homae et al., 2010), concomitant with decreasing between-module connectivity (i.e. greater functional specialization).”
BackgroundA NIRS-fMRI investigation of prefrontal cortex activity during a working memory task
Sato, H., Yahata, N., Funane, T., Takizawa, R., Katura, T., Atsumori, H., Nishimura, Y., Kinoshita, A., Kiguchi, M., Koizumi, H., et al. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.06.043 · Cited by 339 · see citing works
Exploring early human brain development with structural and physiological neuroimaging
Vasung, L., Abaci Turk, E., Ferradal, S. L., Sutin, J., Stout, J. N., Ahtam, B., Lin, P.-Y., & Grant, P. E. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2018.07.041 · Cited by 177 · see citing works
- Authors
- Homae, F., Watanabe, H., Otobe, T., Nakano, T., Go, T., Konishi, Y., & Taga, G.
- Affiliations
- Tokyo Metropolitan University (JP)
- The University of Tokyo (JP)
- Jin-ai Women's College (JP)
- Japan Society for the Promotion of Science (JP)
- Doshisha University (JP)
- Japan Science and Technology Agency (JP)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-04-06
- Volume
- 30
- Issue
- 14
- Pages
- 4877-4882
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6632781
- OpenAlex
- W2114925382
- Cited by
- 206
- References
- 49
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 8 · 2023: 10 · 2022: 17 · 2021: 11 · 2020: 15 · 2019: 10 · 2018: 10 · 2017: 10 · 2016: 18 · 2015: 17 · 2014: 9 · 2013: 20 · 2012: 18
- FWCI
- 10.83
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (20670001, 21613006)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Keywords
- early infancy, spontaneous brain activity, functional connectivity, 1/f fluctuation, interhemispheric connectivity, frontoparietal connectivity, near-infrared spectroscopy, temporal correlation
- MeSH terms
- Age Factors, Brain Mapping, Cerebral Cortex, Female, Humans, Infant, Infant, Newborn, Male, Nerve Net
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