Unrest at rest: Default activity and spontaneous network correlations
Abstract
A series of recent empirical observations demonstrate structured activity patterns that exist during passive task states. One observation is that a network of regions, referred to as the default network, shows preferentially greater activity during passive task states as compared to a wide range of active tasks. The second observation is that distributed regions spontaneously increase and decrease their activity together within functional-anatomic networks, even under anesthesia. We believe these rest activity patterns may reflect neural functions that consolidate the past, stabilize brain ensembles, and prepare us for the future. Accumulating data further suggest that differences in rest activity may be relevant to understanding clinical conditions such as Alzheimer's disease and autism. Maps of spontaneous network correlations also provide tools for functional localization and study of comparative anatomy between primate species. For all of these reasons, we advocate the systematic exploration of rest activity.
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The default network is important for constructing representations of emotion experience and perception in the moment.
“the “default network” that is active when a person is not probed by an external stimulus in fMRI experiments (Buckner & Vincent 2007; Raichle et al. 2001) is not only important to constructing representations of the past and the future, but also for constructing representations of emotion experience and perception in the moment.”
From The brain basis of emotion: a meta-analytic review (2012) · cites this paper as Buckner & Vincent 2007
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- Authors
- Buckner, R. L., & Vincent, J. L.
- Affiliations
- Howard Hughes Medical Institute (US)
- Harvard University (US)
- Corresponding author
- Buckner, Randy L.
- ORCID
- Buckner, Randy L.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2007-10
- Volume
- 37
- Issue
- 4
- Pages
- 1091-1096
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W1984804736
- Cited by
- 523
- References
- 14
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 14 · 2023: 21 · 2022: 11 · 2021: 24 · 2020: 20 · 2019: 22 · 2018: 29 · 2017: 26 · 2016: 44 · 2015: 31 · 2014: 32 · 2013: 43 · 2012: 34
- FWCI
- 2.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Mind wandering and attention
- Keywords
- default mode network, spontaneous neuronal activity, resting state, network correlation, anesthesia, memory consolidation, Alzheimer's disease, autism spectrum disorder, functional localization
- MeSH terms
- Alzheimer Disease, Animals, Brain, Brain Mapping, Electroencephalography, Humans, Magnetic Resonance Imaging, Mental Processes, Nerve Net, Primates, Rest, Species Specificity
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