The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
PICK1 Loss of Function Occludes Homeostatic Synaptic Scaling
Open accessAbstract
Homeostatic synaptic scaling calibrates neuronal excitability by adjusting synaptic strengths during prolonged changes in synaptic activity. The molecular mechanisms that regulate the trafficking of AMPA receptors (AMPARs) during synaptic scaling are largely unknown. Here, we show that chronic activity blockade reduces PICK1 protein level on a time scale that coincides with the accumulation of surface AMPARs. PICK1 loss of function alters the subunit composition and the abundance of GluA2-containing AMPARs. Due to aberrant trafficking of these receptors, the increase in synaptic strength in response to synaptic inactivity is occluded in neurons generated from PICK1 knock-out mouse. In agreement with electrophysiological recordings, no defect of AMPAR trafficking is observed in PICK1 knock-out neurons in response to elevated neuronal activity. Overall, our data reveal an important role of PICK1 in inactivity-induced synaptic scaling by regulating the subunit composition, abundance, and trafficking of GluA2-containing AMPARs.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Neither GRIP1/2 nor PICK1 are required for scaling-down (Tan et al., 2015, Anggono et al., 2011).”
From The AMPA Receptor Code of Synaptic Plasticity (2018) · cites this paper as Anggono et al., 2011
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Prolonged TTX treatment in cultured neurons causes lysosomal degradation of PICK1, while deletion of PICK1 enhances mEPSC amplitude and occludes homeostatic scaling-up, suggesting that decreased activity of PICK1 is an important mediator of scaling-up (Figure 3) (Anggono et al., 2011).”
From The AMPA Receptor Code of Synaptic Plasticity (2018) · cites this paper as Anggono et al., 2011
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Homeostatic plasticity in the developing nervous system
Turrigiano, G. G., & Nelson, S. B. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1327 · Cited by 2,485
Activity-dependent scaling of quantal amplitude in neocortical neurons
Turrigiano, G. G., Leslie, K. R., Desai, N. S., Rutherford, L. C., & Nelson, S. B. (1998) · Nature · doi:10.1038/36103 · Cited by 2,226
Synaptic scaling mediated by glial TNF-α
Stellwagen, D., & Malenka, R. C. (2006) · Nature · doi:10.1038/nature04671 · Cited by 1,715
The self-tuning neuron: synaptic scaling of excitatory synapses
Turrigiano, G. G. (2008) · Cell · doi:10.1016/j.cell.2008.10.008 · Cited by 1,533
The cell biology of synaptic plasticity: AMPA receptor trafficking
Shepherd, J. D., & Huganir, R. L. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123516 · Cited by 978
Self-citationActivity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system
Ehlers, M. D. (2003) · Nature Neuroscience · doi:10.1038/nn1013 · Cited by 977
Evidence for multiple AMPA receptor complexes in hippocampal CA1/CA2 neurons
Wenthold, R., Petralia, R., Blahos J, II, & Niedzielski, A. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-06-01982.1996 · Cited by 850
Arc/Arg3.1 Mediates Homeostatic Synaptic Scaling of AMPA Receptors
Shepherd, J. D., Rumbaugh, G., Wu, J., Chowdhury, S., Plath, N., Kuhl, D., Huganir, R. L., & Worley, P. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.034 · Cited by 779
Self-citationActivity-Dependent Modulation of Synaptic AMPA Receptor Accumulation
O’Brien, R. J., Kamboj, S., Ehlers, M. D., Rosen, K. R., Fischbach, G. D., & Huganir, R. L. (1998) · Neuron · doi:10.1016/s0896-6273(00)80624-8 · Cited by 688
Self-citationSubunit Composition of Synaptic AMPA Receptors Revealed by a Single-Cell Genetic Approach
Lu, W., Shi, Y., Jackson, A. C., Bjorgan, K., During, M. J., Sprengel, R., Seeburg, P. H., & Nicoll, R. A. (2009) · Neuron · doi:10.1016/j.neuron.2009.02.027 · Cited by 660
Cited by
Sorted by citations
Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function
Turrigiano, G. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005736 · Cited by 1,139
The AMPA Receptor Code of Synaptic Plasticity
Diering, G. H., & Huganir, R. L. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.018 · Cited by 844
Self-citationSeminars in Cell & Developmental Biology
Lee, H., & Kirkwood, A. (2011) · Cited by 692
Regulation of AMPA receptor trafficking and synaptic plasticity
Anggono, V., & Huganir, R. L. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.12.006 · Cited by 588
Self-citationEnvironment and Brain Plasticity: Towards an Endogenous Pharmacotherapy
Sale, A., Berardi, N., & Maffei, L. (2014) · Physiological Reviews · doi:10.1152/physrev.00036.2012 · Cited by 402
Metadata
- Authors
- Anggono, V., Clem, R. L., & Huganir, R. L.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Huganir, Richard L.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2011-02-09
- Volume
- 31
- Issue
- 6
- Pages
- 2188-2196
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3071039
- OpenAlex
- W2021088263
- Cited by
- 111
- References
- 43
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 1 · 2023: 5 · 2022: 3 · 2021: 4 · 2020: 6 · 2019: 11 · 2018: 10 · 2017: 10 · 2016: 8 · 2015: 10 · 2014: 10 · 2013: 14 · 2012: 10
- FWCI
- 4.90
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- Johns Hopkins University
- National Institutes of Health
- Medical Research Council
- National Health and Medical Research Council (477108)
- National Institute of Mental Health (F32MH087037)
- National Institute of Neurological Disorders and Stroke (R01NS036715)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Keywords
- PICK1, homeostatic synaptic scaling, AMPA receptor trafficking, GluA2, AMPA receptor subunit composition, neuronal excitability, synaptic homeostasis
- MeSH terms
- Animals, Bicuculline, Carrier Proteins, Cells, Cultured, Cerebral Cortex, Embryo, Mammalian, Gene Expression Regulation, Homeostasis, Humans, Mice, Inbred C57BL, Neuronal Plasticity, Neurons, Nuclear Proteins, Synapses, Tetrodotoxin, Transfection, Receptors, AMPA, Mice, Knockout, Statistics, Nonparametric, Cell Cycle Proteins, Excitatory Postsynaptic Potentials, Biotinylation, Protein Subunits, Protein Transport, Sodium Channel Blockers, RNA, Small Interfering, Green Fluorescent Proteins, Mice, GABA-A Receptor Antagonists
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
