How to scale down postsynaptic strength
Open accessAbstract
Synaptic scaling is a form of synaptic plasticity that contributes to the homeostatic regulation of neuronal activity both in vitro and in vivo, by bidirectionally and proportionally adjusting postsynaptic AMPA receptor (AMPAR) abundance to compensate for chronic perturbations in activity. This proportional regulation of synaptic strength allows synaptic scaling to normalize activity without disrupting the synapse-specific differences in strength thought to underlie memory storage, but how such proportional scaling of synaptic strength is accomplished at the biophysical level is unknown. Here we addressed this question in cultured rat visual cortical pyramidal neurons. We used photoactivation and fluorescence recovery after photobleaching of fluorescently tagged AMPAR to show that scaling down, but not up, decreases the steady-state accumulation of synaptic AMPAR by increasing the rate at which they unbind from and exit the postsynaptic density (Koff). This increase in Koff was not diffusion limited, was independent of AMPAR endocytosis, and was prevented by a scaffold manipulation that specifically blocks scaling down, suggesting that it is accomplished through enhanced dissociation of AMPAR from synaptic scaffold tethers. Finally, simulations show that increasing Koff decreases synaptic strength multiplicatively, by reducing the fractional occupancy of available scaffold "slots." These data demonstrate that scaling down is accomplished through a regulated increase in Koff, which in turn reduces the fractional occupancy of synaptic scaffolds to proportionally reduce synaptic strength.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
AMPAR association with the PSD is reduced during scaling-down by increasing the rate at which AMPARs dissociate from the PSD scaffold.
“AMPAR association with the PSD is reduced during scaling-down by increasing the rate at which AMPARs dissociate from the PSD scaffold (Tatavarty et al., 2013).”
From The AMPA Receptor Code of Synaptic Plasticity (2018) · cites this paper as Tatavarty et al., 2013
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Malenka, R. C., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.012 · Cited by 3,968 · see citing works
AMPA Receptor Trafficking and Synaptic Plasticity
Malinow, R., & Malenka, R. C. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142758 · Cited by 2,588 · see citing works
Homeostatic plasticity in the developing nervous system
Turrigiano, G. G., & Nelson, S. B. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1327 · Cited by 2,485 · see citing works
Self-citationSynaptic plasticity: taming the beast
Abbott, L. F., & Nelson, S. B. (2000) · Nature Neuroscience · doi:10.1038/81453 · Cited by 2,263 · cited 1× · see citing works
“Efficient information storage during learning and memory is thought to depend upon the presence of homeostatic mechanisms such as synaptic scaling that normalize synaptic strengths (Abbott and Nelson, 2000; Turrigiano and Nelson, 2004).”
BackgroundActivity-dependent scaling of quantal amplitude in neocortical neurons
Turrigiano, G. G., Leslie, K. R., Desai, N. S., Rutherford, L. C., & Nelson, S. B. (1998) · Nature · doi:10.1038/36103 · Cited by 2,226 · see citing works
Self-citationHomeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function
Turrigiano, G. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005736 · Cited by 1,139 · cited 1× · see citing works
“Together with a number of studies showing that the molecular underpinnings of scaling up and down are also distinct (Turrigiano, 2012), these data strongly suggest that scaling up and scaling down represent two distinct molecular processes that act in a “push–pull” manner to regulate postsynaptic…”
BackgroundSelf-citationStructural dynamics of dendritic spines in memory and cognition
Kasai, H., Fukuda, M., Watanabe, S., Hayashi-Takagi, A., & Noguchi, J. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.01.001 · Cited by 804 · see citing works
Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking
Chowdhury, S., Shepherd, J. D., Okuno, H., Lyford, G., Petralia, R. S., Plath, N., Kuhl, D., Huganir, R. L., & Worley, P. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.033 · Cited by 792 · see citing works
Arc/Arg3.1 Mediates Homeostatic Synaptic Scaling of AMPA Receptors
Shepherd, J. D., Rumbaugh, G., Wu, J., Chowdhury, S., Plath, N., Kuhl, D., Huganir, R. L., & Worley, P. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.034 · Cited by 779 · see citing works
Role of AMPA Receptor Cycling in Synaptic Transmission and Plasticity
Lüscher, C., Xia, H., Beattie, E. C., Carroll, R. C., von Zastrow, M., Malenka, R. C., & Nicoll, R. A. (1999) · Neuron · doi:10.1016/s0896-6273(00)81119-8 · Cited by 692 · see citing works
The interaction between Stargazin and PSD-95 regulates AMPA receptor surface trafficking
Bats, C., Groc, L., & Choquet, D. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.030 · Cited by 590 · see citing works
FRAP analysis of binding: proper and fitting
Sprague, B. L., & McNally, J. G. (2005) · Trends in Cell Biology · doi:10.1016/j.tcb.2004.12.001 · Cited by 569 · see citing works
Brain extracellular matrix affects AMPA receptor lateral mobility and short-term synaptic plasticity
Frischknecht, R., Heine, M., Perrais, D., Seidenbecher, C. I., Choquet, D., & Gundelfinger, E. D. (2009) · Nature Neuroscience · doi:10.1038/nn.2338 · Cited by 554 · see citing works
AMPA Receptor Incorporation into Synapses during LTP: The Role of Lateral Movement and Exocytosis
Makino, H., & Malinow, R. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.035 · Cited by 501 · see citing works
Waung, M. W., Pfeiffer, B. E., Nosyreva, E. D., Ronesi, J. A., & Huber, K. M. (2008) · Neuron · doi:10.1016/j.neuron.2008.05.014 · Cited by 474 · see citing works
Rapid Synaptic Scaling Induced by Changes in Postsynaptic Firing
Ibata, K., Sun, Q., & Turrigiano, G. G. (2008) · Neuron · doi:10.1016/j.neuron.2008.02.031 · Cited by 446 · see citing works
Self-citationDifferential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptors
Groc, L., Heine, M., Cognet, L., Brickley, K., Stephenson, F. A., Lounis, B., & Choquet, D. (2004) · Nature Neuroscience · doi:10.1038/nn1270 · Cited by 429 · see citing works
Photobleaching and photoactivation: following protein dynamics in living cells.
Lippincott‐Schwartz, J., Altan‐Bonnet, N., & Patterson, G. H. (2003) · PubMed · Cited by 415 · see citing works
Jackson, A. C., & Nicoll, R. A. (2011) · Neuron · doi:10.1016/j.neuron.2011.04.007 · Cited by 410 · see citing works
Verde, E. R., Lee‐Osbourne, J., Worley, P. F., Malinow, R., & Cline, H. T. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.031 · Cited by 403 · see citing works
Jörntell, H., & Hansel, C. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.032 · Cited by 382 · see citing works
Postsynaptic expression of homeostatic plasticity at neocortical synapses
Wierenga, C. J., Ibata, K., & Turrigiano, G. G. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.5217-04.2005 · Cited by 306 · see citing works
Self-citationAshby, M. C., Maier, S. R., Nishimune, A., & Henley, J. M. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1235-06.2006 · Cited by 302 · see citing works
Diffusional trapping of GluR1 AMPA receptors by input-specific synaptic activity
Ehlers, M. D., Heine, M., Groc, L., Lee, M.-C., & Choquet, D. (2007) · Neuron · doi:10.1016/j.neuron.2007.04.010 · Cited by 300 · see citing works
Syntaxin-4 defines a domain for activity-dependent exocytosis in dendritic spines
Kennedy, M. J., Davison, I. G., Robinson, C. G., & Ehlers, M. D. (2010) · Cell · doi:10.1016/j.cell.2010.02.042 · Cited by 294 · see citing works
Homeostatic Scaling Requires Group I mGluR Activation Mediated by Homer1a
Hu, J.-H., Park, J. M., Park, S. J., Xiao, B., Dehoff, M. H., Kim, S., Hayashi, T., Schwarz, M. K., Huganir, R. L., Seeburg, P. H., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.008 · Cited by 263 · see citing works
Patterson, M. A., Szatmari, E. M., & Yasuda, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913875107 · Cited by 259 · see citing works
Single-Cell Optogenetic Excitation Drives Homeostatic Synaptic Depression
Goold, C. P., & Nicoll, R. A. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.020 · Cited by 244 · see citing works
Ashby, M. C., De La Rue, S. A., Ralph, G. S., Uney, J., Collingridge, G. L., & Henley, J. M. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1042-04.2004 · Cited by 244 · see citing works
A Unified Model of the Presynaptic and Postsynaptic Changes During LTP at CA1 Synapses
Lisman, J., & Raghavachari, S. (2006) · Science's STKE · doi:10.1126/stke.3562006re11 · Cited by 241 · see citing works
Synaptic scaling requires the GluR2 subunit of the AMPA receptor
Gainey, M. A., Hurvitz-Wolff, J. R., Lambo, M. E., & Turrigiano, G. G. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3753-08.2009 · Cited by 234 · see citing works
Self-citationRegulation of AMPA receptor surface diffusion by PSD-95 slots
Opazo, P., Sainlos, M., & Choquet, D. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.10.010 · Cited by 234 · see citing works
Seeburg, D. P., Feliú-Mójer, M. I., Gaiottino, J., Pak, D. T. S., & Sheng, M. (2008) · Neuron · doi:10.1016/j.neuron.2008.03.021 · Cited by 230 · see citing works
Molecular dissociation of the role of PSD-95 in regulating synaptic strength and LTD.
Xu, W., Schlüter, O. M., Steiner, P., Czervionke, B. L., Sabatini, B., & Malenka, R. C. (2008) · Neuron · doi:10.1016/j.neuron.2007.11.027 · Cited by 193 · see citing works
A three-step model for the synaptic recruitment of AMPA receptors
Opazo, P., & Choquet, D. (2011) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2010.08.014 · Cited by 190 · see citing works
A readily retrievable pool of synaptic vesicles
Hua, Y., Sinha, R., Thiel, C. S., Schmidt, R., Hüve, J., Martens, H., Hell, S. W., Egner, A., & Klingauf, J. (2011) · Nature Neuroscience · doi:10.1038/nn.2838 · Cited by 181 · see citing works
Synaptic stability and plasticity in a floating world
Gerrow, K., & Triller, A. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.06.010 · Cited by 171 · see citing works
Sharma, K., Fong, D. K., & Craig, A. M. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2006.01.010 · Cited by 150 · see citing works
A Critical and Cell-Autonomous Role for MeCP2 in Synaptic Scaling Up
Blackman, M. P., Djukic, B., Nelson, S. B., & Turrigiano, G. G. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3077-12.2012 · Cited by 136 · see citing works
Self-citationPSD-95 and PSD-93 Play Critical But Distinct Roles in Synaptic Scaling Up and Down
Sun, Q., & Turrigiano, G. G. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5616-10.2011 · Cited by 135 · see citing works
Self-citationRoles of stargazin and phosphorylation in the control of AMPA receptor subcellular distribution
Kessels, H. W. H. G., Kopec, C. D., Klein, M. E., & Malinow, R. (2009) · Nature Neuroscience · doi:10.1038/nn.2340 · Cited by 96 · see citing works
Kerr, J. M., & Blanpied, T. A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2927-11.2012 · Cited by 91 · see citing works
Multiple forms of long-term plasticity at unitary neocortical layer 5 synapses
Sjöström, P. J., Turrigiano, G. G., & Nelson, S. B. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.07.021 · Cited by 90 · see citing works
Self-citationEarnshaw, B. A., & Bressloff, P. C. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3601-06.2006 · Cited by 85 · see citing works
Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation
Evers, D. M., Matta, J. A., Hoe, H., Zarkowsky, D. S., Lee, S. H., Isaac, J. T. R., & Pak, D. T. S. (2010) · Nature Neuroscience · doi:10.1038/nn.2624 · Cited by 73 · see citing works
Dynamin-dependent Membrane Drift Recruits AMPA Receptors to Dendritic Spines
Jaskolski, F., Mayo-Martin, M. B., Jane, D. E., & Henley, J. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808401200 · Cited by 65 · see citing works
Diffusion Barriers Constrain Receptors at Synapses
Renner, M. L., Schweizer, C., Bannai, H., Triller, A., & Lévi, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043032 · Cited by 58 · see citing works
Santamaria, F., Gonzalez, J., Augustine, G. J., & Raghavachari, S. (2010) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000780 · Cited by 53 · see citing works
Adie, E. J., Francis, M. J., Davies, J., Smith, L., Marenghi, A., Hather, C., Hadingham, K. L., Michael, N. P., Milligan, G., & Game, S. M. (2003) · Assay and Drug Development Technologies · doi:10.1089/15406580360545062 · Cited by 31 · see citing works
Lele, T. P., Wagner, S. R., Nickerson, J. A., & Ingber, D. E. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20997 · Cited by 31 · see citing works
An improved mathematical approach for determination of molecular kinetics in living cells with FRAP.
Lele, T. P., Oh, P., Nickerson, J. A., & Ingber, D. E. (2004) · PubMed · Cited by 28 · see citing works
Hugel, S., Abegg, M. H., Paola, V. D., Caroni, P., Gähwiler, B. H., & McKinney, R. A. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn118 · Cited by 25 · see citing works
Linden, D. J. (2012) · Journal of Neurophysiology · doi:10.1152/jn.00824.2011 · Cited by 23 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The AMPA Receptor Code of Synaptic Plasticity
Diering, G. H., & Huganir, R. L. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.018 · Cited by 844 · see citing works
Choquet, D., & Triller, A. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.013 · Cited by 515 · see citing works
Synaptopathies: synaptic dysfunction in neurological disorders – A review from students to students
Lepeta, K., Lourenco, M. V., Schweitzer, B. C., Martino Adami, P. V., Banerjee, P., Catuara‐Solarz, S., de La Fuente Revenga, M., Guillem, A. M., Haidar, M., Ijomone, O. M., et al. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13713 · Cited by 386 · see citing works
Homeostatic Signaling and the Stabilization of Neural Function
Davis, G. W. (2013) · Neuron · doi:10.1016/j.neuron.2013.09.044 · Cited by 271 · see citing works
The dialectic of Hebb and homeostasis
Turrigiano, G. G. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0258 · Cited by 242 · see citing works
Self-citationKrystal, J. H., Anticevic, A., Yang, G., Dragoi, G., Driesen, N. R., Wang, X., & Murray, J. D. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.01.004 · Cited by 195 · see citing works
Diering, G. H., Gustina, A. S., & Huganir, R. L. (2014) · Neuron · doi:10.1016/j.neuron.2014.09.024 · Cited by 153 · see citing works
Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity
Ramalingam, N., Jin, S., Moors, T. E., Fonseca‐Ornelas, L., Shimanaka, K., Shi, L., Cam, H. P., Watson, A. H., Brontesi, L., Ding, L., et al. (2023) · npj Parkinson s Disease · doi:10.1038/s41531-023-00444-w · Cited by 130 · see citing works
MiR‐134‐dependent regulation of Pumilio‐2 is necessary for homeostatic synaptic depression
Fiore, R., Rajman, M., Schwale, C., Bicker, S., Antoniou, A., Bruehl, C., Draguhn, A., & Schratt, G. M. (2014) · The EMBO Journal · doi:10.15252/embj.201487921 · Cited by 103 · see citing works
Hoerndli, F. J., Maxfield, D., Brockie, P. J., Mellem, J. E., Jensen, E., Wang, R., Madsen, D. M., & Maricq, A. V. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.050 · Cited by 103 · see citing works
Keck, T., Hübener, M., & Bonhoeffer, T. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.02.003 · Cited by 93 · see citing works
Neuronal Activity and CaMKII Regulate Kinesin-Mediated Transport of Synaptic AMPARs
Hoerndli, F. J., Wang, R., Mellem, J. E., Kallarackal, A. J., Brockie, P. J., Thacker, C. M., Madsen, D. M., & Maricq, A. V. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.011 · Cited by 84 · see citing works
Is the din really harmless? Long-term effects of non-traumatic noise on the adult auditory system
Gourévitch, B., Edeline, J., Occelli, F., & Eggermont, J. J. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3744 · Cited by 79 · see citing works
Synaptic Size Dynamics as an Effectively Stochastic Process
Statman, A., Kaufman, M., Minerbi, A., Ziv, N. E., & Brenner, N. (2014) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003846 · Cited by 82 · see citing works
Shank and Zinc Mediate an AMPA Receptor Subunit Switch in Developing Neurons
Ha, H., Leal‐Ortiz, S., Lalwani, K., Kiyonaka, S., Hamachi, I., Mysore, S. P., Montgomery, J. M., Garner, C. C., Huguenard, J. R., & Kim, S. A. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00405 · Cited by 66 · see citing works
The Role of Amyloid-Beta and Tau in the Early Pathogenesis of Alzheimer’s Disease
Yin, X., Qiu, Y., Zhao, C., Zhou, Z., Bao, J., & Qian, W. (2021) · Medical Science Monitor · doi:10.12659/msm.933084 · Cited by 48 · see citing works
Richardson, A., Ciampani, V., Stancu, M., Bondarenko, K., Newton, S., Steinert, J. R., Pilati, N., Graham, B. P., Kopp‐Scheinpflug, C., & Forsythe, I. D. (2022) · eLife · doi:10.7554/elife.75219 · Cited by 32 · see citing works
A bidirectional switch in the Shank3 phosphorylation state biases synapses toward up- or downscaling
Wu, C.-H., Tatavarty, V., Beltran, P. M., Guerrero, A., Keshishian, H., Krug, K., MacMullan, M. A., Li, L., Carr, S. A., Cottrell, J. R., et al. (2022) · eLife · doi:10.7554/elife.74277 · Cited by 27 · see citing works
Self-citationGABAA receptor subunit composition and competition at synapses are tuned by GABAB receptor activity
Gerrow, K., & Triller, A. (2014) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2014.04.001 · Cited by 28 · see citing works
Venkatesan, S., Subramaniam, S., Rajeev, P., Chopra, Y., Jose, M., & Nair, D. K. (2020) · eNeuro · doi:10.1523/eneuro.0407-19.2020 · Cited by 25 · see citing works
Testa, G., Olimpico, F., Pancrazi, L., Borello, U., Cattaneo, A., Caleo, M., Costa, M., & Mainardi, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174127 · Cited by 24 · see citing works
Stargazin Dephosphorylation Mediates Homeostatic Synaptic Downscaling of Excitatory Synapses
Louros, S. R., Caldeira, G. L., & Carvalho, A. L. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00328 · Cited by 23 · see citing works
Steinmetz, C. C., Tatavarty, V., Sugino, K., Shima, Y., Joseph, A., Lin, H. K., Rutlin, M. L., Lambo, M. E., Hempel, C. M., Okaty, B. W., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.08.009 · Cited by 22 · see citing works
Self-citationRanft, J., Almeida, L. G., Rodriguez, P. C., Triller, A., & Hakim, V. (2017) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005516 · Cited by 21 · see citing works
Hanger, D. P., Goniotaki, D., & Noble, W. J. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9358-8_9 · Cited by 23 · see citing works
Braegelmann, K. M., Streeter, K., Fields, D. P., & Baker, T. L. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.07.012 · Cited by 20 · see citing works
The biophysical basis underlying the maintenance of early phase long-term potentiation
Becker, M., & Tetzlaff, C. (2021) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1008813 · Cited by 21 · see citing works
Synaptic Vesicles Dynamics in Neocortical Epilepsy
Vannini, E., Restani, L., Dilillo, M., McDonnell, L. A., Caleo, M., & Marra, V. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.606142 · Cited by 16 · see citing works
Clinical implication of high-density EEG sleep recordings in Parkinson’s disease
Amato, N., Caverzasio, S., & Galati, S. (2020) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2020.108746 · Cited by 15 · see citing works
Srinivasan, B., Samaddar, S., Mylavarapu, S. V. S., Clement, J. P., & Banerjee, S. (2021) · PLoS Biology · doi:10.1371/journal.pbio.3001432 · Cited by 13 · see citing works
Cationic peptides cause memory loss through endophilin-mediated endocytosis
Stokes, E. G., Vasquez, J. J., Azouz, G., Nguyen, M. H., Tierno, A. M., Zhuang, Y., Galinato, V. M., Hui, M., Toledano, M., Tyler, I., et al. (2025) · Nature · doi:10.1038/s41586-024-08413-w · Cited by 13 · see citing works
Baines, R., Giachello, C. N., & Lin, W. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804066-9.00024-9 · Cited by 12 · see citing works
Guerrero, A. A., & Turrigiano, G. G. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.0807-25.2025 · Cited by 10 · see citing works
Self-citationChow, D. M., Zuchowski, K. A., & Fetcho, J. R. (2017) · Current Biology · doi:10.1016/j.cub.2017.03.032 · Cited by 9 · see citing works
Classification of Visual Cortex Plasticity Phenotypes following Treatment for Amblyopia
Balsor, J. L., Jones, D. G., & Murphy, K. M. (2019) · Neural Plasticity · doi:10.1155/2019/2564018 · Cited by 8 · see citing works
McMullan, H. M., Gansemer, B. M., & Thayer, S. A. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1369757 · Cited by 7 · see citing works
Photoswitching endogenous glutamate receptors in neural ensembles and single synapses in vivo
Garrido‐Charles, A., Bosch, M., Lee, H., Rovira, X., Pittolo, S., Llobet, A., Wong, H. H., Trapero, A., Matera, C., Papotto, C., et al. (2025) · Brain stimulation · doi:10.1016/j.brs.2025.09.005 · Cited by 5 · see citing works
Díaz-Valdivia, N., Labarca, M., Retamal, C., Espinoza, S., Venegas, J., Catenaccio, A., de la Peña, A., Ricca, M., Jara, C., Cortés-Díaz, D., et al. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01339-7 · Cited by 4 · see citing works
Srinivasan, B., Samaddar, S., Mylavarapu, S. V. S., Clement, J. P., & Banerjee, S. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.01.020164 · Cited by 2 · see citing works
Banerjee, B., MEDDA, B. K., Zhang, J., Tuchscherer, V. J., Babygirija, R., Kannampalli, P., Sengupta, J. N., & Shaker, R. (2016) · Neurogastroenterology & Motility · doi:10.1111/nmo.12834 · Cited by 1 · see citing works
Koesters, A. G., Rich, M. M., & Engisch, K. L. (2025) · eLife · doi:10.7554/elife.90261.5
Koesters, A., Rich, M. M., & Engisch, K. (2025) · eLife · doi:10.7554/elife.90261
Koesters, A. G., Rich, M. M., & Engisch, K. L. (2024) · eLife · doi:10.7554/elife.90261.2
Koesters, A. G., Rich, M. M., & Engisch, K. L. (2025) · eLife · doi:10.7554/elife.90261.3
Vlachos, P. E., & Triesch, J. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.10.648137
Koesters, A. G., Rich, M. M., & Engisch, K. L. (2025) · eLife · doi:10.7554/elife.90261.4
Altered wakeful theta activity characterizes levodopa-induced dyskinesia in Parkinson’s disease
Fiorillo, L., Lombardi, G., Porta, N. L., Arnaud, L., Veneruso, M., Castelnovo, A., Bertaina, I., Staedler, C., Kaelin‐Lang, A., & Galati, S. (2026) · npj Parkinson s Disease · doi:10.1038/s41531-026-01320-z
Stimulation électrique transcrânienne multisite dans l'épilepsie pharmaco-résistante
Denoyer, Y. (2019) · theses.fr (ABES) · doi:10.70675/0c55a83dz3729z4ee8zb7c9zd03118d26e81
Btbd11 regulates glutamatergic synapse organization in GABAergic inhibitory interneuronsPreprint
Brady, M., Zhang, S., Levy, A. D., Schamber, P., Hartman, H., Blanpied, T. A., & Bygrave, A. M. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.22.733761
Gupta, A. K., Parmar, R., G, M. S. M., Vinnakota, R., & Kumar, J. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-44536-1.00018-3
- Authors
- Tatavarty, V., Sun, Q., & Turrigiano, G. G.
- Affiliations
- Brandeis University (US)
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2013-08-07
- Volume
- 33
- Issue
- 32
- Pages
- 13179-13189
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3735890
- OpenAlex
- W2168190460
- Cited by
- 50
- References
- 53
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 6 · 2016: 4 · 2015: 1 · 2014: 5 · 2013: 3
- FWCI
- 2.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (NS036853, R56NS036853, R01NS036853)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- synaptic scaling, synaptic homeostasis, AMPA receptors, postsynaptic density, receptor dissociation rate, synaptic plasticity, synaptic efficacy
- MeSH terms
- Central Nervous System Stimulants, Anesthetics, Local, Animals, Animals, Newborn, Cells, Cultured, Computer Simulation, Endocytosis, Models, Neurological, Picrotoxin, Polymers, Recombinant Proteins, Synapses, Tetrodotoxin, Visual Cortex, N-Methylaspartate, Pyramidal Cells, Receptors, AMPA, Excitatory Amino Acid Agonists, Excitatory Postsynaptic Potentials, Rats, Long-Evans, Fluorescence Recovery After Photobleaching, Photobleaching, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
