ALE meta-analysis workflows via the BrainMap database: Progress towards a probabilistic functional brain atlas
Open accessAbstract
With the ever-increasing number of studies in human functional brain mapping, an abundance of data has been generated that is ready to be synthesized and modeled on a large scale. The BrainMap database archives peak coordinates from published neuroimaging studies, along with the corresponding metadata that summarize the experimental design. BrainMap was designed to facilitate quantitative meta-analysis of neuroimaging results reported in the literature and supports the use of the activation likelihood estimation (ALE) method. In this paper, we present a discussion of the potential analyses that are possible using the BrainMap database and coordinate-based ALE meta-analyses, along with some examples of how these tools can be applied to create a probabilistic atlas and ontological system of describing function-structure correspondences.
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Previous neuroimaging synthesis approaches relied heavily on researchers' manual efforts.
“previous approaches have relied heavily on researchers’ manual efforts (e.g., 7,8)”
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Christophe Lopez, A., Blanke, O., & Mast, F. W. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.03.028 · Cited by 452 · see citing works
Meta-analytical definition and functional connectivity of the human vestibular cortex
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Bzdok, D., Laird, A. R., Zilles, K., Fox, P. T., & Eickhoff, S. B. (2012) · Human Brain Mapping · doi:10.1002/hbm.22138 · Cited by 430 · see citing works
Self-citationA meta-analysis of neurofunctional imaging studies of emotion and cognition in major depression
Diener, C., Kuehner, C., Brusniak, W., Ubl, B., Wessa, M., & Flor, H. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.04.005 · Cited by 420 · see citing works
Cieslik, E. C., Zilles, K., Caspers, S., Roski, C., Kellermann, T. S., Jakobs, O., Langner, R., Laird, A. R., Fox, P. T., & Eickhoff, S. B. (2013) · Cerebral Cortex · doi:10.1093/cercor/bhs256 · Cited by 391 · see citing works
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Self-citationKrall, S. C., Rottschy, C., Oberwelland, E., Bzdok, D., Fox, P. T., Eickhoff, S. B., Fink, G. R., & Konrad, K. (2015) · Brain Structure and Function · doi:10.1007/s00429-014-0803-z · Cited by 351 · see citing works
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Self-citationThree key regions for supervisory attentional control: Evidence from neuroimaging meta-analyses
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Beyond the Tripartite Cognition–Emotion–Interoception Model of the Human Insular Cortex
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Implementation errors in the GingerALE Software: Description and recommendations
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Self-citationThe human amygdala and pain: Evidence from neuroimaging
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How Acute Total Sleep Loss Affects the Attending Brain: A Meta-Analysis of Neuroimaging Studies
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Segregation of the human medial prefrontal cortex in social cognition
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Self-citationMultiple large-scale neural networks underlying emotion regulation
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Gray matter alterations in chronic pain: A network-oriented meta-analytic approach
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The BrainMap strategy for standardization, sharing, and meta-analysis of neuroimaging data
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Clos, M., Amunts, K., Laird, A. R., Fox, P. T., & Eickhoff, S. B. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.06.041 · Cited by 203 · see citing works
Self-citationICA model order selection of task co-activation networks
Ray, K. L., McKay, D., Fox, P. M., Riedel, M. C., Uecker, A. M., Beckmann, C. F., Smith, S. M., Fox, P. T., & Laird, A. R. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00237 · Cited by 203 · see citing works
Self-citationGray matter asymmetries in aging and neurodegeneration: a review and meta-analysis.
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Left inferior parietal lobe engagement in social cognition and language
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Self-citationALE meta-analysis on facial judgments of trustworthiness and attractiveness
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Self-citationGender differences in working memory networks: a BrainMap meta-analysis
Hill, A. C., Laird, A. R., & Robinson, J. L. (2014) · Biological Psychology · doi:10.1016/j.biopsycho.2014.06.008 · Cited by 182 · see citing works
Self-citationRepresenting and Retrieving Video Shots in Human-Centric Brain Imaging Space
Han, J., Ji, X., Hu, X., Zhu, D., Li, K., Jiang, X., Cui, G.-B., Guo, L., & Liu, T. (2013) · IEEE Transactions on Image Processing · doi:10.1109/tip.2013.2256919 · Cited by 182 · see citing works
Computing the Social Brain Connectome Across Systems and States
Alcalá-López, D., Smallwood, J., Jefferies, E., Overwalle, F. V., Vogeley, K. T., Mars, R. B., Turetsky, B. I., Laird, A. R., Fox, P. T., Eickhoff, S. B., et al. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx121 · Cited by 177 · see citing works
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Subspecialization in the human posterior medial cortex
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Self-citationResting brain activity in disorders of consciousness
Hannawi, Y., Lindquist, M. A., Caffo, B. S., Sair, H. I., & Stevens, R. D. (2015) · Neurology · doi:10.1212/wnl.0000000000001404 · Cited by 177 · see citing works
Different functions in the cingulate cortex, a meta-analytic connectivity modeling study
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Networks of task co-activations
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Hoffstaedter, F., Grefkes, C., Caspers, S., Roski, C., Palomero‐Gallagher, N., Laird, A. R., Fox, P. T., & Eickhoff, S. B. (2014) · Human Brain Mapping · doi:10.1002/hbm.22363 · Cited by 164 · see citing works
Self-citationFunctional segregation of the human dorsomedial prefrontal cortex
Eickhoff, S. B., Laird, A. R., Fox, P. T., Bzdok, D., & Hensel, L. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhu250 · Cited by 159 · see citing works
Self-citationDefinition and characterization of an extended multiple-demand network
Camilleri, J. A., Müller, V. I., Fox, P. M., Laird, A. R., Hoffstaedter, F., Tobias Kalenscher, A., & Eickhoff, S. B. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.10.020 · Cited by 159 · see citing works
Self-citationPooling fMRI data: meta-analysis, mega-analysis and multi-center studies
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Automated regional behavioral analysis for human brain images
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Langner, R., Leiberg, S., Hoffstaedter, F., & Eickhoff, S. B. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.04.022 · Cited by 144 · see citing works
Functional Connectivity Mapping of Regions Associated with Self- and Other-Processing
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Age-related differences in brain activity in the subsequent memory paradigm: A meta-analysis
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Human neuroimaging as a “Big Data” science
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Tahmasian, M., Eickhoff, S. B., Giehl, K., Schwartz, F., Herz, D. M., Drzezga, A. E., van Eimeren, T., Laird, A. R., Fox, P. T., Khazaie, H., et al. (2017) · Cortex · doi:10.1016/j.cortex.2017.03.016 · Cited by 134 · see citing works
Self-citationTahmasian, M., Rosenzweig, I., Eickhoff, S. B., Sepehry, A. A., Laird, A. R., Fox, P. T., Morrell, M. J., Khazaie, H., & Eickhoff, C. R. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.03.026 · Cited by 130 · see citing works
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Neuropsychological Sequelae of PTSD and TBI Following War Deployment among OEF/OIF Veterans
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Neurofunctional topography of the human hippocampus
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Piras, F., Piras, F., Caltagirone, C., & Spalletta, G. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.10.008 · Cited by 117 · see citing works
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Balsters, J. H., Laird, A. R., Fox, P. T., & Eickhoff, S. B. (2014) · Human Brain Mapping · doi:10.1002/hbm.22392 · Cited by 113 · see citing works
Self-citationSutherland, M. T., Riedel, M. C., Flannery, J. S., Yanes, J. A., Fox, P. T., Stein, E. A., & Laird, A. R. (2016) · Behavioral and Brain Functions · doi:10.1186/s12993-016-0100-5 · Cited by 114 · see citing works
Self-citationSuarez‐Jimenez, B., Albajes‐Eizagirre, A., Lazarov, A., Zhu, X., Harrison, B. J., Raduà, J., Neria, Y., & Fullana, M. A. (2019) · Psychological Medicine · doi:10.1017/s0033291719001387 · Cited by 116 · see citing works
Anatomic and electro-physiologic connectivity of the language system: A combined DTI-CCEP study
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Affordance processing in segregated parieto-frontal dorsal stream sub-pathways
Sakreida, K., Alkhasli, I., Thill, S., Menz, M. M., Jirak, D., Eickhoff, C. R., Tom Ziemke, B., Eickhoff, S. B., Borghi, A. M., & Binkofski, F. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.07.032 · Cited by 110 · see citing works
Approaches for the Integrated Analysis of Structure, Function and Connectivity of the Human Brain
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Ruan, J., Bludau, S., Palomero‐Gallagher, N., Caspers, S., Mohlberg, H., Eickhoff, S. B., Seitz, R. J., & Amunts, K. (2018) · Brain Structure and Function · doi:10.1007/s00429-018-1738-6 · Cited by 107 · see citing works
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Distributed processing; distributed functions?
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Neural signatures of prosocial behaviors
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Differentiated parietal connectivity of frontal regions for “what” and “where” memory
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Self-citationDifferences in Cortical Structure and Functional MRI Connectivity in High Functioning Autism
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Disentangling the neural mechanisms involved in Hinduism- and Buddhism-related meditations
Tomasino, B., Chiesa, A., & Fabbro, F. (2014) · Brain and Cognition · doi:10.1016/j.bandc.2014.03.013 · Cited by 94 · see citing works
- Authors
- Laird, A. R.
- Affiliations
- The University of Texas at San Antonio Health Science Center (US)
- Corresponding author
- Laird, Angela R.
- ORCID
- Laird, Angela R.
- Venue
- Frontiers in Neuroinformatics
- Publisher
- Frontiers Media SA
- Published
- 2009
- Volume
- 3
- Pages
- 23-23
- ISSN
- 1662-5196 (ISSN-L)
- PMC
- PMC2715269
- OpenAlex
- W1979958927
- Cited by
- 372
- References
- 79
- Citations by year
- 2026: 11 · 2025: 17 · 2024: 17 · 2023: 23 · 2022: 20 · 2021: 22 · 2020: 29 · 2019: 17 · 2018: 26 · 2017: 15 · 2016: 25 · 2015: 26 · 2014: 29 · 2013: 28 · 2012: 29
- FWCI
- 10.85
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Neuroinformatics (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- RWTH Publications (RWTH Aachen) (submittedVersion, other-oa)
- Funders
- National Institutes of Health (5r01mh084812-03)
- National Institute of Mental Health (R01‐MH084812, R01MH074457, MH084812, MH074457)
- National Institute on Deafness and Other Communication Disorders (F32DC009116)
- National Institute of Neurological Disorders and Stroke (T35NS051166)
- National Center for Research Resources (U24RR021992, RR021992)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- activation likelihood estimation, ontological systems
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