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Excitability and Synaptic Communication within the Oligodendrocyte Lineage
Open accessAbstract
The mammalian CNS contains an abundant, widely distributed population of glial cells that serve as oligodendrocyte progenitors. It has been reported that these NG2-immunoreactive cells (NG2(+) cells) form synapses and generate action potentials, suggesting that neural-evoked excitation of these progenitors may regulate oligodendrogenesis. However, recent studies also suggest that NG2(+) cells are comprised of functionally distinct groups that differ in their ability to respond to neuronal activity, undergo differentiation, and experience injury following ischemia. To better define the physiological properties of NG2(+) cells, we used transgenic mice that allowed an unbiased sampling of this population and unambiguous identification of cells in discrete states of differentiation. Using acute brain slices prepared from developing and mature mice, we found that NG2(+) cells in diverse brain regions share a core set of physiological properties, including expression of voltage-gated Na(+) (NaV) channels and ionotropic glutamate receptors, and formation of synapses with glutamatergic neurons. Although small amplitude Na(+) spikes could be elicited in some NG2(+) cells during the first postnatal week, they were not capable of generating action potentials. Transition of these progenitors to the premyelinating stage was accompanied by the rapid removal of synaptic input, as well as downregulation of AMPA and NMDA receptors and NaV channels. Thus, prior reports of physiological heterogeneity among NG2(+) cells may reflect analysis of cells in later stages of maturation. These results suggest that NG2(+) cells are uniquely positioned within the oligodendrocyte lineage to monitor the firing patterns of surrounding neurons.
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“In development, NMDA receptors are most abundant in oligodendrocyte precursors”
From Oligodendroglial NMDA receptors regulate glucose import and axonal energy metabolism (2016) · cites this paper as De Biase et al., 2010
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Cites
Exploration, normalization, and summaries of high density oligonucleotide array probe level data
Irizarry, R. A. (2003) · Biostatistics · doi:10.1093/biostatistics/4.2.249 · Cited by 10,603
Cahoy, J. D., Emery, B., Kaushal, A., Foo, L. C., Zamanian, J. L., Christopherson, K. S., Xing, Y., Lubischer, J. L., Krieg, P. A., Krupenko, S. A., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4178-07.2008 · Cited by 3,129
Spontaneous subthreshold activity at motor nerve endings
Fatt, P., & Katz, B. (1952) · The Journal of Physiology · doi:10.1113/jphysiol.1952.sp004735 · Cited by 1,835
Bowman, E. J., Siebers, A., & Altendorf, K. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.21.7972 · Cited by 1,801
Definition of the readily releasable pool of vesicles at hippocampal synapses.
Rosenmund, C., & Stevens, C. (1996) · Neuron · doi:10.1016/s0896-6273(00)80146-4 · Cited by 1,084
Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus
Bergles, D. E., Roberts, J. D. B., Somogyi, P., & Jahr, C. E. (2000) · Nature · doi:10.1038/35012083 · Cited by 1,062
PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice
Rivers, L. E., Young, K. M., Rizzi, M., Jamen, F., Psachoulia, K., Wade, A., Kessaris, N., & Richardson, W. D. (2008) · Nature Neuroscience · doi:10.1038/nn.2220 · Cited by 961
Back, S. A., Luo, N. L., Borenstein, N. S., Levine, J. M., Volpe, J. J., & Kinney, H. C. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-04-01302.2001 · Cited by 936
Dawson, M. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00210-0 · Cited by 927
Purinergic signalling in neuron–glia interactions
Fields, R. D., & Burnstock, G. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1928 · Cited by 878
Selective Vulnerability of Late Oligodendrocyte Progenitors to Hypoxia–Ischemia
Back, S. A., Han, B. H., Luo, N. L., Chricton, C. A., Xanthoudakis, S., Tam, J., Arvin, K. L., & Holtzman, D. M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-02-00455.2002 · Cited by 795
Neuronal ‘On’ and ‘Off’ signals control microglia
Biber, K., Neumann, H., Inoue, K., & Boddeke, H. W. G. M. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.08.007 · Cited by 787
NMDA receptors are expressed in oligodendrocytes and activated in ischaemia
Káradóttir, R. T., Cavelier, P., Bergersen, L. H., & Attwell, D. (2005) · Nature · doi:10.1038/nature04302 · Cited by 773
NG2 cells generate both oligodendrocytes and gray matter astrocytes
Zhu, X., Bergles, D. E., & Nishiyama, A. (2007) · Development · doi:10.1242/dev.004895 · Cited by 699
Proliferation of oligodendrocyte precursor cells depends on electrical activity in axons
Barres, B. A., & Raff, M. C. (1993) · Nature · doi:10.1038/361258a0 · Cited by 673
Axon-Glial Signaling and the Glial Support of Axon Function
Nave, K., & Trapp, B. D. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094309 · Cited by 664
Widespread recombinase expression using FLPeR (Flipper) mice
Farley, F. W., Soriano, P. M., Steffen, L. S., & Dymecki, S. M. (2000) · genesis · doi:10.1002/1526-968x(200011/12)28:3/4 · Cited by 602
NMDA receptors are expressed in developing oligodendrocyte processes and mediate injury
Salter, M. G., & Fern, R. F. (2005) · Nature · doi:10.1038/nature04301 · Cited by 556
Stevens (2002) · doi:10.1016/s0896-6273(02)01067-x · Cited by 543
Verkhratsky, A., & Steinhäuser, C. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00093-4 · Cited by 508
NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia
Micu, I., Jiang, Q., Coderre, E., Ridsdale, A., Zhang, L., Woulfe, J., Yin, X., Trapp, B. D., McRory, J. E., Rehak, R., et al. (2005) · Nature · doi:10.1038/nature04474 · Cited by 504
Belachew, S. M., Chittajallu, R., Aguirre, A. A., Yuan, X. Q., Kirby, M., Anderson, S. M., & Gallo, V. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200210110 · Cited by 498
Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain
Hayashi, S., Lewis, P. M., Pevny, L., & McMahon, A. P. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(03)00099-6 · Cited by 492
Vesicular release of glutamate from unmyelinated axons in white matter
Ziskin, J. L., Nishiyama, A., Rubio, M. E., Fukaya, M., & Bergles, D. E. (2007) · Nature Neuroscience · doi:10.1038/nn1854 · Cited by 488
Lin, S.-C., & Bergles, D. E. (2003) · Nature Neuroscience · doi:10.1038/nn1162 · Cited by 474
Vesicular glutamate release from axons in white matter
Kukley, M., Capetillo‐Zarate, E., & Dietrich, D. (2007) · Nature Neuroscience · doi:10.1038/nn1850 · Cited by 472
Gallo, V., Jm, Z., McBain, C. J., Wright, P., Knutson, P., & Armstrong, R. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-08-02659.1996 · Cited by 411
Increased expression of the NG2 chondroitin-sulfate proteoglycan after brain injury
Levine, J. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-08-04716.1994 · Cited by 395
Spiking and nonspiking classes of oligodendrocyte precursor glia in CNS white matter
Káradóttir, R. T., Hamilton, N. B., Bakiri, Y., & Attwell, D. (2008) · Nature Neuroscience · doi:10.1038/nn2060 · Cited by 385
Mallon, B. S., Shick, H. E., Kidd, G. J., & Macklin, W. B. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-00876.2002 · Cited by 382
Stevens, C. F., & Tsujimoto, T. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.3.846 · Cited by 368
Back, S. A. (2006) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.20107 · Cited by 327
Rapid Ischemic Cell Death in Immature Oligodendrocytes: A Fatal Glutamate Release Feedback Loop
Fern, R. F., & Möller, T. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00034.2000 · Cited by 321
Regan, M. R., Huang, Y. H., Kim, Y., Dykes‐Hoberg, M., Jin, L., Watkins, A. M., Bergles, D. E., & Rothstein, J. D. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0790-07.2007 · Cited by 314
Ion channel expression by white matter glia: The O-2A glial progenitor cell
Barres, B. A., Koroshetz, W. J., Swartz, K. J., Chun, L. L. Y., & Corey, D. P. (1990) · Neuron · doi:10.1016/0896-6273(90)90109-s · Cited by 306
Sontheimer, H. W., Trotter, J., Schachner, M., & Kettenmann, H. (1989) · Neuron · doi:10.1016/0896-6273(89)90180-3 · Cited by 261
NG2‐positive cells in the mouse white and grey matter display distinct physiological properties
Chittajallu, R., Aguirre, A. A., & Gallo, V. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.074252 · Cited by 258
CNS pericytes: Concepts, misconceptions, and a way out
Krueger, M. W., & Bechmann, I. (2009) · Glia · doi:10.1002/glia.20898 · Cited by 257
Myelin acquisition in the central nervous system of the mouse revealed by an MBP-Lac Z transgene
Foran, D., & Peterson, A. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-12-04890.1992 · Cited by 250
Yuan, X. Q., Eisen, A. M., McBain, C. J., & Gallo, V. (1998) · Development · doi:10.1242/dev.125.15.2901 · Cited by 221
Gudz, T. I., Komuro, H., & Macklin, W. B. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4054-05.2006 · Cited by 213
Effects of reduced vesicular filling on synaptic transmission in rat hippocampal neurones
Zhou, Q., Petersen, C. C. H., & Nicoll, R. A. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.t01-1-00195.x · Cited by 212
Long-Term Potentiation of Neuron-Glia Synapses Mediated by Ca 2+ -Permeable AMPA Receptors
Ge, W., Yang, X.-J., Zhang, Z., Wang, H.-K., Shen, W., Deng, Q.-D., & Duan, S. (2006) · Science · doi:10.1126/science.1124669 · Cited by 208
Climbing Fiber Innervation of NG2-Expressing Glia in the Mammalian Cerebellum
Lin, S.-C., Huck, J. H. J., Roberts, J. D. B., Macklin, W. B., Somogyi, P., & Bergles, D. E. (2005) · Neuron · doi:10.1016/j.neuron.2005.04.025 · Cited by 203
Non-conducting functions of voltage-gated ion channels
Kaczmarek, L. K. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1988 · Cited by 195
Barres, B. A., Chun, L. L. Y., & Corey, D. P. (1989) · Neuron · doi:10.1016/0896-6273(89)90076-7 · Cited by 190
Riddle, A., Luo, N. L., Manese, M., Beardsley, D. J., Green, L., Rorvik, D. A., Kelly, K. A., Barlow, C. H., Kelly, J. J., Hohimer, A. R., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5200-05.2006 · Cited by 186
NG2 cells generate oligodendrocytes and gray matter astrocytes in the spinal cord.
Zhu, X., Hill, R., & Nishiyama, A. (2008) · Neuron Glia Biology · doi:10.1017/s1740925x09000015 · Cited by 168
Huang, Y. H., Sinha, S. R., Tanaka, K., Rothstein, J. D., & Bergles, D. E. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5217-03.2004 · Cited by 167
Sodium channel activity modulates multiple functions in microglia
Black, J. A., Liu, S., & Waxman, S. G. (2008) · Glia · doi:10.1002/glia.20830 · Cited by 156
Synaptic transmission onto hippocampal glial cells with hGFAP promoter activity
Jabs, R., Pivneva, T. A., Hüttmann, K., Wyczynski, A., Nolte, C., Kettenmann, H., & Steinhäuser, C. (2005) · Journal of Cell Science · doi:10.1242/jcs.02515 · Cited by 155
Verity, A. N., & Campagnoni, A. T. (1988) · Journal of Neuroscience Research · doi:10.1002/jnr.490210216 · Cited by 151
GABA‐ and glutamate‐activated currents in glial cells of the mouse corpus callosum slice
Berger, T., Walz, W., Schnitzer, J., & Kettenmann, H. (1992) · Journal of Neuroscience Research · doi:10.1002/jnr.490310104 · Cited by 144
Weisheit, G., Gliem, M., Endl, E., Pfeffer, P., Busslinger, M., & Schilling, K. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04915.x · Cited by 142
Early Postnatal Proteolipid Promoter-Expressing Progenitors Produce Multilineage CellsIn Vivo
Guo, F., Ma, J., McCauley, E., Bannerman, P. G. C., & Pleasure, D. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5653-08.2009 · Cited by 131
Neuropathologic Substrate of Cerebral Palsy
Folkerth, R. D. (2005) · Journal of Child Neurology · doi:10.1177/08830738050200120301 · Cited by 130
Excitotoxic Mechanisms of Ischemic Injury in Myelinated White Matter
Tekkök, S. B., Ye, Z., & Ransom, B. R. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600455 · Cited by 129
Ge, W., Zhou, W., Luo, Q., Jan, L. Y., & Jan, Y. N. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811353106 · Cited by 108
Mangin, J., Kunze, A., Chittajallu, R., & Gallo, V. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1355-08.2008 · Cited by 80
Johnston, M. V., & Hoon, A. H. (2006) · NeuroMolecular Medicine · doi:10.1385/nmm:8:4:435 · Cited by 72
Steljes, T. P. V., Kinoshita, Y., Wheeler, E. F., Oppenheim, R. W., & von Bartheld, C. S. (1999) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(19991105)41:2 · Cited by 55
A glial progenitor cell in the cerebral cortex of the adult rat
Reyners, H., de Reyners, E. G., Regniers, L., & Maisin, J. R. (1986) · Journal of Neurocytology · doi:10.1007/bf02057904 · Cited by 47
Ono, K., Kagawa, T., Tsumori, T., Yokota, S., & Yasui, Y. (2001) · Developmental Neuroscience · doi:10.1159/000048718 · Cited by 30
Chen, P., Cai, W., Wang, L., & Deng, Q. (2008) · Brain Research · doi:10.1016/j.brainres.2008.09.029 · Cited by 25
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Metadata
- Authors
- De Biase, L. M., Nishiyama, A., & Bergles, D. E.
- Affiliations
- University of Connecticut (US)
- Johns Hopkins University (US)
- Corresponding author
- Bergles, Dwight E.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-03-10
- Volume
- 30
- Issue
- 10
- Pages
- 3600-3611
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2838193
- OpenAlex
- W1999272226
- Cited by
- 286
- References
- 65
- Citations by year
- 2026: 16 · 2025: 16 · 2024: 14 · 2023: 21 · 2022: 11 · 2021: 19 · 2020: 16 · 2019: 20 · 2018: 10 · 2017: 23 · 2016: 15 · 2015: 20 · 2014: 14 · 2013: 20 · 2012: 14
- FWCI
- 7.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Multiple Sclerosis Society
- National Alliance for Research on Schizophrenia and Depression
- Multiple Sclerosis Society
- National Institutes of Health
- U.S. Public Health Service (PAR-02-059)
- National Eye Institute (T32EY017203)
- National Institute of Neurological Disorders and Stroke (R01NS049267, NS-049267, NS051509, P30NS050274, R01NS051509)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- oligodendrocyte precursor cells, oligodendrocyte progenitors, oligodendrocyte lineage, action potential, voltage-gated sodium channels, ionotropic glutamate receptors, AMPA receptors, NMDA receptor, oligodendrogenesis, synaptic input, neuronal activity regulation, transgenic mice, brain development
- MeSH terms
- Chondroitin Sulfate Proteoglycan 4, Action Potentials, Animals, Animals, Newborn, Cell Communication, Membrane Proteins, Mice, Transgenic, Oligodendroglia, Chondroitin Sulfate Proteoglycans, Synapses, Cell Lineage, Gene Expression Profiling, Mice
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