Cited by 286Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration Mechanisms

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Excitability and Synaptic Communication within the Oligodendrocyte Lineage

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De Biase, Lindsay M., Nishiyama, Akiko, Bergles, Dwight E.·2010·The Journal of Neuroscience

DOI 10.1523/jneurosci.6000-09.2010PMC PMC2838193

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Abstract

The mammalian CNS contains an abundant, widely distributed population of glial cells that serve as oligodendrocyte progenitors. It has been reported that these NG2-immunoreactive cells (NG2(+) cells) form synapses and generate action potentials, suggesting that neural-evoked excitation of these progenitors may regulate oligodendrogenesis. However, recent studies also suggest that NG2(+) cells are comprised of functionally distinct groups that differ in their ability to respond to neuronal activity, undergo differentiation, and experience injury following ischemia. To better define the physiological properties of NG2(+) cells, we used transgenic mice that allowed an unbiased sampling of this population and unambiguous identification of cells in discrete states of differentiation. Using acute brain slices prepared from developing and mature mice, we found that NG2(+) cells in diverse brain regions share a core set of physiological properties, including expression of voltage-gated Na(+) (NaV) channels and ionotropic glutamate receptors, and formation of synapses with glutamatergic neurons. Although small amplitude Na(+) spikes could be elicited in some NG2(+) cells during the first postnatal week, they were not capable of generating action potentials. Transition of these progenitors to the premyelinating stage was accompanied by the rapid removal of synaptic input, as well as downregulation of AMPA and NMDA receptors and NaV channels. Thus, prior reports of physiological heterogeneity among NG2(+) cells may reflect analysis of cells in later stages of maturation. These results suggest that NG2(+) cells are uniquely positioned within the oligodendrocyte lineage to monitor the firing patterns of surrounding neurons.

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Authors: De Biase, L. M., Nishiyama, A., & Bergles, D. E.
Affiliations: University of Connecticut (US)
Johns Hopkins University (US)
Corresponding author: Bergles, Dwight E.
ORCID: Nishiyama, Akiko
Bergles, Dwight E.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2010-03-10
Volume: 30
Issue: 10
Pages: 3600-3611
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.6000-09.2010
PMC: PMC2838193
OpenAlex: W1999272226
Cited by: 286
References: 65
Citations by year: 2026: 16 · 2025: 16 · 2024: 14 · 2023: 21 · 2022: 11 · 2021: 19 · 2020: 16 · 2019: 20 · 2018: 10 · 2017: 23 · 2016: 15 · 2015: 20 · 2014: 14 · 2013: 20 · 2012: 14
FWCI: 7.18
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 184 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Multiple Sclerosis Society
National Alliance for Research on Schizophrenia and Depression
Multiple Sclerosis Society
National Institutes of Health
U.S. Public Health Service (PAR-02-059)
National Eye Institute (T32EY017203)
National Institute of Neurological Disorders and Stroke (R01NS049267, NS-049267, NS051509, P30NS050274, R01NS051509)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: oligodendrocyte precursor cells, oligodendrocyte progenitors, oligodendrocyte lineage, action potential, voltage-gated sodium channels, ionotropic glutamate receptors, AMPA receptors, NMDA receptor, oligodendrogenesis, synaptic input, neuronal activity regulation, transgenic mice, brain development
MeSH terms: Chondroitin Sulfate Proteoglycan 4, Action Potentials, Animals, Animals, Newborn, Cell Communication, Membrane Proteins, Mice, Transgenic, Oligodendroglia, Chondroitin Sulfate Proteoglycans, Synapses, Cell Lineage, Gene Expression Profiling, Mice

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Excitability and Synaptic Communication within the Oligodendrocyte Lineage

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