Hydration State Controls Stress Responsiveness and Social Behavior
Open accessAbstract
Life stress frequently occurs within the context of homeostatic challenge, requiring integration of physiological and psychological need into appropriate hormonal, cardiovascular, and behavioral responses. To test neural mechanisms underlying stress integration within the context of homeostatic adversity, we evaluated the impact of a pronounced physiological (hypernatremia) challenge on hypothalamic-pituitary-adrenal (HPA), cardiovascular, and behavioral responses to an acute psychogenic stress. Relative to normonatremic controls, rats rendered mildly hypernatremic had decreased HPA activation in response to physical restraint, a commonly used rodent model of psychogenic stress. In addition, acute hypernatremia attenuated the cardiovascular response to restraint and promoted faster recovery to prestress levels. Subsequent to restraint, hypernatremic rats had significantly more c-Fos expression in oxytocin- and vasopressin-containing neurons within the supraoptic and paraventricular nuclei of the hypothalamus. Hypernatremia also completely eliminated the increased plasma renin activity that accompanied restraint in controls, but greatly elevated circulating levels of oxytocin. The endocrine and cardiovascular profile of hypernatremic rats was predictive of decreased anxiety-like behavior in the social interaction test. Collectively, the results indicate that acute hypernatremia is a potent inhibitor of the HPA, cardiovascular, and behavioral limbs of the stress response. The implications are that the compensatory responses that promote renal-sodium excretion when faced with hypernatremia also act on the nervous system to decrease reactivity to psychogenic stressors and facilitate social behavior, which may suppress the anxiety associated with approaching a communal water source and support the social interactions that may be encountered when engaging in drinking behavior.
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In rats, hypernatremia is associated with greater social investigation of a novel intruder.
“For example, in a state of hypernatremia (elevated plasma sodium, which is associated with the perception of thirst), rats exhibit greater social investigation of a novel intruder170.”
From Neural mechanisms of social homeostasis (2019) · cites this paper as [170]
Acute hypernatremia in rats suppresses ATII production.
“Intriguingly, acute hypernatremia in rats is also associated with increased plasma oxytocin, increased c-Fos expression in magnocellular PVN oxytocin neurons, and suppression of ATII production170.”
From Neural mechanisms of social homeostasis (2019) · cites this paper as [170]
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- Authors
- Krause, E. G., de Kloet, A. D., Flak, J. N., Smeltzer, M. D., Solomon, M. B., Evanson, N. K., Woods, S. C., Sakai, R. R., & Herman, J. P.
- Affiliations
- University of Cincinnati (US)
- Cincinnati Children's Hospital Medical Center (US)
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2011-04-06
- Volume
- 31
- Issue
- 14
- Pages
- 5470-5476
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3086063
- OpenAlex
- W1982534831
- Cited by
- 85
- References
- 51
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 11 · 2019: 7 · 2018: 5 · 2017: 4 · 2016: 14 · 2015: 6 · 2014: 4 · 2013: 5 · 2012: 6
- FWCI
- 2.00
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- National Institutes of Health (HL-096830)
- National Heart, Lung, and Blood Institute (R00HL096830, K99HL096830, HL096830)
- National Institute of Mental Health (R01MH049698)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK078201, DK 66596, R01DK017844, R01DK066596, DK66596-05A2S1)
- National Institute of Neurological Disorders and Stroke (F31NS068122)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- hypernatremia, psychogenic stress, physical restraint, hypothalamic-pituitary-adrenal axis, oxytocin, vasopressin, supraoptic nucleus, paraventricular nucleus, Fos expression, plasma renin activity, anxiety-like behavior, social behavior, cardiovascular response, sodium homeostasis, drinking behavior
- MeSH terms
- Adrenocorticotropic Hormone, Analysis of Variance, Animals, Behavior, Animal, Blood Pressure, Corticosterone, Disease Models, Animal, Dose-Response Relationship, Drug, Heart Rate, Male, Osmosis, Oxytocin, Paraventricular Hypothalamic Nucleus, Radioimmunoassay, Social Behavior, Sodium Chloride, Stress, Psychological, Supraoptic Nucleus, Time Factors, Vasoactive Intestinal Peptide, Rats, Sprague-Dawley, Rats, Hypodermoclysis
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