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Astrocytes as secretory cells of the central nervous system: idiosyncrasies of vesicular secretion
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Astrocytes are housekeepers of the central nervous system (CNS) and are important for CNS development, homeostasis and defence. They communicate with neurones and other glial cells through the release of signalling molecules. Astrocytes secrete a wide array of classic neurotransmitters, neuromodulators and hormones, as well as metabolic, trophic and plastic factors, all of which contribute to the gliocrine system. The release of neuroactive substances from astrocytes occurs through several distinct pathways that include diffusion through plasmalemmal channels, translocation by multiple transporters and regulated exocytosis. As in other eukaryotic cells, exocytotic secretion from astrocytes involves divergent secretory organelles (synaptic-like microvesicles, dense-core vesicles, lysosomes, exosomes and ectosomes), which differ in size, origin, cargo, membrane composition, dynamics and functions. In this review, we summarize the features and functions of secretory organelles in astrocytes. We focus on the biogenesis and trafficking of secretory organelles and on the regulation of the exocytotic secretory system in the context of healthy and diseased astrocytes.
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“An accumulating body of evidence emphasizes astrocytes as one of the major secretory cells in the CNS, responsible for secretion of neurotransmitters, growth factors, inflammatory mediators, and toxic proteins [33].”
From Crosstalk between astrocytes and microglia results in increased degradation of α-synuclein and amyloid-β aggregates (2021) · cites this paper as [33]
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Cites
Danbolt, N. C. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00067-8 · Cited by 4,227
Membrane vesicles as conveyors of immune responses
Théry, C., Ostrowski, M., & Segura, É. (2009) · Nature reviews. Immunology · doi:10.1038/nri2567 · Cited by 3,996
Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes
Trajković, K., Hsu, C., Chiantia, S., Rajendran, L., Wenzel, D., Wieland, F., Schwille, P., Brügger, B., & Simons, M. (2008) · Science · doi:10.1126/science.1153124 · Cited by 3,760
The Classical Complement Cascade Mediates CNS Synapse Elimination
Stevens, B., Allen, N. J., Vazquez, L. E., Howell, G. R., Christopherson, K. S., Nouri, N., Micheva, K. D., Mehalow, A. K., Huberman, A. D., Stafford, B., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.036 · Cited by 3,313
SNAP receptors implicated in vesicle targeting and fusion
Söllner, T. H., Whiteheart, S. W., Brunner, M., Erdjument‐Bromage, H., Geromanos, S. J., Tempst, P., & Rothman, J. E. (1993) · Nature · doi:10.1038/362318a0 · Cited by 3,239
Rab27a and Rab27b control different steps of the exosome secretion pathway
Ostrowski, M., Carmo, N., Krumeich, S., Fanget, I., Raposo, G., Savina, A., Moita, C. F., Schauer, K., Hume, A. N., Freitas, R. P., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb2000 · Cited by 2,761
SNAREs — engines for membrane fusion
Jahn, R., & Scheller, R. H. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2002 · Cited by 2,635
Exosomes: Extracellular organelles important in intercellular communication
Mathivanan, S., Ji, H. L., & Simpson, R. J. (2010) · Journal of Proteomics · doi:10.1016/j.jprot.2010.06.006 · Cited by 2,581
SNAREpins: Minimal Machinery for Membrane Fusion
Weber, T., Zemelman, B. V., McNew, J. A., Westermann, B., Gmachl, M., Parlati, F., Söllner, T. H., & Rothman, J. E. (1998) · Cell · doi:10.1016/s0092-8674(00)81404-x · Cited by 2,481
Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution
Sutton, R. B., Fasshauer, D., Jahn, R., & Brunger, A. T. (1998) · Nature · doi:10.1038/26412 · Cited by 2,417 · cited 1×
“This bundle facilitates the fusion of vesicular and plasma membranes (Sutton et al, 1998; Weber et al, 1998).”
Flagged first, then by citations
Research works printed but not linked: 2
- Held H (1909) Über die Neuroglia marginalis der menschlichen Grosshirnrinde. Monatschr f Psychol u Neurol 26 Rdg.‐Heft: 360–416
- Nageotte J (1910) Phenomenes de secretion dans le protoplasma des cellules nevrogliques de la substance grise. C R Soc Biol (Paris) 68: 1068–1069
Cited by
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Items 101–200 of 395
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Stenovec, M., Li, B., Verkhratsky, A., & Zorec, R. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108158 · Cited by 52
Self-citationParpura, V., Fisher, E. S., Lechleiter, J. D., Schousboe, A., Waagepetersen, H. S., Brunet, S., Baltan, S., & Verkhratsky, A. (2016) · Neurochemical Research · doi:10.1007/s11064-016-1848-6 · Cited by 46
Self-citationTargeting astrocytes in bipolar disorder
Peng, L., Li, B., & Verkhratsky, A. (2016) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2016.1171144 · Cited by 45
Self-citationAdolf, A., Rohrbeck, A., Münster‐Wandowski, A., Johansson, M., Kuhn, H. G., Kopp, M. A., Brommer, B., Schwab, J. M., Just, I., Ahnert‐Hilger, G., et al. (2018) · Glia · doi:10.1002/glia.23566 · Cited by 44
Neuroglia: Realising their true potential
Butt, A. M., & Verkhratsky, A. (2018) · Brain and Neuroscience Advances · doi:10.1177/2398212818817495 · Cited by 52
Self-citationSidoryk‐Wȩgrzynowicz, M., Adamiak, K., & Strużyńska, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25053050 · Cited by 48
Gotkine, M., Caraco, Y., Lerner, Y., Blotnick, S., Wanounou, M., Slutsky, S. G., Chebath, J., Kuperstein, G., Estrin, E., Ben‐Hur, T., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-03903-3 · Cited by 42
Bossuyt, J., Herrewegen, Y. V. D., Nestor, L., Buckinx, A., Bundel, D. D., & Smolders, I. J. (2023) · Glia · doi:10.1002/glia.24390 · Cited by 44
Deep insights: intravital imaging with two-photon microscopy
Schießl, I. M., & Castrop, H. (2016) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-016-1832-7 · Cited by 41
The structural and functional evidence for vesicular release from astrocytes in situ
Bohmbach, K., Schwarz, M. K., Schoch, S., & Henneberger, C. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.01.015 · Cited by 47
Sphingosine-1-phosphate induces Ca 2+ signaling and CXCL1 release via TRPC6 channel in astrocytes
Shirakawa, H., Katsumoto, R., Iida, S., Miyake, T., Higuchi, T., Nagashima, T., Nagayasu, K., Nakagawa, T., & Kaneko, S. (2017) · Glia · doi:10.1002/glia.23141 · Cited by 41
Zelentsova, A. S., Deykin, A. V., Soldatov, V. O., Ulezko, A. A., Borisova, A. Y., Belyaeva, V. S., Skorkina, M. Y., & Angelova, P. R. (2022) · eNeuro · doi:10.1523/eneuro.0092-22.2022 · Cited by 41
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Zorec, R., Parpura, V., & Verkhratsky, A. (2018) · FEBS Journal · doi:10.1111/febs.14456 · Cited by 40
Self-citationAstrocytic cell adhesion genes linked to schizophrenia correlate with synaptic programs in neurons
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Astrocyte Gliotransmission in the Regulation of Systemic Metabolism
Murat, C. D. B., & García‐Cáceres, C. (2021) · Metabolites · doi:10.3390/metabo11110732 · Cited by 38
Glia-derived extracellular vesicles in parkinson’s disease.
Marchetti, B., Leggio, L., L’Episcopo, F., Vivarelli, S., Tirolo, C., Paternò, G., Giachino, C., Caniglia, S., Serapide, M. F., & Iraci, N. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9061941 · Cited by 38
Astrocytes release ATP/ADP and glutamate in flashes via vesicular exocytosis
Li, H., Zhao, Y., Dai, R., Geng, P., Weng, D., Wu, W., Yu, F., Lin, R., Wu, Z., Li, Y., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02851-8 · Cited by 41
Impaired ATP Release from Brain Astrocytes May be a Cause of Major Depression
Illés, P., Rubini, P., Yin, H., & Tang, Y. (2020) · Neuroscience Bulletin · doi:10.1007/s12264-020-00494-7 · Cited by 37
González-Molina, L. A., Villar-Vesga, J., Henao-Restrepo, J., Villegas, A., Lopera, F., Cardona-Gómez, G. P., & Posada-Duque, R. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.593927 · Cited by 37
Extracellular vesicles from neurons promote neural induction of stem cells through cyclin D1
Song, L., Tian, X., & Schekman, R. W. (2021) · The Journal of Cell Biology · doi:10.1083/jcb.202101075 · Cited by 34
Attaluri, S., Gonzalez, J. J., Kirmani, M., Vogel, A. D., Upadhya, R., Kodali, M., Madhu, L. N., Rao, S., Shuai, B., Babu, R. S., et al. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1200445 · Cited by 37
Directed glial differentiation and transdifferentiation for neural tissue regeneration
Janowska, J., Gargaś, J., Ziemka‐Nałęcz, M., Zalewska, T., Bużańska, L., & Sypecka, J. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.08.010 · Cited by 36
Salikhova, D. I., Bukharova, T. B., Cherkashova, E. A., Namestnikova, D. D., Leonov, G. E., Nikitina, M., Gubskiy, I. L., Akopyan, G., Elchaninov, A. V., Midiber, K. Y., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094694 · Cited by 38
Know How to Regrow—Axon Regeneration in the Zebrafish Spinal Cord
Tsata, V., & Wehner, D. (2021) · Cells · doi:10.3390/cells10061404 · Cited by 37
Neurodegeneration and inflammation crosstalk: Therapeutic targets and perspectives
Mohamed, W. M. Y., Kumar, J., Alghamdi, B. S. A., Wadan, A.-H. S., & Yamashita, T. (2022) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2022.12.003 · Cited by 40
Primary astrocytic mitochondrial transplantation ameliorates ischemic stroke
Lee, E.-H., Kim, M. K., Ko, S. H., Kim, C., Lee, M., & Park, C. (2023) · BMB Reports · doi:10.5483/bmbrep.2022-0108 · Cited by 36
Investigating brain d ‐serine: Advocacy for good practices
Mothet, J., Billard, J., Pollegioni, L., Coyle, J. T., & Sweedler, J. V. (2019) · Acta Physiologica · doi:10.1111/apha.13257 · Cited by 36
Self-citationExocytosis in non‐neuronal cells
Thorn, P., Zorec, R., Rettig, J., & Keating, D. J. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13602 · Cited by 33
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Is the Immunological Response a Bottleneck for Cell Therapy in Neurodegenerative Diseases?
Salado-Manzano, C., Perpiñá, U., Straccia, M., Molina-Ruiz, F. J., Cozzi, E., Rosser, A., & Canals, J. M. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00250 · Cited by 34
Harcha, P. A., Garcés, P., Arredondo, C., Fernández, G. R., Sáez, J. C., & van Zundert, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041924 · Cited by 38
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Ogaki, A., Ikegaya, Y., & Koyama, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910553 · Cited by 33
Shi, Z., Chen, Y., Lu, C., Dong, L.-M., Lv, J.-W., Tuo, Q.-H., Qin, L., Cheng, S.-W., Bu, L.-L., Lin, N., et al. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.09.002 · Cited by 32
Verkhratsky, A., & Butt, A. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-821565-4.00008-0 · Cited by 31
Self-citationAstroglial vesicular network: evolutionary trends, physiology and pathophysiology
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Self-citationZika virus exposure affects neuron-glia communication in the hippocampal slices of adult rats
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Wang, Y., Xia, Y. F., Kou, L., Yin, S., Chi, X., Li, J., Sun, Y., Wu, J., Zhou, Q., Zou, W., et al. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106224 · Cited by 33
Λεάνδρου, Ε., Chalatsa, I., Anagnostou, D., Machalia, C., Semitekolou, M., Filippa, V., Makridakis, M., Vlahou, A., Anastasiadou, E., Vekrellis, K., et al. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00401-4 · Cited by 33
Olivero, G., Cisani, F., Marimpietri, D., Paolo, D. D., Gagliani, M. C., Podestà, M., Cortese, K., & Pittaluga, A. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.670158 · Cited by 29
Varlamova, E. G., Turovsky, E. A., Babenko, V. A., & Plotnikov, E. Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312825 · Cited by 31
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Zorec, R., Parpura, V., Vardjan, N., & Verkhratsky, A. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.05.021 · Cited by 30
Self-citationVerkhratsky, A., Zorec, R., Rodriguez, J. J., & Parpura, V. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-9913-8_8 · Cited by 32
Self-citationThe role of neuroglia in autism spectrum disorders
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Self-citationMielnicka, A., & Michaluk, P. (2021) · Biomolecules · doi:10.3390/biom11091367 · Cited by 31
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Self-citationEndocytic BDNF secretion regulated by Vamp3 in astrocytes
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Paulo, D. C., Magalhães, N. G. D. M., Miranda, D. D. A., Diniz, D. G., Henrique, E. P., Moraes, I. A. M., Pereira, P. D. C., de Melo, M. A. D., de Lima, C. M., Augusto‐Oliveira, M., et al. (2018) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2017.00126 · Cited by 28
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Li, Z., Gu, Y., Wen, R., Shen, F., Tian, H., Yang, G., & Zhang, Z. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.03.046 · Cited by 28
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Cheng, Y., Zhao, H., Chen, L.-W., Yao, X.-Y., Wang, Y.-L., Huang, Z., Li, G.-P., Wang, Z., & Chen, B. (2019) · Neuroscience Research · doi:10.1016/j.neures.2019.07.007 · Cited by 30
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Bacigaluppi, M., Sferruzza, G., Butti, E., Ottoboni, L., & Martino, G. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146619 · Cited by 29
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Li, X., 合肥230001，中国, 中., Zhang, J., Li, D., Wu, W., Xie, Z., Liu, Q., 合肥230036，中国, 安., 合肥230026，中国, 中., 合肥230001，中国, 中., et al. (2020) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2020.043 · Cited by 28
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Self-citationXia, H., & Xia, Y. (2018) · Materials Science and Engineering C · doi:10.1016/j.msec.2018.05.050 · Cited by 27
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Verkhratsky, A., & Zorec, R. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02644-z · Cited by 34
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Sidoryk‐Wȩgrzynowicz, M., & Strużyńska, L. (2019) · Biochemical Journal · doi:10.1042/bcj20190506 · Cited by 26
Astrocyte signaling and synaptic homeostasis
Benarroch, E. E. (2016) · Neurology · doi:10.1212/wnl.0000000000002875 · Cited by 25
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Grochowska, M. M., Mascaro, A. C., Boumeester, V., Natale, D., Breedveld, G. J., Geut, H., van Cappellen, W. A., Boon, A. J. W., Kievit, A. J. A., Sammler, E. M., et al. (2021) · Acta Neuropathologica · doi:10.1007/s00401-021-02313-3 · Cited by 22
Yue, Q., Zhou, X., Zhang, Z., & Hoi, M. P. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031878 · Cited by 26
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Self-citationVeletić, M., Barros, M. T., Arjmandi, H., Balasubramaniam, S., & Balasingham, I. (2020) · IEEE Transactions on NanoBioscience · doi:10.1109/tnb.2020.2991794 · Cited by 24
P2X7 receptor-mediated depression-like reactions arising in the mouse medial prefrontal cortex
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Matrine promotes NT3 expression in CNS cells in experimental autoimmune encephalomyelitis.
Zhang, M.-L., Zhang, X.-J., Kang, J.-S., Zhang, H.-J., Chen, X.-L., Liu, N., Liu, S., Ma, W.-D., Zhang, G.-X., & Zhu, L. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.04.005 · Cited by 25
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Wang, S. C., Parpura, V., & Wang, Y. (2020) · Neurochemical Research · doi:10.1007/s11064-020-03172-2 · Cited by 24
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Lisjak, M., Potokar, M., Zorec, R., & Jorgačevski, J. (2020) · Cells · doi:10.3390/cells9030735 · Cited by 23
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Schröder, S., Fuchs, U., Gisa, V., Peña, T., Krüger, D. M., Hempel, N., Burkhardt, S., Salinas, G., Schütz, A., Delalle, I., et al. (2024) · Acta Neuropathologica · doi:10.1007/s00401-024-02787-x · Cited by 27
Verkhratsky, A., Zorec, R., Rodriguez, J. J., & Parpura, V. (2017) · Advances in neurobiology · doi:10.1007/978-3-319-57193-5_17 · Cited by 23
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Self-citationAnakor, E., Milla, V., Connolly, O., Martinat, C., Pradat, P., Dumonceaux, J., Duddy, W. J., & Duguez, S. (2022) · Cells · doi:10.3390/cells11050845 · Cited by 21
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Queiroga, C. S. F., Alves, R. M. A., Conde, S. V., Alves, P. M., & Vieira, H. L. A. (2016) · Journal of Cell Science · doi:10.1242/jcs.187260 · Cited by 24
Losurdo, M., & Grilli, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228819 · Cited by 24
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Metadata
- Authors
- Verkhratsky, A., Matteoli, M., Parpura, V., Mothet, J., & Zorec, R.
- Affiliations
- Ikerbasque (ES)
- IRCCS Humanitas Research Hospital (IT)
- Civitan International (US)
- Centre National de la Recherche Scientifique (FR)
- University of Ljubljana (SI)
- Corresponding author
- Verkhratsky, Alexei
- Matteoli, Michela
- Parpura, Vladimir
- Mothet, Jean‐Pierre
- Zorec, Robert
- Venue
- The EMBO Journal
- Published
- 2016-01-12
- Volume
- 35
- Issue
- 3
- Pages
- 239-257
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC4741299
- OpenAlex
- W2237126879
- Cited by
- 397
- References
- 253
- Citations by year
- 2026: 19 · 2025: 35 · 2024: 34 · 2023: 35 · 2022: 27 · 2021: 67 · 2020: 46 · 2019: 41 · 2018: 36 · 2017: 38 · 2016: 18
- FWCI
- 4.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The EMBO Journal (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL AMU (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Funders
- Alzheimer's Research Trust (02.B.49.21.0003)
- The Ministry of Education and Science of the Russian Federation and Lobachevsky State University of Nizhny Novgorod
- Russian Scientific Foundation (14‐15‐00633)
- Italian Ministry of Health (GR‐2011‐02347377)
- Cariplo (2014‐0655)
- Progetto CNR Invecchiamento‐ CUP (B44G13000080005)
- National Institutes of Health (HD078678)
- CNRS
- University Aix Marseille
- Fondation pour la Recherche Medicale
- The Research Agency of Slovenia (P3 310, J3 3236, J3 4051, J3‐4146, J3 6790, J3 6789)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- astrocytes, vesicular secretion, exocytosis, secretory organelles, synaptic-like microvesicles, dense core vesicles, exosomes, ectosome, lysosomes, astrocyte dysfunction
- MeSH terms
- Animals, Astrocytes, Cell Communication, Central Nervous System, Humans, Protein Transport, Secretory Vesicles, Intercellular Signaling Peptides and Proteins, Secretory Pathway
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