Resolving neuroinflammation, the therapeutic potential of the anti-malaria drug family of artemisinin

The biology of VEGF and its receptors

Ferrara, N., Gerber, H.-P., & LeCouter, J. (2003) · Nature Medicine · doi:10.1038/nm0603-669 · Cited by 9,591 · see citing works

Neuroinflammation in Alzheimer's disease

Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226 · see citing works

Astrocyte-endothelial interactions at the blood-brain barrier

Abbott, N. J., Rönnbäck, L., & Hansson, E. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1824 · Cited by 5,595 · see citing works

Structure and function of the blood–brain barrier

Abbott, N. J., Patabendige, A. A. K., Dolman, D. E. M., Yusof, S. R., & Begley, D. J. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.07.030 · Cited by 5,185 · see citing works

Phosphorylation meets ubiquitination: the control of NF-κB activity

Karin, M., & Ben-Neriah, Y. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.621 · Cited by 4,766 · see citing works

Lipopolysaccharide endotoxins

Raetz, C. R. H., & Whitfield, C. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.110601.135414 · Cited by 4,404 · see citing works

Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology

Funk, C. D. (2001) · Science · doi:10.1126/science.294.5548.1871 · Cited by 3,817 · see citing works

Microglia: Active sensor and versatile effector cells in the normal and pathologic brain

Hanisch, U.-K., & Kettenmann, H. (2007) · Nature Neuroscience · doi:10.1038/nn1997 · Cited by 3,676 · see citing works

Mechanisms underlying inflammation in neurodegeneration

Glass, C. K., Saijo, K., Winner, B., Marchetto, M. C., & Gage, F. H. (2010) · Cell · doi:10.1016/j.cell.2010.02.016 · Cited by 3,580 · see citing works

Physiology of Microglia

Kettenmann, H., Hanisch, U.-K., Noda, M., & Verkhratsky, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00011.2010 · Cited by 3,547 · see citing works

Alzheimer’s disease

Blennow, K., de Leon, M. J., & Zetterberg, H. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69113-7 · Cited by 3,134 · see citing works

Cyclooxygenases: Structural, cellular, and molecular biology

Smith, W. L., DeWitt, D. L., & Garavito, R. M. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.145 · Cited by 2,925 · see citing works

Pericytes regulate the blood–brain barrier

Armulik, A., Genové, G., Mäe, M., Nisancioglu, M. H., Wallgard, E., Niaudet, C., He, L., Norlin, J., Lindblom, P., Strittmatter, K., et al. (2010) · Nature · doi:10.1038/nature09522 · Cited by 2,843 · see citing works

Development, maintenance and disruption of the blood-brain barrier

Obermeier, B., Daneman, R., & Ransohoff, R. M. (2013) · Nature Medicine · doi:10.1038/nm.3407 · Cited by 2,452 · see citing works

High-level semi-synthetic production of the potent antimalarial artemisinin

Paddon, C. J., Westfall, P. J., Pitera, D. J., Benjamin, K., Fisher, K., McPhee, D., Leavell, M. D., Tai, A., Main, A., Eng, D., et al. (2013) · Nature · doi:10.1038/nature12051 · Cited by 2,060 · see citing works

Interactions between the microbiota, immune and nervous systems in health and disease

Fung, T. C., Olson, C. A., & Hsiao, E. Y. (2017) · Nature Neuroscience · doi:10.1038/nn.4476 · Cited by 1,900 · see citing works

Targeting the NLRP3 inflammasome in inflammatory diseases

Mangan, M. S. J., Olhava, E. J., Roush, W. R., Seidel, H. M., Glick, G. D., & Latz, E. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.97 · Cited by 1,885 · see citing works

Inflammatory bowel disease

Kaser, A., Zeissig, S., & Blumberg, R. S. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101225 · Cited by 1,806 · see citing works

Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation

Kebir, H., Kreymborg, K., Ifergan, I., Dodelet-Devillers, A., Cayrol, R., Bernard, M., Giuliani, F., Arbour, N., Becher, B., & Prat, A. (2007) · Nature Medicine · doi:10.1038/nm1651 · Cited by 1,759 · see citing works

Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis

Christopherson, K. S., Ullian, E. M., Stokes, C. C. A., Mullowney, C. E., Hell, J. W., Agah, A., Lawler, J., Mosher, D. F., Bornstein, P., & Barres, B. A. (2005) · Cell · doi:10.1016/j.cell.2004.12.020 · Cited by 1,688 · see citing works

Neuroinflammation: The Devil Is in the Details

DiSabato, D. J., Quan, N., & Godbout, J. P. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13607 · Cited by 1,640 · see citing works

The central nervous system and the gut microbiome

Sharon, G., Sampson, T. R., Geschwind, D. H., & Mazmanian, S. K. (2016) · Cell · doi:10.1016/j.cell.2016.10.027 · Cited by 1,513 · see citing works

Inflammation meets cancer, with NF-κB as the matchmaker

Ben‐Neriah, Y., & Karin, M. (2011) · Nature Immunology · doi:10.1038/ni.2060 · Cited by 1,379 · see citing works

Control of Synaptic Strength by Glial TNFα

Beattie, E. C., Stellwagen, D., Morishita, W., Bresnahan, J. C., Ha, B. K., Von Zastrow, M., Beattie, M. S., & Malenka, R. C. (2002) · Science · doi:10.1126/science.1067859 · Cited by 1,344 · see citing works

Microglia: new roles for the synaptic stripper

Kettenmann, H., Kirchhoff, F., & Verkhratsky, A. (2013) · Neuron · doi:10.1016/j.neuron.2012.12.023 · Cited by 1,173 · see citing works

Glial regulation of the cerebral microvasculature

Iadecola, C., & Nedergaard, M. (2007) · Nature Neuroscience · doi:10.1038/nn2003 · Cited by 1,153 · see citing works

Social stress induces neurovascular pathology promoting depression

Menard, C., Pfau, M. L., Hodes, G. E., Kana, V., Wang, V. X., Bouchard, S., Takahashi, A., Flanigan, M. E., Aleyasin, H., LeClair, K. B., et al. (2017) · Nature Neuroscience · doi:10.1038/s41593-017-0010-3 · Cited by 1,028 · see citing works

From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways

Rogers, G. B., Keating, D. J., Young, R. L., Wong, M.-L., Licinio, J., & Wesselingh, S. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.50 · Cited by 969 · see citing works

Qinghaosu (Artemisinin): The Price of Success

White, N. J. (2008) · Science · doi:10.1126/science.1155165 · Cited by 954 · see citing works

NF-kappaB Signaling Pathways in Neurological Inflammation: A Mini Review

Shih, R., Wang, C.-Y., & Yang, C. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2015.00077 · Cited by 912 · see citing works

Artemisinin—A Gift from Traditional Chinese Medicine to the World (Nobel Lecture)

Tu, Y. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201601967 · Cited by 815 · see citing works

The myeloid cells of the central nervous system parenchyma

Ransohoff, R. M., & Cardona, A. E. (2010) · Nature · doi:10.1038/nature09615 · Cited by 804 · see citing works

Neuronal ‘On’ and ‘Off’ signals control microglia

Biber, K., Neumann, H., Inoue, K., & Boddeke, H. W. G. M. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.08.007 · Cited by 787 · see citing works

Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation

Lee, J. W., Lee, Y. K., Yuk, D. Y., Choi, D. Y., Ban, S. B., Oh, K. W., & Hong, J. T. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-37 · Cited by 772 · see citing works

The Evolution of Iron Chelators for the Treatment of Iron Overload Disease and Cancer

Kalinowski, D. S., & Richardson, D. R. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.4.2 · Cited by 721 · see citing works

Depression and coronary heart disease

Carney, R. M., & Freedland, K. E. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.181 · Cited by 705 · see citing works

VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown

Argaw, A. T., Gurfein, B. T., Zhang, Y., Zameer, A., & John, G. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808698106 · Cited by 666 · see citing works

Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum

Wang, J., Zhang, C., Chia, W. N., Loh, C. S., Li, Z., Lee, Y. M., He, Y., Yuan, L., Lim, T. K., Liu, M., et al. (2015) · Nature Communications · doi:10.1038/ncomms10111 · Cited by 636 · see citing works

Identification of an antimalarial synthetic trioxolane drug development candidate

Vennerstrom, J. L., Arbe‐Barnes, S., Brun, R., Charman, S. A., Chiu, F. C. K., Chollet, J., Dong, Y., Dorn, A., Hunziker, D., Matile, H., et al. (2004) · Nature · doi:10.1038/nature02779 · Cited by 622 · see citing works

The dynamic blood–brain barrier

Keaney, J., & Campbell, M. (2015) · The FEBS Journal · doi:10.1111/febs.13412 · Cited by 616 · see citing works

The Relationship Between Intestinal Microbiota and the Central Nervous System in Normal Gastrointestinal Function and Disease

Collins, S. M., & Bercik, P. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.01.075 · Cited by 612 · see citing works

Neurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity

Xanthos, D. N., & Sandkühler, J. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3617 · Cited by 580 · see citing works

Prostanoids in health and disease

Smyth, E. M., Großer, T., Wang, M., Yu, Y., & FitzGerald, G. A. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800094-jlr200 · Cited by 546 · see citing works

Glial influence on the blood brain barrier

Alvarez, J. I., Katayama, T., & Prat, A. (2013) · Glia · doi:10.1002/glia.22575 · Cited by 542 · see citing works

Membrane Prostaglandin E Synthase-1: A Novel Therapeutic Target

Samuelsson, B. O., Morgenstern, R., & Jakobsson, P. (2007) · Pharmacological Reviews · doi:10.1124/pr.59.3.1 · Cited by 538 · see citing works

Artemisinins: Pharmacological actions beyond anti-malarial

Ho, W. E., Peh, H. Y., Chan, T. K., & Wong, W. S. F. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.12.001 · Cited by 480 · see citing works

The Transcription Factor Nrf2 Is a Therapeutic Target against Brain Inflammation

Innamorato, N. G., Rojo, A. I., García‐Yagüe, Á. J., Yamamoto, M. P., CEBALLOS, M. L. D., & Cuadrado, A. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.1.680 · Cited by 479 · see citing works

Artemisinin: Discovery from the Chinese Herbal Garden

Miller, L. H., & Su, X. (2011) · Cell · doi:10.1016/j.cell.2011.08.024 · Cited by 436 · see citing works

Mood and gut feelings

Forsythe, P., Sudo, N., Dinan, T., Taylor, V. H., & Bienenstock, J. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.05.058 · Cited by 429 · see citing works

Astrocytes as secretory cells of the central nervous system: idiosyncrasies of vesicular secretion

Verkhratsky, A., Matteoli, M., Parpura, V., Mothet, J., & Zorec, R. (2016) · The EMBO Journal · doi:10.15252/embj.201592705 · Cited by 397 · see citing works

Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases

González, H., Elgueta, D., Montoya, A., & Pacheco, R. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.07.012 · Cited by 352 · see citing works

Astrocyte regulation of synaptic behavior

Allen, N. J. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100913-013053 · Cited by 343 · see citing works

Effects of Naturally Occurring Compounds on Fibril Formation and Oxidative Stress of β-Amyloid

Kim, H., Park, B., Lee, K., Choi, C. Y., Jang, S. S., Kim, Y., & Lee, S. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf051985c · Cited by 297 · see citing works

TNFα disrupts blood brain barrier integrity to maintain prolonged depressive-like behavior in mice

Cheng, Y., Desse, S., Martinez, A., Worthen, R. J., Jope, R. S., & Beurel, E. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.02.003 · Cited by 292 · see citing works

Artemisinin Directly Targets Malarial Mitochondria through Its Specific Mitochondrial Activation

Wang, J., Huang, L., Li, J., Fan, Q., Long, Y., Li, Y., & Zhou, B. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009582 · Cited by 256 · see citing works

Neurovascular unit dysfunction with blood-brain barrier hyperpermeability contributes to major depressive disorder: a review of clinical and experimental evidence

Najjar, S., Pearlman, D. M., Devinsky, O., Najjar, A., & Zagzag, D. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-142 · Cited by 248 · see citing works

The blood–brain barrier endothelium: a target for pro-inflammatory cytokines

Rochfort, K. D., & Cummins, P. M. (2015) · Biochemical Society Transactions · doi:10.1042/bst20140319 · Cited by 246 · see citing works

Neurological Disease as a Failure of Brain-Immune Crosstalk: The Multiple Faces of Neuroinflammation

Schwartz, M., & Deczkowska, A. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.08.001 · Cited by 246 · see citing works

Artemisinin and its derivatives: an important new class of antimalarial agents

Balint, G. A. (2001) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(01)00140-1 · Cited by 244 · see citing works

Hybrid systems through natural product leads: An approach towards new molecular entities

Mehta, G., & Singh, V. K. (2002) · Chemical Society Reviews · doi:10.1039/b204748a · Cited by 244 · see citing works

Toxicity of the antimalarial artemisinin and its dervatives

Efferth, T., & Kaina, B. (2010) · Critical Reviews in Toxicology · doi:10.3109/10408441003610571 · Cited by 241 · see citing works

Pharmacokinetics of Artemisinin-Type Compounds

Navaratnam, V., Mansor, S. M., Sit, N. W., et al. (2000) · Clinical Pharmacokinetics · doi:10.2165/00003088-200039040-00002 · Cited by 220 · see citing works

The role of APP and BACE1 trafficking in APP processing and amyloid-β generation

Zhang, X., & Song, W. (2013) · Alzheimer s Research & Therapy · doi:10.1186/alzrt211 · Cited by 216 · see citing works

Artemisinin analogue SM934 ameliorates DSS-induced mouse ulcerative colitis via suppressing neutrophils and macrophages

Yan, Y., Shao, M., Qi, Q., Xu, Y., Yang, X., Zhu, F., He, S., He, P., Feng, C., Wu, Y., et al. (2018) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.185 · Cited by 205 · see citing works

Immune Surveillance of the CNS following Infection and Injury

Russo, M. V., & McGavern, D. B. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.08.002 · Cited by 191 · see citing works

The antimalarial drug artemisinin alkylates heme in infected mice

Robert, A., Benoit‐Vical, F., Claparols, C., & Meunier, B. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500972102 · Cited by 190 · see citing works

Evidence for interplay among antibacterial-induced gut microbiota disturbance, neuro-inflammation, and anxiety in mice

Jang, H.-M., Lee, H.-J., Jang, S.-E., Han, M. J., & Kim, D.-H. (2018) · Mucosal Immunology · doi:10.1038/s41385-018-0042-3 · Cited by 181 · see citing works

Activated glia induce neuron death via MAP kinase signaling pathways involving JNK and p38

Xie, Z., Smith, C. J., & Eldik, L. J. V. (2003) · Glia · doi:10.1002/glia.10314 · Cited by 165 · see citing works

Neuron–Microglia Interactions in Mental Health Disorders: “For Better, and For Worse”

Wohleb, E. S. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00544 · Cited by 164 · see citing works

Pregnane X receptor as a target for treatment of inflammatory bowel disorders

Cheng, J., Shah, Y. M., & Gonzalez, F. J. (2012) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2012.03.003 · Cited by 159 · see citing works

Antimalarial Bioavailability and Disposition of Artesunate in Acute Falciparum Malaria

Newton, P. N., Suputtamongkol, Y., Teja‐Isavadharm, P., Pukrittayakamee, S., Navaratnam, V., Bates, I., & White, N. J. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.4.972-977.2000 · Cited by 158 · see citing works

Inflammation-Dependent Cerebral Deposition of Serum Amyloid A Protein in a Mouse Model of Amyloidosis

Guo, J.-T., Yu, J., Grass, D., de Beer, F. C., & Kindy, M. S. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-14-05900.2002 · Cited by 153 · see citing works

Innate and adaptive immune responses in the CNS

Waisman, A., Liblau, R., & Becher, B. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00141-6 · Cited by 151 · see citing works

Anti‐Inflammatory and Immunoregulatory Functions of Artemisinin and Its Derivatives

Shi, C., Li, H., Yang, Y., & Hou, L. (2015) · Mediators of Inflammation · doi:10.1155/2015/435713 · Cited by 151 · see citing works

Role of neuro-immunological factors in the pathophysiology of mood disorders

Bhattacharya, A., Derecki, N. C., Lovenberg, T. W., & Drevets, W. C. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4214-0 · Cited by 149 · see citing works

Protective autoimmunity functions by intracranial immunosurveillance to support the mind: The missing link between health and disease

Schwartz, M., & Shechter, R. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.31 · Cited by 129 · see citing works

SR-A/MARCO–mediated ligand delivery enhances intracellular TLR and NLR function, but ligand scavenging from cell surface limits TLR4 response to pathogens

Mukhopadhyay, S., Varin, A., Chen, Y., Liu, B., Tryggvason, K., & Gordon, S. (2010) · Blood · doi:10.1182/blood-2010-03-276733 · Cited by 118 · see citing works

Neurotoxic Mode of Action of Artemisinin

Schmuck, G., Roehrdanz, E., Haynes, R. K., et al. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.3.821-827.2002 · Cited by 117 · see citing works

Antimalarial Drug Artemisinin Extenuates Amyloidogenesis and Neuroinflammation in APP swe/ PS 1dE9 Transgenic Mice via Inhibition of Nuclear Factor‐κ B and NLRP 3 Inflammasome Activation

Shi, J., Zhang, C., Sun, X., Cheng, X., Wang, J., Zhang, Y., Xu, J. L., & Zou, H. (2013) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12066 · Cited by 116 · see citing works

Neurotoxicity of artemisinin analogs in vitro

WESCHE, D. L., DeCoster, M. A., Tortella, F. C., & Brewer, T. G. (1994) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.38.8.1813 · Cited by 112 · see citing works

Antimalarial Drug Artemether Inhibits Neuroinflammation in BV2 Microglia Through Nrf2-Dependent Mechanisms

Okorji, U. P., Velagapudi, R., El‐Bakoush, A., Fiebich, B. L., & Olajide, O. A. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9543-1 · Cited by 112 · see citing works

Effects of artemisinin-tagged holotransferrin on cancer cells

Lai, H. C., Sasaki, T., Singh, N. P., & Messay, A. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.08.020 · Cited by 107 · see citing works

Advanced glycation end-products disrupt the blood–brain barrier by stimulating the release of transforming growth factor–β by pericytes and vascular endothelial growth factor and matrix metalloproteinase–2 by endothelial cells in vitro

Shimizu, F., Sano, Y., Tominaga, O., Maeda, T., Abe, M., & Kanda, T. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.01.012 · Cited by 106 · see citing works

Pharmacokinetic and Toxicological Profile of Artemisinin Compounds: An Update

Medhi, B., Patyar, S., Rao, R. S., Prasad Byrav, D. S., & Prakash, A. (2009) · Pharmacology · doi:10.1159/000252658 · Cited by 101 · see citing works

Role of microglial redox balance in modulation of neuroinflammation

Innamorato, N. G., Lastres‐Becker, I., & Cuadrado, A. (2009) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32832a3225 · Cited by 100 · see citing works

Up-regulation of heme oxygenase-1 expression through CaMKII-ERK1/2-Nrf2 signaling mediates the anti-inflammatory effect of bisdemethoxycurcumin in LPS-stimulated macrophages

Kim, A. N., Jeon, W.-K., Lee, J. J., & Kim, B.-C. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.04.015 · Cited by 100 · see citing works

Artemisinin Neurotoxicity: Neuropathology in Rats and Mechanistic Studies in Vitro

Kamchonwongpaisan, S., McKeever, P. E., Hossler, P. A., Ziffer, H., & Meshnick, S. R. (1997) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1997.56.7 · Cited by 98 · see citing works

Studies of the neurotoxicity of oral artemisinin derivatives in mice.

Nontprasert, A., Pukrittayakamee, S., Nosten‐Bertrand, M., et al. (2000) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2000.62.409 · Cited by 93 · see citing works

Ataxia and Slurred Speech after Artesunate Treatment for Falciparum Malaria

Miller, L. G., & Panosian, C. B. (1997) · New England Journal of Medicine · doi:10.1056/nejm199705013361818 · Cited by 92 · see citing works

Natural products as a hunting ground for combinatorial chemistry

Ganesan, A. (2004) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2004.09.002 · Cited by 92 · see citing works

Immunomodulatory and Anti-inflammatory Properties of Artesunate in Experimental Colitis

Yang, Z., Ding, J., Yang, C., et al. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712803251575 · Cited by 92 · see citing works

Neuropathologic toxicity of artemisinin derivatives in a mouse model.

Nontprasert, A., Pukrittayakamee, S., Dondorp, A. M., Clemens, R. L., Looareesuwan, S., & White, N. J. (2002) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2002.67.423 · Cited by 90 · see citing works

Matrix Metalloproteinase-9 Leads to Claudin-5 Degradation via the NF-κB Pathway in BALB/c Mice with Eosinophilic Meningoencephalitis Caused by Angiostrongylus cantonensis

Chiu, P.-S., & Lai, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053370 · Cited by 85 · see citing works

Artemisinin protects human retinal pigment epithelial cells from hydrogen peroxide-induced oxidative damage through activation of ERK/CREB signaling

Chong, C., & Zheng, W. (2016) · Redox Biology · doi:10.1016/j.redox.2016.06.002 · Cited by 82 · see citing works

Molecular Basis of Etiological Implications in Alzheimer’s Disease: Focus on Neuroinflammation

Niranjan, R. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8428-4 · Cited by 81 · see citing works

Artesunate enhances the antibacterial effect of β-lactam antibiotics against Escherichia coli by increasing antibiotic accumulation via inhibition of the multidrug efflux pump system AcrAB-TolC

Li, B., Yao, Q., Pan, X., et al. (2011) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkr017 · Cited by 80 · see citing works

Pharmacokinetics and Pharmacodynamics of Endoperoxide Antimalarials

Gautam, A., Ahmed, T., Paliwal, J. K., et al. (2009) · Current Drug Metabolism · doi:10.2174/138920009787846323 · Cited by 79 · see citing works

The toxicity of artemisinin and related compounds on neuronal and glial cells in culture

Fishwick, J., McLean, W. G., Edwards, G., & Ward, S. A. (1995) · Chemico-Biological Interactions · doi:10.1016/0009-2797(94)03597-2 · Cited by 78 · see citing works

Artemisinin conferred ERK mediated neuroprotection to PC12 cells and cortical neurons exposed to sodium nitroprusside-induced oxidative insult

Zheng, W., Chong, C., Wang, H., Zhou, X., Zhang, L., Wang, R., Meng, Q., Lazarovici, P., & Fang, J. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.05.023 · Cited by 78 · see citing works

Artemisinin Attenuates Lipopolysaccharide-Stimulated Proinflammatory Responses by Inhibiting NF-κB Pathway in Microglia Cells

Zhu, C., Xiong, Z., Chen, X., Peng, F., Hu, X., Chen, Y., & Wang, Q. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035125 · Cited by 74 · see citing works

Artemether and Artesunate Show the Highest Efficacies in Rescuing Mice with Late-Stage Cerebral Malaria and Rapidly Decrease Leukocyte Accumulation in the Brain

Clemmer, L., Martins, Y. C., Zaniní, G. M., Frangos, J. A., & Carvalho, L. J. M. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01277-10 · Cited by 73 · see citing works

Artemisinin and Artemisia annua leaves alleviate Eimeria tenella infection by facilitating apoptosis of host cells and suppressing inflammatory response

Jiao, J., Yang, Y., Liu, M., et al. (2018) · Veterinary Parasitology · doi:10.1016/j.vetpar.2018.03.017 · Cited by 73 · see citing works

Plasmodium sensitivity to artemisinins: magic bullets hit elusive targets

Ding, X. C., Beck, H., & Raso, G. (2010) · Trends in Parasitology · doi:10.1016/j.pt.2010.11.006 · Cited by 71 · see citing works

Early morphofunctional plasticity of microglia in response to acute lipopolysaccharide

Madore, C., Joffre, C., Delpech, J.-C., Smedt, V. D., Aubert, A., Coste, L., Layé, S., & Nadjar, A. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.08.008 · Cited by 70 · see citing works

Artemisinins and immune system

Shakir, L., Hussain, M., Javeed, A., Ashraf, M., & Riaz, A. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.06.044 · Cited by 69 · see citing works

Neurotoxicity and efficacy of arteether related to its exposure times and exposure levels in rodents.

Li, Q., Mog, S. R., Z., Y., et al. (2002) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2002.66.516 · Cited by 67 · see citing works

Dose-Dependent Brainstem Neuropathology Following Repeated Arteether Administration in Rats

Genovese, R. F., Newman, D. B., Li, Q., et al. (1998) · Brain Research Bulletin · doi:10.1016/s0361-9230(97)00339-0 · Cited by 66 · see citing works

Dihydroartemisinin exerts cytotoxic effects and inhibits hypoxia inducible factor-1α activation in C6 glioma cells

Huang, X.-J., Ma, Z.-Q., Zhang, W., Lu, Y., & Wei, E.-Q. (2007) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.59.6.0011 · Cited by 66 · see citing works

Induction of heme oxygenase-1 attenuates lipopolysaccharide-induced cyclooxygenase-2 expression in mouse brain endothelial cells

Shih, R., & Yang, C. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-86 · Cited by 66 · see citing works

Design of Drug Delivery Systems Containing Artemisinin and Its Derivatives

Aderibigbe, B. A. (2017) · Molecules · doi:10.3390/molecules22020323 · Cited by 66 · see citing works

Fish Oil Prevents Lipopolysaccharide-Induced Depressive-Like Behavior by Inhibiting Neuroinflammation

Shi, Z., Ren, H., Huang, Z., Peng, Y., He, B., Yao, X., Yuan, T.-F., & Su, H. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-0212-9 · Cited by 62 · see citing works

Artesunate suppresses oxidative and inflammatory processes by activating Nrf2 and ROS‑dependent p38 MAPK and protects against cerebral ischemia‑reperfusion injury

Lu, H., Wang, B., Cui, N., & Zhang, Y. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8666 · Cited by 62 · see citing works

Artesunate Attenuates Lipopolysaccharide-Stimulated Proinflammatory Responses by Suppressing TLR4, MyD88 Expression, and NF-κB Activation in Microglial Cells

Wang, D., Shi, J., Lv, S., Xu, W., Li, J., Ge, W., Xiao, C., Geng, D., & Liu, Y. (2015) · Inflammation · doi:10.1007/s10753-015-0172-7 · Cited by 60 · see citing works

Artesunate activates Nrf2 pathway-driven anti-inflammatory potential through ERK signaling in microglial BV2 cells

Lee, I., Ryu, D.-K., Lim, J., Cho, S., Kang, B. Y., & Choi, H. J. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.12.034 · Cited by 60 · see citing works

Artemisinin Prevents Glutamate-Induced Neuronal Cell Death Via Akt Pathway Activation

Lin, S.-P., Li, W., Winters, A., et al. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00108 · Cited by 59 · see citing works

Artesunate Protected Blood–Brain Barrier via Sphingosine 1 Phosphate Receptor 1/Phosphatidylinositol 3 Kinase Pathway After Subarachnoid Hemorrhage in Rats

Zuo, S.-L., Ge, H.-F., Li, Q., Zhang, X., Hu, R., Hu, S.-L., Liu, X., Zhang, J. H., Chen, Y.-J., & Feng, H. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9732-6 · Cited by 56 · see citing works

Artemisinin Derivatives and Synthetic Trioxane Trigger Apoptotic Cell Death in Asexual Stages of Plasmodium

Gunjan, S., Sharma, T., Yadav, K., et al. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00256 · Cited by 54 · see citing works

Neuropathological assessment of artemether-treated severe malaria

Hien, T. T., Turner, G. D. H., Nth., M., Phu, N., Bethell, D., Blakemore, W. F., Cavanagh, J., Dayan, A. D., Medana, I. M., Weller, R. O., et al. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13974-8 · Cited by 53 · see citing works

Induction of neurite outgrowth in PC12 cells by artemisinin through activation of ERK and p38 MAPK signaling pathways

Sarina, Yagi, Y., Nakano, O., Hashimoto, T., Kimura, K., Asakawa, Y., Zhong, M., Narimatsu, S., & Gohda, E. (2012) · Brain Research · doi:10.1016/j.brainres.2012.10.059 · Cited by 52 · see citing works

Enhanced in vitro neurotoxicity of artemisinin derivatives in the presence of haemin

Smith, S. L., Fishwick, J., McLean, W. G., Edwards, G., & Ward, S. A. (1997) · Biochemical Pharmacology · doi:10.1016/s0006-2952(96)00591-6 · Cited by 47 · see citing works

Are currently deployed artemisinins neurotoxic?

Toovey, S. (2006) · Toxicology Letters · doi:10.1016/j.toxlet.2006.06.001 · Cited by 47 · see citing works

Artemisinin Protects Retinal Neuronal Cells against Oxidative Stress and Restores Rat Retinal Physiological Function from Light Exposed Damage

Yan, F., Wang, H., Gao, Y., Xu, J., & Zheng, W. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00021 · Cited by 47 · see citing works

Pharmacokinetics, tissue distribution and mass balance of radiolabeled dihydroartemisinin in male rats

Xie, L. H., Li, Q., Zhang, J., et al. (2009) · Malaria Journal · doi:10.1186/1475-2875-8-112 · Cited by 46 · see citing works

Differential Effect of Artemisinin Against Cancer Cell Lines

Tilaoui, M., Mouse, H. A., Jaafari, A., & Zyad, A. (2014) · Natural Products and Bioprospecting · doi:10.1007/s13659-014-0024-4 · Cited by 45 · see citing works

Inhibition of TNF-α protects in vitro brain barrier from ischaemic damage

Abdullah, Z., Rakkar, K., Bath, P. M., & Bayraktutan, U. (2015) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2015.11.003 · Cited by 42 · see citing works

Toxicokinetic and toxicodynamic (TK/TD) evaluation to determine and predict the neurotoxicity of artemisinins

Li, Q., & Hickman, M. R. (2010) · Toxicology · doi:10.1016/j.tox.2010.09.005 · Cited by 41 · see citing works

The role of glutathione in the neurotoxicity of artemisinin derivatives in vitro22Abbreviations: AEM, artemether; DHA, dihydroartemisinin; and SOD, superoxide dismutase.

Smith, S. L., Sadler, C. J., Dodd, C. C., Edwards, G., Ward, S. A., Park, B. K., & McLean, W. G. (2001) · Biochemical Pharmacology · doi:10.1016/s0006-2952(00)00556-6 · Cited by 40 · see citing works

SnapShot: Microglia in Disease

Beggs, S., & Salter, M. W. (2016) · Cell · doi:10.1016/j.cell.2016.05.036 · Cited by 40 · see citing works

Nanoparticle Delivery of Artesunate Enhances the Anti-tumor Efficiency by Activating Mitochondria-Mediated Cell Apoptosis

Liu, R., Yu, X., Su, C., et al. (2017) · Nanoscale Research Letters · doi:10.1186/s11671-017-2169-7 · Cited by 39 · see citing works

Artesunate Activates the Intrinsic Apoptosis of HCT116 Cells through the Suppression of Fatty Acid Synthesis and the NF-κB Pathway

Chen, X., Wong, Y., Lim, T. K., Lim, W., Lin, Q., Wang, J., & Hua, Z. (2017) · Molecules · doi:10.3390/molecules22081272 · Cited by 38 · see citing works

A semi-synthetic derivative of artemisinin, artesunate inhibits prostaglandin E2 production in LPS/IFNγ-activated BV2 microglia

Okorji, U. P., & Olajide, O. A. (2014) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2014.07.007 · Cited by 36 · see citing works

Artemisinin protects against dextran sulfate-sodium-induced inflammatory bowel disease, which is associated with activation of the pregnane X receptor

Hu, D., Wang, Y., Chen, Z., Ma, Z.-C., You, Q., Zhang, X., Zhou, T., Xiao, Y., Liang, Q., Tan, H.-L., et al. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.04.050 · Cited by 34 · see citing works

Understanding artemisinin-induced brainstem neurotoxicity

Genovese, R. F., & Newman, D. B. (2007) · Archives of Toxicology · doi:10.1007/s00204-007-0252-z · Cited by 32 · see citing works

Neuroauditory Toxicity of Artemisinin Combination Therapies—Have Safety Concerns Been Addressed?

Ramos-Martin, V., González-Martínez, C., Mackenzie, I., et al. (2014) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.13-0702 · Cited by 30 · see citing works

A mitochondria-targeting artemisinin derivative with sharply increased antitumor but depressed anti-yeast and anti-malaria activities

Sun, C., Cao, Y. J., Zhu, P., et al. (2017) · Scientific Reports · doi:10.1038/srep45665 · Cited by 30 · see citing works

Cytotoxic profiling of artesunic and betulinic acids and their synthetic hybrid compound on neurons and gliomas

Ackermann, A., Çapcı, A., Ghoochani, A., Buchfelder, M., Eyüpoglu, I. Y., Tsogoeva, S. B., & Savaskan, N. E. (2017) · Oncotarget · doi:10.18632/oncotarget.18390 · Cited by 30 · see citing works

Potential long-term toxicity of repeated orally administered doses of artemether in rats.

Xiao, S.-H., Yang, Y., You, Q., et al. (2002) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2002.66.30 · Cited by 29 · see citing works

Dihydroartemisinin Induces Apoptosis in Human Bladder Cancer Cell Lines Through Reactive Oxygen Species, Mitochondrial Membrane Potential, and Cytochrome C Pathway

Poupel, F., Aghaei, M., Movahedian, A., et al. (2017) · International Journal of Preventive Medicine · doi:10.4103/ijpvm.ijpvm_258_17 · Cited by 29 · see citing works

Establishment of anIn Vitro screening model for neurodegeneration induced by antimalarial drugs of the artemisinin-type

Schmuck, G., & Haynes, R. K. (2000) · Neurotoxicity Research · doi:10.1007/bf03033326 · Cited by 27 · see citing works

Artesunate Exerts a Direct Effect on Endothelial Cell Activation and NF- κ B Translocation in a Mechanism Independent of Plasmodium Killing

de Souza, M. C., Paixao, F., Ferraris, F. K., Ribeiro, I., & Henriques, M. D. G. M. O. (2012) · Malaria Research and Treatment · doi:10.1155/2012/679090 · Cited by 26 · see citing works

Role of dihydroartemisinin in regulating prostaglandin E2 synthesis cascade and inflammation in endothelial cells

Yin, J., Xia, W., Zhang, Y., et al. (2018) · Heart and Vessels · doi:10.1007/s00380-018-1190-9 · Cited by 26 · see citing works

Dihydroartemisinin inhibits the viability of cervical cancer cells by upregulating caveolin 1 and mitochondrial carrier homolog 2: Involvement of p53 activation and NAD(P)H:quinone oxidoreductase 1 downregulation

Zhang, T., Hu, Y., Wang, T., & Cai, P. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.2980 · Cited by 23 · see citing works

Mechanisms of the pH- and Oxygen-Dependent Oxidation Activities of Artesunate

Tsuda, K., Miyamoto, L., Hamano, S., Morimoto, Y., Kangawa, Y., Fukue, C., Kagawa, Y., Horinouchi, Y., Xu, W., Ikeda, Y., et al. (2018) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b17-00855 · Cited by 23 · see citing works

Artesunate Reduces Serum Lipopolysaccharide in Cecal Ligation/Puncture Mice via Enhanced LPS Internalization by Macrophages through Increased mRNA Expression of Scavenger Receptors

Li, B., Yu, M., Pan, X., et al. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15011143 · Cited by 22 · see citing works

Small Molecular-Sized Artesunate Attenuates Ocular Neovascularization via VEGFR2, PKCα and PDGFR Targets

Zong, Y., Yuan, Y., Qian, X., et al. (2016) · Scientific Reports · doi:10.1038/srep30843 · Cited by 20 · see citing works

Artesunate restores spatial learning of rats with hepatic encephalopathy by inhibiting ammonia-induced oxidative damage in neurons and dysfunction of glutamate signaling in astroglial cells

Wu, Y., Zhang, L., Li, W., Yang, Y., & Zhao, J.-M. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.09.104 · Cited by 20 · see citing works

The antimalarial drug artemisinin induces an additional, Sod1-supressible anti-mitochondrial action in yeast

Sun, C., & Zhou, B. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2017.04.014 · Cited by 20 · see citing works

Subchronic Toxicological Study of Two Artemisinin Derivatives in Dogs

Yin, J.-Y., Wang, H., Wang, Q., Dong, Y., Han, G., Guan, Y.-B., Ke-yong, Z., Qu, W.-S., Yuan, Y., Gao, X., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094034 · Cited by 19 · see citing works

Neurotoxicity and Toxicokinetics of Artelinic Acid Following Repeated Oral Administration in Rats

Si, Y., Li, Q., Xie, L. H., Bennett, K., Weina, P. J., Mog, S. R., & Johnson, T. O. (2007) · International Journal of Toxicology · doi:10.1080/10915810701582913 · Cited by 19 · see citing works

The role of iron in neurotoxicity: a study of novel antimalarial drugs.

Smith, S. L., Maggs, J. L., Edwards, G., et al. (1998) · PubMed · Cited by 18 · see citing works

Misattribution of Central Nervous System Dysfunction to Artesunate

Newton, P. N., Day, N. P. J., & White, N. J. (2005) · Clinical Infectious Diseases · doi:10.1086/498033 · Cited by 17 · see citing works

Neurological Dysfunction Following Malaria: Disease- or Drug-Related?

White, N. J. (2000) · Clinical Infectious Diseases · doi:10.1086/313776 · Cited by 16 · see citing works

Morphological and immunocytochemical effects of dihydroartemisinin on differentiating NB2a neuroblastoma cells.

Fishwick, J., Edwards, G., Ward, S. A., et al. (1998) · PubMed · Cited by 16 · see citing works

Postsynaptic dopamine (D2)-mediated behavioural effects of high acute doses of artemisinin in rodents

Amos, S., Chindo, B. A., Abbah, J., Vongtau, H. O., Edmond, I., Binda, L., Akah, P. A., Wambebe, C. O., & Gamaniel, K. (2003) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2003.09.016 · Cited by 15 · see citing works

Neurotoxic effects of 25mg/kg/bodyweight of artemether on the histology of the trapezoid nuclei and behavioural functions in adult male Wistar rats

Akinlolu, A. A., & Shokunbi, M. T. (2008) · Acta Histochemica · doi:10.1016/j.acthis.2008.09.006 · Cited by 14 · see citing works

Increased systemic exposures of artemether and dihydroartemisinin in infants under 5 kg with uncomplicated Plasmodium falciparum malaria treated with artemether-lumefantrine (Coartem®)

Tiono, A. B., Tinto, H., Alao, M. J., Meremikwu, M. M., Tshefu, A. K., Ogutu, B. R., Ouédraogo, A., Lingani, M., Cousin, M., Lefèvre, G. Y., et al. (2015) · Malaria Journal · doi:10.1186/s12936-015-0682-7 · Cited by 14 · see citing works

Dihydroartemisinin induces caspase-8-dependent apoptosis in murine GT1-7 hypothalamic neurons

Raghavamenon, A. C., Muyiwa, A. F., Davis, L. K., & Uppu, R. M. (2011) · Toxicology Mechanisms and Methods · doi:10.3109/15376516.2011.552534 · Cited by 7 · see citing works

Neurotoxicity Assessment of Artemether in Juvenile Rats

Beckman, D. A., Youreneff, M., & Butt, M. T. (2013) · Birth Defects Research Part B Developmental and Reproductive Toxicology · doi:10.1002/bdrb.21054 · Cited by 5 · see citing works

Are currently deployed artemisinins neurotoxic?

Adjei, G. O., Goka, B. Q., Kurtzhals, J. A. L., et al. (2006) · Toxicology Letters · doi:10.1016/j.toxlet.2006.09.001 · Cited by 2 · see citing works

Chronic stress-induced depression requires the recruitment of peripheral Th17 cells into the brain

Peng, Z., Peng, S., Lin, K., Zhao, B., Wei, L., Tuo, Q., Liao, D., Yuan, T., & Shi, Z. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02543-6 · Cited by 95 · see citing works

Dihydroartemisinin protects blood–brain barrier permeability during sepsis by inhibiting the transcription factor <scp>SNAI1</scp>

Liu, F., Liu, J., Xiang, H., Sun, Z., Li, Y., Li, X., Liu, Y., & Liu, J. (2022) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13683 · Cited by 9 · see citing works

Artemisia annua glandular secretory trichomes： the biofactory of antimalarial agent artemisinin

Ling, Xiao, X., Hexin, et al. (2016) · 中国科学通报：英文版

Is Artemisinin the Only Antiplasmodial Compound in the Artemisia annua Tea Infusion? An in Vitro Study

Mouton, J., Jansen, O., Frédérich, M., & van der Kooy, F. (2013) · Planta Medica · doi:10.1055/s-0032-1328324 · Cited by 20 · see citing works

Research achievements in the synthetic biology and metabolic engineering of artemisinin

Zeng, Q. (2011) · Chinese Science Bulletin

Effect of Development Stage on the Artemisinin Content and the Sequence Characterized Amplified Region （SCAR） Marker of High-Artemisinin Yielding Strains of Artemisia annua L.

Long, Zhang, He-Chun, et al. (2006) · Acta Scientiarum Naturalium Universitatis Sunyatseni · Cited by 1 · see citing works

Artemisia annua glandular secretory trichomes: the biofactory of antimalarial agent artemisinin

Ling Zhi, X. I. A. O., Tan, H., & Zhang, L. (2016) · 中国科学通报：英文版 · doi:10.1007/s11434-015-0980-z · Cited by 94 · see citing works