Cited by 19Fatty Acid Research and HealthTryptophan and brain disordersNeuroinflammation and Neurodegeneration Mechanisms

Targeting neuroinflammation: The therapeutic potential of ω-3 PUFAs in substance abuse

Peng, Sha, Peng, Zhuang, Qin, Meng, Huang, Lu, Zhao, Bin, Wei, Lai, Ning, Jie, Tuo, Qin-hui +3 more·2021·Nutrition

Abstract

Substance abuse is a chronic relapsing disorder that results in serious health and socioeconomic issues worldwide. Addictive drugs induce long-lasting morphologic and functional changes in brain circuits and account for the formation of compulsive drug-seeking and drug-taking behaviors. Yet, there remains a lack of reliable therapy. In recent years, accumulating evidence indicated that neuroinflammation was implicated in the development of drug addiction. Findings from both our and other laboratories suggest that ω-3 polyunsaturated fatty acids (PUFAs) are effective in treating neuroinflammation-related mental diseases, and indicate that they could exert positive effects in treating drug addiction. Thus, in the present review, we summarized and evaluated recently published articles reporting the neuroinflammation mechanism in drug addiction and the immune regulatory ability of ω-3 PUFAs. We also sought to identify some of the challenges ahead in the translation of ω-3 PUFAs into addiction treatment.

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Crossref · 10.1016/j.nut.2020.111058

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  • Activated astrocytes and microglia respond rapidly to pathological stimuli with morphological and functional changes, thereby exacerbating neuroinflammation.

    “Activated astrocytes and microglia respond rapidly to pathological stimuli with morphological and functional changes, thereby exacerbating neuroinflammation [40, 59].”

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Authors
Peng, S., Peng, Z., Qin, M., Huang, L., Zhao, B., Wei, L., Ning, J., Tuo, Q.-H., Yuan, T.-F., Shi, Z., & Liao, D.-F.
Affiliations
  • Hunan University of Traditional Chinese Medicine (CN)
  • Beijing University of Chemical Technology (CN)
  • Jinan University (CN)
  • Henan Medical University (CN)
  • Shanghai Jiao Tong University (CN)
Corresponding author
  • Shi, Zhe
  • Liao, Duan-fang
Venue
Nutrition
Publisher
Elsevier BV
Published
2021-03
Volume
83
Pages
111058
ISSN
0899-9007 (ISSN-L)
OpenAlex
W3103309482
Cited by
18
References
166
Citations by year
2026: 6 · 2025: 5 · 2024: 1 · 2023: 2 · 2022: 4
FWCI
0.18
Type
journal article
Language
en
Open access
closed
Locations
  • Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Scientific Research Foundation of Hunan Provincial Education Department
  • National Natural Science Foundation of China
  • Natural Science Foundation of Guangdong Province
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
omega-3 polyunsaturated fatty acids, neuroinflammation, drug addiction, substance abuse, immune regulation, addiction treatment, translational research
MeSH terms
Humans, Fatty Acids, Omega-3, Behavior, Addictive, Substance-Related Disorders

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