Targeting neuroinflammation: The therapeutic potential of ω-3 PUFAs in substance abuse
Abstract
Substance abuse is a chronic relapsing disorder that results in serious health and socioeconomic issues worldwide. Addictive drugs induce long-lasting morphologic and functional changes in brain circuits and account for the formation of compulsive drug-seeking and drug-taking behaviors. Yet, there remains a lack of reliable therapy. In recent years, accumulating evidence indicated that neuroinflammation was implicated in the development of drug addiction. Findings from both our and other laboratories suggest that ω-3 polyunsaturated fatty acids (PUFAs) are effective in treating neuroinflammation-related mental diseases, and indicate that they could exert positive effects in treating drug addiction. Thus, in the present review, we summarized and evaluated recently published articles reporting the neuroinflammation mechanism in drug addiction and the immune regulatory ability of ω-3 PUFAs. We also sought to identify some of the challenges ahead in the translation of ω-3 PUFAs into addiction treatment.
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Activated astrocytes and microglia respond rapidly to pathological stimuli with morphological and functional changes, thereby exacerbating neuroinflammation.
“Activated astrocytes and microglia respond rapidly to pathological stimuli with morphological and functional changes, thereby exacerbating neuroinflammation [40, 59].”
From Chronic stress-induced depression requires the recruitment of peripheral Th17 cells into the brain (2022) · cites this paper as [59]
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Zhou, L., Xiong, J., Chai, Y.-Q., Huang, L., Tang, Z.-Y., Zhang, X., Liu, B., & Zhang, J.-T. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.933704 · Cited by 115 · see citing works
Self-citationChronic stress-induced depression requires the recruitment of peripheral Th17 cells into the brain
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Self-citationNutritional interventions to counteract the detrimental consequences of early-life stress
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Self-citationDepression, type 2 diabetes mellitus, and omega-3 polyunsaturated fatty acids
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- Authors
- Peng, S., Peng, Z., Qin, M., Huang, L., Zhao, B., Wei, L., Ning, J., Tuo, Q.-H., Yuan, T.-F., Shi, Z., & Liao, D.-F.
- Affiliations
- Hunan University of Traditional Chinese Medicine (CN)
- Beijing University of Chemical Technology (CN)
- Jinan University (CN)
- Henan Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Shi, Zhe
- Liao, Duan-fang
- Venue
- Nutrition
- Publisher
- Elsevier BV
- Published
- 2021-03
- Volume
- 83
- Pages
- 111058
- ISSN
- 0899-9007 (ISSN-L)
- OpenAlex
- W3103309482
- Cited by
- 18
- References
- 166
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 1 · 2023: 2 · 2022: 4
- FWCI
- 0.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Scientific Research Foundation of Hunan Provincial Education Department
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- omega-3 polyunsaturated fatty acids, neuroinflammation, drug addiction, substance abuse, immune regulation, addiction treatment, translational research
- MeSH terms
- Humans, Fatty Acids, Omega-3, Behavior, Addictive, Substance-Related Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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