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ESCRT‐mediated lysosome repair precedes lysophagy and promotes cell survival
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The ESCRT-I subunit TSG101 is required for efficient ESCRT-III recruitment.
“The ESCRT-I subunit TSG101 is also required for efficient ESCRT-III recruitment22.”
From TMEM55B links autophagy flux, lysosomal repair, and TFE3 activation in response to oxidative stress (2024) · cites this paper as [22]
Incubation with LLOMe at 300 μM for 10 h has minimal effect on cell viability and no differences between Null and TMEM55B-KO cells.
“As previously described, incubation with LLOMe at 300 μM for 10 h had minimal effect on cell viability22 and no differences were observed between Null and TMEM55B-KO cells (Supplementary Fig. 6a, b).”
From TMEM55B links autophagy flux, lysosomal repair, and TFE3 activation in response to oxidative stress (2024) · cites this paper as [22]
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Citations
Cites
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.
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Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury
Maejima, I., Takahashi, A., Omori, H., Kimura, T., Takabatake, Y., Saitoh, T., Yamamoto, A., Hamasaki, M., Noda, T., Isaka, Y., et al. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.171 · Cited by 642 · cited 5×
“Previous work has uncovered a lysosome-protective function of heat-shock protein 70 (Kirkegaard et al , 2010) and the existence of an autophagic pathway that sequesters and degrades damaged lysosomes (Hung et al , 2013; Maejima et al , 2013).”
InfluentialHsp70 stabilizes lysosomes and reverts Niemann–Pick disease-associated lysosomal pathology
Kirkegaard, T., Roth, A. G., Petersen, N. H. T., Mahalka, A. K., Olsen, O. D., Moilanen, I., Zylicz, A., Knudsen, J., Sandhoff, K., Arenz, C., et al. (2010) · Nature · doi:10.1038/nature08710 · Cited by 519
A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy
Ronan, B., Flamand, O., Vescovi, L., Dureuil, C., Durand, L., Fassy, F., Bachelot, M.-F., Lamberton, A., Mathieu, M., Bertrand, T., et al. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1681 · Cited by 500
ALIX and the multivesicular endosome: ALIX in Wonderland
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Detection and Clearance of Damaged Lysosomes by the Endo-Lysosomal Damage Response and Lysophagy
Papadopoulos, C., & Meyer, H. (2017) · Current Biology · doi:10.1016/j.cub.2017.11.012 · Cited by 230 · cited 5×
“This pathway, termed lysophagy, is triggered by sensing of lysosomal membrane lesions by cytosolic lectins such as Galectin-3, which recognize exposed intraluminal carbohydrate chains of lysosomal glycoproteins (Maejima et al , 2013; Papadopoulos & Meyer, 2017).”
Influential
Flagged first, then by citations
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Self-citationAutophagy in inflammation, infection, and immunometabolism
Deretic, V. (2021) · Immunity · doi:10.1016/j.immuni.2021.01.018 · Cited by 862
Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal
Jia, J., Claude-Taupin, A., Gu, Y., Choi, S. W., Peters, R., Bissa, B., Mudd, M. H., Allers, L., Pallikkuth, S., Lidke, K. A., et al. (2020) · Developmental Cell · doi:10.1016/j.devcel.2019.10.025 · Cited by 434
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TMEM55B links autophagy flux, lysosomal repair, and TFE3 activation in response to oxidative stress
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Metadata
- Authors
- Radulovic, M., Schink, K. O., Wenzel, E. M., Nähse, V., Bongiovanni, A., Lafont, F., & Stenmark, H.
- Venue
- The EMBO Journal
- Published
- 2018-10-12
- Volume
- 37
- Issue
- 21
- ISSN
- 0261-4189
- 1460-2075
- Cited by
- 496
- References
- 7
- Language
- en
- Funders
- South‐Eastern Norway Regional Health Authority (2015014, 2016087)
- Norwegian Cancer Society (182698)
- ANR (15‐CE15‐0017)
- Research Council of Norway (262652)
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