ALIX and the multivesicular endosome: ALIX in Wonderland

Membrane vesicles as conveyors of immune responses

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Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

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Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

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The ESCRT Pathway

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Ebola virus entry requires the cholesterol transporter Niemann–Pick C1

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Selective Enrichment of Tetraspan Proteins on the Internal Vesicles of Multivesicular Endosomes and on Exosomes Secreted by Human B-lymphocytes

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Localization of phosphatidylinositol 3‐phosphate in yeast and mammalian cells

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Hydration forces between phospholipid bilayers

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ExoCarta 2012: database of exosomal proteins, RNA and lipids

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The Golgi apparatus (complex)-(1954-1981)-from artifact to center stage.

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Proteomic and Biochemical Analyses of Human B Cell-derived Exosomes

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The mannose 6-phosphate receptor and the biogenesis of lysosomes

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Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants.

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Protein-lipid interplay in fusion and fission of biological membranes.

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A lipid associated with the antiphospholipid syndrome regulates endosome structure and function

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Membrane budding and scission by the ESCRT machinery: it's all in the neck

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The biogenesis of multivesicular endosomes

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Role of LBPA and Alix in Multivesicular Liposome Formation and Endosome Organization

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Small molecule inhibitors reveal Niemann–Pick C1 is essential for Ebola virus infection

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Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport

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Curvature, Lipid Packing, and Electrostatics of Membrane Organelles: Defining Cellular Territories in Determining Specificity

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Maternal Pumilio acts together with Nanos in germline development in Drosophila embryos

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Follicular Dendritic Cells Carry MHC Class II-Expressing Microvesicles at Their Surface

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Separation and Characterization of Late Endosomal Membrane Domains

Kobayashi, T., Beuchat, M.-H., Chevallier, J., Makino, A., Mayran, N., Escola, J.-M., Lebrand, C., Cosson, P., Kobayashi, T., & Gruenberg, J. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202838200 · Cited by 409 · see citing works

Mechanisms of pathogen entry through the endosomal compartments

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Endosome-to-cytosol transport of viral nucleocapsids

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The Tetraspanin CD63/lamp3 Cycles between Endocytic and Secretory Compartments in Human Endothelial Cells

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Multilamellar endosome-like compartment accumulates in the yeast vps28 vacuolar protein sorting mutant.

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The Endosomal Sorting Complex ESCRT-II Mediates the Assembly and Architecture of ESCRT-III Helices

Henne, W. M., Buchkovich, N. J., Zhao, Y., & Emr, S. D. (2012) · Cell · doi:10.1016/j.cell.2012.08.039 · Cited by 243 · see citing works

Lysobisphosphatidic Acid Controls Endosomal Cholesterol Levels

Chevallier, J., Chamoun, Z., Jiang, G., Prestwich, G. D., Sakai, N., Matile, S., Parton, R. G., & Gruenberg, J. E. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801463200 · Cited by 220 · see citing works

Receptor-mediated endocytosis of epidermal growth factor by rat hepatocytes: receptor pathway.

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Hijacking Multivesicular Bodies Enables Long-Term and Exosome-Mediated Long-Distance Action of Anthrax Toxin

Abrami, L., Brandi, L., Moayeri, M., Brown, M. J., Krantz, B. A., Leppla, S. H., & van der Goot, F. G. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.10.019 · Cited by 216 · see citing works

Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway

Abrami, L., Lindsay, M. R., Parton, R. G., Leppla, S. H., & van der Goot, F. G. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200312072 · Cited by 214 · see citing works

Bro1 is an endosome-associated protein that functions in the MVB pathway in Saccharomyces cerevisiae

Odorizzi, G., Katzmann, D. J., Babst, M., Audhya, A., & Emr, S. D. (2003) · Journal of Cell Science · doi:10.1242/jcs.00395 · Cited by 213 · see citing works

Bro1 coordinates deubiquitination in the multivesicular body pathway by recruiting Doa4 to endosomes

Luhtala, N., & Odorizzi, G. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200403139 · Cited by 201 · see citing works

Get on the exosome bus with ALIX

Hurley, J. H., & Odorizzi, G. (2012) · Nature Cell Biology · doi:10.1038/ncb2530 · Cited by 197 · see citing works

Conical Lipids in Flat Bilayers Induce Packing Defects Similar to that Induced by Positive Curvature

Vamparys, L., Gautier, R., Vanni, S., Bennett, W. F., Tieleman, D. P., Antonny, B., Etchebest, C., & Fuchs, P. (2013) · Biophysical Journal · doi:10.1016/j.bpj.2012.11.3836 · Cited by 188 · see citing works

Degradation of Endocytosed Epidermal Growth Factor and Virally Ubiquitinated Major Histocompatibility Complex Class I Is Independent of Mammalian ESCRTII

Bowers, K., Piper, S. C., Edeling, M. A., Gray, S. R., Owen, D. J., Lehner, P. J., & Luzio, J. P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508632200 · Cited by 187 · see citing works

Governance of Endocytic Trafficking and Signaling by Reversible Ubiquitylation

Clague, M. J., Liu, H., & Urbé, S. (2012) · Developmental Cell · doi:10.1016/j.devcel.2012.08.011 · Cited by 177 · see citing works

ALIX binds a YPX3L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting

Dores, M. R., Chen, B., Lin, H., Soh, U. J. K., Paing, M. M., Montagne, W. A., Meerloo, T., & Trejo, J. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201110031 · Cited by 163 · see citing works

Lipid Sorting and Multivesicular Endosome BiogenesisPreprint

Bissig, C., & Gruenberg, J. E. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016816 · Cited by 162 · see citing works

In Vitro Budding of Intralumenal Vesicles into Late Endosomes Is Regulated by Alix and Tsg101

Falguières, T., Luyet, P., Bissig, C., Scott, C. C., Velluz, M., & Gruenberg, J. E. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-03-0239 · Cited by 155 · see citing works

Old World Arenaviruses Enter the Host Cell via the Multivesicular Body and Depend on the Endosomal Sorting Complex Required for Transport

Pasqual, G., Rojek, J. M., Masin, M., Chatton, J., & Kunz, S. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002232 · Cited by 155 · see citing works

The Bro1-related protein HD-PTP/PTPN23 is required for endosomal cargo sorting and multivesicular body morphogenesis

Doyotte, A., Mironov, A., McKenzie, E., & Woodman, P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707601105 · Cited by 154 · see citing works

Localization of the epidermal growth factor (EGF) receptor within the endosome of EGF-stimulated epidermoid carcinoma (A431) cells.

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Viral Infection Controlled by a Calcium-Dependent Lipid-Binding Module in ALIX

Bissig, C., Lenoir, M., Velluz, M., Kufareva, I., Abagyan, R. A., Overduin, M., & Gruenberg, J. E. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.04.003 · Cited by 126 · see citing works

Recruitment of UBPY and ESCRT Exchange Drive HD-PTP-Dependent Sorting of EGFR to the MVB

Ali, N., Zhang, L., Taylor, S., Mironov, A., Urbé, S., & Woodman, P. G. (2013) · Current Biology · doi:10.1016/j.cub.2013.02.033 · Cited by 121 · see citing works

Alix/AIP1 Antagonizes Epidermal Growth Factor Receptor Downregulation by the Cbl-SETA/CIN85 Complex

Schmidt, M. H. H., Hoeller, D., Yu, J., Furnari, F. B., Cavenee, W. K., Đikić, I., & Bögler, O. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.20.8981-8993.2004 · Cited by 121 · see citing works

Cellular pathology of Niemann–Pick type C disease

Ikonen, E., & Hölttä‐Vuori, M. (2004) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2004.03.001 · Cited by 108 · see citing works

Hrs and SNX3 Functions in Sorting and Membrane Invagination within Multivesicular Bodies

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The Yeast Alix Homolog Bro1 Functions as a Ubiquitin Receptor for Protein Sorting into Multivesicular Endosomes

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ALIX Is a Lys63-Specific Polyubiquitin Binding Protein that Functions in Retrovirus Budding

Dowlatshahi, D. P., Sandrin, V., Vivona, S., Shaler, T. A., Kaiser, S. E., Melandri, F. D., Sundquist, W. I., & Kopito, R. R. (2012) · Developmental Cell · doi:10.1016/j.devcel.2012.10.023 · Cited by 86 · see citing works

Direct visualization of the phosphorylated epidermal growth factor receptor during its internalization in A-431 cells.

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Dual mechanisms specify Doa4‐mediated deubiquitination at multivesicular bodies

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Bro1 binding to Snf7 regulates ESCRT-III membrane scission activity in yeast

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Structure‐based in silico identification of ubiquitin‐binding domains provides insights into the ALIX‐V:ubiquitin complex and retrovirus budding

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The ESCRT‐I Subunit TSG101 Controls Endosome‐to‐Cytosol Release of Viral RNA

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Do Alix and ALG‐2 really control endosomes for better or for worse?

Sadoul, R. (2005) · Biology of the Cell · doi:10.1042/bc20050007 · Cited by 60 · see citing works

Yeast Npi3/Bro1 is involved in ubiquitin‐dependent control of permease trafficking

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AP-3 regulates PAR1 ubiquitin-independent MVB/lysosomal sorting via an ALIX-mediated pathway

Dores, M. R., Paing, M. M., Lin, H., Montagne, W. A., Marchese, A., & Trejo, J. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e12-03-0251 · Cited by 56 · see citing works

Differential post‐translational modification of CD63 molecules during maturation of human dendritic cells

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Regulation of the MVB Pathway by SCAMP3

Falguières, T., Castle, D. J., & Grüenberg, J. (2011) · Traffic · doi:10.1111/j.1600-0854.2011.01291.x · Cited by 45 · see citing works

Spectroscopic Evidence for the Unusual Stereochemical Configuration of an Endosome‐Specific Lipid

Tan, H., Makino, A., Sudesh, K., Greimel, P., & Kobayashi, T. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201106470 · Cited by 42 · see citing works

Role of SNX16 in the Dynamics of Tubulo-Cisternal Membrane Domains of Late Endosomes

Brankatschk, B., Pons, V., Parton, R. G., & Gruenberg, J. E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021771 · Cited by 30 · see citing works

ESCRT proteins, endosome organization and mitogenic receptor down-regulation

Woodman, P. G. (2009) · Biochemical Society Transactions · doi:10.1042/bst0370146 · Cited by 23 · see citing works

Scientific Side Trips: Six Excursions from the Beaten Path

Brown, M. S., & Goldstein, J. L. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.x112.381681 · Cited by 7 · see citing works

Shedding light on the cell biology of extracellular vesicles

van Niel, G., D'Angelo, G., & Raposo, G. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.125 · Cited by 8,369 · see citing works

Biogenesis and secretion of exosomes

Kowal, J., Tkach, M., & Théry, C. (2014) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.05.004 · Cited by 1,781 · see citing works

Ectosomes and exosomes: shedding the confusion between extracellular vesicles

Cocucci, E., & Meldolesi, J. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.01.004 · Cited by 1,435 · see citing works

Extracellular vesicles as drug delivery systems: Why and how?

Elsharkasy, O. M., Nordin, J. Z., Hagey, D. W., de Jong, O. G., Schiffelers, R. M., Andaloussi, S. E., & Vader, P. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.04.004 · Cited by 1,217 · see citing works

Macrophage defense mechanisms against intracellular bacteria

Weiss, G., & Schaible, U. E. (2015) · Immunological Reviews · doi:10.1111/imr.12266 · Cited by 989 · see citing works

The many functions of ESCRTs

Vietri, M., Radulovic, M., & Stenmark, H. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0177-4 · Cited by 962 · see citing works

Focus on Extracellular Vesicles: Introducing the Next Small Big Thing

Kalra, H., Drummen, G. P. C., & Mathivanan, S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020170 · Cited by 865 · see citing works

Endosome maturation, transport and functions

Scott, C. C., Vacca, F., & Gruenberg, J. E. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.03.034 · Cited by 581 · see citing works

ESCRT-mediated lysosome repair precedes lysophagy and promotes cell survival

Radulovic, M., Bongiovanni, A., Schink, K., Nähse, V., Wenzel, E. M., Lafont, F., & Stenmark, H. (2018) · bioRxiv · doi:10.15252/embj.201899753 · Cited by 423 · see citing works

ALIX- and ESCRT-III–dependent sorting of tetraspanins to exosomes

Larios, J., Mercier, V., Roux, A., & Gruenberg, J. (2020) · Journal of Cell Biology · doi:10.1083/jcb.201904113 · Cited by 422 · see citing works

Regulation of exosome production and cargo sorting

Wei, H., Chen, Q., Lin, L., Sha, C., Li, T., Liu, Y., Yin, X., Xu, Y., Chen, L., Gao, W., et al. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.53671 · Cited by 385 · see citing works

Q&A: What are exosomes, exactly?

Edgar, J. R. (2016) · BMC Biology · doi:10.1186/s12915-016-0268-z · Cited by 337 · see citing works

Relaxation of Loaded ESCRT-III Spiral Springs Drives Membrane Deformation

Chiaruttini, N., Redondo‐Morata, L., Colom, A., Humbert, F., Lenz, M., Simon Scheuring, A., & Roux, A. (2015) · Cell · doi:10.1016/j.cell.2015.10.017 · Cited by 331 · see citing works

The function and clinical application of extracellular vesicles in innate immune regulation

Zhou, X., Xie, F., Wang, L., Zhang, L., Zhang, S., Fang, M., & Zhou, F. (2020) · Cellular & Molecular Immunology · doi:10.1038/s41423-020-0391-1 · Cited by 294 · see citing works

Endocytosis and Endosomal Trafficking in Plants

Paéz-Valencia, J., Goodman, K., & Otegui, M. S. (2016) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-043015-112242 · Cited by 264 · see citing works

Non-viral Delivery of Nucleic Acids: Insight Into Mechanisms of Overcoming Intracellular Barriers

Durymanov, M. O., & Reineke, J. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00971 · Cited by 258 · see citing works

Nonlytic viral spread enhanced by autophagy components

Bird, S. W., Maynard, N. D., Covert, M. W., & Kirkegaard, K. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1401437111 · Cited by 250 · see citing works

Life in the lumen: The multivesicular endosome

Gruenberg, J. E. (2019) · Traffic · doi:10.1111/tra.12715 · Cited by 212 · see citing works

Exosomes in developmental signalling

McGough, I. J., & Vincent, J. (2016) · Development · doi:10.1242/dev.126516 · Cited by 207 · see citing works

Extracellular Vesicles from Bovine Follicular Fluid Support Cumulus Expansion1

Hung, W., Hong, X., Christenson, L. K., & McGinnis, L. K. (2015) · Biology of Reproduction · doi:10.1095/biolreprod.115.132977 · Cited by 206 · see citing works

Delivery of Oligonucleotide Therapeutics: Chemical Modifications, Lipid Nanoparticles, and Extracellular Vesicles

Bost, J., Barriga, H. M. G., Holme, M. N., Gallud, A., Maugeri, M., Gupta, D., Lehto, T., Valadi, H., Esbjörner, E. K., Stevens, M. M., et al. (2021) · ACS Nano · doi:10.1021/acsnano.1c05099 · Cited by 187 · see citing works

Assessing the role of surface glycans of extracellular vesicles on cellular uptake

Williams, C., Pazos, R., Royo, F., González, E., Roura‐Ferrer, M., Martinez, A., Gamiz, J., Reichardt, N., & Falcón‐Pérez, J. M. (2019) · Scientific Reports · doi:10.1038/s41598-019-48499-1 · Cited by 181 · see citing works

Exosomes taken up by neurons hijack the endosomal pathway to spread to interconnected neurons

Polanco, J. C., Li, C., Durisic, N., Sullivan, R., & Götz, J. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0514-4 · Cited by 180 · see citing works

Biology and Role of Extracellular Vesicles (EVs) in the Pathogenesis of Thrombosis

Zarà, M., Guidetti, G. F., Camera, M., Canobbio, I., Amadio, P., Torti, M., Tremoli, E., & Barbieri, S. S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112840 · Cited by 168 · see citing works

Endosomal Retrieval of Cargo: Retromer Is Not Alone

McNally, K. E., & Cullen, P. J. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.06.005 · Cited by 164 · see citing works

Exosomes derived from osteogenic tumor activate osteoclast differentiation and concurrently inhibit osteogenesis by transferring COL1A1‐targeting miRNA‐92a‐1‐5p

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Exosomes in Viral Disease

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