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Oxidative stress‐induced phosphorylation of JIP4 regulates lysosomal positioning in coordination with TRPML1 and ALG2

Sasazawa, Yukiko, Souma, Sanae, Furuya, Norihiko, Miura, Yoshiki, Kazuno, Saiko, Kakuta, Soichiro, Suzuki, Ayami, Hashimoto, Ryota, Hirawake‐Mogi, Hiroko, Date, Yuki, Imoto, Masaya, Ueno, Takashi, Kataura, Tetsushi, Korolchuk, Viktor I, Tsunemi, Taiji, Hattori, Nobutaka, Saiki, Shinji·2022·The EMBO Journal
DOI 10.15252/embj.2022111476PMC PMC9670204
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Abstract

Retrograde transport of lysosomes is recognised as a critical autophagy regulator. Here, we found that acrolein, an aldehyde that is significantly elevated in Parkinson's disease patient serum, enhances autophagy by promoting lysosomal clustering around the microtubule organising centre via a newly identified JIP4‐TRPML1‐ALG2 pathway. Phosphorylation of JIP4 at T217 by CaMK2G in response to Ca 2+ fluxes tightly regulated this system. Increased vulnerability of JIP4 KO cells to acrolein indicated that lysosomal clustering and subsequent autophagy activation served as defence mechanisms against cytotoxicity of acrolein itself. Furthermore, the JIP4‐TRPML1‐ALG2 pathway was also activated by H 2 O 2 , indicating that this system acts as a broad mechanism of the oxidative stress response. Conversely, starvation‐induced lysosomal retrograde transport involved both the TMEM55B‐JIP4 and TRPML1‐ALG2 pathways in the absence of the JIP4 phosphorylation. Therefore, the phosphorylation status of JIP4 acts as a switch that controls the signalling pathways of lysosoma l distribution depending on the type of autophagy‐inducing signal.

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Metadata

Authors
Sasazawa, Y., Souma, S., Furuya, N., Miura, Y., Kazuno, S., Kakuta, S., Suzuki, A., Hashimoto, R., Hirawake‐Mogi, H., Date, Y., Imoto, M., Ueno, T., Kataura, T., Korolchuk, V. I., Tsunemi, T., Hattori, N., & Saiki, S.
Venue
The EMBO Journal
Publisher
Springer Science and Business Media LLC
Published
2022-10-11
Volume
41
Issue
22
ISSN
  • 0261-4189
  • 1460-2075
DOI
10.15252/embj.2022111476
PMC
PMC9670204
Cited by
31
References
9
Language
en
Licence
Funders
  • Ministry of Education, Culture, Sports, Science and Technology (MEXT) ¦ Japan Society for the Promotion of Science (18KT0027, 18KK0242, 18H02744, 22H02986, 21K07425, 20H05340, 18K15464, 16H06276)
  • Naito Foundation

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