The DOI matches its Crossref record; 40 of the 41 references it cites were found in a registry or an index.
Age-associated changes in hypothalamic-pituitary-testicular function in middle-aged and older men are modified by weight change and lifestyle factors: longitudinal results from the European male ageing study
Open accessAbstract
OBJECTIVE: Health and lifestyle factors are associated with variations in serum testosterone levels in ageing men. However, it remains unclear how age-related changes in testosterone may be attenuated by lifestyle modifications. The objective was to investigate the longitudinal relationships between changes in health and lifestyle factors with changes in hormones of the reproductive endocrine axis in ageing men. DESIGN: A longitudinal survey of 2736 community-dwelling men aged 40-79 years at baseline recruited from eight centres across Europe. Follow-up assessment occurred mean (±S.D.) 4.4±0.3 years later. RESULTS: Paired testosterone results were available for 2395 men. Mean (±S.D.) annualised hormone changes were as follows: testosterone -0.1±0.95 nmol/l; free testosterone (FT) -3.83±16.8 pmol/l; sex hormone-binding globulin (SHBG) 0.56±2.5 nmol/l and LH 0.08±0.57 U/l. Weight loss was associated with a proportional increase, and weight gain a proportional decrease, in testosterone and SHBG. FT showed a curvilinear relationship to weight change; only those who gained or lost ≥15% of weight showed a significant change (in the same direction as testosterone). Smoking cessation was associated with a greater decline in testosterone than being a non-smoker, which was unrelated to weight change. Changes in number of comorbid conditions or physical activity were not associated with significant alterations in hypothalamic-pituitary-testicular (HPT) axis function. CONCLUSIONS: Body weight and lifestyle factors influence HPT axis function in ageing. Weight loss was associated with a rise, and weight gain a fall, in testosterone, FT and SHBG. Weight management appears to be important in maintaining circulating testosterone in ageing men, and obesity-associated changes in HPT axis hormones are reversible following weight reduction.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Finally, as discussed in more detail in section 5, weight loss, whether by diet or surgery, increases testosterone levels proportional to the amount of weight lost.1934”
From Lowered testosterone in male obesity: Mechanisms, morbidity and management (2014) · cites this paper as [34]
In the citing paper
“The results of the EMAS in 2736 men (mean age 58.4 years), showed that weight loss of minimal 5% of body weight in obese men resulted in a significant increase in total testosterone levels.”
From Treatment of Men with Central Hypogonadism: Alternatives for Testosterone Replacement Therapy (2020) · cites this paper as [20]
In the citing paper
“Only a weight loss of minimal 15% had significant effects on free testosterone levels.”
From Treatment of Men with Central Hypogonadism: Alternatives for Testosterone Replacement Therapy (2020) · cites this paper as [20]
In the citing paper
“Conversely, weight gain was associated with rising testosterone levels [20].”
From Treatment of Men with Central Hypogonadism: Alternatives for Testosterone Replacement Therapy (2020) · cites this paper as [20]
In the citing paper
“Men who quit smoking showed a greater decrease in testosterone levels than non-smokers.”
From Treatment of Men with Central Hypogonadism: Alternatives for Testosterone Replacement Therapy (2020) · cites this paper as [20]
In the citing paper
“Free T concentrations usually range around 1–2% of total T and are also age-dependent in women (Haring et al., 2012) and men (Camacho et al., 2013, Damgaard-Olesen et al., 2016).”
From Intracrine androgen biosynthesis, metabolism and action revisited (2018) · cites this paper as Camacho et al., 2013
In the citing paper
“In men, the decline can be explained by simultaneous age-related reductions of both adrenal and testicular androgen biosynthesis (Beattie et al., 2015, Camacho et al., 2013, Golan et al., 2015, Labrie et al., 1997b).”
From Intracrine androgen biosynthesis, metabolism and action revisited (2018) · cites this paper as Camacho et al., 2013
In the citing paper
“This results in a decline of circulating T concentrations of approximately 0.1 nmol/L per year (Camacho et al., 2013).”
From Intracrine androgen biosynthesis, metabolism and action revisited (2018) · cites this paper as Camacho et al., 2013
In the citing paper
“While exact mechanisms are unknown, the reversal of HPT axis suppression with weight loss 43,46,47 suggests a pathogenic role for excess adipose tissue.”
From Hypogonadism and male obesity: Focus on unresolved questions (2018) · cites this paper as [43]
In the citing paper
“Longitudinal data from EMAS have reported similar findings in older less obese men (mean age 58 years; BMI, 27.6 kg/m2) (22).”
From A Perspective on Middle-Aged and Older Men With Functional Hypogonadism: Focus on Holistic Management (2017) · cites this paper as [22]
In the citing paper
“This weight loss of 5% was associated with an increase in total testosterone [+2 nmol/L (+58 ng/dL)] but not in free testosterone.”
From A Perspective on Middle-Aged and Older Men With Functional Hypogonadism: Focus on Holistic Management (2017) · cites this paper as [22]
In the citing paper
“During 4.4 years, weight loss of 5% was associated a significant linear rise in serum sex hormone–binding globulin, probably because insulin resistance improved (22).”
From A Perspective on Middle-Aged and Older Men With Functional Hypogonadism: Focus on Holistic Management (2017) · cites this paper as [22]
In the citing paper
“Weight loss > 15% was associated with more marked increases in total testosterone [+5.7 nmol/L (+164 ng/dL)], LH (+2.2 IU/L), and free testosterone [+52 pmol/L (+52 pg/mL)] (22).”
From A Perspective on Middle-Aged and Older Men With Functional Hypogonadism: Focus on Holistic Management (2017) · cites this paper as [22]
In the citing paper
“30% of weight loss after bariatric surgery with the increase of total testosterone by 8.7 nmol/L (3, 20, 22)”
From Effects of liraglutide on obesity-associated functional hypogonadism in men (2019) · cites this paper as [22]
Citations
Cites
A Critical Evaluation of Simple Methods for the Estimation of Free Testosterone in Serum
Vermeulen, A., Verdonck, L., & Kaufman, J. M. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.10.6079 · Cited by 3,824
The physical activity scale for the elderly (PASE): Development and evaluation
Washburn, R. A., Smith, K. W., Jette, A. M., & Janney, C. A. (1993) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(93)90053-4 · Cited by 3,256
Longitudinal Effects of Aging on Serum Total and Free Testosterone Levels in Healthy Men
Harman, S. M., Metter, E. J., Tobin, J. D., Pearson, J., & Blackman, M. R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.2.7219 · Cited by 2,760
Feldman, H. A., Longcope, C., Derby, C. A., Johannes, C. B., Araujo, A. B., Coviello, A. D., Bremner, W. J., & McKinlay, J. B. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.2.8201 · Cited by 1,861
The Decline of Androgen Levels in Elderly Men and Its Clinical and Therapeutic Implications
Kaufman, J. M., & Vermeulen, A. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0013 · Cited by 1,079
Wu, F. C. W., Tajar, A., Pye, S. R., Silman, A. J., Finn, J. D., O'Neill, T. W., Bartfai, G., Casanueva, F., Forti, G., Giwercman, A., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1972 · Cited by 939
Self-citationMorley, J. E., Kaiser, F. E., Perry, H. M., Patrick, P., Morley, P. M. K., Stauber, P. M., Vellas, B., Baumgartner, R. N., & Garry, P. J. (1997) · Metabolism · doi:10.1016/s0026-0495(97)90057-3 · Cited by 830
Kupelian, V., Page, S. T., Araujo, A. B., Travison, T. G., Bremner, W. J., & McKinlay, J. B. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1326 · Cited by 561
Vermeulen, A. (1996) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.81.5.1821 · Cited by 455
Role of Endocytosis in Cellular Uptake of Sex Steroids
Hammes, A., Andreassen, T. K., Spoelgen, R., Raila, J., Hubner, N., Schulz, H., Metzger, J., Schweigert, F. J., Luppa, P. B., Nykjaer, A., et al. (2005) · Cell · doi:10.1016/j.cell.2005.06.032 · Cited by 413
Flagged first, then by citations
1 of the 41 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- 2012, ENDOCRINE ABSTRACTS, 28, 39
- 2010, JOURNALS OF GERONTOLOGY SERIES A BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 65, 503
- Gapstur, 2002, Cancer Epidemiology Biomarkers & Prevention, 11, 1041
Cited by
Sorted by citations
Items 101–200 of 391
Yeap, B. B., Page, S. T., & Grossmann, M. (2018) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(17)30416-3 · Cited by 43
Yeap, B. B., & Wu, F. C. W. (2018) · Clinical Endocrinology · doi:10.1111/cen.13888 · Cited by 45
Self-citationRelationship of Vitamin D status with testosterone levels: a systematic review and meta-analysis
D’Andrea, S., Martorella, A., Coccia, F., Castellini, C., Minaldi, E., Totaro, M., Parisi, A., Francavilla, F., Francavilla, S., & Barbonetti, A. (2020) · Endocrine · doi:10.1007/s12020-020-02482-3 · Cited by 43
Bann, D., Wu, F. C. W., Keevil, B. G., Lashen, H., Adams, J. E., Hardy, R., Terrera, G. M., Kuh, D. J., Ben‐Shlomo, Y., & Ong, K. K. (2015) · Obesity · doi:10.1002/oby.21092 · Cited by 41
Self-citationAndropause – lessons from the European Male Ageing Study
Huhtaniemi, I. T. (2014) · Annales d Endocrinologie · doi:10.1016/j.ando.2014.03.005 · Cited by 44
Self-citationThe rate of change in declining steroid hormones: a new parameter of healthy aging in men?
Walther, A., Philipp, M., Lozza, N., & Ehlert, U. (2016) · Oncotarget · doi:10.18632/oncotarget.11752 · Cited by 40
Giagulli, V. A., Castellana, M., Murro, I., Pelusi, C., Guastamacchia, E., Triggiani, V., & Pergola, G. D. (2019) · Nutrients · doi:10.3390/nu11122975 · Cited by 42
Vascular Pathways of Testosterone: Clinical Implications
Lorigo, M., Mariana, M., Oliveira, N., Lemos, M. C., & Cairrão, E. (2019) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-019-09939-5 · Cited by 44
Ng Tang Fui, M., Hoermann, R., Prendergast, L. A., Zajac, J. D., & Grossmann, M. (2017) · International Journal of Obesity · doi:10.1038/ijo.2016.242 · Cited by 40
Male and female sexual dysfunction in diabetic subjects: Focus on new antihyperglycemic drugs
Corona, G., Isidori, A. M., Aversa, A., Bonomi, M., Ferlin, A., Foresta, C., Vignera, S. L., Maggi, M., Pivonello, R., Vignozzi, L., et al. (2019) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-019-09535-7 · Cited by 48
Leisegang, K., Roychoudhury, S., Sláma, P., & Finelli, R. (2021) · Antioxidants · doi:10.3390/antiox10111834 · Cited by 40
Damgaard–Olesen, A., Johannsen, T. H., Holmboe, S. A., Søeborg, T., Petersen, J. H., Andersson, A., Aadahl, M., Linneberg, A., & Juul, A. (2016) · Clinica Chimica Acta · doi:10.1016/j.cca.2015.12.042 · Cited by 39
Erectile dysfunction is a prognostic indicator of comorbidities in men with late onset hypogonadism
Almehmadi, Y., Yassin, D., & Yassin, A. A. (2015) · The Aging Male · doi:10.3109/13685538.2015.1046044 · Cited by 39
Male Obesity Associated Gonadal Dysfunction and the Role of Bariatric Surgery
Sultan, S., Patel, A. G., El-Hassani, S., Whitelaw, B., Leca, B. M., Vincent, R. P., le Roux, C. W., Rubino, F., Aywlin, S. J. B., & Dimitriadis, G. K. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00408 · Cited by 39
Yassin, A. A., Nettleship, J. E., Almehmadi, Y., Salman, M., & Saad, F. (2016) · Andrologia · doi:10.1111/and.12514 · Cited by 38
Correlates of testosterone change as men age
Kanabar, R., Mazur, A., Plum, A., & Schmied, J. (2022) · The Aging Male · doi:10.1080/13685538.2021.2023493 · Cited by 38
Yeap, B. B., Marriott, R. J., Antonio, L., Bhasin, S., Dobs, A. S., Dwivedi, G., Flicker, L. A., Matsumoto, A. M., Ohlsson, C., ORWOLL, E. S., et al. (2020) · Clinical Endocrinology · doi:10.1111/cen.14342 · Cited by 35
Self-citationSalonia, A., Ventimiglia, E., Capogrosso, P., Serino, A., Boeri, L., Colicchia, M., Croce, G. L., Scano, R., Papaleo, E., Damiano, R., et al. (2016) · Asian Journal of Andrology · doi:10.4103/1008-682x.175783 · Cited by 37
Late-onset hypogonadism: beyond testosterone
Foresta, C., Calogero, A. E., Lombardo, F. P., Lenzi, A., & Ferlin, A. (2014) · Asian Journal of Andrology · doi:10.4103/1008-682x.135985 · Cited by 37
Clifton, S., Macdowall, W. G., Copas, A. J., Tanton, C., Keevil, B. G., Lee, D. M., Mitchell, K. R., Field, N. M., Sonnenberg, P., Bancroft, J., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-1669 · Cited by 35
Self-citationFode, M. M., Salonia, A., Minhas, S., Burnett, A. L. “., & Shindel, A. W. (2019) · European Urology Focus · doi:10.1016/j.euf.2019.02.021 · Cited by 36
Secular trends in testosterone- findings from a large state-mandate care provider
Chodick, G., Epstein, S., & Shalev, V. (2020) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-020-00575-2 · Cited by 38
Sex steroids and glucose metabolism
Allan, C. A. (2014) · Asian Journal of Andrology · doi:10.4103/1008-682x.122589 · Cited by 38
New perspectives in functional hypogonadotropic hypogonadism: beyond late onset hypogonadism
Spaziani, M., Carlomagno, F., Tarantino, C., Angelini, F., Vincenzi, L., & Gianfrilli, D. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1184530 · Cited by 37
Collet, T., Ewing, S. K., Ensrud, K. E., Laughlin, G. A., Hoffman, A. R., Varosy, P. D., Stefanick, M. L., Stone, K. L., ORWOLL, E. S., & Bauer, D. C. (2020) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaa038 · Cited by 31
The Double Edge Sword of Testosterone’s Role in the COVID-19 Pandemic
Younis, J. S., Skorecki, K. L., & Abassi, Z. A. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.607179 · Cited by 32
Obesity and age as dominant correlates of low testosterone in men irrespective of diabetes status
Fui, M. N. T., Hoermann, R., Cheung, A. S., Gianatti, E., Zajac, J. D., & Grossmann, M. (2013) · Andrology · doi:10.1111/j.2047-2927.2013.00124.x · Cited by 33
Decrease in semen quality and Leydig cell function in infertile men: a longitudinal study
Olesen, I. A., Joensen, U. N., Petersen, J. H., Almstrup, K., Meyts, E. R., Carlsen, E., McLachlan, R. I., Juul, A., & Jørgensen, N. (2018) · Human Reproduction · doi:10.1093/humrep/dey283 · Cited by 33
Metabolic syndrome and smoking are independent risk factors of male idiopathic infertility
the ALIFERT collaborative group, Dupont, C., Faure, C., Daoud, F., Gautier, B., Czernichow, S., & Lévy, R. (2019) · Basic and Clinical Andrology · doi:10.1186/s12610-019-0090-x · Cited by 34
Banica, T., Verroken, C., Reyns, T., Mahmoud, A., T’Sjoen, G., Fiers, T., Kaufman, J.-M., & Lapauw, B. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa915 · Cited by 32
Ageing male (part I): Pathophysiology and diagnosis of functional hypogonadism
Huhtaniemi, I. T., & Wu, F. C. W. (2022) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2022.101622 · Cited by 31
Self-citationEnclomiphene citrate for the treatment of secondary male hypogonadism
Rodríguez, K. M. G., Pastuszak, A. W., & Lipshultz, L. I. (2016) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2016.1204294 · Cited by 32
Risk of health status worsening in primary infertile men: A prospective 10‐year follow‐up study
Boeri, L., Ventimiglia, E., Cazzaniga, W., Pederzoli, F., Fallara, G., Pozzi, E., Belladelli, F., Baudo, A., Frego, N., Capogrosso, P., et al. (2021) · Andrology · doi:10.1111/andr.13090 · Cited by 32
Role of Glucose-Lowering Medications in Erectile Dysfunction
Cignarelli, A., Genchi, V. A., D’Oria, R., Giordano, F., Caruso, I., Perrini, S., Natalicchio, A., Laviola, L., & Giorgino, F. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10112501 · Cited by 30
Androgens Modulate Endothelial Function and Endothelial Progenitor Cells in Erectile Physiology
Traish, A. M., & Galoosian, A. (2013) · Korean journal of urology · doi:10.4111/kju.2013.54.11.721 · Cited by 30
Individual testosterone decline and future mortality risk in men
Holmboe, S. A., Skakkebæk, N. E., Juul, A., Scheike, T., Jensen, T. K., Linneberg, A. R., Thuesen, B. H., & Andersson, A. (2017) · European Journal of Endocrinology · doi:10.1530/eje-17-0280 · Cited by 32
Tinahones, F. J., Fernández-García, J., Molina‐Vega, M., Asenjo‐Plaza, M., Banderas-Donaire, M. J., Hernández-Ollero, M., Rodríguez-Moreno, S., Álvarez‐Millán, J. J., Cabezas-Sánchez, P., Cardona, F., et al. (2019) · Asian Journal of Andrology · doi:10.4103/aja.aja_106_19 · Cited by 30
Approach to Obesity in the Older Population
Buch, A., Marcus, Y., Shefer, G., Zimmet, P., & Stern, N. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab359 · Cited by 31
Anand‐Ivell, R., Heng, K., Severn, K. E., Antonio, L., Bártfai, G., Casanueva, F. F., Huhtaniemi, I. T., Giwercman, A., Maggi, M., O’Neill, T. W., et al. (2022) · Andrology · doi:10.1111/andr.13220 · Cited by 30
Self-citationNew horizons in testosterone and the ageing male
Ahern, T., & Wu, F. C. W. (2015) · Age and Ageing · doi:10.1093/ageing/afv007 · Cited by 31
Self-citationSteeves, J. A., Fitzhugh, E. C., Bradwin, G., McGlynn, K. A., Platz, E. A., & Joshu, C. E. (2016) · Andrology · doi:10.1111/andr.12169 · Cited by 29
Shen, X., Wang, R., Yu, N. H., Shi, Y., Li, H., Xiong, C., Li, Y., Wells, E. M., & Zhou, Y. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164116 · Cited by 27
Byberg, S., Futtrup, J., Andreassen, M., & Krogh, J. (2019) · Endocrine Connections · doi:10.1530/ec-19-0286 · Cited by 28
Reproductive aging and telomeres: Are women and men equally affected?
Chico-Sordo, L., Córdova-Oriz, I., Polonio, A. M., S-Mellado, L. S., Medrano, M., García-Velasco, J. A., & Varela, E. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111541 · Cited by 27
The impact of testosterone in men’s health
Ide, H. (2023) · Endocrine Journal · doi:10.1507/endocrj.ej22-0604 · Cited by 32
Androgen deficiency and type 2 diabetes mellitus
Gibb, F. W., & Strachan, M. W. J. (2014) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2014.04.004 · Cited by 29
The Circle of Lifestyle and Erectile Dysfunction
Kirby, M. G. (2015) · Sexual Medicine Reviews · doi:10.1002/smrj.52 · Cited by 27
An Ensemble Perspective of Aging-Related Hypoandrogenemia in Men
Liu, P. Y., Takahashi, P. Y., & Veldhuis, J. D. (2017) · Springer eBooks · doi:10.1007/978-3-319-53298-1_16 · Cited by 27
Salman, M., Yassin, D., Shoukfeh, H., Nettleship, J. E., & Yassin, A. A. (2017) · The Aging Male · doi:10.1080/13685538.2016.1260107 · Cited by 26
Conjectures Concerning Cross-Sex Hormone Treatment of Aging Transsexual Persons
Gooren, L. J., & Lips, P. T. A. M. (2014) · The Journal of Sexual Medicine · doi:10.1111/jsm.12563 · Cited by 26
Fui, M. N. T., Hoermann, R., Nolan, B. J., Clarke, M., Zajac, J. D., & Grossmann, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-27481-3 · Cited by 26
Effects of treatment for diabetes mellitus on testosterone concentrations: A systematic review
Cauwenberghe, J. V., Block, C. E. M. D., Vanderschueren, D., & Antonio, L. (2022) · Andrology · doi:10.1111/andr.13318 · Cited by 25
Self-citationEquey, T., Salamin, O., Ponzetto, F., Nicoli, R., Kuuranne, T., SAUGY, J. J., Saugy, M., Aikin, R. A., & Baume, N. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad085 · Cited by 25
Grossmann, M., Jayasena, C. N., & Anawalt, B. D. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad180 · Cited by 25
Featured paper Andropause – State of the art 2015 and review of selected aspects
Jakiel, G., Makara‐Studzińska, M., Ciebiera, M., & Słabuszewska-Jóźwiak, A. (2015) · Menopause Review/Przegląd Menopauzalny · doi:10.5114/pm.2015.49998 · Cited by 28
The relationships between bariatric surgery and sexual function: current evidence based medicine
Liu, S., Cao, D., Ren, Z., Li, J., Peng, L., Zhang, Q., Cheng, B., Cheng, Z., Ai, J., Zheng, X. S., et al. (2020) · BMC Urology · doi:10.1186/s12894-020-00707-1 · Cited by 24
GREEN, D. J., Chasland, L. C., Yeap, B. B., & Naylor, L. H. (2024) · Sports Medicine - Open · doi:10.1186/s40798-024-00703-x · Cited by 28
Is Rising Obesity Causing a Secular (Age-Independent) Decline in Testosterone among American Men?
Mazur, A., Westerman, R., & Mueller, U. O. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076178 · Cited by 23
Testosterone and depressive symptoms among men in the Diabetes Prevention Program
Kim, C., Barrett-Connor, E. L., Aroda, V. R., Mather, K. J., Christophi, C. A., Horton, E. S., Pi-Sunyer, X., Bray, G. A., Labrie, F., & Golden, S. H. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.06.009 · Cited by 24
Obesity, Body Composition, and Sex Hormones: Implications for Cardiovascular Risk
Singh, P., Covassin, N., Marlatt, K. L., Gadde, K. M., & Heymsfield, S. B. (2021) · Comprehensive physiology · doi:10.1002/cphy.c210014 · Cited by 44
Mechanism associated with changes in male reproductive functions during ageing process
Ajayi, A. F., Onaolapo, M. C., Omole, A. I., Adeyemi, W. J., & Oluwole, D. T. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112232 · Cited by 26
Grossmann, M., Anawalt, B. D., & Wu, F. C. W. (2014) · Clinical Endocrinology · doi:10.1111/cen.12594 · Cited by 23
Self-citationJones, T. H., Dobs, A. S., Randeva, H. S., Moore, W., & Parkin, J. (2023) · European Journal of Endocrinology · doi:10.1093/ejendo/lvad099 · Cited by 27
The effect of obesity on inflammatory cytokine and leptin production following acute mental stress
Caslin, H. L., Franco, R. L., Crabb, E. B., Huang, C., Bowen, M. K., & Acevedo, E. O. (2015) · Psychophysiology · doi:10.1111/psyp.12568 · Cited by 22
Late onset hypogonadism of men is not equivalent to the menopause
Saad, F., & Gooren, L. J. (2014) · Maturitas · doi:10.1016/j.maturitas.2014.06.016 · Cited by 22
Oxidative Stress, Nutritional Antioxidants, and Testosterone Secretion in Men
Mj, G., & Smith, K. (2015) · Cited by 21
Effect of Testosterone Treatment on Adipokines and Gut Hormones in Obese Men on a Hypocaloric Diet
Fui, M. N. T., Hoermann, R., & Grossmann, M. (2017) · Journal of the Endocrine Society · doi:10.1210/js.2017-00062 · Cited by 22
Male-specific consequences of obesity — functional hypogonadism and fertility disorders
Rabijewski, M. (2023) · Endokrynologia Polska · doi:10.5603/ep.95626 · Cited by 24
Sex Differences in Aging and Associated Biomarkers
Thomas, N., Gurvich, C., & Kulkarni, J. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-25650-0_4 · Cited by 21
Cardiovascular and metabolic actions of the androgens: Is testosterone a Janus-faced molecule?
Stallone, J. N., & Oloyo, A. K. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115347 · Cited by 22
Muram, D., Zhang, X., Cui, Z. L., & Matsumoto, A. M. (2015) · The Journal of Sexual Medicine · doi:10.1111/jsm.12968 · Cited by 21
Sex steroids and cardiovascular disease
Yeap, B. B. (2014) · Asian Journal of Andrology · doi:10.4103/1008-682x.122357 · Cited by 20
Testosterone, Diabetes Risk, and Diabetes Prevention in Men
Yeap, B. B., & Wittert, G. (2022) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2021.11.004 · Cited by 19
Yeap, B. B. (2018) · Asian Journal of Andrology · doi:10.4103/aja.aja_50_17 · Cited by 19
Gore, A. C., Hall, J. E., & Hayes, F. J. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397175-3.00037-5 · Cited by 19
Telgenkamp, I., Kusters, Y. H. A. M., Schalkwijk, C. G., Houben, A. J. H. M., Kooi, M. E., Lindeboom, L., Bons, J. A. P., Schaper, N. C., Joris, P. J., Plat, J., et al. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-02378 · Cited by 18
Bioavailable testosterone is associated with symptoms of depression in adult men
Chen, Z., Shen, X., Tian, K., Liu, Y., Xiong, S., Yu, Q., Dai, L., Shi, Y., Zhang, R., Zeng, R., et al. (2020) · Journal of International Medical Research · doi:10.1177/0300060520941715 · Cited by 22
Marriott, R. J., Murray, K., Hankey, G. J., Manning, L. A., Dwivedi, G., Wu, F. C. W., & Yeap, B. B. (2021) · Clinical Endocrinology · doi:10.1111/cen.14648 · Cited by 18
Self-citationTestosterone therapy in older men: clinical implications of recent landmark trials
Grossmann, M., Anawalt, B. D., & Yeap, B. B. (2024) · European Journal of Endocrinology · doi:10.1093/ejendo/lvae071 · Cited by 18
The marketing of testosterone treatments for age-related low testosterone or ‘Low T’
Mintzes, B. J. (2018) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000412 · Cited by 18
Testosterone and Dehydroepiandrosterone Treatment in Ageing Men: Are We All Set?
Walther, A., & Seuffert, J. (2019) · The World Journal of Men s Health · doi:10.5534/wjmh.190006 · Cited by 20
Matsumoto, A. M., & Bremner, W. J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-29738-7.00019-8 · Cited by 18
Busnelli, A., Somigliana, E., & Vercellini, P. (2017) · Human Reproduction · doi:10.1093/humrep/dex032 · Cited by 17
Shigehara, K., Konaka, H., Nohara, T., Izumi, K., Kitagawa, Y., Kadono, Y., Iwamoto, T., Koh, E., Mizokami, A., & Namiki, M. (2017) · Andrologia · doi:10.1111/and.12815 · Cited by 18
Endogenous testosterone and mortality risk
Meyer, E. J., & Wittert, G. (2018) · Asian Journal of Andrology · doi:10.4103/aja.aja_70_17 · Cited by 17
Lifestyle, metabolic disorders and male hypogonadism – A one-way ticket?
Crisóstomo, L., Pereira, S., Monteiro, M. P., Raposo, J. F., Oliveira, P. F., & Alves, M. G. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.110945 · Cited by 19
Effects of androgens on glucose metabolism
Umapathysivam, M. M., Grossmann, M., & Wittert, G. (2022) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2022.101654 · Cited by 18
Testosterone: Relationships with Metabolic Disorders in Men—An Observational Study from SPECT-China
Cheng, J., Han, B., Qin, L., Xia, F., Zhai, H., Wang, N., Jensen, M. D., & Lu, Y. (2017) · International Journal of Endocrinology · doi:10.1155/2017/4547658 · Cited by 18
Verderame, M., Migliaccio, V., & Scudiero, R. (2018) · Comptes Rendus Biologies · doi:10.1016/j.crvi.2018.07.002 · Cited by 16
Meissner, V. H., Schroeter, L., Köhn, F., Kron, M., Zitzmann, M., Arsov, C., Imkamp, F., Hadaschik, B. A., Gschwend, J. E., & Herkommer, K. (2019) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2019.04.018 · Cited by 19
Khera, M. (2016) · Urologic Clinics of North America · doi:10.1016/j.ucl.2016.01.004 · Cited by 16
Effects of Exercise on Testosterone and Implications of Drug Abuse: A Review
Perreault, B., Hammond, N., & Thanos, P. K. (2023) · Clinical Neuropharmacology · doi:10.1097/wnf.0000000000000546 · Cited by 15
Jastrzębska, S., Walczak-Jędrzejowska, R., Kramek, E., Marchlewska, K., Oszukowska, E., Filipiak, E., Kula, K., & Słowikowska‐Hilczer, J. (2014) · Endokrynologia Polska · doi:10.5603/ep.2014.0028 · Cited by 15
Self-citationPrimary, secondary, and compensated hypogonadism: A novel risk stratification for infertile men
Ventimiglia, E., Capogrosso, P., Boeri, L., Cazzaniga, W., Pederzoli, F., Frego, N., Oreggia, D., Dehò, F., Gaboardi, F., Mirone, V., et al. (2017) · European Urology Supplements · doi:10.1016/s1569-9056(17)30509-2 · Cited by 15
Higher premorbid serum testosterone predicts COVID-19-related mortality risk in men
Yeap, B. B., Marriott, R. J., Manning, L. A., Dwivedi, G., Hankey, G. J., Wu, F. C. W., Nicholson, J. K., & Murray, K. (2022) · European Journal of Endocrinology · doi:10.1530/eje-22-0104 · Cited by 14
Self-citationAbootalebi, M., Vizeshfar, F., Heydari, N., & Azizi, F. (2019) · The Aging Male · doi:10.1080/13685538.2019.1696766 · Cited by 14
Gleicher, S., Daugherty, M., Ferry, E., & Byler, T. (2020) · International Urology and Nephrology · doi:10.1007/s11255-020-02557-0 · Cited by 14
Hormones and Cardiovascular Disease in Older Men
Yeap, B. B., & Flicker, L. A. (2014) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.12.004 · Cited by 15
Sato, K., Samocha‐Bonet, D., Handelsman, D. J., Fujita, S., Wittert, G., & Heilbronn, L. K. (2014) · Diabetes & Metabolism · doi:10.1016/j.diabet.2014.03.006 · Cited by 13
Aging and sex hormones in males
Decaroli, M. C., Vincentis, S. D., & Rochira, V. (2021) · Vitamins and hormones · doi:10.1016/bs.vh.2020.12.014 · Cited by 14
Metadata
- Authors
- Camacho, E. M., Huhtaniemi, I. T., O'Neill, T. W., Finn, J. D., Pye, S. R., Lee, D. M., Tajar, A., Bartfai, G., Boonen, S., Casanueva, F. F., Forti, G., Giwercman, A., Han, T. S., Kula, K., Keevil, B., Lean, M. E., Pendleton, N., Punab, M., Vanderschueren, D., Wu, F. C. W., & _, _.
- Affiliations
- University of Manchester (GB)
- Imperial College London (GB)
- KU Leuven (BE)
- Universidade de Santiago de Compostela (ES)
- University of Florence (IT)
- Skåne University Hospital (SE)
- University College London (GB)
- Medical University of Lodz (PL)
- University of Glasgow (GB)
- Salford Royal NHS Foundation Trust (GB)
- Tartu University Hospital (EE)
- Corresponding author
- Wu, F C W
- ORCID
- Venue
- European Journal of Endocrinology
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-03
- Volume
- 168
- Issue
- 3
- Pages
- 445-455
- ISSN
- 0804-4643 (ISSN-L)
- 1479-683X
- OpenAlex
- W2132200219
- Cited by
- 392
- References
- 41
- Citations by year
- 2026: 16 · 2025: 24 · 2024: 34 · 2023: 30 · 2022: 30 · 2021: 28 · 2020: 32 · 2019: 26 · 2018: 27 · 2017: 34 · 2016: 33 · 2015: 31 · 2014: 31 · 2013: 15
- FWCI
- 28.84
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- Locations
- European Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- RUNA. Repositorio Institucional del Sergas (Servicio Gallego de Salud (SERGAS)) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Keywords
- hypothalamic-pituitary-testicular axis, testosterone, free testosterone, sex hormone-binding globulin, luteinizing hormone, older men, weight change, weight loss, weight gain, obesity, smoking cessation, comorbidities, physical activity, lifestyle factors, European Male Ageing Study
- MeSH terms
- Adult, Aged, Aging, Europe, Follow-Up Studies, Humans, Hypothalamo-Hypophyseal System, Luteinizing Hormone, Life Style, Longitudinal Studies, Male, Middle Aged, Prospective Studies, Sex Hormone-Binding Globulin, Testis, Testosterone, Cohort Studies, Weight Gain, Weight Loss, Smoking Cessation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
