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Cited by 501

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Impact of maternal obesity on offspring obesity and cardiometabolic disease risk

Open access
Drake, Amanda J, Reynolds, Rebecca M·2010·Reproduction
DOI 10.1530/rep-10-0077
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Abstract

The prevalence of obesity among pregnant women is increasing. In addition to the short-term complications of obesity during pregnancy in both mother and child, it is now recognised that maternal obesity has long-term adverse outcomes for the health of her offspring in later life. Evidence from both animal and human studies indicates that maternal obesity increases the risk for the offspring in developing obesity and altering body composition in child- and adulthood and, additionally, it also has an impact on the offspring's cardiometabolic health with dysregulation of metabolism including glucose/insulin homoeostasis, and development of hypertension and vascular dysfunction. Potential mechanisms include effects on the development and function of adipose tissue, pancreas, muscle, liver, the vasculature and the brain. Further studies are required to elucidate the mechanisms underpinning the programming of disease risk in the offspring as a consequence of maternal obesity. The ultimate aim is to identify potential targets, which may be amenable to prevention or early intervention in order to improve the health of this and future generations.

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Metadata

Authors
Drake, A. J., & Reynolds, R. M.
Venue
Reproduction
Publisher
Oxford University Press (OUP)
Published
2010-09-01
Volume
140
Issue
3
Pages
387-398
ISSN
  • 1470-1626 (ISSN-L)
  • 1741-7899
DOI
10.1530/rep-10-0077
OpenAlex
W2061444003
Cited by
501
References
9
FWCI
22.57
Type
journal article
Language
en
Open access
bronze

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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