Cited by 104Chromosomal and Genetic VariationsGenetic Mapping and Diversity in Plants and AnimalsGenomic variations and chromosomal abnormalities

Megabase-scale inversion polymorphism in the wild ancestor of maize

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Fang, Zhou, Pyhäjärvi, Tanja, Weber, Allison L, Dawe, R Kelly, Glaubitz, Jeffrey C, González, José de Jesus Sánchez, Ross-Ibarra, Claudia, Doebley, John +2 more·2012·Genetics

Abstract

Chromosomal inversions are thought to play a special role in local adaptation, through dramatic suppression of recombination, which favors the maintenance of locally adapted alleles. However, relatively few inversions have been characterized in population genomic data. On the basis of single-nucleotide polymorphism (SNP) genotyping across a large panel of Zea mays, we have identified an ∼50-Mb region on the short arm of chromosome 1 where patterns of polymorphism are highly consistent with a polymorphic paracentric inversion that captures >700 genes. Comparison to other taxa in Zea and Tripsacum suggests that the derived, inverted state is present only in the wild Z. mays subspecies parviglumis and mexicana and is completely absent in domesticated maize. Patterns of polymorphism suggest that the inversion is ancient and geographically widespread in parviglumis. Cytological screens find little evidence for inversion loops, suggesting that inversion heterozygotes may suffer few crossover-induced fitness consequences. The inversion polymorphism shows evidence of adaptive evolution, including a strong altitudinal cline, a statistical association with environmental variables and phenotypic traits, and a skewed haplotype frequency spectrum for inverted alleles.

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Crossref · 10.1534/genetics.112.138578

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  • More often, hybrids heterozygous for inversions, especially for inversions that are polymorphic within species, do not show visible reductions in fertility.

    “More often, hybrids heterozygous for inversions, especially for inversions that are polymorphic within species, do not show visible reductions in fertility (Kianian and Quiros, 1992; Lowry and Willis, 2010; Fang et al., 2012; Stathos and Fishman, 2014; Ostevik et al., 2016; Huang et al., 2020).”

    From Genomics of plant speciation (2023) · cites this paper as Fang et al., 2012

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Authors
Fang, Z., Pyhäjärvi, T., Weber, A. L., Dawe, R. K., Glaubitz, J. C., González, J. D. J. S., Ross-Ibarra, C., Doebley, J., Morrell, P. L., & Ross-Ibarra, J.
Affiliations
  • University of Minnesota (US)
  • University of California, Davis (US)
  • University of Wisconsin–Madison (US)
  • University of Georgia (US)
  • Cornell University (US)
  • Centro Universitario de Ciencias Biológicas y Agropecuarias, Universidad de Guadalajara, Zapopan, Jalisco, Mexico CP45110
  • Department of Plant Sciences and
Venue
Genetics
Published
2012-07-01
Volume
191
Issue
3
Pages
883-894
ISSN
  • 0016-6731 (ISSN-L)
  • 1943-2631
OpenAlex
W2125064018
Cited by
104
References
90
Citations by year
2026: 3 · 2025: 8 · 2024: 6 · 2023: 4 · 2022: 7 · 2021: 8 · 2020: 12 · 2019: 13 · 2018: 5 · 2017: 7 · 2016: 8 · 2015: 8 · 2014: 7 · 2013: 6 · 2012: 2
FWCI
8.41
Type
journal article
Language
en
Open access
Locations
  • Genetics (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of Minnesota
  • Division of Integrative Organismal Systems
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
Keywords
chromosomal inversions, paracentric inversion, maize, Tripsacum, single nucleotide polymorphisms, chromosome 1, recombination suppression, local adaptation, altitudinal cline, adaptive evolution, inversion heterozygotes, domestication
MeSH terms
Alleles, Zea mays, Haplotypes, Chromosome Inversion, Polymorphism, Genetic, Time Factors, Evolution, Molecular, Polymorphism, Single Nucleotide, Chromosomes, Plant

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