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Cited by 75Hormonal and reproductive studiesLipoproteins and Cardiovascular HealthMenopause: Health Impacts and Treatments

Beneficial Effects of Testosterone Undecanoate on the Lipoprotein Profiles in Healthy Elderly Men. A Placebo Controlled Study.

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UYANIK, Bekir Sami, ARI, Zeki, GÜMÜS, Bilali, YIGITOGLU, M. Ramazan, ARSLAN, Taciser·1997·Japanese Heart Journal
DOI 10.1536/ihj.38.73
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Abstract

BACKGROUND AND METHODS: In order to assess the effects of testosterone undecanoate (TU; 120 mg/d orally for 2 months) on serum lipid, lipoprotein, and apolipoprotein levels in healthy elderly men, the placebo (PL) controlled study was performed on 37 elderly men, aged between 53 and 89 years. In all subjects venous blood samples were taken after an overnight (10 hours) fast and sera were stored -70 degrees C until analysis. RESULTS: In PL group, neither hormonal data nor lipid, lipoprotein, and apolipoprotein levels showed significant changes. After TU supplementation, serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and estradiol (E2) levels decreased from 198 +/- 30.7 mg/dl to 174 +/- 41.9 mg/dl (p < 0.05), from 111 +/- 18.14 mg/dl to 87.9 +/- 29.4 mg/dl (p < 0.01), and from 86.2 +/- 16.9 pmol/l to 70.5 +/- 18 pmol/l (p < 0.01), respectively. Statistically significant differences were not observed in the serum triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and apolipoprotein (apo) A-1 and apo B levels after TU treatment. The mean ratios TC/HDL-C and LDL-C/HDL-C as coronary risk factor criteria decreased significantly in the TU but not in the PL group. No obvious side effect was observed in those who took TU except for reported pyrosis in 2 of 17 elderly men. CONCLUSIONS: These data indicate that the increased serum levels of total testosterone (TT) produced by administration of TU, 120 mg/d orally for 2 months lead to suppressed levels of TC and LDL-C and E2 but not significantly changed levels of TC, HDL-C, apo A-1 and apo B. Thus, we conclude that TU may be an effective drug for protecting coronary heart disease in healthy elderly men with lowered TT and FT levels. It may also have beneficial effects for sexual function and behavior.

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  1. Kupperman HS. Treating menopausal women and climacteric men. Medical World News 1974; 15: 32-41.
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  7. Byerley Lo, Lee WN, Swerdloff RS. Effect of modulating serum testosterone levels in the normal male range on protein, glucose, and lipid metabolism in men: implications for testosterone replacement therapy. Endoer J 1993; 1: 253-62
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Authors
UYANIK, B. S., ARI, Z., GÜMÜS, B., YIGITOGLU, M. R., & ARSLAN, T.
Affiliations
  • Department of Biochemistry University of Celal Bayar
  • Department of Urology, University of Celal Bayar
  • Manisa Celal Bayar University (TR)
Venue
Japanese Heart Journal
Publisher
International Heart Journal (Japanese Heart Journal)
Published
1997
Volume
38
Issue
1
Pages
73-82
ISSN
  • 0021-4868 (ISSN-L)
  • 1348-673X
DOI
10.1536/ihj.38.73
OpenAlex
W2319096290
Cited by
75
References
34
Citations by year
2023: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2016: 1 · 2015: 4 · 2014: 4 · 2013: 4 · 2012: 4
FWCI
1.87
Type
journal article
Language
en
Open access
Locations
  • Japanese Heart Journal (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords
testosterone undecanoate, testosterone replacement therapy, lipoprotein profile, serum cholesterol, LDL cholesterol, estradiol, apolipoprotein A-I, apolipoprotein B, HDL cholesterol, triglycerides, coronary heart disease risk, older men, sexual function
MeSH terms
Aged, Aged, 80 and over, Apolipoproteins A, Apolipoproteins B, Cholesterol, Humans, Lipoproteins, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Testosterone, Triglycerides, Body Mass Index, Testosterone Congeners

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