Amyloid in the brains of aged squirrel monkeys
Abstract
In this immunocytochemical study, the brains of nine squirrel monkeys (Saimiri sciureus), ranging from 8 to 27 years of age, were examined for the presence and distribution of beta/A4 amyloid, a 4-kilodalton peptide. In aged squirrel monkeys, amyloid is associated primarily with intracerebral and meningeal capillaries and arterioles and occurs to a lesser degree as small and/or diffuse deposits in the neural parenchyma and in the dense cores of senile plaques. Cerebrovascular amyloid is found primarily in neocortex, amygdala, and septum verum and is rare or nonexistent in other subcortical gray structures, white matter, cerebellum, and spinal cord; this pattern of localization is comparable to that in humans with cerebral amyloid angiopathy. There is a significant correlation between cerebrovascular and parenchymal deposits of amyloid. However, cerebrovascular amyloid is always the most abundant form in squirrel monkeys, even in cases of severe cerebral amyloidosis. In contrast to squirrel monkeys, aged rhesus monkeys (Macaca mulatta) develop mostly parenchymal deposits of amyloid and have relatively less vascular amyloid. This species difference in the histological distribution of amyloid suggests that separate mechanisms may influence the accumulation of amyloid in cerebral blood vessels and in the neural parenchyma. These data also indicate that the squirrel monkey can serve as a model for investigations of cerebrovascular amyloidosis.
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Squirrel monkeys have extensive Aβ accumulation after 12 years of age, primarily in the form of CAA in arterioles and capillaries.
“Squirrel monkeys have extensive Aβ accumulation after 12 years of age, primarily in the form of CAA in arterioles and capillaries [22, 36, 167, 168].”
From Alzheimer's disease: experimental models and reality (2017) · cites this paper as [168]
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- Authors
- Walker, L. C., Masters, C., Beyreuther, K., & Price, D. L.
- Affiliations
- Johns Hopkins University (US)
- Venue
- Acta Neuropathologica
- Published
- 1990-08
- Volume
- 80
- Issue
- 4
- Pages
- 381-387
- ISSN
- 0001-6322 (ISSN-L)
- 1432-0533
- OpenAlex
- W2045658045
- Cited by
- 119
- References
- 51
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 1 · 2021: 4 · 2019: 1 · 2017: 3 · 2016: 4 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 5
- FWCI
- 6.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Acta Neuropathologica (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r35ag007914-03)
- National Institute on Aging (AG07914, P50AG005146, AG 05146)
- National Institute of Neurological Disorders and Stroke (NS-20471)
- Topics
- Health Sciences › Medicine › Neurology › Intracerebral and Subarachnoid Hemorrhage Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Amyloidosis: Diagnosis, Treatment, Outcomes
- Keywords
- cerebral amyloid angiopathy, squirrel monkey, Saimiri sciureus, cerebral amyloidosis, cerebrovascular amyloid, amyloid plaques, arterioles, rhesus monkeys, species differences, animal models
- MeSH terms
- Aging, Amyloidosis, Animals, Brain Chemistry, Brain Diseases, Female, Male, Saimiri, Amyloid beta-Peptides
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