Cited by 169Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

Nonhuman Primate Models of Alzheimer-Like Cerebral Proteopathy

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Heuer, Eric, F. Rosen, Rebecca, Cintron, Amarallys, C. Walker, Lary·2012·Current Pharmaceutical Design

Abstract

Nonhuman primates are useful for the study of age-associated changes in the brain and behavior in a model that is biologically proximal to humans. The Aβ and tau proteins, two key players in the pathogenesis of Alzheimer's disease (AD), are highly homologous among primates. With age, all nonhuman primates analyzed to date develop senile (Aβ) plaques and cerebral β-amyloid angiopathy. In contrast, significant tauopathy is unusual in simians, and only humans manifest the profound tauopathy, neuronal degeneration and cognitive impairment that characterize Alzheimer's disease. Primates thus are somewhat paradoxical models of AD-like pathology; on the one hand, they are excellent models of normal aging and naturally occurring Aβ lesions, and they can be useful for testing diagnostic and therapeutic agents targeting aggregated forms of Aβ. On the other hand, the resistance of monkeys and apes to tauopathy and AD-related neurodegeneration, in the presence of substantial cerebral Aβ deposition, suggests that a comparative analysis of human and nonhuman primates could yield informative clues to the uniquely human predisposition to Alzheimer's disease.

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  • Memory impairments in great apes appear mild, more similar to typical age-related memory decline than the extensive cognitive decline seen in AD.

    “Also, memory impairments appear to be mild; appearing more similar to typical age-related memory decline, rather than the extensive cognitive decline seen in AD[57].”

    From Alzheimer's disease: experimental models and reality (2017) · cites this paper as [57]

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Research works printed but not linked: 5

  1. [3]Hauw JJ Duyckaerts C Alzheimer's Disease Oxford University Press New York 2001
  2. [6]Bekris LM Yu CE Bird TD Tsuang DW Genetics of Alzheimer disease J Geriatr Psychiatry Neurol 2010 23 213 27 21045163 PMC3044597
  3. [8]Selkoe DJ Terry RD Katzman R Bick KL Sisodia SS Biology of β-Amyloid Precursor Protein and the Mechanism of Alzheimer Disease Alzheimer Disease Lippincott Williams & Wilkins Philadelphia, PA 1999 293 310
  4. [25]Levine H Walker LC Michael Conn P Models of Alzheimer's disease Academic Press, Elsevier New York 121 134 2006
  5. [134]Wei LH Walker LC Levy E Cystatin C. Icelandic-like mutation inan animal model of cerebrovascular beta-amyloidosis Stroke 1996 27 2080 5 8898820

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Authors
Heuer, E., F. Rosen, R., Cintron, A., & C. Walker, L.
Affiliations
Emory University (US)
Venue
Current Pharmaceutical Design
Published
2012-03-01
Volume
18
Issue
8
Pages
1159-1169
ISSN
1381-6128 (ISSN-L)
OpenAlex
W2152340197
Cited by
169
References
143
Citations by year
2026: 3 · 2025: 18 · 2024: 15 · 2023: 16 · 2022: 10 · 2021: 14 · 2020: 14 · 2019: 17 · 2018: 7 · 2017: 12 · 2016: 17 · 2015: 10 · 2014: 8 · 2013: 4 · 2012: 1
FWCI
4.93
Type
journal article
Language
en
Open access
Locations
  • Current Pharmaceutical Design (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (P51OD011132)
  • National Institute on Aging (P01AG026423, P50AG025688)
  • National Institute of Neurological Disorders and Stroke (R21NS077049)
  • National Center for Research Resources (RR-00 165, P51RR000165)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
Alzheimer's disease, non-human primates, amyloid-beta, tau protein, amyloid plaques, tauopathy, neurodegeneration, primate aging, comparative neurobiology, animal models of Alzheimer's disease
MeSH terms
Aging, Alzheimer Disease, Animals, Behavior, Animal, Brain, Disease Models, Animal, Humans, Primates, Species Specificity, Amyloid beta-Peptides, tau Proteins

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