Early Alzheimer's disease–type pathology in the frontal cortex of wild mountain gorillas ( Gorilla beringei beringei )
Open accessAbstract
Amyloid beta (Aβ) and tau pathology have been described in the brains of captive aged great apes, but the natural progression of these age-related pathologies from wild great apes, including the gorilla, is unknown. In our previous study of Western lowland gorillas (Gorilla gorilla gorilla) who were housed in American Zoos and Aquariums-accredited facilities, we found an age-related increase in Aβ-positive plaques and vasculature, tau-positive astrocytes, oligodendrocyte coiled bodies, and neuritic clusters in the neocortex as well as hippocampus in older animals. Here, we demonstrate that aged wild mountain gorillas (Gorilla beringei beringei), who spent their entire lives in their natural habitat, also display an age-related increase in amyloid precursor protein (APP) and/or Aβ-immunoreactive blood vessels and plaques, but very limited tau pathology, in the frontal cortex. These results indicate that Aβ and tau lesions are age-related events that occur in the brain of gorillas living in captivity and in the wild.
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Great apes accumulate Aβ in the brain, resulting in the development of amyloid plaques and CAA in aged animals.
“Great apes accumulate Aβ in the brain, resulting in the development of amyloid plaques and CAA in aged animals [43, 44, 78, 112, 113, 124].”
From Alzheimer's disease: experimental models and reality (2017) · cites this paper as [113]
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- Authors
- Perez, S. E., Sherwood, C. C., Cranfield, M. R., Erwin, J. M., Mudakikwa, A., Hof, P. R., & Mufson, E. J.
- Affiliations
- Barrow Neurological Institute (US)
- George Washington University (US)
- University of California, Davis (US)
- Rwanda Development Board (RW)
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Perez, Sylvia E.
- Mufson, Elliott J.
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 39
- Pages
- 195-201
- ISSN
- 0197-4580 (ISSN-L)
- PMC
- PMC6317356
- OpenAlex
- W2199397523
- Cited by
- 50
- References
- 47
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 9 · 2020: 1 · 2019: 6 · 2018: 5 · 2017: 4 · 2016: 5
- FWCI
- 5.36
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (AG014308)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Social Psychology › Primate Behavior and Ecology
- Keywords
- Alzheimer's disease, amyloid-beta, tau pathology, mountain gorillas, Gorilla beringei beringei, frontal cortex, amyloid precursor protein, amyloid plaques, normal aging
- MeSH terms
- Aging, Alzheimer Disease, Animals, Animals, Wild, Animals, Zoo, Astrocytes, Female, Frontal Lobe, Gorilla gorilla, Hippocampus, Male, Oligodendroglia, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, tau Proteins, Neocortex, Plaque, Amyloid
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