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Cited by 91Birth, Development, and HealthChild and Adolescent HealthChild Abuse and Trauma

The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.

Leveraging the Biology of Adversity and Resilience to Transform Pediatric Practice

Shonkoff, Jack P., Boyce, W. Thomas, Levitt, Pat, Martinez, Fernando D., McEwen, Bruce·2021·Pediatrics
DOI 10.1542/peds.2019-3845
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Abstract

Advances in science are fundamentally changing the way we understand how inextricable interactions among genetic predispositions, physical and social environments, and developmental timing influence early childhood development and the foundations of health and how significant early adversity can lead to a lifetime of chronic health impairments. This article and companion article illustrate the extent to which differential outcomes are shaped by ongoing interactive adaptations to context that begin at or even before conception and continue throughout life, with increasing evidence pointing to the importance of the prenatal period and early infancy for the developing brain, the immune system, and metabolic regulation. Although new discoveries in the basic sciences are transforming tertiary medical care and producing breakthrough outcomes in treating disease, this knowledge is not being leveraged effectively to inform new approaches to promoting whole-child development and preventing illness. The opportunity for pediatrics to serve as the leading edge of science-based innovation across the early childhood ecosystem has never been more compelling. In this article, we present a framework for leveraging the frontiers of scientific discovery to inform new strategies in pediatric practice and advocacy to protect all developing biological systems from the disruptive effects of excessive early adversity beyond providing information on child development for parents and enriched learning…

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Crossref · 10.1542/peds.2019-3845

Cites

46 of 46 references verified0 citation errors · 0 not checkable

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Claims other papers make about this one

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  • Pediatrics has moved toward a coordinated, whole-child, two-generation approach.

    “similar to those accruing from the shift in pediatrics to a coordinated, whole-child, 2-generation philosophy.1,4,5”

    From The transition to parenthood in obstetrics: enhancing prenatal care for 2-generation impact (2022) · cites this paper as [1]

  • In the US, millions of children have diagnosed neurobehavioral conditions, including ADHD, behavior problems, anxiety, and learning, emotional, or speech disabilities.

    “6.1 million children have been diagnosed with attention deficit hyperactivity disorder (ADHD), 4.5 million children have been diagnosed with behavior problems, 4.4 million children have been diagnosed with anxiety, and nearly 7 million children are classified as disabled based on learning difficulties, emotional disturbance, and speech or language impairment.”

    From The transition to parenthood in obstetrics: enhancing prenatal care for 2-generation impact (2022) · cites this paper as [1]

Citations

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Research works printed but not linked: 3

  1. National Academies of Sciences, Engineering, and Medicine, 2019, Vibrant and Healthy Kids: Aligning Science, Practice, and Policy to Advance Health Equity
  2. Garner, Preventing childhood toxic stress: partnering with families and communities to buffer adversity and build resilience, Pediatrics
  3. National Academics of Sciences, Engineering and Medicine, 2017, Communities in Action: Pathways to Health Equity

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Metadata

Authors
Shonkoff, J. P., Boyce, W. T., Levitt, P., Martinez, F. D., & McEwen, B.
Affiliations
  • Boston Children's Hospital (US)
  • University of California, San Francisco (US)
  • University of Southern California (US)
  • Asthma and Airway Disease Research Center, The University of Arizona, Tucson, Arizona; and
  • Rockefeller University (US)
Corresponding author
Shonkoff, Jack P.
ORCID
Venue
Pediatrics
Publisher
American Academy of Pediatrics (AAP)
Published
2021-02-01
Volume
147
Issue
2
ISSN
  • 0031-4005 (ISSN-L)
  • 1098-4275
DOI
10.1542/peds.2019-3845
OpenAlex
W3122944761
Cited by
91
References
46
Citations by year
2026: 17 · 2025: 7 · 2024: 22 · 2023: 22 · 2022: 13 · 2021: 10
FWCI
16.55
Type
journal article
Language
en
Open access
closed
Locations
  • PEDIATRICS (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Child and Adolescent Health
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Keywords
early childhood adversity, resilience, developmental origins of health and disease, early childhood development, prenatal development, infant development, brain development, immune system development, metabolic regulation, holistic child development, pediatric practice, health promotion, genetic susceptibility, social environment
MeSH terms
Child Health, Adverse Childhood Experiences, Child, Child Development, Child Welfare, Child, Preschool, Environment, Family Relations, Humans, Infant, Infant, Newborn, Object Attachment, Pediatrics, Primary Health Care, Social Environment, Stress, Physiological, Stress, Psychological, Systems Theory, Ecosystem, Stress Disorders, Traumatic, Systems Biology, Resilience, Psychological, Social Determinants of Health

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