Biological embedding of stress through inflammation processes in childhood
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A novel frameshift mutation in UPF3B identified in brothers affected with childhood onset schizophrenia and autism spectrum disorders
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Most findings, but not all, suggest a robust correlation between ELS/CT and adult CRP levels.
“Most findings, but not all, suggest a robust correlation between ELS/CT and adult CRP levels (165, 166, 170, 199–202).”
From Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation (2019) · cites this paper as [200]
The opening section reports that adults exposed to childhood maltreatment had elevated inflammation biomarkers, particularly when they also had depression. It does not identify those adult biomarkers as CRP or assess whether most findings across studies show a robust correlation; this paper’s own hsCRP measurements were taken in children aged 12. (LLM, conf=0.85)
Experimental — accuracy not yet measuredChildren exposed to physical maltreatment before age 10 and depressed at age 12 exhibited significantly higher levels of CRP relative to children with depression only, maltreatment only, and neither depression nor maltreatment.
“children who were exposed to physical maltreatment before age 10 and depressed at age 12 exhibited significantly higher levels of CRP relative to children with depression only, maltreatment only, and neither depression nor maltreatment”
From From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. (2014) · cites this paper as Danese et al., 2011
The paper’s main text (page not specified in our copy) reports that children maltreated during their first decade and depressed at age 12 had significantly higher hsCRP than children with neither condition. It says the depression-only and maltreatment-only groups had levels similar to controls, but does not report significant pairwise differences between those groups and the combined group. (LLM, conf=0.88)
Experimental — accuracy not yet measuredChildhood adversity is associated with alterations in the inflammatory arm of the immune system.
“and the inflammatory arm of the immune system (Carpenter et al., 2010; Danese et al., 2011; Danese, Pariante, Caspi, Taylor, & Poulton, 2007; Slopen, Kubzansky, McLaughlin, & Koenen, 2013; Taylor, Lehman, Kiefe, & Seeman, 2006).”
From Developmental psychoneuroendocrine and psychoneuroimmune pathways from childhood adversity to disease (2017) · cites this paper as Danese et al., 2011
Twelve-year-old children exposed to physical maltreatment by their mothers and who also have elevated depression symptoms have elevated C-reactive protein.
“For example, 12-year old children exposed to physical maltreatment by their mothers who also have elevated symptoms of depression have elevated CRP (Danese et al., 2011).”
From Developmental psychoneuroendocrine and psychoneuroimmune pathways from childhood adversity to disease (2017) · cites this paper as Danese et al., 2011
The association between early life trauma and increased inflammation was replicated in 12-year-old children.
“we have been able to replicate the association between early life trauma and increased inflammation also in 12-year-old children (Danese et al., 2011)”
From Why are depressed patients inflamed? A reflection on 20 years of research on depression, glucocorticoid resistance and inflammation (2017) · cites this paper as Danese et al., 2011
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Self-citationRussell, A. E., Heron, J., Gunnell, D., Ford, T. J., Hemani, G., Joinson, C. J., Moran, P., Relton, C. L., Suderman, M. J., & Mars, B. (2019) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13100 · Cited by 62 · see citing works
Adversity in childhood and depression: linked through SIRT1
Iacono, L. L., Visco‐Comandini, F., Valzania, A., Viscomi, M. T., Coviello, M., Giampà, A., Roscini, L., Bisicchia, E., Siracusano, A., Troisi, A., et al. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.125 · Cited by 62 · see citing works
Raineki, C., Bodnar, T. S., Holman, P. J., Baglot, S. L., Lan, N., & Weinberg, J. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.07.001 · Cited by 60 · see citing works
Annual Research Review: Neuroimmune network model of depression: a developmental perspective
Nusslock, R., Alloy, L. B., Brody, G. H., & Miller, G. E. (2024) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13961 · Cited by 63 · see citing works
Slopen, N. B., Goodman, E., Koenen, K. C., & Kubzansky, L. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064418 · Cited by 59 · see citing works
Parenting quality and childrenʼs mental health
Scott, S. (2012) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e328354a1c5 · Cited by 57 · see citing works
Rosenbaum, S., Zeng, S., Campos, F. A., Gesquiere, L. R., Jeanne Altmann, A., Alberts, S. C., Li, F., & Archie, E. A. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2004524117 · Cited by 50 · see citing works
Weathering the storm; a review of pre-pregnancy stress and risk of spontaneous abortion
Frazier, T., HOGUE, C. J. R., Bonney, E. A., Yount, K. M., & Pearce, B. D. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.03.001 · Cited by 53 · see citing works
Prenatal and childhood adverse life events, inflammation and depressive symptoms across adolescence
Flouri, E., Francesconi, M., Midouhas, E., & Lewis, G. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.09.024 · Cited by 53 · see citing works
Kraynak, T. E., Marsland, A. L., Hanson, J. L., & Gianaros, P. J. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.08.186 · Cited by 52 · see citing works
Watt, T. T., Ceballos, N. A., Kim, S., Pan, X., & Sharma, S. (2019) · Journal of Child & Adolescent Trauma · doi:10.1007/s40653-019-00270-4 · Cited by 53 · see citing works
Association between C-reactive protein and suicidal behavior in an adult inpatient population
Gibbs, H. M., Davis, L., Han, X., Clothier, J. L., Eads, L. A., & Cáceda, R. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.04.002 · Cited by 49 · see citing works
Lacey, R. E., Bartley, M., Kelly‐Irving, M., Bevilacqua, L., Iob, E., Kelly, Y. J., & Howe, L. D. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.104914 · Cited by 50 · see citing works
Early adversities accelerate epigenetic aging into adulthood: a 10‐year, within‐subject analysis
Copeland, W., Shanahan, L., McGinnis, E. W., Åberg, K. A., & van den Oord, E. J. C. G. (2022) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13575 · Cited by 48 · see citing works
Petruso, F., Giff, A., Milano, B. A., Rossi, M. M. D., & Saccaro, L. F. (2023) · Neuronal Signaling · doi:10.1042/ns20220077 · Cited by 51 · see citing works
Adversity in preschool-aged children: Effects on salivary interleukin-1β
Tyrka, A. R., Parade, S. H., Valentine, T. R., Eslinger, N. M., & Seifer, R. (2015) · Development and Psychopathology · doi:10.1017/s0954579415000164 · Cited by 46 · see citing works
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Danese, A., & McCrory, E. J. P. (2015) · Wiley eBooks · doi:10.1002/9781118381953.ch29 · Cited by 45 · see citing works
Self-citationOlashore, A. A., Paruk, S., Akanni, O. O., Tomita, A. M., & Chiliza, B. (2020) · AIDS and Behavior · doi:10.1007/s10461-020-03100-z · Cited by 45 · see citing works
- Authors
- Danese, A., Caspi, A., Williams, B., Ambler, A., Sugden, K., Mika, J., Werts, H., Freeman, J., Pariante, C. M., Moffitt, T. E., & Arseneault, L.
- Affiliations
- King's College London (GB)
- Duke University (US)
- Corresponding author
- Danese, A
- Venue
- Molecular Psychiatry
- Published
- 2010-02-16
- Volume
- 16
- Issue
- 3
- Pages
- 244-246
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- PMC
- PMC4212809
- OpenAlex
- W2062221375
- Semantic Scholar
- 6d3ee956cf490db40e8116041c9c1b4022c4fb30
- Cited by
- 301
- References
- 10
- Citations by year
- 2026: 11 · 2025: 11 · 2024: 15 · 2023: 17 · 2022: 26 · 2021: 32 · 2020: 29 · 2019: 24 · 2018: 20 · 2017: 17 · 2016: 25 · 2015: 17 · 2014: 16 · 2013: 16 · 2012: 13
- FWCI
- 14.02
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Economic and Social Research Council (ES/H034897/1)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD061298)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- childhood stress, neuroinflammation, inflammation, childhood trauma, anxiety, P2X7 receptor, child sexual abuse, depressive symptoms, cortical thickness
- MeSH terms
- C-Reactive Protein, Child, Environment, Humans, Inflammation, Longitudinal Studies, Stress, Psychological, Twin Studies as Topic
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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