Cited by 1,434Cystic Fibrosis Research AdvancesPancreatitis Pathology and TreatmentSalivary Gland Disorders and Functions

The DOI matches its Crossref record.

A TEST FOR CONCENTRATION OF ELECTROLYTES IN SWEAT IN CYSTIC FIBROSIS OF THE PANCREAS UTILIZING PILOCARPINE BY IONTOPHORESIS

Gibson, Lewis E., Cooke, Robert E.·1959·Pediatrics

DOI 10.1542/peds.23.3.545

Open this paper in CoChat — free account

Abstract

A method of performing the test for chloride or sodium in the sweat of patients with cystic fibrosis of the pancreas is presented. It utilizes pilocarpine by iontophoresis and has the advantage of being both rapid and painless. Data are presented to show that the method is reliable.

Integrity signals

Registry

Crossref · 10.1542/peds.23.3.545

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 201–300 of 999

Carotenoid levels in normal children and in children with cystic fibrosis
Homnick, D. N., Cox, J. H., DeLoof, M. J., et al. (1993) · The Journal of Pediatrics · doi:10.1016/s0022-3476(06)80008-9 · Cited by 74
Self-administered chest physiotherapy in cystic fibrosis: A comparative study of high-pressure pep and autogenic drainage
Pfleger, A., Theissl, B., Oberwaldner, B., et al. (1992) · Lung · doi:10.1007/bf00177578 · Cited by 73
Mutations of the Cystic Fibrosis Gene and Intermediate Sweat Chloride Levels in Children
Lebecque, P., Leal, T., Boeck, C. D., Jaspers, M., Cuppens, H., & Cassiman, J. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.165.6.2104073 · Cited by 73
Applying Cystic Fibrosis Transmembrane Conductance Regulator Genetics and CFTR2 Data to Facilitate Diagnoses
Sosnay, P. R., Salinas, D. B., White, T. B., Ren, C. L., Farrell, P. M., Raraigh, K. S., Girodon, E., & Castellani, C. (2017) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2016.09.063 · Cited by 74
Implementation of the French Nationwide Cystic Fibrosis Newborn Screening Program
Munck, À., Dhondt, J., Sahler, C., et al. (2008) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2008.02.028 · Cited by 73
Chloride-Sensitive Fluorescent Indicators
Geddes, C. D., Apperson, K., Karolin, J. O., et al. (2001) · Analytical Biochemistry · doi:10.1006/abio.2001.5103 · Cited by 73
Variability of airways hyper-reactivity and allergy in cystic fibrosis.
Holzer, F. J., Olinsky, A., & Phelan, P. D. (1981) · Archives of Disease in Childhood · doi:10.1136/adc.56.6.455 · Cited by 73
Sixty-five years since the New York heat wave: Advances in sweat testing for cystic fibrosis
Collie, J. T. B., Massie, J., Jones, O. A. H., LeGrys, V. A., & Greaves, R. F. (2013) · Pediatric Pulmonology · doi:10.1002/ppul.22945 · Cited by 73
“The standardization of the sweat test, by Gibson and Cooke [Gibson and Cooke (1959) Pediatrics 1959;23:5], followed observations of excessive dehydration amongst patients with CF and confirmed the utility as a diagnostic test.”
Method
CFTR genotypes in patients with normal or borderline sweat chloride levels
Feldmann, D., Couderc, R., Audrézet, M., Férec, C., Bienvenu, T., Desgeorges, M., Claustres, M., Mittre, H., Blayau, M., Bozon, D., et al. (2003) · Human Mutation · doi:10.1002/humu.9183 · Cited by 72
“Sweat secretion was induced by pilocarpine iontophoresis described in the Gibson and Cooke method [Gibson et al., 1959] and collected using different systems, such as Exsudose R patch, Macroduct R coil or onto gauze or filter paper.”
Method
Pathological changes of the lateral nasal wall in patients with cystic fibrosis (mucoviscidosis)
Brihaye, P., Clement, P. A. R., Dab, I., et al. (1994) · International Journal of Pediatric Otorhinolaryngology · doi:10.1016/0165-5876(94)90005-1 · Cited by 72
THE ECCRINE SWEAT DEFECT IN CYSTIC FIBROSIS OF THE PANCREAS (MUCOVISCIDOSIS)
di Sant'Agnese, P. A., & Powell, G. F. (1962) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1962.tb30494.x · Cited by 72
Saliva as a potential tool for cystic fibrosis diagnosis
Gonçalves, A. C., Marson, F. A. L., de Mendonça, R. M. H., Ribeiro, J. D., Ribeiro, A. F., Paschoal, I. A., & Levy, C. E. (2013) · Diagnostic Pathology · doi:10.1186/1746-1596-8-46 · Cited by 71
“Gibson LE, Cooke RE: A test for concentration of electrolytes in sweat in cystic fibrosis of the pancreas utilizing pilocarpine by iontophoresis.”
BackgroundInfluential
Oligohydrosis and Hyperthermia: Pilot Study of a Novel Topiramate Adverse Effect
Ben‐Zeev, B., Watemberg, N. M., Augarten, A., Brand, N. R., Yahav, Y., Efrati, O., Topper, L., & Blatt, I. (2003) · Journal of Child Neurology · doi:10.1177/08830738030180041001 · Cited by 71
Reliability of sweat-testing by the Macroduct collection method combined with conductivity analysis in comparison with the classic Gibson and Cooke technique
Mastella, G., Cesare, G. D., Borruso, A., Menin, L., & Zanolla, L. (2000) · Acta Paediatrica · doi:10.1080/080352500750043378 · Cited by 68
Practical considerations in iontophoresis of fluoride for desensitizing dentin
Gangarosa, L. P., & Park, N. H. (1978) · Journal of Prosthetic Dentistry · doi:10.1016/s0022-3913(78)80017-1 · Cited by 70
Sweat conductivity and chloride titration for cystic fibrosis diagnosis in 3834 subjects
Lezana, J. L., Vargas, M. H., Bechara, J. K., Vergara, R. S. A., & Furuya, M. E. Y. (2003) · Journal of Cystic Fibrosis · doi:10.1016/s1569-1993(02)00146-7 · Cited by 68
Cystic fibrosis at a Brazilian center of excellence: clinical and laboratory characteristics of 104 patients and their association with genotype and disease severity
Alvarez, A. E., Ribeiro, A. F., Hessel, G., et al. (2004) · Jornal de Pediatria · doi:10.2223/1221 · Cited by 70
Development and Critical Evaluation of Fluorescent Chloride Nanosensors
Graefe, A., Stanca, S. E., Nietzsche, S., Kubicová, L., Beckert, R., Biskup, C. U., & Mohr, G. J. (2008) · Analytical Chemistry · doi:10.1021/ac800115u · Cited by 70
Report of the Committee for a Study for Evaluation of Testing for Cystic Fibrosis
(1976) · The Journal of Pediatrics · doi:10.1016/s0022-3476(76)81041-4 · Cited by 70
Newborn screening for cystic fibrosis: Its evolution and a review of the current situation
Wilcken, B. M. (1993) · Screening · doi:10.1016/0925-6164(93)90017-d · Cited by 70
Physiologic Evidence for the Efficacy of Positive Expiratory Pressure as an Airway Clearance Technique in Patients With Cystic Fibrosis
Darbee, J. C., Ohtake, P. J., Grant, B. J. B., et al. (2004) · Physical Therapy · doi:10.1093/ptj/84.6.524 · Cited by 69
Determinants of chronic infection with Staphylococcus aureus in patients with bronchiectasis
Shah, P. L., Mawdsley, S., Nash, K. L., Cullinan, P., COLE, P. J., & Wilson, R. (1999) · European Respiratory Journal · doi:10.1183/09031936.99.14613409 · Cited by 66
Hydrogel Micropatch and Mass Spectrometry–Assisted Screening for Psoriasis-Related Skin Metabolites
Dutkiewicz, E. P., Hsieh, K.-T., Wang, Y., et al. (2016) · Clinical Chemistry · doi:10.1373/clinchem.2016.256396 · Cited by 69
Psychological impact of false-positive results when screening for cystic fibrosis
Tluczek, A., Mischler, E. H., Bowers, B. J., Peterson, N. M., Morris, M. E., Farrell, P. M., Bruns, W. T., Colby, H., McCarthy, C., Fost, N., et al. (1991) · Pediatric Pulmonology · doi:10.1002/ppul.1950110707 · Cited by 69
Long-Term Outcomes of Children with Intermediate Sweat Chloride Values in Infancy
Groves, T., Robinson, P. D., Wiley, V. C., & Fitzgerald, D. A. (2015) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2015.01.052 · Cited by 67
“Sweat chloride levels were determined using the method established by Gibson and Cooke throughout the entire study period.(16) A retrospective medical chart review was performed of all patients with an intermediate sweat chloride value who progressed to a delayed formal CF diagnosis, termed “delayed CF.”
Method
Cystic fibrosis: Exploiting its genetic basis in the hunt for new therapies
Kreindler, J. L. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.10.006 · Cited by 72
“These findings led directly to the development of the sweat test as a diagnostic test for CF (Gibson & Cooke, 1959).”
Background
Aerosolized Recombinant Human DNase in Hospitalized Cystic Fibrosis Patients With Acute Pulmonary Exacerbations
Wilmott, R. W., Amin, R. S., Colin, A. A., et al. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.153.6.8665055 · Cited by 68
Uncertainty in the diagnosis of cystic fibrosis: Possible role of in vivo nasal potential difference measurements
Wilson, D. C., Ellis, L. E., Zielenski, J., et al. (1998) · The Journal of Pediatrics · doi:10.1016/s0022-3476(98)70345-2 · Cited by 68
Identification of Allergic Bronchopulmonary Aspergillosis in Cystic Fibrosis Patients by Recombinant Aspergillus Fumigatus I/A-Specific Serology
Nikolaizik, W. H., Moser, M., Crameri, R., et al. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.152.2.7633719 · Cited by 68
Benign missense variations in the cystic fibrosis gene.
The University of North Carolina at Chapel Hill University Libraries (2020) · PubMed · doi:10.17615/aa3b-we90 · Cited by 68
Assessment of Aspergillus sensitization or persistent carriage as a factor in lung function impairment in cystic fibrosis patients
Fillaux, J., Brémont, F., Murris, M., Cassaing, S., Rittié, J. L., Tetu, L., Segonds, C., Abbal, M., Bieth, É., Berry, A., et al. (2012) · Scandinavian Journal of Infectious Diseases · doi:10.3109/00365548.2012.695454 · Cited by 66
Genotype–phenotype correlation and functional studies in patients with cystic fibrosis bearing CFTR complex alleles
Terlizzi, V., Castaldo, G., Salvatore, D., et al. (2016) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2016-103985 · Cited by 67
Activation of CFTR chloride current by nitric oxide in human T lymphocytes.
Dong, Y., Chao, A. C., Kouyama, K., et al. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07270.x · Cited by 67
Sputum induction in young cystic fibrosis patients
Boeck, K. D., Alifier, M., & Vandeputte, S. (2000) · European Respiratory Journal · doi:10.1034/j.1399-3003.2000.16a16.x · Cited by 67
Sputum peroxidase activity correlates with the severity of lung disease in cystic fibrosis
Regelmann, W. E., Siefferman, C. M., Herron, J. M., et al. (1995) · Pediatric Pulmonology · doi:10.1002/ppul.1950190102 · Cited by 66
Deficiency of vitamins E and A in cystic fibrosis is independent of pancreatic function and current enzyme and vitamin supplementation
Lancellotti, L., D’Orazio, C., Mastella, G., et al. (1996) · European Journal of Pediatrics · doi:10.1007/bf02002713 · Cited by 66
Home nebulizer use among patients with cystic fibrosis
Rosenfeld, M., Emerson, J., Astley, S. J., et al. (1998) · The Journal of Pediatrics · doi:10.1016/s0022-3476(98)70497-4 · Cited by 66
The Molecular Biology of Cystic Fibrosis
Sferra, T. J., & Collins, F. S. (1993) · Annual Review of Medicine · doi:10.1146/annurev.me.44.020193.001025 · Cited by 66
Cystic Fibrosis—A Challenging Long-Term Chronic Disease
Matthews, L. W., & Drotar, D. (1984) · Pediatric Clinics of North America · doi:10.1016/s0031-3955(16)34541-2 · Cited by 66
Severe bradycardia due to interaction of timolol eye drops and verapamil.
Pringle, S. D., & MacEwen, C. J. (1987) · BMJ · doi:10.1136/bmj.294.6565.155-a · Cited by 65
Respiratory impedance in children with cystic fibrosis using forced oscillations in clinic
Gangell, C. L., Horak, F., Patterson, H. J., Sly, P. D., Stick, S. M., & Hall, G. L. (2007) · European Respiratory Journal · doi:10.1183/09031936.00003407 · Cited by 64
Female patients with cystic fibrosis suffer from reproductive endocrinological disorders despite good clinical status
Johannesson, M., Landgren, B.-M., Csemiczky, G., Hjelte, L., & Gottlieb, C. (1998) · Human Reproduction · doi:10.1093/humrep/13.8.2092 · Cited by 67
“The criteria were: (i) diagnosis of CF in childhood with positive sweat test (Gibson and Cooke, 1959), (ii) known age at menarche, (iii) 20–35 years of age, (iv) regular menstruation (25–35 days), (v) stable good clinical condition without signs of acute exacerbation of the illness, (vi) no liver…”
Method
Cystic fibrosis in the Ohio Amish: Gene frequency and founder effect
Klinger, K. W. (1983) · Human Genetics · doi:10.1007/bf00286641 · Cited by 64
Mutations of the CFTR Gene in Pancreatic Disease
Pezzilli, R., Morselli‐Labate, A. M., Mantovani, V., et al. (2003) · Pancreas · doi:10.1097/00006676-200311000-00011 · Cited by 64
Sweat secretion, stratum corneum hydration, small nerve function and pruritus in patients with advanced chronic renal failure
Yosipovitch, G., Reis, J., Tur, E., Sprecher, E., Yarnitsky, D., & Boner, G. (1995) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1995.tb02705.x · Cited by 64
Cystic fibrosis‐related deaths in infancy and the effect of newborn screening
Doull, I. J. M., Ryley, H. C., Weller, P. H., et al. (2001) · Pediatric Pulmonology · doi:10.1002/ppul.1059 · Cited by 64
Rise in total IgE as an indicator of allergic bronchopulmonary aspergillosis in cystic fibrosis.
Marchant, J. L., Warner, J. O., & Bush, A. (1994) · Thorax · doi:10.1136/thx.49.10.1002 · Cited by 64
3849+10 kb C→T mutation and disease severity in cystic fibrosis
Stern, R. C., Doershuk, C. F., & Drumm, M. L. (1995) · The Lancet · doi:10.1016/s0140-6736(95)92165-6 · Cited by 64
Fabrication of laser-induced graphene-based multifunctional sensing platform for sweat ion and human motion monitoring
Lee, C., Jeong, S., Kwon, Y., Lee, J.-U., Cho, S., & Shin, B. S. (2021) · Sensors and Actuators A Physical · doi:10.1016/j.sna.2021.113320 · Cited by 67
Microprocessor controlled transdermal drug delivery
Subramony, J. A., Sharma, A., & Phipps, J. B. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.03.053 · Cited by 63
Genotype–Phenotype Correlations for the Paranasal Sinuses in Cystic Fibrosis
Jorissen, M., Boeck, K. D., & Cuppens, H. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.159.5.9712056 · Cited by 63
Novel, rare and common pathogenic variants in the CFTR gene screened by high-throughput sequencing technology and predicted by in silico tools
Pereira, S. V.-N., Ribeiro, J. D., Ribeiro, A. F., Bertuzzo, C. S., & Marson, F. A. L. (2019) · Scientific Reports · doi:10.1038/s41598-019-42404-6 · Cited by 61
The sweat test: Sodium and chloride values
Shwachman, H., Mahmoodian, A., & Neff, R. K. (1981) · The Journal of Pediatrics · doi:10.1016/s0022-3476(81)80764-0 · Cited by 62
Sweat conductivity: An accurate diagnostic test for cystic fibrosis?
Mattar, A. C. V., Leone, C., Rodrigues, J. C., & Adde, F. V. (2014) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2014.01.002 · Cited by 60
Cystic fibrosis in Asians.
Bowler, I. M., Estlin, E., & Littlewood, J. M. (1993) · Archives of Disease in Childhood · doi:10.1136/adc.68.1.120 · Cited by 60
Physiologic Evidence for High-Frequency Chest Wall Oscillation and Positive Expiratory Pressure Breathing in Hospitalized Subjects With Cystic Fibrosis
Darbee, J. C., Kanga, J. F., & Ohtake, P. J. (2005) · Physical Therapy · doi:10.1093/ptj/85.12.1278 · Cited by 61
Effects of beta-carotene supplementation for six months on clinical and laboratory parameters in patients with cystic fibrosis
Renner, S. (2001) · Thorax · doi:10.1136/thorax.56.1.48 · Cited by 60
Integrated non-invasive biochemical and biophysical sensing systems for health and performance monitoring: A systems perspective
Yokus, M. A., & Daniele, M. A.-A. (2021) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2021.113249 · Cited by 62
Point-of-need diagnosis of cystic fibrosis using a potentiometric ion-selective electrode array
Lynch, A., Diamond, D., & Leader, M. (2000) · The Analyst · doi:10.1039/b006379g · Cited by 61
Pancreatic function and gene deletion F508 in cystic fibrosis.
Borgo, G., Mastella, G., Gasparini, P., et al. (1990) · Journal of Medical Genetics · doi:10.1136/jmg.27.11.665 · Cited by 59
Low sweat electrolytes in a patient with cystic fibrosis
Davis, P. B., Hubbard, V. S., & di Sant'Agnese, P. A. (1980) · The American Journal of Medicine · doi:10.1016/0002-9343(80)90482-9 · Cited by 59
CFTR mutations and IVS8-5T variant in newborns with hypertrypsinaemia and normal sweat test.
Castellani, C., Bonizzato, A., & Mastella, G. (1997) · Journal of Medical Genetics · doi:10.1136/jmg.34.4.297 · Cited by 59
The significance of sweat Cl/Na ratio in patients with borderline sweat test
Augarten, A., Hacham, S., Kerem, E., Kerem, B. S., Szeinberg, A., Laufer, J., Doolman, R., Altshuler, R., Blau, H., Bentur, L., et al. (1995) · Pediatric Pulmonology · doi:10.1002/ppul.1950200606 · Cited by 58
CHRONIC PSEUDOMONAS AERUGINOSA LUNG INFECTION IN CYSTIC FIBROSIS
Schiøtz, P. O., Jørgensen, M. H., Flensborg, E. W., et al. (1983) · Acta Paediatrica · doi:10.1111/j.1651-2227.1983.tb09712.x · Cited by 58
Effects of inhaled gentamicin prophylaxis on acquisition of Pseudomonas aeruginosa in children with cystic fibrosis: A pilot study*
Heinzl, B., Eber, E., Oberwaldner, B., Haas, G., & Zach, M. S. (2001) · Pediatric Pulmonology · doi:10.1002/ppul.10019 · Cited by 58
Conductivity of Drugs Used for Iontophoresis
Gangarosa, L. P., Park, N. H., Fong, B. C., et al. (1978) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600671031 · Cited by 58
Epidermal Wearable Biosensors for Monitoring Biomarkers of Chronic Disease in Sweat
Yuan, X., Li, C., Yin, X., Yang, Y., Ji, B., Niu, Y., & Ren, L. M. (2023) · Biosensors · doi:10.3390/bios13030313 · Cited by 58
“In 1959, Gibson and Cooke [94] developed the iontophoresis method; they used the cationic drug pilocarpine to produce sweat.”
Method
Nanoduct® sweat testing for rapid diagnosis in newborns, infants and children with cystic fibrosis
Desax, M.-C., Ammann, R. A., Hammer, J., Schoeni, M. H., & Barben, J. (2007) · European Journal of Pediatrics · doi:10.1007/s00431-007-0485-0 · Cited by 56
“In 13 patients, the diagnosis of CF was ruled out either by using genetic testing or normal chloride by conventional Macroduct® or Gibson and Cooke.”
MethodInfluential
Cystic-fibrosis-like disease unrelated to the cystic fibrosis transmembrane conductance regulator
Mekus, F., Ballmann, M., Bronsveld, I., et al. (1998) · Human Genetics · doi:10.1007/s004390050744 · Cited by 57
“On the occasion of severe pneumonia at the age of 17, he was diagnosed as having CF as the result of having a chloride concentration of 102 mmol/l in the pilocarpine iontophoresis sweat test (Gibson and Cooke 1959).”
BackgroundMethodInfluential
Increased nasal potential difference and amiloride sensitivity in neonates with cystic fibrosis
Gowen, C. W., Lawson, E. E., Gingras-Leatherman, J. L., Gatzy, J. T., Boucher, R. C., & Knowles, M. R. (1986) · The Journal of Pediatrics · doi:10.1016/s0022-3476(86)80825-3 · Cited by 57
Sweat tests to diagnose cystic fibrosis in adults.
Hodson, M. E., Beldon, I., Power, R. G., et al. (1983) · BMJ · doi:10.1136/bmj.286.6375.1381 · Cited by 57
Proteomic profiling of eccrine sweat reveals its potential as a diagnostic biofluid for active tuberculosis
Adewole, O., Erhabor, G. E., Adewole, T. O., Ojo, A. O., Oshokoya, H., Wolfe, L. M., & Prenni, J. E. (2016) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201500071 · Cited by 55
“Despite this, the only current clinical utility of sweat has been in the diagnosis of cystic fibrosis based on sweat chloride content, a specific reflection of the pathophysiology of this disease [20].”
Background
Wearable non-invasive monitors of diabetes and hypoxia through continuous analysis of sweat
Karpova, E. V., Karyakina, E. E., & Karyakin, A. A. (2020) · Talanta · doi:10.1016/j.talanta.2020.120922 · Cited by 59
Circulating Adhesion Molecules in Cystic Fibrosis
Rose, V. D., OLIVA, A., Messore, B., et al. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.4.9704134 · Cited by 56
“The diagnosis of cystic fibrosis was based on a typical clinical profile with a positive sweat test; sweat test was carried out by quantitative pilocarpine iontophoresis according to Gibson and Cooke (25), and repeatedly elevated sweat chloride levels ( .”
Method
Chest physiotherapy in hospitalized patients with cystic fibrosis: a study of lung function effects and sputum production
Oberwaldner, B., Theissl, B., Rucker, A., et al. (1991) · European Respiratory Journal · doi:10.1183/09031936.93.04020152 · Cited by 56
Laboratory Diagnosis of Cystic Fibrosis
Webster, H. L., & Rundell, C. A. (1982) · CRC Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408368209085074 · Cited by 55
Accelerating implementation of biomedical research advances: critical elements of a successful 10 year Cystic Fibrosis Foundation healthcare delivery improvement initiative
Marshall, B. C., & Nelson, E. C. (2014) · BMJ Quality & Safety · doi:10.1136/bmjqs-2013-002790 · Cited by 54
A comparative study of copper, lead, cadmium and zinc in human sweat and blood
Stauber, J. L., & Florence, T. M. (1988) · The Science of The Total Environment · doi:10.1016/0048-9697(88)90140-4 · Cited by 55
Psychological Effects of False-Positive Results in Cystic Fibrosis Newborn Screening: A Two-Year Follow-Up
Beucher, J., Leray, E., Deneuville, E., et al. (2010) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2009.12.003 · Cited by 54
Sweat lipid mediator profiling: a noninvasive approach for cutaneous research
Agrawal, K., Hassoun, L. A., Foolad, N., Pedersen, T. L., Sivamani, R. K., & Newman, J. W. I. (2016) · Journal of Lipid Research · doi:10.1194/jlr.m071738 · Cited by 54
Primary Sclerosing Cholangitis in Childhood is Associated with Abnormalities in Cystic Fibrosis–Mediated Chloride Channel Function
Pall, H., Zielenski, J., Jonas, M. M., et al. (2007) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2007.03.062 · Cited by 54
Indirect measurements of sweat electrolyte concentration in the laboratory diagnosis of cystic fibrosis
Heeley, M. E. (2000) · Archives of Disease in Childhood · doi:10.1136/adc.82.5.420 · Cited by 52
Comparing the American and European diagnostic guidelines for cystic fibrosis: same disease, different language?
Ooi, C. Y., Dupuis, A., Ellis, L. E., Jarvi, K. A., Martin, S., Gonska, T. Y., Dorfman, R., Kortan, P. P., Solomon, M. P., Tullis, E. D., et al. (2012) · Thorax · doi:10.1136/thoraxjnl-2011-201454 · Cited by 50
Analysis of the entire coding region of the cystic fibrosis transmembrane regulator gene in idiopathic pancreatitis
Castellani, C., Gomez‐Lira, M., Frulloni, L., et al. (2001) · Human Mutation · doi:10.1002/humu.1172 · Cited by 53
Correction of Linoleic Acid Deficiency in Cystic Fibrosis
Mischler, E. H., Parrell, S. W., Farrell, P. M., et al. (1986) · Pediatric Research · doi:10.1203/00006450-198601000-00010 · Cited by 53
“All patients had a quantitative sweat test by the method of Gibson and Cooke (9) of pilocarpine iontophoresis, plasma fatty acid profile, red blood cell fatty acid analysis, plasma carotene, tocopherol, tests intended to detect any possible side effects of Microlipid (platelet count, serum cholesterol, triglycerides,…”
Method
Does extensive genotyping and nasal potential difference testing clarify the diagnosis of cystic fibrosis among patients with single-organ manifestations of cystic fibrosis?
Ooi, C. Y., Dupuis, A., Ellis, L. E., et al. (2013) · Thorax · doi:10.1136/thoraxjnl-2013-203832 · Cited by 52
Cystic fibrosis on the African continent
Stewart, C., & Pepper, M. S. (2015) · Genetics in Medicine · doi:10.1038/gim.2015.157 · Cited by 55
Differential cytokine profile in children with cystic fibrosis
Brázová, J., Šedivá, A., Pospísilová, D., et al. (2005) · Clinical Immunology · doi:10.1016/j.clim.2005.01.013 · Cited by 52
Serum antibodies to Pseudomonas aeruginosa in cystic fibrosis.
Brett, M. M., Ghoneim, A. T. M., & Littlewood, J. M. (1986) · Archives of Disease in Childhood · doi:10.1136/adc.61.11.1114 · Cited by 52
Conductivity determined by a new sweat analyzer compared with chloride concentrations for the diagnosis of cystic fibrosis
Barben, J., Ammann, R. A., Metlagel, A., & Schoeni, M. H. (2005) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2004.08.085 · Cited by 51
Increased mole fraction of arachidonic acid in bronchial phospholipids in patients with cystic fibrosis
Gilljam, H., Strandvik, B., Ellin, Å., et al. (1986) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365518609083706 · Cited by 52
Pulmonary Function and Clinical Observations in Men With Congenital Bilateral Absence of the Vas Deferens
Colin, A. A., Sawyer, S. M., Mickle, J. E., Oates, R. D., Milunsky, A., & Amos, J. A. (1996) · CHEST Journal · doi:10.1378/chest.110.2.440 · Cited by 50
THE SWEAT TEST IN CYSTIC FIBROSIS
Shwachman, H., & Antonowicz, I. (1962) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1962.tb30495.x · Cited by 51
Iontophoresis–gentamicin delivery into the rabbit cornea, using a hydrogel delivery probe
Frucht‐Pery, J., Mechoulam, H., Siganos, C. S., et al. (2003) · Experimental Eye Research · doi:10.1016/s0014-4835(03)00215-x · Cited by 51
Relation of sweat chloride concentration to severity of lung disease in cystic fibrosis
Davis, P. B., SCHLUCHTER, M. D., & Konstan, M. W. (2004) · Pediatric Pulmonology · doi:10.1002/ppul.20054 · Cited by 51
Iontophoresis: an alternative to the use of carriers in cutaneous drug delivery
Singh, P., & Maïbach, H. I. (1996) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(95)00082-i · Cited by 51
Improved sweat test method for the diagnosis of cystic fibrosis.
Carter, E. P., Barrett, A. D. T., Heeley, A. F., & Kuzemko, J. A. (1984) · Archives of Disease in Childhood · doi:10.1136/adc.59.10.919 · Cited by 47
Serum fatty acid profiles in cystic fibrosis patients and their parents
Christophe, A., Warwick, W. J., & Holman, R. T. (1994) · Lipids · doi:10.1007/bf02536629 · Cited by 51
Normativa del diagnóstico y el tratamiento de la afección respiratoria en la fibrosis quística
Máiz, L., Baranda, F., Coll, R., Prados, C., Vendrell, M., Escribano, A., Gärtner, S., de Gracia, S., Martínez, M. T., Salcedo, A., et al. (2001) · Archivos de Bronconeumología · doi:10.1016/s0300-2896(01)75101-0 · Cited by 49
The Biogenesis, Traffic, and Function of the Cystic Fibrosis Transmembrane Conductance Regulator
Jilling, T., & Kirk, K. L. (1997) · International review of cytology · doi:10.1016/s0074-7696(08)62361-x · Cited by 51

Authors: Gibson, L. E., & Cooke, R. E.
Affiliations: Johns Hopkins University (US)
Venue: Pediatrics
Publisher: American Academy of Pediatrics (AAP)
Published: 1959-03-01
Volume: 23
Issue: 3
Pages: 545-549
ISSN: 0031-4005 (ISSN-L)
1098-4275
DOI: 10.1542/peds.23.3.545
OpenAlex: W1946951765
Cited by: 1,434
References: 0
Citations by year: 2026: 17 · 2025: 21 · 2024: 24 · 2023: 24 · 2022: 15 · 2021: 34 · 2020: 41 · 2019: 37 · 2018: 37 · 2017: 42 · 2016: 37 · 2015: 32 · 2014: 35 · 2013: 30 · 2012: 39
FWCI: 27.70
Type: journal article
Language: en
Open access: closed
Locations: PEDIATRICS (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
Health Sciences › Medicine › Physiology (medical) › Salivary Gland Disorders and Functions
Keywords: cystic fibrosis, sweat test, sweat electrolytes, chloride, sodium, pilocarpine, iontophoresis
MeSH terms: Chlorides, Cystic Fibrosis, Electrolytes, Humans, Iontophoresis, Pilocarpine, Sodium, Sodium, Dietary, Sweat

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A TEST FOR CONCENTRATION OF ELECTROLYTES IN SWEAT IN CYSTIC FIBROSIS OF THE PANCREAS UTILIZING PILOCARPINE BY IONTOPHORESIS

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks