Cited by 1,434Cystic Fibrosis Research AdvancesPancreatitis Pathology and TreatmentSalivary Gland Disorders and Functions

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A TEST FOR CONCENTRATION OF ELECTROLYTES IN SWEAT IN CYSTIC FIBROSIS OF THE PANCREAS UTILIZING PILOCARPINE BY IONTOPHORESIS

Gibson, Lewis E., Cooke, Robert E.·1959·Pediatrics

DOI 10.1542/peds.23.3.545

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Abstract

A method of performing the test for chloride or sodium in the sweat of patients with cystic fibrosis of the pancreas is presented. It utilizes pilocarpine by iontophoresis and has the advantage of being both rapid and painless. Data are presented to show that the method is reliable.

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Crossref · 10.1542/peds.23.3.545

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BackgroundMethod
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Method
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Pathogenesis and Physiopathology of Cystic Fibrosis of the Pancreas
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Influential
Cystic fibrosis
Mall, M. A., Burgel, P., Castellani, C., Davies, J. C., Salathe, M. A., & Taylor‐Cousar, J. L. (2024) · Nature Reviews Disease Primers · doi:10.1038/s41572-024-00538-6 · Cited by 236
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Background
Delivery of Gentamicin to the Rabbit Eye by Drug-Loaded Hydrogel Iontophoresis
Eljarrat‐Binstock, E., Raiskup, F., Stepensky, D., Domb, A. J., & Frucht‐Pery, J. (2004) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.03-1294 · Cited by 192
Inflammatory Responses to Individual Microorganisms in the Lungs of Children With Cystic Fibrosis
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Method
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State of Sweat: Emerging Wearable Systems for Real-Time, Noninvasive Sweat Sensing and Analytics
Ghaffari, R., Yang, D. S., Kim, J., Mansour, A., Wright, J. A., Model, J. B., Wright, D. E., Rogers, J. A., & Ray, T. R. (2021) · ACS Sensors · doi:10.1021/acssensors.1c01133 · Cited by 187
“Established clinically in 1959 148 , quantitative evaluation of sweat chloride in neonates remains the only widely available method for confirmatory diagnosis of cystic fibrosis.”
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Self-citation
Quantitative assessment of exocrine pancreatic function in infants and children
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Recent progress in ocular drug delivery for posterior segment disease: Emphasis on transscleral iontophoresis
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Early Diagnosis of Fibrocystic Disease
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“The second group (n = 11) was composed of patients with chronic inflammatory lung disease (bronchiectasis) who had been previously shown not to have cystic fibrosis by pilocarpine iontophoresis (14).”
Background
Wearable Devices for Precision Medicine and Health State Monitoring
Jeong, I. C., Bychkov, D., & Searson, P. C. (2019) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2018.2871638 · Cited by 155
“150 mM [196], [197], much higher than in healthy individuals (typically 10–40 mM), and hence sweat chloride testing is the most widely used assay for diagnosis of CF [196], [198].”
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Lubamba, B., Dhooghe, B., Noël, S., & Leal, T. (2012) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2012.05.034 · Cited by 151
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“Sweat chloride analysis was performed in 23% of CBAVD alleles (50/220) and 12% of those with 59 individuals (Gibson and Cooke, 1959).”
Method
Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation
Stefano, D. D., Villella, V. R., Esposito, S., Tosco, A., Sepe, A. O., Gregorio, F. D., Salvadori, L., Grassia, R., Leone, C. A., Rosa, G. D., et al. (2014) · Autophagy · doi:10.4161/15548627.2014.973737 · Cited by 149
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Method
Micropuncture studies of the sweat formation in cystic fibrosis patients
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Mild cystic fibrosis and normal or borderline sweat test in patients with the 3849 + 10 kb C → T mutation
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BackgroundMethod
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“Based on the observation that the sweat of CF patients is salty, which was first made by Paul di Sant’Agnese in 1953 [10], Gibson and Cooke developed in 1959 [11] the standardized sweat test by pilocarpine iontophoresis, which still remains the gold standard for diagnosing CF and demonstrating the associated Cl− defec…”
Background
Sweat Composition in Relation to Rate of Sweating in Patients with Cystic Fibrosis of the Pancreas
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Targeting a genetic defect: cystic fibrosis transmembrane conductance regulator modulators in cystic fibrosis
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Authors: Gibson, L. E., & Cooke, R. E.
Affiliations: Johns Hopkins University (US)
Venue: Pediatrics
Publisher: American Academy of Pediatrics (AAP)
Published: 1959-03-01
Volume: 23
Issue: 3
Pages: 545-549
ISSN: 0031-4005 (ISSN-L)
1098-4275
DOI: 10.1542/peds.23.3.545
OpenAlex: W1946951765
Cited by: 1,434
References: 0
Citations by year: 2026: 17 · 2025: 21 · 2024: 24 · 2023: 24 · 2022: 15 · 2021: 34 · 2020: 41 · 2019: 37 · 2018: 37 · 2017: 42 · 2016: 37 · 2015: 32 · 2014: 35 · 2013: 30 · 2012: 39
FWCI: 27.70
Type: journal article
Language: en
Open access: closed
Locations: PEDIATRICS (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
Health Sciences › Medicine › Physiology (medical) › Salivary Gland Disorders and Functions
Keywords: cystic fibrosis, sweat test, sweat electrolytes, chloride, sodium, pilocarpine, iontophoresis
MeSH terms: Chlorides, Cystic Fibrosis, Electrolytes, Humans, Iontophoresis, Pilocarpine, Sodium, Sodium, Dietary, Sweat

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A TEST FOR CONCENTRATION OF ELECTROLYTES IN SWEAT IN CYSTIC FIBROSIS OF THE PANCREAS UTILIZING PILOCARPINE BY IONTOPHORESIS

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