Molecular and metabolic insights of creatine supplementation on resistance training
Open accessAbstract
En los últimos años el problema de investigación en el campo de la suplementación deportiva ha cambiado al punto de explicar los mecanismos metabólicos por los cuales la administración de creatina (Cr) incrementa el rendimiento en ciertos deportes o simplemente beneficia la adaptación muscular. Esta revisión analiza por primera vez los mecanismos bioquímicos de la ingesta de Cr desde la perspectiva de señalización celular, enfocándose en la mayor biodisponibilidad energética de Cr y optimización de la acción buffer espacial/ temporal que ofrece el sistema Cr/PCr/CK. Además, se examinan aspectos relacionados con el incremento en los procesos de proliferación y diferenciación de células musculares (IGF-I/PI3K/Akt-PKB, SPHK1/ MAPK/p38/MRFs, mTOR, hinchamiento celular, actividad mitótica de células satélite, polimerización de actina y fusión de mioblastos) y la inactivación y/o reducción en la expresión de proteínas con funciones ergolíticas (GSK3β, miostatina y regulación de AMPK). De esta manera, se explican el aumento de la masa muscular, la fuerza, la resistencia a la fatiga y el rendimiento en ejercicios de alta intensidad, producidos por la suplementación con monohidrato de Cr, desde un punto de vista metabólico.
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Egzersiz Sonrası Kullanılan Toparlanma Stratejilerinin Fizyolojik Parametrelere Etkisi
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- Authors
- Bonilla, D. A., & Moreno, Y.
- Affiliations
- Universidad Distrital Francisco José de Caldas (CO)
- University of Southampton (GB)
- ORCID
- Bonilla, Diego A.
- Venue
- Revista Colombiana de Química
- Publisher
- Universidad Nacional de Colombia
- Published
- 2016-02-08
- Volume
- 44
- Issue
- 1
- Pages
- 11-18
- ISSN
- 0120-2804 (ISSN-L)
- 2357-3791
- OpenAlex
- W2266145772
- Cited by
- 14
- References
- 76
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 1 · 2018: 3
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
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- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Redalyc (Universidad Autónoma del Estado de México) (submittedVersion)
- Greater South Information System
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Biochemical effects in animals
- Keywords
- creatine supplementation, creatine monohydrate, resistance training, creatine kinase, phosphocreatine, satellite cells, myoblast fusion, mTOR signaling, MAPK signaling, GSK3β, myostatin, AMPK, muscle hypertrophy, fatigue resistance, athletic performance
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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