Cited by 14Muscle metabolism and nutritionMuscle Physiology and DisordersBiochemical effects in animals

Molecular and metabolic insights of creatine supplementation on resistance training

Open access
Bonilla, Diego A., Moreno, Yurany·2016·Revista Colombiana de Química

Abstract

En los últimos años el problema de investigación en el campo de la suplementación deportiva ha cambiado al punto de explicar los mecanismos metabólicos por los cuales la administración de creatina (Cr) incrementa el rendimiento en ciertos deportes o simplemente beneficia la adaptación muscular. Esta revisión analiza por primera vez los mecanismos bioquímicos de la ingesta de Cr desde la perspectiva de señalización celular, enfocándose en la mayor biodisponibilidad energética de Cr y optimización de la acción buffer espacial/ temporal que ofrece el sistema Cr/PCr/CK. Además, se examinan aspectos relacionados con el incremento en los procesos de proliferación y diferenciación de células musculares (IGF-I/PI3K/Akt-PKB, SPHK1/ MAPK/p38/MRFs, mTOR, hinchamiento celular, actividad mitótica de células satélite, polimerización de actina y fusión de mioblastos) y la inactivación y/o reducción en la expresión de proteínas con funciones ergolíticas (GSK3β, miostatina y regulación de AMPK). De esta manera, se explican el aumento de la masa muscular, la fuerza, la resistencia a la fatiga y el rendimiento en ejercicios de alta intensidad, producidos por la suplementación con monohidrato de Cr, desde un punto de vista metabólico.

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Registry

Crossref · 10.15446/rev.colomb.quim.v44n1.53978

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75 of 75 references verified0 citation errors · 0 not checkable

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Authors
Bonilla, D. A., & Moreno, Y.
Affiliations
  • Universidad Distrital Francisco José de Caldas (CO)
  • University of Southampton (GB)
Venue
Revista Colombiana de Química
Published
2016-02-08
Volume
44
Issue
1
Pages
11-18
ISSN
  • 0120-2804 (ISSN-L)
  • 2357-3791
OpenAlex
W2266145772
Cited by
14
References
76
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 1 · 2018: 3
FWCI
0.92
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Revista Colombiana de Química (publishedVersion, cc-by)
  • Magazine Portal Bibliotech Digital (Universidad Nacional de Colombia) (publishedVersion)
  • Repositorio Institucional UN - Biblioteca Digital (acceptedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Redalyc (Universidad Autónoma del Estado de México) (submittedVersion)
  • Greater South Information System
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Physiology › Biochemical effects in animals
Keywords
creatine supplementation, creatine monohydrate, resistance training, creatine kinase, phosphocreatine, satellite cells, myoblast fusion, mTOR signaling, MAPK signaling, GSK3β, myostatin, AMPK, muscle hypertrophy, fatigue resistance, athletic performance

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