Cited by 181Bipolar Disorder and TreatmentTreatment of Major DepressionSchizophrenia research and treatment

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Brain-derived neurotrophic factor and neuroplasticity in bipolar disorder

Kapczinski, Flavio, Frey, Benicio N, Kauer-Sant’Anna, Marcia, Grassi-Oliveira, Rodrigo·2008·Expert Review of Neurotherapeutics

DOI 10.1586/14737175.8.7.1101

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Abstract

Initial descriptions of bipolar disorder (BD) emphasized that patients returned to a baseline condition after acute episodes. Such definitions were operational in teasing bipolar disorder apart from schizophrenia, where patients were described to be permanently impaired after the initial episodes. However, this view of BD as a disorder where cognition and overall functioning was spared has been changing after the scrutiny of new research. Currently, the cognitive impairment and neuroanatomical changes related to cumulative mood episodes, particularly manic episodes, are well described. In terms of neuropathological findings, recent data suggest that changes in neuronal plasticity, particularly in cell resilience and connectivity, are the main findings in BD. Data from differential lines of research converge to BDNF as an important contributor to the pathophysiology of BD. Serum BDNF levels have been shown to be decreased in depressive and manic episodes, returning to normal levels in euthymia. Moreover, factors that negatively influence the course of BD, such as life stress and trauma, have been shown to be associated with a decrease in serum BDNF levels among bipolar patients. These findings suggest that BDNF plays a central role in the transduction of psychosocial stress and recurrent episodes into the neurobiology of bipolar disorder. The present review discusses the role of BDNF as a mediator of the neuroplastic changes that occur in portion with mood episodes and the pot…

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Authors: Kapczinski, F., Frey, B. N., Kauer-Sant’Anna, M., & Grassi-Oliveira, R.
Affiliations: McMaster University (CA)
ORCID: Frey, Benicio N
Venue: Expert Review of Neurotherapeutics
Publisher: Informa UK Limited
Published: 2008-07
Volume: 8
Issue: 7
Pages: 1101-1113
ISSN: 1473-7175 (ISSN-L)
1744-8360
DOI: 10.1586/14737175.8.7.1101
OpenAlex: W1976870407
Cited by: 181
References: 136
Citations by year: 2026: 2 · 2025: 7 · 2024: 7 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 8 · 2019: 5 · 2018: 5 · 2017: 6 · 2016: 11 · 2015: 10 · 2014: 16 · 2013: 20 · 2012: 14
FWCI: 2.67
Type: journal article
Language: en
Open access: closed
Locations: Expert Review of Neurotherapeutics (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords: brain-derived neurotrophic factor, bipolar disorder, neuroplasticity, cognitive impairment, manic episodes, serum BDNF, biomarkers, psychosocial stress, neuronal resilience, mood episodes, neuroanatomical changes
MeSH terms: Animals, Bipolar Disorder, Cognition Disorders, Humans, Neuronal Plasticity, Brain-Derived Neurotrophic Factor

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Brain-derived neurotrophic factor and neuroplasticity in bipolar disorder

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