Developments and challenges in the diagnosis and treatment of ADHD
Open accessAbstract
Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder, often associated with other psychiatric comorbidities, functional impairments, and poor long-term outcomes. The objective of this selected review is to describe current advances and challenges in the diagnosis and treatment of ADHD. The disorder is associated with neurobiological underpinnings and is highly heterogeneous in various aspects, such as symptom profiles, cognitive impairments, and neurobiological and genetic features. The efficacy and safety of short-term pharmacological treatments across the life cycle is well studied, but further research investigating long-term treatment, impact of treatment in preschoolers, and non-pharmacological interventions is needed. Future research is also needed to better characterize the neurodevelopmental pathways of the disorder, linking clinical and neurobiological information, less investigated populations, and new interventions.
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These existing studies have focused on individual hypotheses, without addressing the potential interactions of these theoretical models.
“However, these existing studies have focused on individual hypotheses, without addressing the potential interactions of these theoretical models (Dias et al., 2013).”
From A Review of Heterogeneity in Attention Deficit/Hyperactivity Disorder (ADHD) (2019) · cites this paper as Dias et al., 2013
Cites
Willcutt, E. G., Doyle, A. E., Nigg, J. T., Faraone, S. V., & Pennington, B. F. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.02.006 · Cited by 3,568 · see citing works
(1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.12.1073 · Cited by 3,372 · see citing works
FARAONE, S. V., BIEDERMAN, J., & MICK, E. (2006) · Psychological Medicine · doi:10.1017/s003329170500471x · Cited by 2,267 · see citing works
The Prevalence of DSM-IV Attention-Deficit/Hyperactivity Disorder: A Meta-Analytic Review
Willcutt, E. G. (2012) · Neurotherapeutics · doi:10.1007/s13311-012-0135-8 · Cited by 2,160 · see citing works
Pliszka, S. (2007) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e318054e724 · Cited by 1,765 · see citing works
Biederman, J. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.5.816 · Cited by 1,498 · see citing works
Molina, B. S. G., Hinshaw, S. P., Swanson, J. M., Arnold, L. E., Vitiello, B., Jensen, P. S., Epstein, J. N., Hoza, B., Hechtman, L., Abikoff, H. B., et al. (2009) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e31819c23d0 · Cited by 1,182 · see citing works
Toward systems neuroscience of ADHD: a meta-analysis of 55 fMRI studies
Cortese, S., Kelly, C., Chabernaud, C., Proal, E., Di Martino, A., Milham, M. P., & Castellanos, F. X. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.11101521 · Cited by 1,067 · see citing works
Kooij, S. J., Bejerot, S., Blackwell, A., Caci, H., Casas-Brugué, M., Carpentier, P. J., Edvinsson, D., Fayyad, J., Foeken, K., Fitzgerald, M., et al. (2010) · BMC Psychiatry · doi:10.1186/1471-244x-10-67 · Cited by 928 · see citing works
Psychological heterogeneity in AD/HD—a dual pathway model of behaviour and cognition
Sonuga-Barke, E. J. S. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00432-6 · Cited by 901 · see citing works
Hart, H., Radua, J., Nakao, T., Mataix-Cols, D., & Rubia, K. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.277 · Cited by 764 · see citing works
Shaw, M., Hodgkins, P., Caci, H., Young, S., Kahle, J., Woods, A. G., & Arnold, L. E. (2012) · BMC Medicine · doi:10.1186/1741-7015-10-99 · Cited by 759 · see citing works
The neural correlates of attention deficit hyperactivity disorder: an ALE meta‐analysis
Dickstein, S. G., Bannon, K., Xavier Castellanos, F., & Milham, M. P. (2006) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2006.01671.x · Cited by 745 · see citing works
Practitioner Review: What have we learnt about the causes of ADHD?
Thapar, A., Cooper, M., Eyre, O., & Langley, K. (2013) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2012.02611.x · Cited by 701 · see citing works
NIGG, J. T., & CASEY, B. J. (2005) · Development and Psychopathology · doi:10.1017/s0954579405050376 · Cited by 593 · see citing works
Comparing the efficacy of stimulants for ADHD in children and adolescents using meta-analysis
Faraone, S. V., & Buitelaar, J. (2010) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-009-0054-3 · Cited by 485 · see citing works
Fair, D. A., Bathula, D., Nikolas, M. A., & Nigg, J. T. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1115365109 · Cited by 464 · see citing works
Meta-Analysis of Genome-Wide Association Studies of Attention-Deficit/Hyperactivity Disorder
Neale, B. M., Medland, S. E., Ripke, S., Asherson, P., Franke, B., Lesch, K.-P., Faraone, S. V., Nguyen, T. T., Schäfer, H., Holmans, P., et al. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2010.06.008 · Cited by 450 · see citing works
Molecular Genetics of Attention Deficit Hyperactivity Disorder
Faraone, S. V., & Mick, E. (2010) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2009.12.004 · Cited by 411 · see citing works
Safren, S. A., Sprich, S., Mimiaga, M. J., Surman, C., Knouse, L., Groves, M., & Otto, M. W. (2010) · JAMA · doi:10.1001/jama.2010.1192 · Cited by 374 · see citing works
Atypical default network connectivity in youth with attention-deficit/hyperactivity disorder
Fair, D. A., Posner, J., Nagel, B. J., Bathula, D., Dias, T. G. C., Mills, K. L., Blythe, M. S., Giwa, A., Schmitt, C. F., & Nigg, J. T. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.07.003 · Cited by 354 · see citing works
Self-citationADHD Medications and Risk of Serious Cardiovascular Events in Young and Middle-aged Adults
Habel, L. A., Cooper, W. O., Sox, C. M., Chan, K. A., Fireman, B. H., Arbogast, P. G., Cheetham, T. C., Quinn, V. P., Dublin, S., Boudreau, D. M., et al. (2011) · JAMA · doi:10.1001/jama.2011.1830 · Cited by 297 · see citing works
Rapport, M. D., Bolden, J., Kofler, M. J., Sarver, D. E., Raiker, J. S., & Alderson, R. M. (2009) · Journal of Abnormal Child Psychology · doi:10.1007/s10802-008-9287-8 · Cited by 265 · see citing works
Measured gene-by-environment interaction in relation to attention-deficit/hyperactivity disorder
Nigg, J., Nikolas, M., & Burt, S. A. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2010.01.025 · Cited by 259 · see citing works
Biederman, J., Monuteaux, M. C., Spencer, T., Wilens, T. E., MacPherson, H. A., & Faraone, S. V. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07091486 · Cited by 239 · see citing works
HECHTMAN, L., ABIKOFF, H., KLEIN, R. G., WEISS, G., RESPITZ, C., KOURI, J., BLUM, C., GREENFIELD, B., ETCOVITCH, J., FLEISS, K., et al. (2004) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000128796.84202.eb · Cited by 197 · see citing works
Taylor, F. B., & Russo, J. (2001) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-200104000-00015 · Cited by 189 · see citing works
Lee, P.-C., Niew, W.-I., Yang, H.-J., Chen, V. C.-H., & Lin, K.-C. (2012) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2012.05.011 · Cited by 176 · see citing works
Adler, L. A., Liebowitz, M., Kronenberger, W., Qiao, M., Rubin, R., Hollandbeck, M., Deldar, A., Schuh, K., & Durell, T. (2009) · Depression and Anxiety · doi:10.1002/da.20549 · Cited by 176 · see citing works
Psychosocial Interventions in Attention Deficit Hyperactivity Disorder
Antshel, K. M., & Barkley, R. (2008) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2007.11.005 · Cited by 172 · see citing works
Scheffler, R. M., Brown, T. T., Fulton, B. D., Hinshaw, S. P., Levine, P., & Stone, S. (2009) · Pediatrics · doi:10.1542/peds.2008-1597 · Cited by 160 · see citing works
Jain, R., Segal, S., Kollins, S. H., & Khayrallah, M. (2011) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2010.11.005 · Cited by 142 · see citing works
Durell, T. M., Adler, L. A., Williams, D. W., Deldar, A., McGough, J. J., Glaser, P. E., Rubin, R. L., Pigott, T. A., Sarkis, E. H., & Fox, B. K. (2013) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31827d8a23 · Cited by 64 · see citing works
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A Review of Heterogeneity in Attention Deficit/Hyperactivity Disorder (ADHD)
Luo, Y., Weibman, D., Halperin, J. M., & Li, X. (2019) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2019.00042 · Cited by 394 · see citing works
“However, these existing studies have focused on individual hypotheses, without addressing the potential interactions of these theoretical models (Dias et al., 2013).”
BackgroundCenit, M. C., Nuevo, I. C., Codoñer-Franch, P., Dinan, T. G., & Sanz, Y. (2017) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-017-0969-z · Cited by 163 · see citing works
Neuropsychological functioning of individuals at clinical evaluation of adult ADHD
Guo, N., Fuermaier, A. B. M., Koerts, J., Mueller, B. W., Diers, K., Mroß, A., Mette, C., Tucha, L., & Tucha, O. (2021) · Journal of Neural Transmission · doi:10.1007/s00702-020-02281-0 · Cited by 37 · see citing works
Lewis, N., Villani, A., & Lagopoulos, J. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.01.031 · Cited by 25 · see citing works
- Authors
- Dias, T. G. C., Kieling, C., Graeff-Martins, A. S., Moriyama, T. S., Rohde, L. A., & Polanczyk, G. V.
- Affiliations
- Universidade de São Paulo (BR)
- Universidade Federal do Rio Grande do Sul (BR)
- Universidade de Sao Paulo, Brazil; National Institute of Developmental Psychiatry for Children and Adolescents; USP, Brazil; Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Brazil
- National Institute of Developmental Psychiatry for Children and Adolescents; Universidade Federal do Rio Grande do Sul, Brazil
- Venue
- Revista Brasileira de Psiquiatria
- Publisher
- EDITORA SCIENTIFIC
- Published
- 2013
- Volume
- 35
- Issue
- suppl 1
- Pages
- S40-S50
- ISSN
- 1516-4446 (ISSN-L)
- OpenAlex
- W2097425992
- Cited by
- 62
- References
- 33
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 9 · 2022: 4 · 2021: 15 · 2020: 5 · 2019: 5 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 6 · 2014: 5 · 2013: 1
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- Brazilian Journal of Psychiatry (publishedVersion, cc-by-nc)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- PubMed (publishedVersion)
- Americanae (AECID Library) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Lume (Universidade Federal do Rio Grande do Sul) (submittedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-sa)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Developmental and Educational Neuropsychology
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Keywords
- attention deficit hyperactivity disorder, ADHD diagnosis, ADHD treatment, pharmacotherapy, long-term treatment, preschool children, non-pharmacological treatment, neurodevelopmental pathways, genetic characteristics, psychiatric comorbidity, symptom heterogeneity, cognitive impairment
- MeSH terms
- Adult, Attention Deficit Disorder with Hyperactivity, Child, Child, Preschool, Humans, Risk Factors
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