Effectiveness of mindfulness-integrated cognitive behavior therapy on anxiety, depression and hope in multiple sclerosis patients: a randomized clinical trial
Open accessAbstract
INTRODUCTION: Multiple sclerosis (MS) is a chronic medical condition that attracts particular attention because of the high risks associated with it. MS patients suffer from medical problems, depression, anxiety, and reduced hopefulness. These issues can increase the severity of the disease and treatment resistance and reduce patients' individual and social efficacy. Mindfulness-integrated cognitive behavior therapy (MICBT) is a new approach that is being applied in chronic diseases and can be used in combination with existing treatments. Therefore, the present study investigated the efficacy of MICBT in terms of anxiety, depression, and hope in MS patients. METHODS: A sample of 20 patients with MS was randomly selected at Shafa Hospital in Kerman City, Iran. Patients were then assigned to one of two groups of 10 people using a random number table. The experimental group received MICBT. The control group also received the same therapy after study completion. The assessment tools used in this study included the Beck Depression Inventory-Second Edition (BDI-II), Beck Anxiety Inventory (BAI), and Miller Hope Scale (MHS). Measurements were conducted at three stages: pre-test, post-test, and follow-up. For data analysis, means and standard deviations were calculated and one-way analysis of covariance was conducted using SPSS 24. RESULTS: Compared with controls, MICBT was effective for reducing depression (P < 0.001, F = 72.55), anxiety (P < 0.001, F = 100.75). Additionally, MICBT was effective in improving hope (P < 0.001, F = 45.36). Changes were maintained in the follow-up phase. CONCLUSION: The MICBT affects depression, anxiety and hope of MS patients. Therefore, mental health professionals can benefit from the results obtained in the present study to reduce depression and anxiety and increase hope in this group of patients. CLINICAL TRIAL REGISTRATION: Iranian Registry of Clinical Trials, IRCT201601030258N4.
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Dialectical behavior therapy (DBT), mindfulness-integrated cognitive behavior therapy (MICBT), logotherapy, internet-based cognitive behavioral therapy (ICBT), and self-management have an influential role in decreasing anxiety in patients with multiple sclerosis (MS).
“dialectical behavior therapy (DBT), Mindfulness-integrated cognitive behavior therapy, Logotherapy and internet-based cognitive behavioral therapy (ICBT) and self-management have had an influential role in decreasing the anxiety of these patients.”
From Psychological interventions for decreasing anxiety in people with multiple sclerosis (MS): A systematic review (2023) · cites this paper as [25]
The Discussion (page unavailable) reports that MICBT significantly reduced anxiety in MS patients compared with controls, with the effect sustained at follow-up. The paper does not establish anxiety reductions from DBT, logotherapy, ICBT, or self-management, so it supports only the MICBT part of the attributed claim. (LLM, conf=0.88)
Experimental — accuracy not yet measuredRandom sequence generation bias was evaluated as low risk in 20% of included studies and unknown risk in 75%.
“The bias of random sequence generation was evaluated as low risk in 20% of studies(23, 29, 31, 33, 44), and as unknown risk in 75% of studies”
Evidence for the efficacy of MiCBT is building across different conditions, including depression, anxiety and depression in individuals with multiple sclerosis, anxiety and depression during pregnancy, sports anxiety, pain and pain self-efficacy in patients with breast cancer, and chronic pain in the general population.
“Evidence for the efficacy of MiCBT is building across different conditions, including depression, anxiety and depression in individuals with multiple sclerosis (29, 30), anxiety and depression during pregnancy (31), sports anxiety (32), pain and pain self-efficacy in patients with breast cancer (33), and chronic pain in the general population (34).”
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- Authors
- Pouyanfard, S., Mohammadpour, M., ParviziFard, A. A., & Sadeghi, K.
- Affiliations
- Kermanshah University of Medical Sciences (IR)
- Venue
- Trends in Psychiatry and Psychotherapy
- Publisher
- FapUNIFESP (SciELO)
- Published
- 2020-03
- Volume
- 42
- Issue
- 1
- Pages
- 55-63
- ISSN
- 2237-6089 (ISSN-L)
- 2238-0019
- OpenAlex
- W3017297837
- Cited by
- 49
- References
- 31
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 11 · 2023: 9 · 2022: 9 · 2021: 3
- FWCI
- 2.10
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Trends in Psychiatry and Psychotherapy (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, cc-by-nc)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- multiple sclerosis, depression, anxiety, hope, psychological intervention, chronic disease, mental health
- MeSH terms
- Adult, Anxiety, Depression, Female, Humans, Iran, Male, Middle Aged, Multiple Sclerosis, Cognitive Behavioral Therapy, Outcome Assessment, Health Care, Mindfulness, Hope
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