The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Mechanical Signaling for Bone Modeling and Remodeling
Open accessAbstract
Proper development of the skeleton in utero and during growth requires mechanical stimulation. Loading results in adaptive changes in bone that strengthen bone structure. Bone's adaptive response is regulated by the ability of resident bone cells to perceive and translate mechanical energy into a cascade of structural and biochemical changes within the cells a process known as mechanotransduction. Mechanotransduction pathways are among the most anabolic in bone, and consequently, there is great interest in elucidating how mechanical loading produces its observed effects, including increased bone formation, reduced bone loss, changes in bone cell differentiation and lifespan, among others. A molecular understanding of these processes is developing, and with it comes a profound new insight into the biology of bone. In this article, we review the nature of the physical stimulus to which bone cells mount an adaptive response, including the identity of the sensor cells, their attributes and physical environment, and putative mechanoreceptors they express. Particular attention is allotted to the focal adhesion and Wnt signaling, in light of their emerging role in bone mechanotransduction. Te cellular mechanisms for increased bone loss during disuse, and reduced bone loss during loading are considered. Finally, we summarize the published data on bone cell accommodation, whereby bone cells stop responding to mechanical signaling events. Collectively, these data highlight the complex yet finely orchestrated process of mechanically regulated bone homeostasis.
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Citations
Cites
Mechanical Stimulation of Bone in Vivo Reduces Osteocyte Expression of Sost/Sclerostin
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Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease
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Cited by
Molecular mechanosensors in osteocytes
Qin, L., Liu, W., Cao, H., & Xiao, G. (2020) · Bone Research · doi:10.1038/s41413-020-0099-y · Cited by 484
Osteoclasts Provide Coupling Signals to Osteoblast Lineage Cells Through Multiple Mechanisms
Sims, N. A., & Martin, T. J. (2020) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021119-034425 · Cited by 286
A systematic review and meta-analysis of bone loss in space travelers
Stavnichuk, M., Mikolajewicz, N., Corlett, T., Morris, M., & Komarova, S. V. (2020) · npj Microgravity · doi:10.1038/s41526-020-0103-2 · Cited by 217
Sibonga, J., Matsumoto, T., Jones, J., Shapiro, J., Lang, T., Shackelford, L., Smith, S. M., Young, M., Keyak, J., Kohri, K., et al. (2019) · Bone · doi:10.1016/j.bone.2019.07.013 · Cited by 142
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Metadata
- Authors
- Robling, A. G., & Turner, C. H.
- Venue
- Critical Reviews™ in Eukaryotic Gene Expression
- Publisher
- Begell House
- Published
- 2009
- Volume
- 19
- Issue
- 4
- Pages
- 319-338
- ISSN
- 1045-4403 (ISSN-L)
- OpenAlex
- W2035671623
- Cited by
- 422
- References
- 9
- FWCI
- 3.24
- Type
- journal article
- Language
- en
- Open access
- green
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