Wolbachia in Dirofilaria repens, an Agent Causing Human Subcutaneous Dirofilariasis
Abstract
Human subcutaneous dirofilariasis is an increasingly reported zoonosis caused by several filarial species, in particular by Dirofilaria (Nochtiella) repens. Like many filarial worms, D. repens harbors the bacterial endosymbiont Wolbachia that has been implicated in the inflammatory features of filarial infection. Immunohistochemical staining against the Wolbachia surface protein (WSP) was carried out on 14 skin nodules and showed numerous bacteria within the intact worms and occasional positive staining within the surrounding inflammatory infiltrate. Serum samples from 11 of these patients resulted positive for total immunoglobulin G titers against WSP as examined in enzyme-linked immunosorbent assay. This is the first description of Wolbachia distribution in D. repens and the first report of specific immune response to Wolbachia in patients with subcutaneous dirofilariasis.
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Wolbachia or its molecules are present in cytoplasm of leukocytes of dogs and humans with cardiopulmonary or subcutaneous dirofilariasis.
“the presence of Wolbachia or of its molecules in the cytoplasm of leukocytes of dogs and humans with cardiopulmonary or subcutaneous dirofilariasis has been shown by immunohistochemistry (162, 216)”
From Human and animal dirofilariasis: The emergence of a zoonotic mosaic (2012) · cites this paper as [162]
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Human and animal dirofilariasis: The emergence of a zoonotic mosaic
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- Authors
- Grandi, G., Morchon, R., Kramer, L., Kartashev, V., & Simon, F.
- Affiliations
- University of Parma (IT)
- Rostov State Medical University (RU)
- Venue
- Journal of Parasitology
- Publisher
- American Society of Parasitologists
- Published
- 2008-12
- Volume
- 94
- Issue
- 6
- Pages
- 1421-1423
- ISSN
- 0022-3395 (ISSN-L)
- 1937-2345
- OpenAlex
- W1984891621
- Cited by
- 33
- References
- 26
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2013: 2 · 2012: 4
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Parasitology (publishedVersion)
- PubMed (publishedVersion)
- BioOne Complete (BioOne) (submittedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Keywords
- Wolbachia, Dirofilaria repens, subcutaneous dirofilariasis, Wolbachia surface protein, skin nodules, zoonoses
- MeSH terms
- Adult, Animals, Antibodies, Bacterial, Bacterial Proteins, Dirofilaria, Dirofilariasis, Female, Granuloma, Humans, Immunoglobulin G, Immunohistochemistry, Male, Membrane Proteins, Middle Aged, Skin Diseases, Parasitic, Symbiosis, Wolbachia, Young Adult
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