Cited by 33Parasitic Diseases Research and TreatmentResearch on Leishmaniasis StudiesParasites and Host Interactions

Wolbachia in Dirofilaria repens, an Agent Causing Human Subcutaneous Dirofilariasis

Grandi, G., Morchon, R., Kramer, L., Kartashev, V., Simon, F.·2008·Journal of Parasitology

Abstract

Human subcutaneous dirofilariasis is an increasingly reported zoonosis caused by several filarial species, in particular by Dirofilaria (Nochtiella) repens. Like many filarial worms, D. repens harbors the bacterial endosymbiont Wolbachia that has been implicated in the inflammatory features of filarial infection. Immunohistochemical staining against the Wolbachia surface protein (WSP) was carried out on 14 skin nodules and showed numerous bacteria within the intact worms and occasional positive staining within the surrounding inflammatory infiltrate. Serum samples from 11 of these patients resulted positive for total immunoglobulin G titers against WSP as examined in enzyme-linked immunosorbent assay. This is the first description of Wolbachia distribution in D. repens and the first report of specific immune response to Wolbachia in patients with subcutaneous dirofilariasis.

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Registry

Crossref · 10.1645/ge-1575.1

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26 of 26 references verified0 citation errors · 0 not checkable

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  • Wolbachia or its molecules are present in cytoplasm of leukocytes of dogs and humans with cardiopulmonary or subcutaneous dirofilariasis.

    “the presence of Wolbachia or of its molecules in the cytoplasm of leukocytes of dogs and humans with cardiopulmonary or subcutaneous dirofilariasis has been shown by immunohistochemistry (162, 216)”

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Authors
Grandi, G., Morchon, R., Kramer, L., Kartashev, V., & Simon, F.
Affiliations
  • University of Parma (IT)
  • Rostov State Medical University (RU)
Venue
Journal of Parasitology
Published
2008-12
Volume
94
Issue
6
Pages
1421-1423
ISSN
  • 0022-3395 (ISSN-L)
  • 1937-2345
OpenAlex
W1984891621
Cited by
33
References
26
Citations by year
2026: 2 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2013: 2 · 2012: 4
FWCI
1.30
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Parasitology (publishedVersion)
  • PubMed (publishedVersion)
  • BioOne Complete (BioOne) (submittedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
Keywords
Wolbachia, Dirofilaria repens, subcutaneous dirofilariasis, Wolbachia surface protein, skin nodules, zoonoses
MeSH terms
Adult, Animals, Antibodies, Bacterial, Bacterial Proteins, Dirofilaria, Dirofilariasis, Female, Granuloma, Humans, Immunoglobulin G, Immunohistochemistry, Male, Membrane Proteins, Middle Aged, Skin Diseases, Parasitic, Symbiosis, Wolbachia, Young Adult

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