Androgen inactivation and steroid-converting enzyme expression in abdominal adipose tissue in men

Biochemical and Biophysical Research Communications

Rc, A. N., On Filamentous Bacteriophage, M., Hoffmann, S., & Willbold, D. (1960) · Nature · doi:10.1038/186124d0 · Cited by 6,690 · see citing works

Adipose Tissue as an Endocrine Organ

Kershaw, E. E., & Flier, J. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0395 · Cited by 5,522 · see citing works

The Disease Burden Associated With Overweight and Obesity

Must, A. (1999) · JAMA · doi:10.1001/jama.282.16.1523 · Cited by 4,804 · see citing works

Metabolism of Isolated Fat Cells

Rodbell, M. (1964) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)51687-2 · Cited by 4,647 · see citing works

JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM

Hoskins, R. G. (1953) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-13-4-473 · Cited by 3,806 · see citing works

THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

(1911) · JAMA · doi:10.1001/jama.1911.04260070032017 · Cited by 3,355 · see citing works

Molecular and cellular endocrinology

(1995) · Journal of Endocrinology · doi:10.1677/joe.0.147so19 · Cited by 1,986 · see citing works

METABOLISM OF ISOLATED FAT CELLS. I. EFFECTS OF HORMONES ON GLUCOSE METABOLISM AND LIPOLYSIS.

Rodbell, M. (1964) · PubMed · Cited by 1,387 · see citing works

Disordered Fat Storage and Mobilization in the Pathogenesis of Insulin Resistance and Type 2 Diabetes

Lewis, G. F., Carpentier, A. C., Adeli, K., & Giacca, A. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.2.0461 · Cited by 1,328 · see citing works

Regional distribution of body fat, plasma lipoproteins, and cardiovascular disease.

Després, J. P., Moorjani, S., Lupien, P. J., Tremblay, A., Nadeau, A., & Bouchard, C. (1990) · Arteriosclerosis: An Official Journal of the American Heart Association, Inc. · doi:10.1161/01.atv.10.4.497 · Cited by 1,248 · see citing works

The Journal of Steroid Biochemistry and Molecular Biology

(2011) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(11)00143-9 · Cited by 1,233 · see citing works

Arteriosclerosis, Thrombosis, and Vascular Biology

(2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atv.0b013e31822a51e2 · Cited by 1,108 · see citing works

Adipose tissue as an endocrine and paracrine organ

Mohamed‐Ali, V., Pinkney, J. H., & Coppack, S. W. (1998) · International Journal of Obesity · doi:10.1038/sj.ijo.0800770 · Cited by 999 · see citing works

Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging

Labrie, F., Bélanger, A., Cusan, L., Gomez, J.-L., & Candas, B. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.8.4160 · Cited by 713 · see citing works

Elevated C-Reactive Protein

Lemieux, I., Pascot, A., Prud’homme, D., Alméras, N., Bogaty, P. M., Nadeau, A., Bergeron, J., & Després, J. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.6.961 · Cited by 593 · see citing works

Androgens Stimulate Myogenic Differentiation and Inhibit Adipogenesis in C3H 10T1/2 Pluripotent Cells through an Androgen Receptor-Mediated Pathway

Singh, R., Artaza, J. N., Taylor, W. E., Gonzalez-Cadavid, N. F., & Bhasin, S. (2003) · Endocrinology · doi:10.1210/en.2003-0741 · Cited by 555 · see citing works

The effects of testosterone treatment on body composition and metabolism in middle-aged obese men.

Mårin, P., Holmäng, S., Jönsson, L., Sjöström, L., Kvist, H., Holm, G., Lindstedt, G., & Björntorp, P. A. (1992) · PubMed · Cited by 553 · see citing works

Tissue-specific changes in peripheral cortisol metabolism in obese women: increased adipose 11beta-hydroxysteroid dehydrogenase type 1 activity.

Rask, E., Walker, B., Söderberg, S., Livingstone, D., Eliasson, M., Johnson, O., Andrew, R., & Olsson, T. (2002) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jcem.87.7.8661 · Cited by 467 · see citing works

Increased Fat Intake, Impaired Fat Oxidation, and Failure of Fat Cell Proliferation Result in Ectopic Fat Storage, Insulin Resistance, and Type 2 Diabetes Mellitus

Ravussin, É., & Smith, S. R. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04292.x · Cited by 461 · see citing works

Testosterone supplementation in men with type 2 diabetes, visceral obesity and partial androgen deficiency

Boyanov, M. A., Boneva, Z., & Christov, V. G. (2003) · The Aging Male · doi:10.1080/tam.6.1.1.7 · Cited by 381 · see citing works

Testosterone Inhibits Adipogenic Differentiation in 3T3-L1 Cells: Nuclear Translocation of Androgen Receptor Complex with β-Catenin and T-Cell Factor 4 May Bypass Canonical Wnt Signaling to Down-Regulate Adipogenic Transcription Factors

Singh, R., Artaza, J. N., Taylor, W. E., Braga, M., Yuan, X., Gonzalez-Cadavid, N. F., & Bhasin, S. (2006) · Endocrinology · doi:10.1210/en.2004-1649 · Cited by 369 · see citing works

Assimilation and mobilization of triglycerides in subcutaneous abdominal and femoral adipose tissue in vivo in men: effects of androgens.

Mårin, P., Odén, B., & Björntorp, P. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.1.7829619 · Cited by 332 · see citing works

Effects of sex steroids on components of the insulin resistance syndrome in transsexual subjects

Elbers, J. M. H., Giltay, E. J., Teerlink, T., Scheffer, P. G., Asscheman, H., Seidell, J. C., & Gooren, L. J. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01753.x · Cited by 318 · see citing works

Improved Real-Time RT-PCR Method for High-Throughput Measurements using Second Derivative Calculation and Double Correction

Luu-The, V., Paquet, N., Calvo, E. L., & Cumps, J. (2005) · BioTechniques · doi:10.2144/05382rr05 · Cited by 284 · see citing works

Disordered Fat Storage and Mobilization in the Pathogenesis of Insulin Resistance and Type 2 Diabetes

Lewis, G. F. (2002) · Endocrine Reviews · doi:10.1210/er.23.2.201 · Cited by 281 · see citing works

Fat Tissue: A Steroid Reservoir and Site of Steroid Metabolism

DESLYPERE, J. P., VERDONCK, L., & VERMEULEN, A. (1985) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-61-3-564 · Cited by 272 · see citing works

Human Cytosolic 3α-Hydroxysteroid Dehydrogenases of the Aldo-keto Reductase Superfamily Display Significant 3β-Hydroxysteroid Dehydrogenase Activity

Steckelbroeck, S., Jin, Y., Gopishetty, S., Oyesanmi, B., & Penning, T. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313308200 · Cited by 270 · see citing works

Characteristics of a Highly Labile Human Type 5 17β-Hydroxysteroid Dehydrogenase1

Dufort, I., Rheault, P., Huang, X.-F., Soucy, P., & Luu-The, V. (1999) · Endocrinology · doi:10.1210/endo.140.2.6531 · Cited by 255 · see citing works

Effect of BMI and age on adipose tissue cellularity and differentiation capacity in women

van Harmelen, V., Skurk, T., Röhrig, K., Lee, Y.-M., Halbleib, M., Aprath-Husmann, I., & Hauner, H. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802314 · Cited by 249 · see citing works

Lower endogenous androgens predict central adiposity in men

Khaw, K., & Barrett-Connor, E. L. (1992) · Annals of Epidemiology · doi:10.1016/1047-2797(92)90012-f · Cited by 247 · see citing works

Serum androgen concentrations in young men: a longitudinal analysis of associations with age, obesity, and race. The CARDIA male hormone study.

Gapstur, S. M., Gann, P. H., Kopp, P. A., Colangelo, L. A., Longcope, C., & Liu, K. (2002) · PubMed · Cited by 247 · see citing works

Adipose Tissue Intracrinology: Potential Importance of Local Androgen/Estrogen Metabolism in the Regulation of Adiposity

Bélanger, C., Luu-The, V., Dupont, P., & Tchernof, A. (2002) · Hormone and Metabolic Research · doi:10.1055/s-2002-38265 · Cited by 246 · see citing works

Effects of sex steroid hormones on regional fat depots as assessed by magnetic resonance imaging in transsexuals

Elbers, J. M. H., Asscheman, H., Seidell, J. C., & Gooren, L. J. G. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.2.e317 · Cited by 236 · see citing works

Late onset of obesity in male androgen receptor-deficient (AR KO) mice

Sato, T., Μatsumoto, T., Yamada, T., Watanabe, T., Kawano, H., & Kato, S. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02774-2 · Cited by 196 · see citing works

Androgen generation in adipose tissue in women with simple obesity – a site-specific role for 17β-hydroxysteroid dehydrogenase type 5

Quinkler, M. O., Sinha, B., Tomlinson, J., Bujalska, I. J., Stewart, P. M., & Arlt, W. (2004) · Journal of Endocrinology · doi:10.1677/joe.1.05762 · Cited by 189 · see citing works

Reduced testosterone and adrenal C19 steroid levels in obese men

Tchernof, A., Després, J.-P., Bélanger, A., Dupont, A., Prud'homme, D., Moorjani, S., Lupien, P. J., & Labrie, F. (1995) · Metabolism · doi:10.1016/0026-0495(95)90060-8 · Cited by 175 · see citing works

Concentration of Sex Steroids in Adipose Tissue after Menopause

Szymczak, J., Milewicz, A., Thijssen, J. H. H., Blankenstein, M. A., & Daroszewski, J. (1998) · Steroids · doi:10.1016/s0039-128x(98)00019-1 · Cited by 169 · see citing works

Insulin and okadaic acid induce Rab4 redistribution in adipocytes.

Cormont, M., Tanti, J., Zahraoui, A., OBBERGHEN, E. V., Tavitian, A., & MARCHAND‐BRUSTEL, Y. L. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36542-1 · Cited by 150 · see citing works

Demonstration of estrogen receptor subtypes α and β in human adipose tissue: influences of adipose cell differentiation and fat depot localization

Pedersen, S. B., Bruun, J. M., Hube, F., Kristensen, K., Hauner, H., & Richelsen, B. (2001) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(01)00557-3 · Cited by 140 · see citing works

The Androgen Metabolite, 5α-Androstane-3β, 17β-Diol, Is a Potent Modulator of Estrogen Receptor-β1-Mediated Gene Transcription in Neuronal Cells

Pak, T. R., Chung, W. C. J., Lund, T. D., Hinds, L. R., Clay, C. M., & Handa, R. J. (2004) · Endocrinology · doi:10.1210/en.2004-0871 · Cited by 139 · see citing works

Cultures of Human Adipose Precursor Cells

Hauner, H., Skurk, T., & Wabitsch, M. (2003) · Humana Press eBooks · doi:10.1385/1-59259-231-7:239 · Cited by 123 · see citing works

Characterization of a human 20alpha-hydroxysteroid dehydrogenase

Zhang, Y., Dufort, I., Rheault, P., & Luu-The, V. (2000) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0250221 · Cited by 109 · see citing works

A micromethod for assay of lipoprotein lipase activity in needle biopsy samples of human adipose tissue and skeletal muscle

Taskinen, M., Nikkilä, E. A., Huttunen, J. K., & Hilden, H. (1980) · Clinica Chimica Acta · doi:10.1016/0009-8981(80)90140-0 · Cited by 91 · see citing works

Omental and subcutaneous adipose tissue steroid levels in obese men

Bélanger, C., Hould, F.-S., Lebel, S., Biron, S., Brochu, G., & Tchernof, A. (2006) · Steroids · doi:10.1016/j.steroids.2006.04.008 · Cited by 89 · see citing works

Sex steroids and leptin regulate 11β-hydroxysteroid dehydrogenase I and P450 aromatase expressions in human preadipocytes: Sex specificities

Dieudonné, M., Sammari, A., Santos, E. D., Leneveu, M.-C., Giudicelli, Y., & Pecquery, R. (2006) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2006.01.007 · Cited by 85 · see citing works

The insulin resistance syndrome: implications for thrombosis and cardiovascular disease

Juhan-Vague, I., Morange, P., & Alessi, M. (2002) · Pathophysiology of Haemostasis and Thrombosis · doi:10.1159/000073579 · Cited by 75 · see citing works

Human Types 1 and 3 3α-Hydroxysteroid Dehydrogenases: Differential Lability and Tissue Distribution1

Dufort, I., Labrie, F., & Luu-The, V. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.2.7216 · Cited by 73 · see citing works

The effect of obesity on the ratio of type 3 17β-hydroxysteroid dehydrogenase mRNA to cytochrome P450 aromatase mRNA in subcutaneous abdominal and intra-abdominal adipose tissue of women

Corbould, A., Bawden, M., Lavranos, T. C., Rodgers, R., & Judd, S. (2002) · International Journal of Obesity · doi:10.1038/sj.ijo.0801886 · Cited by 67 · see citing works

Expression and activity of steroid aldoketoreductases 1C in omental adipose tissue are positive correlates of adiposity in women

Blouin, K., Blanchette, S., Richard, C., Dupont, P., Luu-The, V., & Tchernof, A. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00312.2004 · Cited by 67 · see citing works

A comparative study of steroid concentrations in human adipose tissue and the peripheral circulation

Fehér, T. D., & Bodrogi, L. (1982) · Clinica Chimica Acta · doi:10.1016/0009-8981(82)90029-8 · Cited by 65 · see citing works

Preadipocyte Number in Omental and Subcutaneous Adipose Tissue of Obese Individuals

Bakker, A. H. F., van Dielen, F. M. H., Greve, J. W. M., Adam, J. A., & Buurman, W. A. (2004) · Obesity Research · doi:10.1038/oby.2004.55 · Cited by 63 · see citing works

Local Androgen Inactivation in Abdominal Visceral Adipose Tissue

Blouin, K., Richard, C., Bélanger, C., Dupont, P., Daris, M., Laberge, P. Y., Luu-The, V., & Tchernof, A. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030535 · Cited by 59 · see citing works

Microdetermination of glycerol using bacterial NADH-linked luciferase

KATHER, H., Schröder, F., & Simon, B. (1982) · Clinica Chimica Acta · doi:10.1016/0009-8981(82)90370-9 · Cited by 54 · see citing works

Influence of Adipose Tissue Distribution on the Biological Activity of Androgensa

KILLINGER, D. W., Perel, E., Daniilescu, D., Kharlip, L., & Lindsay, W. R. N. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb34293.x · Cited by 52 · see citing works

Pathophysiology of Haemostasis and Thrombosis

(2017) · Pathophysiology of Haemostasis and Thrombosis · doi:10.1159/issn.1424-8832 · Cited by 43 · see citing works

Androstane-3α,17β-Diol Glucuronide as a Steroid Correlate of Visceral Obesity in Men*

Tchernof, A., Labrie, F., Bélanger, A., Prud’homme, D., Bouchard, C., Tremblay, A., Nadeau, A., & Després, J. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.5.3924 · Cited by 38 · see citing works

Expression and Activity of 20α-Hydroxysteroid Dehydrogenase (AKR1C1) in Abdominal Subcutaneous and Omental Adipose Tissue in Women

Blanchette, S., Blouin, K., Richard, C., Dupont, P., Luu-The, V., & Tchernof, A. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0583 · Cited by 31 · see citing works

Mechanistic Pathways of Sex Differences in Cardiovascular Disease

Regitz‐Zagrosek, V., & Kararigas, G. (2016) · Physiological Reviews · doi:10.1152/physrev.00021.2015 · Cited by 738 · see citing works

Androgens and body fat distribution

Blouin, K., Boivin, A., & Tchernof, A. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2007.09.001 · Cited by 306 · see citing works

The Dark Side of Testosterone Deficiency: I. Metabolic Syndrome and Erectile Dysfunction

Traish, A. M., Guay, A. T., Feeley, R. J., & Saad, F. (2008) · Journal of Andrology · doi:10.2164/jandrol.108.005215 · Cited by 282 · see citing works

Development of selective androgen receptor modulators (SARMs)

Narayanan, R., Coss, C. C., & Dalton, J. T. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.06.013 · Cited by 251 · see citing works

The Anti-Inflammatory Effects of Testosterone

Bianchi, V. E. (2018) · Journal of the Endocrine Society · doi:10.1210/js.2018-00186 · Cited by 253 · see citing works

Intracrine androgen biosynthesis, metabolism and action revisited

Schiffer, L., Arlt, W., & Storbeck, K.-H. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.08.016 · Cited by 217 · see citing works

Understanding androgen action in adipose tissue

O’Reilly, M. W., House, P. J., & Tomlinson., J. W. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.04.008 · Cited by 180 · see citing works

Androgen metabolism in adipose tissue: Recent advances

Blouin, K., Veilleux, A., Luu-The, V., & Tchernof, A. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.10.035 · Cited by 149 · see citing works

Steroid biosynthesis in adipose tissue

Li, J., Papadopoulos, V., & Vihma, V. (2015) · Steroids · doi:10.1016/j.steroids.2015.03.016 · Cited by 130 · see citing works

Effects of androgens on adipocyte differentiation and adipose tissue explant metabolism in men and women

Blouin, K., Nadeau, M., Perreault, M., Veilleux, A., Drolet, R., Marceau, P., Mailloux, J. R., Luu‐The, V., & Tchernof, A. (2009) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2009.03645.x · Cited by 131 · see citing works

Adipose tissue and reproductive health

Mathew, H., Castracane, V. D., & Mantzoros, C. S. (2017) · Metabolism · doi:10.1016/j.metabol.2017.11.006 · Cited by 109 · see citing works

Pathways of adipose tissue androgen metabolism in women: depot differences and modulation by adipogenesis

Blouin, K., Nadeau, M., Mailloux, J. R., Daris, M., Lebel, S., Luu-The, V., & Tchernof, A. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00039.2008 · Cited by 92 · see citing works

Obesity and sex interact in the regulation of Alzheimer's disease

Moser, V. A., & Pike, C. J. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.08.021 · Cited by 89 · see citing works

Adrenocortical dysregulation as a major player in insulin resistance and onset of obesity

Roberge, C., Carpentier, A. C., Langlois, M., Baillargeon, J., Ardilouze, J., Maheux, P., & Gallo‐Payet, N. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00516.2007 · Cited by 87 · see citing works

Effect of Exercise on Serum Sex Hormones in Men

Hawkins, V. N., Foster‐Schubert, K. E., Chubak, J., Sorensen, B. E., Ulrich, C. M., Stancyzk, F. Z., Plymate, S. R., Stanford, J. L., White, E., Potter, J. D., et al. (2008) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31815bbba9 · Cited by 87 · see citing works

Androgens and the Regulation of Adiposity and Body Fat Distribution in Humans

Tchernof, A., Brochu, D., Maltais‐Payette, I., Mansour, M. F., Marchand, G. B., Carreau, A., & Kapeluto, J. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170009 · Cited by 110 · see citing works

Testosterone modulates cardiac contraction and calcium homeostasis: cellular and molecular mechanisms

Ayaz, O., & Howlett, S. E. (2015) · Biology of Sex Differences · doi:10.1186/s13293-015-0027-9 · Cited by 85 · see citing works

Lack of functional and expression homology between human and mouse aldo-keto reductase 1C enzymes: implications for modelling human cancers

Veliça, P., Davies, N., Rocha, P. P., Schrewe, H., Ride, J. P., & Bunce, C. M. (2009) · Molecular Cancer · doi:10.1186/1476-4598-8-121 · Cited by 80 · see citing works

Updated survey of the steroid-converting enzymes in human adipose tissues

Tchernof, A., Mansour, M. F., Pelletier, M., Boulet, M.-M., Nadeau, M., & Luu-The, V. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.11.011 · Cited by 73 · see citing works

The expression of sex steroid synthesis and inactivation enzymes in subcutaneous adipose tissue of PCOS patients

Wang, L., Li, S., Zhao, A., Tao, T., Mao, X., Zhang, P., & Liu, W. (2012) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2012.02.003 · Cited by 71 · see citing works

Aldo-Keto Reductase 1C1 (AKR1C1) as the First Mutated Gene in a Family with Nonsyndromic Primary Lipedema

Michelini, S., Chiurazzi, P., Marino, V., Dell’Orco, D., Manara, E., Baglivo, M., Fiorentino, A., Maltese, P. E., Pinelli, M., Herbst, K. L., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176264 · Cited by 67 · see citing works

Acne and obesity: A nationwide study of 600,404 adolescents

Snast, I., Dalal, A., Twig, G., Astman, N., Kedem, R., Levin, D., Erlich, Y., Leshem, Y. A., Lapidoth, M., Hodak, E., et al. (2019) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2019.04.009 · Cited by 65 · see citing works

Recent advances in 17beta-hydroxysteroid dehydrogenases

Prehn, C. P., Möller, G., & Adamski, J. (2009) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2008.12.024 · Cited by 55 · see citing works

Differential androgen and estrogen substrates specificity in the mouse and primates type 12 17β-hydroxysteroid dehydrogenase

Blanchard, P.-G., & Luu-The, V. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0144 · Cited by 54 · see citing works

Expression of cortisol metabolism-related genes shows circadian rhythmic patterns in human adipose tissue

Morante, J. J. H., Gómez‐Santos, C., Milagro, F. I., Campión, J., Martínez, J. A., Zamora, S., & Garaulet, M. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.4 · Cited by 54 · see citing works

Are Metabolic Syndrome and Its Components Associated With Lower Urinary Tract Symptoms? Results From a Chinese Male Population Survey

Gao, Y., Wang, M., Zhang, H., Tan, A., Yang, X., Qin, X., Hu, Y., Zhang, Y., Liao, M., & Mo, Z. (2011) · Urology · doi:10.1016/j.urology.2011.07.1399 · Cited by 54 · see citing works

The Role of Androgen in the Adipose Tissue of Males

Lee, H.-K., Lee, J. K., & Cho, B. (2013) · The World Journal of Men s Health · doi:10.5534/wjmh.2013.31.2.136 · Cited by 51 · see citing works

Adverse health effects of testosterone deficiency (TD) in men

Traish, A. M. (2014) · Steroids · doi:10.1016/j.steroids.2014.05.010 · Cited by 51 · see citing works

17β-Estradiol and Estradiol Fatty Acyl Esters and Estrogen-Converting Enzyme Expression in Adipose Tissue in Obese Men and Women

Wang, F., Vihma, V., Soronen, J., Turpeinen, U., Hämäläinen, E. K., Savolainen-Peltonen, H. M., Mikkola, T. S., Naukkarinen, J., Pietiläinen, K. H., Jauhiainen, M., et al. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2605 · Cited by 48 · see citing works

Negative Impact of Testosterone Deficiency and 5α-Reductase Inhibitors Therapy on Metabolic and Sexual Function in Men

Traish, A. M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-70178-3_22 · Cited by 49 · see citing works

Dehydroepiandrosterone reduces preadipocyte proliferation via androgen receptor

Fujioka, K., Kajita, K., Wu, Z., Hanamoto, T., Ikeda, T., Mori, I., Okada, H., Yamauchi, M., Uno, Y., Morita, H., et al. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00112.2011 · Cited by 43 · see citing works

Sex differences on adipose tissue remodeling: from molecular mechanisms to therapeutic interventions

Moreira‐Pais, A., Ferreira, R. M., Neves, J. S., Vitorino, R. M. P., Moreira‐Gonçalves, D., & Nogueira‐Ferreira, R. (2020) · Journal of Molecular Medicine · doi:10.1007/s00109-020-01890-2 · Cited by 50 · see citing works

Sex‐ and age‐specific associations between cardiometabolic risk and white matter brain age in the UK Biobank cohort

Subramaniapillai, S., Suri, S., Barth, C., Maximov, I. I., Voldsbekk, I., van der Meer, D., Gurholt, T. P., Beck, D., Draganski, B., Andreassen, O. A., et al. (2022) · Human Brain Mapping · doi:10.1002/hbm.25882 · Cited by 40 · see citing works

Androgens, body fat Distribution and Adipogenesis

Zerradi, M., Dereumetz, J., Boulet, M., & Tchernof, A. (2014) · Current Obesity Reports · doi:10.1007/s13679-014-0119-6 · Cited by 41 · see citing works

The Potential Impact of Metabolic Syndrome on Erectile Dysfunction in Aging Taiwanese Males

Lee, Y., Liu, C., Huang, C., Li, W., Wu, W., Yeh, H., Wang, C., Huang, C., & Huang, S. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01852.x · Cited by 40 · see citing works

A Possible Relationship Between Testosterone and Lower Urinary Tract Symptoms in Men

Chang, I. H., Oh, S., & Kim, S. C. (2009) · The Journal of Urology · doi:10.1016/j.juro.2009.02.123 · Cited by 41 · see citing works

In vitro tissue-engineered adipose constructs for modeling disease

Murphy, C. S., Liaw, L., & Reagan, M. R. (2019) · BMC Biomedical Engineering · doi:10.1186/s42490-019-0027-7 · Cited by 40 · see citing works

Glucocorticoid-induced androgen inactivation by aldo-keto reductase 1C2 promotes adipogenesis in human preadipocytes

Veilleux, A., Côté, J.-A., Blouin, K., Nadeau, M., Pelletier, M., Marceau, P., Laberge, P. Y., Luu-The, V., & Tchernof, A. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00069.2011 · Cited by 39 · see citing works

Differential Proinflammatory and Oxidative Stress Response and Vulnerability to Metabolic Syndrome in Habitual High-Fat Young Male Consumers Putatively Predisposed by Their Genetic Background

González‐Muniesa, P., Marrades, M. P., Martínez, J. A., & Moreno-Aliaga, M. J. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140917238 · Cited by 37 · see citing works

Regulation of human aldoketoreductase 1C3 (AKR1C3) gene expression in the adipose tissue

Svensson, P., Gabrielsson, B. G., Jernås, M., Gummesson, A., & Sjöholm, K. (2008) · Cellular & Molecular Biology Letters · doi:10.2478/s11658-008-0025-6 · Cited by 37 · see citing works

Changes of metabolic profile in men treated for androgenetic alopecia with 1 mg finasteride

Dušková, M., Hill, M., & Stárka, L. (2010) · Endocrine Regulations · doi:10.4149/endo_2010_01_3 · Cited by 33 · see citing works

Testosterone Deficiency and Risk Factors in the Metabolic Syndrome: Implications for Erectile Dysfunction

Guay, A. T., & Traish, A. M. (2011) · Urologic Clinics of North America · doi:10.1016/j.ucl.2011.02.004 · Cited by 32 · see citing works

Targeting human glutathione transferase A3-3 attenuates progesterone production in human steroidogenic cells

Raffalli‐Mathieu, F., Orre, C., Stridsberg, M., Edalat, M., & Mannervik, B. (2008) · Biochemical Journal · doi:10.1042/bj20080397 · Cited by 28 · see citing works

Metabolism of sex steroids is influenced by acquired adiposity-A study of young adult male monozygotic twin pairs

Vihma, V., Naukkarinen, J., Turpeinen, U., Hämäläinen, E., Kaprio, J., Rissanen, A., Heinonen, S., Hakkarainen, A., Lundbom, J., Lundbom, N., et al. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2017.06.007 · Cited by 27 · see citing works

Androgens and the Regulation of Adiposity and Body Fat Distribution in Humans

Tchernof, A., Brochu, D., Maltais‐Payette, I., Mansour, M. F., Marchand, G. B., Carreau, A., & Kapeluto, J. (2018) · Comprehensive physiology · doi:10.1002/j.2040-4603.2018.tb00043.x · Cited by 27 · see citing works

Human 3α-hydroxysteroid dehydrogenase type 3: structural clues of 5α-DHT reverse binding and enzyme down-regulation decreasing MCF7 cell growth

Zhang, B., Hu, X., Wang, X., Thériault, J.-F., Zhu, D., Shang, P., Labrie, F., & Lin, S. (2016) · Biochemical Journal · doi:10.1042/bcj20160083 · Cited by 25 · see citing works

Overview of human 20 alpha-hydroxysteroid dehydrogenase (AKR1C1): Functions, regulation, and structural insights of inhibitors

Chu, X., He, S., Liu, Y., Liu, Y., Feng, F., Guo, Q., Zhao, L., & Sun, H. (2021) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2021.109746 · Cited by 26 · see citing works

The Role of Non-Aromatizable Testosterone Metabolite in Metabolic Pathways

Dušková, M., & Pospíšilová, H. (2011) · Physiological Research · doi:10.33549/physiolres.932080 · Cited by 25 · see citing works

Testosterone is sequestered in dysfunctional adipose tissue, modifying androgen-responsive genes

Nisio, A. D., Šabović, I., Toni, L. D., Rocca, M. S., Dall’Acqua, S., Azzena, B., Ponce, M. D. R., & Foresta, C. (2020) · International Journal of Obesity · doi:10.1038/s41366-020-0568-9 · Cited by 24 · see citing works

Steroid hormones interrelationships in the metabolic syndrome: An introduction to the ponderostat hypothesis

Alemany, M. (2012) · HORMONES · doi:10.14310/horm.2002.1356 · Cited by 20 · see citing works

Sex Differences in Body Fat Distribution

Veilleux, A., & Tchernof, A. (2011) · Springer eBooks · doi:10.1007/978-1-4614-0965-6_5 · Cited by 17 · see citing works

Adipose organ dysfunction and type 2 diabetes: Role of nitric oxide

Bahadoran, Z., Mirmiran, P., & Ghasemi, A. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116043 · Cited by 17 · see citing works

Lower Likelihood of Having Moderate-to-severe Lower Urinary Tract Symptoms in Middle-aged Healthy Korean Men With Metabolic Syndrome

Kim, J. H., Doo, S. W., Yun, J. H., & Yang, W. J. (2014) · Urology · doi:10.1016/j.urology.2014.05.019 · Cited by 17 · see citing works

Metabolic Syndrome, Adipokines and Hormonal Factors in Pharmacologically Untreated Adult Elderly Subjects from the Brisighella Heart Study Historical Cohort

Cicero, A. F. G., Magni, P., Morè, M., Ruscica, M., Borghi, C., & Strollo, F. (2012) · Obesity Facts · doi:10.1159/000339575 · Cited by 17 · see citing works

Sex Differences in Body Fat Distribution

Mansour, M. F., Chan, C.-W. J., Laforest, S., Veilleux, A., & Tchernof, A. (2017) · Springer eBooks · doi:10.1007/978-3-319-52031-5_8 · Cited by 16 · see citing works

Adipokines and Sexual Hormones Associated with the Components of the Metabolic Syndrome in Pharmacologically Untreated Subjects: Data from the Brisighella Heart Study

Cicero, A. F. G., Magni, P., Morè, M., Ruscica, M., Dozio, E., Steffani, L., Borghi, C., & Strollo, F. (2011) · International Journal of Endocrinology · doi:10.1155/2011/724816 · Cited by 16 · see citing works

Rapid Comparison of Metabolites in Humans and Rats of Different Sexes Using Untargeted Ultraperformance Liquid Chromatography Coupled to Time-of-Flight Mass Spectrometry and an in-house Software Platform

Liang, Q., Wang-yan-jun, X., Hong, Q., Yang, C. X. L., Ma, Z.-C., Wang, Y., Tan, H.-L., Tang, X., & Gao, Y. (2015) · European Journal of Mass Spectrometry · doi:10.1255/ejms.1395 · Cited by 16 · see citing works

Characteristics of polycystic ovary syndrome rat models induced by letrozole, testosterone propionate and high-fat diets

Hu, R., Huang, Y., Liu, Z., Dong, H., Ma, W., Song, K., Xu, X., Wu, X. W., Geng, Y., Li, F., et al. (2024) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2024.104296 · Cited by 14 · see citing works

Effects of time-restricted feeding (TRF)-model of intermittent fasting on adipose organ: a narrative review

Bahadoran, Z., Mirmiran, P., Kashfi, K., & Ghasemi, A. (2024) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/s40519-024-01709-w · Cited by 13 · see citing works

The relationship between remnant cholesterol and the risk of testosterone deficiency in US adults: a cross-sectional study based on the NHANES database

Mei, Y., Chen, Y., Wang, X., Xu, R., & Feng, X. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1458193 · Cited by 13 · see citing works

Hemiscrotal agenesis: Pathogenesis and management strategies

Nishio, H., Mizuno, K., Moritoki, Y., Kamisawa, H., Naiki, T., Kurokawa, S., Nakane, A., Okada, A., Yasui, T., & Hayashi, Y. (2016) · International Journal of Urology · doi:10.1111/iju.13079 · Cited by 13 · see citing works

Mechanisms of androgenic action in adipose tissue

Veilleux, A., & Blouin, K. (2009) · Clinical Lipidology · doi:10.2217/clp.09.16 · Cited by 10 · see citing works

The impact of metabolic syndrome on the responsiveness to α1-blocker in men with BPH/LUTS

Lee, Y.-C., Liu, C., Juan, Y., Wu, W., Li, W., Yeh, H., Wang, C.-J., Huang, C., Huang, C.-H., & Huang, S.-P. (2013) · International Journal of Clinical Practice · doi:10.1111/ijcp.12086 · Cited by 10 · see citing works

Sex Differences in Energy Balance, Body Composition, and Body Fat Distribution

Tchernof, A. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-250-6_1 · Cited by 10 · see citing works

The differences between aromatizable and non-aromatizable androgens in relation to body composition and metabolic syndrome risk factors in men

Pospíšilová, H., Vaňková, M., Hill, M., Meloun, M., Bendlová, B., Dušková, M., & Stárka, L. (2012) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2012.02.005 · Cited by 10 · see citing works

Changes of BMI, steroid metabolome and psychopathology in patients with anorexia nervosa during hospitalization

Bulant, J., Hill, M., Velíková, M., Yamamotová, A., Pavel Martasek, E., & Papežová, H. (2019) · Steroids · doi:10.1016/j.steroids.2019.108523 · Cited by 9 · see citing works

Adipose tissue and androgens: the ins and outs

Jia, Y., Lacombe, M., Muller, C., & Milhas, D. (2025) · Adipocyte · doi:10.1080/21623945.2025.2508885 · Cited by 10 · see citing works

Gonadal function in young adult males with metabolic syndrome

Choudhury, B. K., Choudhury, S. D., Saikia, U. K., & Sarma, D. (2013) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2013.06.013 · Cited by 8 · see citing works

The role of adipose tissue in puberty and reproductive health

Ning, X., Huang, Q. B., Guo, D., Zhou, Y., Li, Y., & Li, X. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1543787 · Cited by 6 · see citing works

Dynamics of Body Composition in Male Patients during Chronic Obstructive Pulmonary Disease (COPD) Development

Makarevich, A. E., & Lemiasheuskaya, S. (2015) · Advances in respiratory medicine · doi:10.5603/piap.2015.0070 · Cited by 6 · see citing works

Anatomy of the Prepuce

Fahmy, M. (2020) · Springer eBooks · doi:10.1007/978-3-030-37621-5_5 · Cited by 5 · see citing works

Effects of testosterone deficiency and therapy on the cardiometabolic syndrome in men

Saad, F., & Traish, A. M. (2025) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2025.08.004 · Cited by 2 · see citing works

From testosterone to 11-oxygenated androgens: Integrating endocrine biology, nutrition, and systemic health across the lifespan

Xu, H., Zhang, H., Yang, R., Xie, X., Cao, Z., Zhao, Y. (., Lin, H., Lu, D., Bischoff, F. Z., Zhang, X., et al. (2026) · The Innovation Nutrition · doi:10.59717/j.xinn-nutri.2026.100004 · Cited by 2 · see citing works

Association Between Acne Vulgaris and Body Mass Index in Adult Population: A Tertiary Hospital-Based Retrospective Study in Riyadh, Saudi Arabia

Alowairdhi, Y. A., Alrasheed, F., Alghubaywi, F. A., Alqirnas, M. Q., & Alajroush, W. (2022) · Cureus · doi:10.7759/cureus.32867 · Cited by 2 · see citing works

Testosterone Deficiency Linked to Lower Urinary Tract Symptoms

Chul, S. H. (2012) · InTech eBooks · doi:10.5772/25618 · Cited by 1 · see citing works

Role of Testosterone Replacement Therapy on Plasma Ghrelin Level before and after Orchiectomy in Male Albino Rats

Elsawy, S. A., & Hashish, A. (2008) · Bulletin of Egyptian Society for Physiological Sciences · doi:10.21608/besps.2008.36953 · Cited by 1 · see citing works

Radioactive Tracing of Testosterone Reveals Minimal Formation of 5α-DHT in SGBS Cells and Human Primary Adipocytes

Huacachino, A. A., Marques, C. F., Mesaros, C., & Penning, T. M. (2025) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaf087 · Cited by 1 · see citing works

Scrotal Maldevelopment Anomalies

Fahmy, M. (2021) · Springer eBooks · doi:10.1007/978-3-030-83305-3_11 · Cited by 1 · see citing works

Sex steroid metabolism and body composition

Swanson, C. (2009) · Gothenburg University Publications Electronic Archive (Gothenburg University)

Structure and biological function of human 3-alpha hydroxysteroid dehydrogenase type 3 in breast cancer

Zhang, B. (2014) · Corpus Université Laval (Université Laval)

and onset of obesity

Roberge, C., Carpentier, A. C., Langlois, M., Baillargeon, J., Ardilouze, J., & Gallo‐Payet, N. (2007)

Unravelling the link between insulin resistance and androgen excess

O’Reilly, M. (2015) · University of Birmingham Institutional Research Archive (University of Birmingham)

Testosterone and Risk Factors in the Metabolic Syndrome: Implications for Erectile Dysfunction

Guay, A. T., & Traish, A. M. (2011)

Characterization of GSTA3 Gene Products in Multiple Species and Demonstration of their Conservation in Divergent Species

Peer, S. M. (2015) · OakTrust (Texas A&M University Libraries)

Defining Your Shape

Denton, N. (2021) · doi:10.1093/med/9780198865278.003.0007

Morphology and Anthropometric Measurements of Scrotum

Fahmy, M., & Springer, A. (2021) · Springer eBooks · doi:10.1007/978-3-030-83305-3_9

Sources of steroid hormones

Honour, J. W. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-818124-9.00009-7

Association between cardiometabolic index and risk of testosterone deficiency in adult men: a cross-sectional study

Mei, Y., Zhang, B., Wang, X., Xu, R., Xia, W., Chen, Y., & Feng, X. (2025) · BMC Public Health · doi:10.1186/s12889-024-21230-0

Scrotal Maldevelopment Anomalies (Agenesis and Hypoplasia)

Fahmy, M. (2026) · Springer eBooks · doi:10.1007/978-3-032-23855-9_10

Bioactivation and physiological role of steroid fatty acyl esters in adipose tissue

Wang, F. (2013) · Työväentutkimus Vuosikirja

Local Androgen Inactivation in Abdominal Visceral Adipose Tissue

Blouin, K., Richard, C., Bélanger, C., Dupont, P., Daris, M., Laberge, P. Y., Luu-The, V., & Tchernof, A. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030535 · Cited by 59 · see citing works

Androgen metabolism in adipose tissue: Recent advances

Blouin, K., Veilleux, A., Luu-The, V., & Tchernof, A. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.10.035 · Cited by 149 · see citing works

0021-972X/03/$15.00/0 The Journal of Clinical Endocrinology & Metabolism 88(12):5944–5950 Printed in U.S.A. Copyright © 2003 by The Endocrine Society doi: 10.1210/jc.2003-030535 Local Androgen Inactivation in Abdominal Visceral Adipose Tissue

Daris, M., Laberge, P., Luu-the, V., & Tchernof, A. (2013)

Pathways of adipose tissue androgen metabolism in women: depot differences and modulation by adipogenesis

Blouin, K., Nadeau, M., Mailloux, J. R., Daris, M., Lebel, S., Luu-The, V., & Tchernof, A. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00039.2008 · Cited by 92 · see citing works

Glucocorticoid-induced androgen inactivation by aldo-keto reductase 1C2 promotes adipogenesis in human preadipocytes

Veilleux, A., Côté, J.-A., Blouin, K., Nadeau, M., Pelletier, M., Marceau, P., Laberge, P. Y., Luu-The, V., & Tchernof, A. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00069.2011 · Cited by 39 · see citing works