The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
HMGB1 Contributes to Kidney Ischemia Reperfusion Injury
Open accessAbstract
High-mobility group box 1 (HMGB1), a nuclear factor released extracellularly as an inflammatory cytokine, is an endogenous ligand for Toll-like receptor 4 (TLR4). TLR4 activation mediates kidney ischemia-reperfusion injury (IRI), but whether HMGB1 contributes to IRI is unknown. Here, treating wild-type mice with neutralizing anti-HMGB1 antibody protected them against kidney IRI, evidenced by lower serum creatinine and less tubular damage than untreated mice. Mice treated with anti-HMGB1 had significantly less tubulointerstitial infiltration by neutrophils (day 1) and macrophages (day 5) and markedly reduced apoptosis of tubular epithelial cells. Furthermore, anti-HMGB1 antibody-treated IRI kidneys had significantly lower levels of IL-6, TNFα, and monocyte chemoattractant protein 1 (MCP1). mRNA, which are downstream of HMGB1. Conversely, administration of rHMGB1 after reperfusion exacerbated kidney IRI in wild-type mice. TLR4 deficient (TLR4(-/-)) mice were protected against kidney IRI; administration of neither anti-HMGB1 antibody nor rHMGB1 affected this renoprotection. In conclusion, endogenous HMGB1 promotes kidney damage after IRI, possibly through the TLR4 pathway. Administration of a neutralizing antibody to HMGB1 either before or soon after ischemia-reperfusion affords significant protection, suggesting therapeutic potential for acute kidney injury.
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Kang, R., Chen, R., Zhang, Q., Hou, W., Wu, S., Cao, L., Huang, J., Yu, Y., Fan, X.-G., Yan, Z., et al. (2014) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2014.05.001 · Cited by 956
Metadata
- Authors
- Wu, H., Ma, J., Wang, P., Corpuz, T. M., Panchapakesan, U., Wyburn, K. R., & Chadban, S. J.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2010-11
- Volume
- 21
- Issue
- 11
- Pages
- 1878-1890
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2140655321
- Cited by
- 358
- References
- 47
- FWCI
- 14.35
- Type
- journal article
- Language
- en
- Open access
- green
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- Wu, H., Ma, J., Wang, P., Corpuz, T. M., Panchapakesan, U., Wyburn, K. R., & Chadban, S. J. (2010). HMGB1 Contributes to Kidney Ischemia Reperfusion Injury. Journal of the American Society of Nephrology. https://doi.org/10.1681/asn.2009101048
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