Pilot safety and feasibility study of treadmill aerobic exercise in Parkinson disease with gait impairment
Abstract
This pilot study evaluated the safety and feasibility of a 3-month progressive treadmill aerobic exercise (TM-AEX) program for persons with Parkinson disease with gait impairment. Eight subjects underwent a treadmill stress test to determine eligibility. Of these subjects, three were referred for further cardiac evaluation and five were enrolled. In 136 TM-AEX sessions, 11 falls or near falls and 9 episodes (8 asymptomatic) of systolic blood pressure drops >20 mmHg occurred. Harness supports prevented injury from falls. TM-AEX significantly improved the subjects' total Unified Parkinson's Disease Rating Scale scores and peak ambulatory workload capacities. This study suggests that an aerobic exercise program is feasible for persons who have Parkinson disease with gait impairment; however, precautions must be taken to prevent falls. Systolic blood pressure instability during exercise points to the need for autonomic dysfunction monitoring. Our data indicate that TM-AEX may reduce symptom severity and improve fitness. Further studies are needed for a better understanding of the risks and benefits of TM-AEX in this population.
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Differences in amount of feedback and cognitive engagement during practice may explain discrepant gait outcomes among treadmill studies.
“One possible explanation for this discrepancy in gait outcomes may be due to differences in the amount of feedback and cognitive engagement during practice 26, 27.”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [27]
A few treadmill studies have shown no significant improvement in gait capacity despite similar practice.
“While the majority of treadmill studies have reported these benefits, a few studies have shown that despite a similar period of practice, no significant improvement in gait capacity occurred.”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [27]
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- Authors
- Skidmore, F. M.
- Affiliations
- Veterans Health Administration (US)
- Corresponding author
- Skidmore, Frank M.
- Venue
- The Journal of Rehabilitation Research and Development
- Published
- 2008-12-01
- Volume
- 45
- Issue
- 1
- Pages
- 117-124
- ISSN
- 0742-3241 (ISSN-L)
- 0748-7711
- OpenAlex
- W2127034601
- Cited by
- 60
- References
- 23
- Citations by year
- 2024: 3 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 3 · 2018: 5 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 7 · 2013: 8 · 2012: 6
- FWCI
- 11.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Rehabilitation Research and Development (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (P60AG012583)
- Topics
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Keywords
- Parkinson's disease, gait disturbance, exercise safety, exercise feasibility, falls, orthostatic hypotension, autonomic dysfunction, Unified Parkinson's Disease Rating Scale, exercise therapy
- MeSH terms
- Accidental Falls, Aged, Postural Balance, Exercise Test, Exercise Therapy, Feasibility Studies, Female, Humans, Male, Middle Aged, Parkinson Disease, Pilot Projects, Exercise, Treatment Outcome, Statistics, Nonparametric, Gait Disorders, Neurologic
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