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Cited by 4Neuroendocrine regulation and behaviorStress Responses and CortisolNeuropeptides and Animal Physiology

Anti-stress Effect of Hypothalamic Oxytocin, Importance of Somatosensory Stimulation and Social Buffering: Takahashi T et al. Oxytocin and stress

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Takahashi, Toku, Department of Surgery, Medical College of Wisconsin, and Clement J Zablocki VA Medical Center, Milwaukee, Wisconsin, the United States, Babygirija, Reji, Ludwig, Kirk·2015·International Journal of Neurology Research
DOI 10.17554/j.issn.2313-5611.2015.01.18
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Abstract

A growing body of evidence suggests that stress stimuli, both acute and chronic, promote different physiological mechanisms and neuroendocrine responses. Oxytocin (OXT) is mainly synthesized in the paraventricular nucleus (PVN) and supraoptic nucleus (SON) of the hypothalamus. Central OXT has an anxiolytic effect and attenuates the hypothalamic–pituitary–adrenal (HPA) axis in response to stress. Anti-stress effect of OXT has been explained by its inhibitory effect on corticotropin releasing factor (CRF) expression at the PVN via GABA A receptors. Repeated experience with the same stressor produces habituation, or diminution of behavioral responses and HPA axis responses. Up-regulated OXT expression in the PVN is involved in mediating habituation in response to chronic homotypic stress in rats. In contrast to chronic homotypic stress, no habituation is observed when rats are singly housed and received different types of stressors for 7 days (chronic heterotypic stress). Increased CRF expression and reduced OXT expression at the PVN are observed following chronic heterotypic stress in singly housed rats. Thus, it is conceivable that stress responses to chronic heterotypic stress would be diminished if endogenous OXT expression is upregulated. Various manual therapies such as massage, acupuncture and transcutaneous electrical nerve stimulation (TENS) involve the stimulation of somatosensory neurons. OXT system is activated by manual therapies. TENS increases OXT expression and decreases CRF expression at the PVN following chronic heterotypic stress in singly housed rats. OXT has been implicated in a number of social behaviors, including maternal care, affiliation and social attachment. Social attachment is known to stimulate OXT release in the hypothalamus in rats. A recent study demonstrates an increased OXT expression following chronic heterotypic stress when rats are pair-housed. Somatosensory stimulation is a promising treatment for stress-associated diseases. A social interaction is also important to adapt to our daily life stress.

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  • Activation of CT fibers and other nerves from skin, as well as auditory, visual, and olfactory stimuli, contributes to oxytocin release during social interaction between humans.

    “Activation of the CT fibers and also of other types of nerves originating in the skin as well as auditory, visual, and olfactory stimuli contributes to the release of oxytocin induced as a consequence of social interaction between humans (Takahashi et al., 2015).”

    From The Oxytocinergic System as a Mediator of Anti-stress and Instorative Effects Induced by Nature: The Calm and Connection Theory (2021) · cites this paper as Takahashi et al., 2015

    Section 2-3 (page not provided) says daily social interaction activates the oxytocin-release system in males and females, and discusses somatosensory stimulation increasing oxytocin in rats. The paper does not identify CT fibers or say that auditory, visual, and olfactory stimuli contribute to oxytocin release during human social interaction. (LLM, conf=0.87)

    Experimental — accuracy not yet measured

  • Oxytocin increases sensitivity to touch, and infusions of oxytocin increase touch-induced oxytocin release.

    “Oxytocin also increases the sensitivity to touch, and infusions of oxytocin have been shown to increase touch induced oxytocin release (Velandia, 2012), during positive interaction and thereby to the oxytocin mediated effects (Takahashi et al., 2015).”

    From The Oxytocinergic System as a Mediator of Anti-stress and Instorative Effects Induced by Nature: The Calm and Connection Theory (2021) · cites this paper as Takahashi et al., 2015

  • Oxytocin is released during social interaction between humans.

    “Oxytocin is released during social interaction between humans.”

    From The Oxytocinergic System as a Mediator of Anti-stress and Instorative Effects Induced by Nature: The Calm and Connection Theory (2021) · cites this paper as Takahashi et al., 2015

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1 of the 50 references couldn’t be matched to a known paper.

Research works printed but not linked: 4

  1. Camilleri M. Review article: tegaserod. Aliment Pharmacol Ther 2001;15:277-89.
  2. Hendelman W, Humphreys P, Skinner C. The integrated nervous sytem. CRC press 2010.
  3. Uvnas-Moberg K, Petersson M. Oxytocin, a mediator of anti- stress, well-being, social interaction, growth and healing. Z Psy- chosom Med Psychother 2005;51:57-80.
  4. Peer reviewer: Janney Sun, Editor-In-Chief, International Journal of Neurology Research, UNIT E, A1, 7/F, Cheuk Nang Plaza, 250

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Authors
Takahashi, T., Department of Surgery, M. C. O. W., Babygirija, R., & Ludwig, K.
Affiliations
Medical College of Wisconsin (US)
ORCID
Babygirija, Reji
Venue
International Journal of Neurology Research
Publisher
ACT Publishing Group
Published
2015
Volume
1
Issue
3
Pages
96-101
ISSN
2313-5611 (ISSN-L)
DOI
10.17554/j.issn.2313-5611.2015.01.18
OpenAlex
W1897251293
Cited by
4
References
50
Citations by year
2022: 1 · 2021: 1 · 2020: 1 · 2019: 1
FWCI
0.00
Type
journal article
Language
en
Open access
Locations
International Journal of Neurology Research (publishedVersion)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
oxytocin, hypothalamus, stress, hypothalamic-pituitary-adrenal axis, corticotropin-releasing factor, paraventricular nucleus, supraoptic nucleus, habituation, somatosensory stimulation, transcutaneous electrical nerve stimulation, massage, acupuncture, social buffering, social attachment, anxiolytic effects

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