The inverted CD4:CD8 ratio is associated with gender-related changes in oxidative stress during aging
Open accessAbstract
Aging has been associated with increased generation of free radicals as well as immunosenescence. Previous studies have identified older individuals with inverted T CD4:CD8 cell ratio and increased immunity to cytomegalovirus (CMV). Here, we investigated markers of oxidative stress and antioxidant defences in older individuals with inverted CD4:CD8 T-cell ratio. Sixty-one subjects were identified with inverted CD4:CD8 ratio. Older individuals with a CD4:CD8 ratio <1 had increased levels of plasma advanced oxidation protein products (AOPP) and ferric reducing ability of plasma (FRAP), but reduced levels of thiobarbituric acid reactive substances (TBARS) as compared to subjects with normal CD4:CD8 ratio. The CMV IgG serology was negatively correlated with CD4:CD8 ratio. These markers were more evident among elderly men than women. Our data suggest a close relationship between chronic CMV infection and oxidative profile in older individuals in the midst of its influence on the peripheral T-cell subsets.
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Individuals over the age of 60 years with a CD4:CD8 ratio <1.0 exhibit high levels of plasma advanced oxidation products and high plasma antioxidant capacity, indicative of a compensatory 'antioxidant response' to oxidative stress.
“For example, it has been shown that individuals over the age of 60 years, with a CD4:CD8 ratio <1.0, exhibit high levels of plasma advanced oxidation products, and high plasma antioxidant capacity—indicative of a compensatory “antioxidant response” to oxidative stress (Muller et al. 2015).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Muller et al. 2015
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Molecular Markers of Blood Cell Populations Can Help Estimate Aging of the Immune System
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CD4/CD8 ratio, comorbidities, and aging in treated HIV infected individuals on viral suppression
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Nutrition as a Tool to Reverse Immunosenescence?
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The Aging Features of Thyrotoxicosis Mice: Malnutrition, Immunosenescence and Lipotoxicity
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Effect of proanthocyanidins on cognitive improvement in thyroxin-induced aging mice
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Healthy Ageing Reflected in Innate and Adaptive Immune Parameters
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Gender Features of Radical Oxidation of Lipids in Menopausal Women and Men in Andropause
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Sex as a confounding factor in the effects of ageing on rat lymph node t cell compartment
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The Role of Soluble Costimulatory Molecules as the Biomarkers for Aging Predictors
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Activation of T‐cell proliferation by Enseki sandbath
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Self-citationEnseki Far-Infrared Sandbath: Its Basic and Future Therapeutic Possibilities
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Immunosenescence of Lymphocytes T and Implications for Age-Related DisordersPreprint
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Microglia Mediated Neuroinflammation: A Silent Contributor to Alzheimer’s DiseasePreprint
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Phytosterols content of Keunnunjami germ and its antioxidative effects in adult rats
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The immunosenescence and lipotoxicity in thyrotoxicosis micePreprint
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Ageing of long-term allogeneic hematopoietic cells recipients compared to their donorsPreprint
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Immunological Insights of Bat Coexistence with Viruses and beyond: A Holistic Review
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Impact of proliferative stress on both adaptive and innate immune response
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- Authors
- Muller, G. C., Gottlieb, M. G. V., Luz Correa, B., Filho, I. G., Moresco, R. N., & Bauer, M. E.
- Affiliations
- Pontifícia Universidade Católica do Rio Grande do Sul (BR)
- Universidade Federal de Santa Maria (BR)
- Venue
- Cellular Immunology
- Publisher
- Elsevier BV
- Published
- 2015-08
- Volume
- 296
- Issue
- 2
- Pages
- 149-154
- ISSN
- 0008-8749 (ISSN-L)
- OpenAlex
- W382993912
- Cited by
- 55
- References
- 71
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 4 · 2023: 7 · 2022: 8 · 2021: 4 · 2020: 10 · 2019: 4 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 1
- FWCI
- 2.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cellular Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- FAPERGS
- CNPq
- CAPES (2785/09-9)
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Keywords
- oxidative stress, aging, immunosenescence, cytomegalovirus infection, advanced oxidation protein products, ferric reducing ability of plasma, lipid peroxidation, sex differences, T cell subsets, antioxidant defense, free radicals
- MeSH terms
- Aged, Aged, 80 and over, Aging, Antibodies, Viral, C-Reactive Protein, Cytomegalovirus Infections, Cytomegalovirus, Female, Humans, Male, Middle Aged, Sex Factors, CD4-Positive T-Lymphocytes, Interleukin-6, Immunophenotyping, T-Lymphocyte Subsets, CD4-CD8 Ratio, Glycation End Products, Advanced, Thiobarbituric Acid Reactive Substances, Oxidative Stress, CD8-Positive T-Lymphocytes
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