Cited by 55Antioxidant Activity and Oxidative StressExercise and Physiological ResponsesCytomegalovirus and herpesvirus research

The inverted CD4:CD8 ratio is associated with gender-related changes in oxidative stress during aging

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Muller, Guilherme Cerutti, Gottlieb, Maria Gabriela Valle, Luz Correa, Bruna, Filho, Irênio Gomes, Moresco, Rafael Noal, Bauer, Moisés Evandro·2015·Cellular Immunology

Abstract

Aging has been associated with increased generation of free radicals as well as immunosenescence. Previous studies have identified older individuals with inverted T CD4:CD8 cell ratio and increased immunity to cytomegalovirus (CMV). Here, we investigated markers of oxidative stress and antioxidant defences in older individuals with inverted CD4:CD8 T-cell ratio. Sixty-one subjects were identified with inverted CD4:CD8 ratio. Older individuals with a CD4:CD8 ratio <1 had increased levels of plasma advanced oxidation protein products (AOPP) and ferric reducing ability of plasma (FRAP), but reduced levels of thiobarbituric acid reactive substances (TBARS) as compared to subjects with normal CD4:CD8 ratio. The CMV IgG serology was negatively correlated with CD4:CD8 ratio. These markers were more evident among elderly men than women. Our data suggest a close relationship between chronic CMV infection and oxidative profile in older individuals in the midst of its influence on the peripheral T-cell subsets.

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Crossref · 10.1016/j.cellimm.2015.05.006

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  • Individuals over the age of 60 years with a CD4:CD8 ratio <1.0 exhibit high levels of plasma advanced oxidation products and high plasma antioxidant capacity, indicative of a compensatory 'antioxidant response' to oxidative stress.

    “For example, it has been shown that individuals over the age of 60 years, with a CD4:CD8 ratio <1.0, exhibit high levels of plasma advanced oxidation products, and high plasma antioxidant capacity—indicative of a compensatory “antioxidant response” to oxidative stress (Muller et al. 2015).”

    From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Muller et al. 2015

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Authors
Muller, G. C., Gottlieb, M. G. V., Luz Correa, B., Filho, I. G., Moresco, R. N., & Bauer, M. E.
Affiliations
  • Pontifícia Universidade Católica do Rio Grande do Sul (BR)
  • Universidade Federal de Santa Maria (BR)
Venue
Cellular Immunology
Publisher
Elsevier BV
Published
2015-08
Volume
296
Issue
2
Pages
149-154
ISSN
0008-8749 (ISSN-L)
OpenAlex
W382993912
Cited by
55
References
71
Citations by year
2026: 5 · 2025: 2 · 2024: 4 · 2023: 7 · 2022: 8 · 2021: 4 · 2020: 10 · 2019: 4 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 1
FWCI
2.51
Type
journal article
Language
en
Open access
Locations
  • Cellular Immunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • FAPERGS
  • CNPq
  • CAPES (2785/09-9)
Topics
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
Keywords
oxidative stress, aging, immunosenescence, cytomegalovirus infection, advanced oxidation protein products, ferric reducing ability of plasma, lipid peroxidation, sex differences, T cell subsets, antioxidant defense, free radicals
MeSH terms
Aged, Aged, 80 and over, Aging, Antibodies, Viral, C-Reactive Protein, Cytomegalovirus Infections, Cytomegalovirus, Female, Humans, Male, Middle Aged, Sex Factors, CD4-Positive T-Lymphocytes, Interleukin-6, Immunophenotyping, T-Lymphocyte Subsets, CD4-CD8 Ratio, Glycation End Products, Advanced, Thiobarbituric Acid Reactive Substances, Oxidative Stress, CD8-Positive T-Lymphocytes

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